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Post-sulfonation에 의한 SBS 이온교환막의 제조 및 특성
최용재 ( Yong Jae Chol ),황의환 ( Eui Hwan Hwang ),황택성 ( Taek Sung Hwang ) 한국화학공학회 2010 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.48 No.6
본 연구에서는 post sulfonation 반응을 통하여 SBS 양이온교환막을 제조하였다. 술폰화 양이온교환막의 술폰화도, 함수율, 이온교환용량, 전기저항 및 전기전도도등 막의 전기적 특성을 술폰화 시간을 변수로 하여 확인하였다. 술폰화 SBS 막의 술폰화도는 반응시간 및 황산의 농도가 증가함에 따라 증가하였으며 최대 술폰화도는 24.0%이었다. 또한 막의 함수율과 이온교환용량은 술폰화도가 증가함에 따라 증가하였으며 각각 41.2%, 0.80meq/g로 가장 높았으며, 전기저항과 전기전도도는 각각 23.6 Ω·cm2, 4.24×10-4 S/cm이었다. In this study, the sulfonated SBS cation-exchange membrane was prepared by post-sulfonation. Degree of sulfonation (DS), water-uptake, ion exchange capacity and electrical resistance and conductivity of sulfonated SBS were investigated as a function of sulfonation time. The DS of sulfonated SBS membrane was increased with increasing the reaction time and concentration of sulfuric acid. The maximum value of DS was 24.0%. And also, the water uptake and ion exchange capacity of the sulfonated SBS membrane were increased as increasing the value of DS. The values of water uptake and IEC were 41.2% and 0.80meq/g, respectively. The electrical resistance and conductivity of the membrane showed 23.6 Ω·cm2 and 4.24×10-4 S/cm, respectively.
Development of a New Annual Dose Evaluation System Using On-Site Network Data
Jae Hee Roh,Hyun Jik Kim,Hyong Chol Kim,Si Young Kim,Seok Ju Hwang 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
A new annual dose evaluation system called E-DOSE has been developed. The system is based on the methodology of the previous version, K-DOSE60, which uses the dose evaluation methods of the International Commission on Radiological Protection (ICRP-60). However, E-DOSE is coded in ABAP to be compatible with the KHNP’s enterprise resource planning (ERP) system, SAP. This allows E-DOSE to use the real-time data from SAP, which minimizes the need for user intervention. The socio-environmental data, which was previously managed by the staff of each plant sites, can now managed in the system in a centralized manner. This is a significant improvement over the previous system, as it reduces the risk of errors and makes it easier to track and manage data. The system also automatically generates the reports required by regulations. EDOSE is expected to minimize the occurrence of human errors in preparing and managing the input data. This is because the system uses the data from SAP, which is less prone to errors than manually entered data. Additionally, the automatic generation of reports reduces the risk of errors in report preparation. E-DOSE is also expected to improve work efficiency. This is because the system automates many of the tasks involved in annual dose evaluation, such as data entry, calculation, and report generation. Overall, E-DOSE is a significant improvement over the previous annual dose evaluation system. It is more efficient, accurate, and user-friendly.
결핵균 및 기타 3종 Mycobacteria 의 파쇄추출항원과 교차반응하는 폐결핵환자의 항체분석
황응수,조명제,심영수,김익상,차창용,국윤호,이승훈,한용철,배길한,김상재 대한미생물학회 1985 大韓微生物學會誌 Vol.20 No.1
It is important to discriminate between tuberculosis and tuberculosis-like disease by Mycobacteria other than tuberculosis in the serodiagnosis of tuberculosis. But because common antigens share among Mycobacteria, their antigenicities to human are similar. Therefore degree of cross-reactivity of anti-body in the sera of patients with tuberculosis between M. tuberculosis and Mycobacteria other than tu- berculosis should be checked to increase the specificity in the serodiagnosis of tuberculosis. The activity levels of IgG antibody in the sera of 106 patients confirmed as active pulmonary tuber-culosis and 30 normal healthy control person to the pressate extract antigen (TE, BE, AE, and FE antigen) from M. tuberculosis, M. bovis, M. avium, and M. fortuitum were measured by enzyme-linked immunosorbe:nt assay and the crossreactivity of IgG antibody with mycobacterial species was analysed. The results were as follows; 1. The activity level (O.D. at 492nm) of 1gG to TE antigen in sera of patients with pulmonary tuber- culosis was 0.228±0.167 in minimal tuberculosis; moderately advanced, 0.556±0.616; far advanced, 1.116±0.651 and 0.315±0.245 in miliary tuberculosis. 2. The actiivity level (O.D. at 492nm) of IgG to BE antigen in sera of patients with pulmonary tu-berculosis was 0.190+0.162 in minima1 tuberculosis; moderately advanced, 0.337+0.361; far advanced, 0.713+0.460 and 0.204±0.162 in miliary tuberculosis. 3. The activity level (O.D. at 492nm) of IgG to AE antigen in sera of patients with pulmonary tu-berculosis was 0.165±0.114 in minimal tuberculosis; moderately advanced, 0.392±0.494; far adven- ced, 0.751±0.512 and 0.2330.191 in miliary tuberculosis. 4. The activity level (O.D. at 492nm) of IgG to FE antigen in sera of patients with pulmonary tub- erculosis was 0.280±0.227 in minimal tuberculosis; moderately advanced, 0.460±0.564; far advan- ced, 0.845±0.573 and 0.257±0.103 in miliary tuberculosis. 5. The activity level (O.D. at 492nm) of IgG in sera of healthy control person was 0.126±0.084 to TE antigen, 0.105±0.041to BE antigen, 0.103±0.052 to AE antigen, and 0.095±0.061 to FE antigen. 6. Degree of correlation(r) in activity level of IgG between TE antigen and BE antigen was 0.905; between TE antigen and AE antigen, 0.760; between TE antigen and FE antigen, 0.790, and be- tween AE antigen and FE antigen,0.945. 7. As O.D. above 0.200 was determined positive for the serodiagnosis of pulmonary tuberculosis, the sensitivity and specificity in ELISA using TE antigen were 80% and 87% respectively, whereas in the case of using BE antigen, 66% and 100%; in the case of using AE antigen, 62% and 100 %, and in the case of using FE antigen, 72% and 93%, respecitively.
