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주요 우울장애가 동반된 혈액 종양 환자에서 Paroxetine의 효과 및 안정성
배치운,이혁재,김정진,이창욱,이수정,이철,백인호 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.4
Objectives : The efficacy and safety of paroxetine in the treatment of depressive disorders are well known, however its efficacy and safety for the treatment of depression in patients with cancer has been poorly studied. This study therefore aimed to evaluate the efficacy and safety of paroxetine in treatment of depressed patients with hematological malignancy (HM). Methods : Fifty-two patients with major depressive disorder (MDD) based on DSM-IV criteria along with comorbid HM were allotted to 8 weeks trial with a flexible-dose regime of paroxetine in combination with their chemotherapy or supportive pharmacotherapy. Treatment response was assessed at baseline, week 2, week 4, and week 8 with 17-item Hamilton Rating Scale for Depression (HAM-D17), Montgomery A sberg Depression Rating Scale (MADRS), and Clinical Global Impression-severity (CGI-S). Side effects were collected with the reported adverse events and laboratory test throughout the study period. Results : 44.2% of 52 patients completed the eight weeks trial. Scores on the HAM-D17, MADRS, and CGI-s (last Observation carried forward, LOCF) at baseline were significantly reduced with mean reduction of 30.5%, 32.8%, and 39.1%, respectively, after 8 weeks treatment with paroxetine. Forty-six patients (88.5%) reported at least one adverse event. The most common adverse event observed in this study was nausea and no serious adverse event was found. Conclusion : In this preliminary study, overall results showed paroxetine could be used for the treatment of depressed patients with HM, but more controlled study is needed to confirm the efficacy and safety of paroxetine in this area.
원격 모니터링을 위한 소형 저전력 기반의 인퓨전 펌프 장치의 개발
이강휘(Kang-Hwi Lee),이성수(Sung-Su Lee),조성동 (Sung-Dong Jo),이혁재(Hyek-Jae Lee),김동준(Dong-Jun Kim),이정환(Jeong-Whan Lee) 대한전기학회 2017 대한전기학회 학술대회 논문집 Vol.2017 No.2
본 연구에서는 소형 저전력 기반의 인퓨전 펌프의 개발을 통해 환자의 수액 투여량을 미세 조절 하여 사용의 편의성 및 안전성을 증대 시키고 이중 체크밸브 및 연동형 기어 모터를 사용하여 제작 원가를 낮추어 인퓨전 펌프의 사용자 부담을 줄이고자 하였다. 그리고 의료진의 수액 투여에 관한 환자 관리의 효율성을 높이기 위해 무선 통신 기반의 원격 모니터링 기능을 구현하였다. 기존의 인퓨전 펌프는 튜브 내의 수액을 이동시키기 위하여 회전형 또는 직선형 Peristaltic Pump 구조를 사용한다. 이는 강한 회전 토크를 필요로 하기 때문에 모터의 크기가 커지고 이를 위해 대용량의 배터리를 사용하게 되어 인퓨전 펌프의 전체 부피가 커져 이동이 필요한 수액 투여 환자들에게 부담감을 증가시킨다. 본 연구에서는 이를 개선하기 위해 생체모방형 Muscle Pump 구조를 가지는 이중 체크 밸브를 고안하여 소형, 저가의 DC 기어 모터 기반의 인퓨전 펌프구조를 설계하였다. 본 연구에서는 수액 흐름을 미세하게 제어하기 위하여 연동형 기어 모터 구조를 최적화 하였으며 마이크로컨트롤러의 PWM 제어를 통해 수액유출량을 측정 하는 실험을 수행하여 기존 장비와의 성능비교를 통해 기능을 검증하였다. 고안된 인퓨전 펌프를 통해 수액 주입량을 실시간 모니터링 하면 관리자의 편의성을 증대 시킬 뿐만 아니라 저렴한 비용으로 보다 많은 환자에게 정밀한 수액 투여 환경을 제공할 수 있다.
( Jae In Lee ),( Dong Hyek Jang ),( Joo Yoon Bae ),( Hong Lim Kim ),( Hye Jung Jung ),( Ji Young Ahn ),( Mi Youn Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Patients manage acne by themselves in a variety of ways. Among that methods, acne patches are easy to buy and use. So patients use them a lot. But there is little accurate information on them by physicians. Objectives: Investigate the patient's perception and usage of acne patches. Methods: A questionnaire survey was conducted on 80 acne patients who visited the outpatient department of the National Medical Center. Results: 42 patients (52.5%) answered that they had used an acne patches and 38 patients (47.5%) answered that they had never used it. The question about the how they knew about the acne patches, 26 respondents (61.904%) answered that they recommended by their acquaintances. And 12 patients (28.571%) knew the product name of they used. 27 patients (64.285%) responded that they used the patches on inflammatory lesions. A large number of patients were using an acne patches after extracting themselves. Conclusion: Patients use acne patches a lot because of their ease of purchase and use. However, they don’t know how to choose the product that fits their skin and use them properly. Therefore, it is necessary to educate the patients on how to select products and how to use them by doctors.
