http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Suyeon Jin ),( Chan Joo Lee ),( Gibbeum Lim ),( Sungha Park ),( Sang-hak Lee ),( Ji Hyung Chung ),( Jaewon Oh ),( Seok-min Kang ) 생화학분자생물학회 2023 BMB Reports Vol.56 No.12
C-reactive protein (CRP) is an inflammatory marker and risk factor for atherosclerosis and cardiovascular diseases. However, the mechanism through which CRP induces myocardial damage remains unclear. This study aimed to determine how CRP damages cardiomyocytes via the change of mitochondrial dynamics and whether survivin, an anti-apoptotic protein, exerts a cardioprotective effect in this process. We treated H9c2 cardiomyocytes with CRP and found increased intracellular ROS production and shortened mitochondrial length. CRP treatment phosphorylated ERK1/2 and promoted increased expression, phosphorylation, and translocation of DRP1, a mitochondrial fission-related protein, from the cytoplasm to the mitochondria. The expression of mitophagy proteins PINK1 and PARK2 was also increased by CRP. YAP, a transcriptional regulator of PINK1 and PARK2, was also increased by CRP. Knockdown of YAP prevented CRP-induced increases in DRP1, PINK1, and PARK2. Furthermore, CRP-induced changes in the expression of DRP1 and increases in YAP, PINK1, and PARK2 were inhibited by ERK1/2 inhibition, suggesting that ERK1/2 signaling is involved in CRP-induced mitochondrial fission. We treated H9c2 cardiomyocytes with a recombinant TAT-survivin protein before CRP treatment, which reduced CRP-induced ROS accumulation and reduced mitochondrial fission. CRP-induced activation of ERK1/2 and increases in the expression and activity of YAP and its downstream mitochondrial proteins were inhibited by TAT-survivin. This study shows that mitochondrial fission occurs during CRPinduced cardiomyocyte damage and that the ERK1/2-YAP axis is involved in this process, and identifies that survivin alters these mechanisms to prevent CRP-induced mitochondrial damage. [BMB Reports 2023; 56(12): 663-668]
Chung, Ji-Yun,Park, Hee Ra,Lee, Su-Jin,Lee, Sun-Hye,Kim, Jin Sik,Jung, Youn-Sang,Hwang, Sang Hyun,Ha, Nam-Chul,Seol, Won-Gi,Lee, Jaewon,Park, Bum-Joon United States and Canadian Academy of Pathology [e 2013 Laboratory investigation Vol.93 No.6
<P>Parkinson's disease (PD) is the second leading neurodegenerative disease, and is known to be induced by environmental factors or genetic mutations. Among the verified genetic mutations of PD, Parkin, isolated from the PARK2 locus, shows an autosomal recessive inheritance pattern and is known to be an E3 ligase. However, the physiological target of Parkin and the molecular mechanism of Parkin-deficiency-induced PD have not been clearly demonstrated until now. It has recently been proposed that inflammation, suggesting as a causal factor for PD, is enhanced by Parkin deficiency. Thus, we examined the relationship between inflammation-related factors and Parkin. Here, we provide the evidence that Parkin suppresses inflammation and cytokine-induced cell death by promoting the proteasomal degradation of TRAF2/6 (TNF-α receptor-associated factor 2/6). Overexpression of Parkin can reduce the half-lives of TRAF2 and TRAF6, whereas si-Parkin can extend them. However, mutant Parkins did not alter the expression of TRAF2/6. Thus, loss of Parkin enhances sensitivity to TNF-α- or IL-1β-induced JNK activation and NF-κB activation. Indeed, si-Parkin-induced apoptosis is suppressed by the knockdown of TRAF6 or TRAF2. We also observed elevated expression levels of TRAF6 and a reduction of IκB in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mouse model. Moreover, elevated expression levels or aggregation of TRAF6 were detected in approximately half of the human PD tissues (7/15 cases) and 2 cases, respectively. In addition, TRAF6 and Parkin expression levels show a reverse relationship in human PD tissues. Our results strongly suggest that the reduction of Parkin or overexpression of TRAF2/6 by chronic inflammation would be the reason for occurrence of PD.</P>
Systematic Risks in the Options Market: Evidence from S&P 500 Index Options
Jaewon Park,Tong S. Kim 한국재무학회 2009 한국재무학회 학술대회 Vol.2009 No.05
The assumption of dynamic replication in no-arbitrage option pricing models does not hold in practice due to discreteness of trading hours as well as trading costs, which suggests the potential presence of preference-driven risk premiums. In this paper, we empirically show that discretely hedged S&P 500 index option portfolios are exposed to covariance and coskewness risk with the market portfolio. Using the three-moment CAPM of Kraus and Litzenberger (1976), we find that the rate of return of the portfolio significantly loads on the two risk factors, and their risk premiums are significantly positive. The equilibrium model complements the prevailing approach of the no-arbitrage framework, and reveals that the volatility smile is linked to investors’ preference on the unhedged market risks.
Park, Jooyeon,Kim, Bokyoung,Han, Jin,Oh, Jaewon,Park, Subeom,Ryu, Seungmi,Jung, Subin,Shin, Jung-Youn,Lee, Beom Seob,Hong, Byung Hee,Choi, Donghoon,Kim, Byung-Soo American Chemical Society 2015 ACS NANO Vol.9 No.5
<P>Mesenchymal stem cell (MSC) implantation has emerged as a potential therapy for myocardial infarction (MI). However, the poor survival of MSCs implanted to treat MI has significantly limited the therapeutic efficacy of this approach. This poor survival is primarily due to reactive oxygen species (ROS) generated in the ischemic myocardium after the restoration of blood flow. ROS primarily causes the death of implanted MSCs by inhibiting the adhesion of the MSCs to extracellular matrices at the lesion site (<I>i.e.</I>, anoikis). In this study, we proposed the use of graphene oxide (GO) flakes to protect the implanted MSCs from ROS-mediated death and thereby improve the therapeutic efficacy of the MSCs. GO can adsorb extracellular matrix (ECM) proteins. The survival of MSCs, which had adhered to ECM protein-adsorbed GO flakes and were subsequently exposed to ROS <I>in vitro</I> or implanted into the ischemia-damaged and reperfused myocardium, significantly exceeded that of unmodified MSCs. Furthermore, the MSC engraftment improved by the adhesion of MSCs to GO flakes prior to implantation enhanced the paracrine secretion from the MSCs following MSC implantation, which in turn promoted cardiac tissue repair and cardiac function restoration. This study demonstrates that GO can effectively improve the engraftment and therapeutic efficacy of MSCs used to repair the injury of ROS-abundant ischemia and reperfusion by protecting implanted cells from anoikis.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-5/nn507149w/production/images/medium/nn-2014-07149w_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn507149w'>ACS Electronic Supporting Info</A></P>
Jaewon Park 한국지역사회간호학회 2023 지역사회간호학회지 Vol.34 No.4
Purpose: This study aims to describe the structure of the experience related to acceptance of illness among people with early-stage dementia (PWED). Methods: Participants were six people who had Alzheimer’s disease or vascular dementia. Their clinical dementia rating scores were 0.5 or 1. Data were collected from individual in-depth interviews. The collected qualitative data were analyzed based on Giorgi’s descriptive phenomenological method. Results: The five constituents and eight sub-constituents were derived from the experience related to acceptance of illness among PWED; ‘Facing the changed me’, ‘Facing changes in roles and relationships with others’, ‘Conflict between recognizing and denying dementia in daily life’, ‘Perceiving the limits and accepting dementia’, and ‘Reconstructing daily life for the prolongation of the current health status’. Conclusion: This study contributes to the expansion of the in-depth understanding of the experience related to acceptance of illness among PWED. The results of the study will be helpful as basic data for community health nurses to develop interventions to improve acceptance of illness of PWED.
The effect of personalized bowel preparation using the smartphone camera application: A pilot study
( Jaewon Jung ),( Jongha Park ),( Seunghyun Park ),( Ju Won Lee ),( Jonghwa Park ),( Gi Jung Jeon ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: Despite several attempts to improve the bowel preparation quality, they were not enough improved patients’ satisfaction and compliance during bowel preparation for colonoscopy. We aimed to investigate the effectiveness of the smartphone application which analyze and judge the optimal dosage of polyethylene glycol (PEG) for bowel preparation. Design: This prospective randomized controlled trial was investigator-blinded. Patients were assigned to usethe smartphone camera application (app group, n=30) for bowel preparation or just received the written instructions (non-app group, n=30). The app group used the smartphone camera application which was programmed to judge the bowel preparation quality automatically from the bowel preparation status. Application let them stop taking more PEG solution if their bowel preparation was appropriate as “pass or fail”. In contrast the non-app group took 4 liters of PEG solution as the provided manual. Results: The primary outcome was the quality of bowel preparation based on blinded ratings by the Ottawa bowel preparation scale (OBPS). The secondary outcomes were the difference of dosage of PEG between two groups and the acceptability of the camera application in the app group. The primary outcome showed no statistically significant difference of OBPS total score between the two groups (mean OBPS 2.53 ±1.264 vs. 2.79 ± 2.064, p=0.950). The secondary outcomes revealed that the app group took lower dose of PEG than non-app group (mean dosage (mL): 3713.16 ± 405.81 vs. 3979.17 ±102.06, p=0.001). The acceptability of the camera application showed good response in the app group (5-point Likert scale; 1=not acceptable, 5=very acceptable; mean score 4.37± 0.895, p<0.001). Conclusions: Although taking lower dose PEG, the bowel preparation using the smartphone camera application showed the similar quality of bowel preparation compared to conventional preparation group. Moreover, personalized bowel preparation using the smartphone camera application enhanced compliance of bowel preparation and patients’ satisfaction.