A case of lyme disease presenting with erythema migrans
( Jae In Lee ),( Dong Hyek Jang ),( Joo Yoon Bae ),( Hong Lim Kim ),( Mi Youn Park ),( Hye Jung Jung ),( Ji Young Ahn ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Lyme disease is a spirochetal infection, which is transmitted by the bite of infected Ixodes ticks. The clinical manifestations of Lyme disease can generally be divided into three phases : early localized, early disseminated, and late disease. Early localized Lyme disease is characterized by the appearance of erythema migrans(EM). EM usually occurs within one month following the tick bite. Early disseminated disease is characterized by multiple EM lesions and/or neurologic and/or cardiac findings. Late Lyme disease is typically associated with intermittent or persistent arthritis involving one or a few large joints, especially the knee. A 61 year old man presented with round erythematous patch on his abdomen to our dermatologic clinic. The lesion occurred 1 week ago and he was felt being bitten by an insect. The patient complained of pain, pruritus and a heating sensation. Laboratory tests showed a mild elevation of CRP and ESR. The skin biopsy from a papule which is suspected to be bitten by an insect showed a suspected mouth of a tick. And the skin biopsy from the erythema in the periphery lesion revealed mild acanthosis in the epidermis and cellular infiltration in the dermis, composed of lympho-histiocytes, neutrophils and eosinophils. He was treated by doxycycline and the lesion disappeared after twenty days. We report this rare case of Lyme disease in Korea.
이기동,권승혁,이명희,김숙경,주길재,권중호 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2004 한국식품저장유통학회지 Vol.11 No.1
고품질 참외 농축액을 제조하기 위해 농축공정에서 중요한 변수로 작용하는 가열시간을 달리하면서 제조한 농축물에 대한 관능적 평가를 실시한 결과, 가열 후 맛이 최대평점을 나타낸 조건은 가열온도가 96.63 ℃ 및 가열시간이 14.31 min일 때 였으며, 전반적인 기호도가 가장 높은 조건은 가열온도가 97.18℃ 및 가열시간이 14.55 min 일 때 였다. 가열온도 및 가열시간을 달리하면서 실험한 결과 참외 농축액 제조를 위해서는 가열온도 98℃로, 가열시간 13 min으로 처리하는 것이 적당하였다. This study was carried out to observe the change of organoleptic properties of the juice prepared with various heating temperature and heating time. Organoleptic color showed maximum value at 94.95℃ and 21.63 min and organoleptic aroma showed maximum value at 63.14℃ and 20.38 min. Organoleptic taste showed maximum value at 96.63℃ and 14.31 min and overall palatability showed maximum value at 97.18℃ and 14.55 min The best condition was 98℃(heating temperature) and 13 min(heating time) at oragnoleptic evaluation of oriental melon juice.
Perception of Wheezing in the Elderly Asthmatics
(Jae Hak Joo),(Gun Il Lim),(Moon Jeong Seo),(Sang Joon Park),(Jun Hyek Lee),(Soo Taek Uh),(Yong Hoon Kim),(Choon Sik Park) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.4
N/A Background: In elderly asthmatics, underdiagnosis is one of the important features. The main reason for underdiagnosis is thought to be a low frequency in complaining of symptoms due to the reduction of intellectual recognition and physical activity. Among the various symptoms, wheezing is the principal clue in diagnosing bronchial asthma, and decreased complaints for wheezing are also noted in elderly asthmatics. The objective of this study is to determine if less complaints of wheezing in elderly asthmatic is due to a decrease in the development of wheezing. Methods: 61 young (20-39 years old), 68 middle-aged (40-59 years old) and 65 elderly (older than 60 years old) stable asthmatic subjects were studied (each group shall be called, hereafter, Young Group, Middle-aged Group and Old Group, respectively). During the methacholine induced airway narrowing, lung auscultation and questionnaire survey about presence and perception of wheezing were conducted in 194 asthmatics. Results: One hundred and sixty-nine patients (87%) developed wheezing during the methacholine induced airway obstruction. The frequency of wheezing during the methacholine challenge was found to be comparable among the groups. The methacholine concentration, % fall in FEV1, and FEV1 levels of the initial detection of wheezing were not different among the groups. Among the patients who developed wheezing, 47 patients (77%), 42 patients (61.8%) and 26 patients (40%) complained of wheezing in Young, Middle and Old Group, respectively. Conclusion: In conclusion, the decreased perception of wheezing is a main factor for the low frequency of complaints of wheezing in elderly asthmatics.
( Jae-in Lee ),( Hyun-yi Suh ),( Dong-hyek Jang ),( Joo-yoon Bae ),( Mi-youn Park ),( Ji-young Ahn ),( Hye-jung Jung ),( Yong-bum Yoon ),( Sung-hwan Youn ),( Jai-il Youn ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: There are evidences supporting a strong relationship between psoriasis and NAFLD. Recent studies reveal that NAFLD is significantly higher in psoriatic patients than in matched controls and psoriatic patients with NAFLD have more severe psoriasis than those without NAFLD. Objectives: The aim of this study to reveal association between psoriatic patients with abnormal liver function tests and fatty liver. Methods: We evaluated the laboratory results of psoriatic patients who visited the Department of Dermatology, National Medical Center from September 2012 to June 2017. Results: In total, 307 psoriatic patients excluding viral hepatitis B and C infection and severe alcoholics took liver function tests (LFTs) and 46 patients (16.1%) had abnormal LFTs. Among psoriatic patients with abnormal LFTs, 34 of 46 patients (73.9%) were diagnosed with NAFLD. Among psoriatic patients with abnormal LFTs, moderate to severe psoriatic patients significantly had more fatty liver (87.5%) than mild psoriatic patients (59.1%). Among psoriatic patients with abnormal LFTs, moderate to severe psoriatic patients significantly had more moderate to severe fatty liver (66.7%) than mild psoriatic patients (31.8%). Conclusion: Moderate to severe psoriatic patients had more NAFLD than mild psoriatic patients and moderate to severe psoriatic patients significantly had more severe fatty liver than mild psoriatic patients.