沈在喆,黃祐翊 고려대학교 의과대학 1988 고려대 의대 잡지 Vol.25 No.1
This study was devised to observe the inhibitory effects of water extracts of the Trichosanthes semen against the growth of human rectum cancer cells, HRT-18, in vitro. The changes of doubling time, growth rate, size distribution and phase of HRT-18 cells by the effect of incubation time and concentration of the extracts in the culture medium (DMEM) were determined. The results obtained are summarized as follows; 1. The doubling time of HRT-18 was about 20 hours, 2. The dry weight of water extract of Trichosanthes Semen was about 52.2 mg/g, and the inhibitory activity per mg of the extract was about 50 units. 3. The growth rate of HRT-18 cultured medium containing 35 ug/ml of the extract were inhibited over10 times compared with control group. 4. The HRT-18 cultured in medium containing 175 ug/ml of the extract was destroied over 67% of initial cell number in early stage and then their growth was almost rest. 5. The size of HRT-18 cells cultured inmedium containing 35 to 175 ug/ml of the extract was changed significantly to small piece and their phase was deformed.
( Shin Hwang ),( Hee-jung Wang ),( Jae-won Joh ),( Dong-goo Kim ),( Kyung Sik Kim ),( Kyung-suk Suh ),( Seong Hoon Kim ),( Hee-chul Yu ),( Chol-kyoon Cho ),( Ki-hun Kim ),( Young-joo Lee ),( Sung-gyu 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: We previously demonstrated that multiplication of α-fetoprotein (AFP), des-γ-carboxy prothrombin (DCP) and tumor volume (TV) (ADV score, expressed in log10) is an integrated surrogate marker of post-resection prognosis for hepatocellular carcinoma (HCC). Positron emission tomography (PET) reflects the tumor biology. We intended to assess whether preoperative ADV score combined with PET finding can predict the prognosis for large HCC. Methods: Nine institutions participated in this study supported by KASL research fund. Selection criteria were preoperative measurement of AFP and DCP, FDG-PET and macroscopic curative resection of solitary HCC ≥8 cm, by which 526 patients who underwent surgery between 2008 and 2014 were selected. Results: Median values were 11.0 cm for tumor diameter, 402 mL for tumor volume, and 8.3 for ADV score. Expression levels of AFP and DCP were not correlated (r<sup>2</sup>=0.02, p=0.002). Tumor recurrence and patient survival were significantly different according to ADV score cutoffs of 6 and 9 (p=0.000) and PET findings (p=0.000). Both ADV score cutoff at 6 and hypermetabolic PET were independent risk factors for tumor recurrence (HR 1.9 and 1.8) and patient survival (HR 2.3 and 3.0), respectively. Combination of ADV score cutoff at 6 and PET (ADV6-PET) resulted in great prognostic contrasts in tumor recurrence and patient survival (Fig. 1; all p=0.000). After exclusion of preoperative treatment cases, such prognostic contrast was further enhanced. Independent risk factors for tumor recurrence and patient survival were ADV6-PET (HR 1.6 and 2.7), microvascular invasion (HR 1.7 and 1.9), macrovascular invasion (HR 1.5 and 1.5) and satellite nodule (HR 1.5 and 2.0), respectively. Conclusions: The prognostic power of ADV6-PET was quite comparable to that of well-known pathological risk factors, thus that it can be used to predict the post-resection outcomes during preoperative planning for resection of large HCC.
Role of surgical treatment for peripheral arterial disease in endovascular era
Sang Jun Park,Jae Chol Hwang,Hong Rae Cho,Ho Jong Park,Sang Jin Kim,Bong Won Park 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.84 No.6
Purpose: The purpose of this study is to review the roll changes of surgical treatment for peripheral artery disease in endovascular era. Methods: One hundred and twelve surgically treated cases of peripheral artery disease at a single institution during the period from 2006 to 2011 were studied retrospectively. The cases were divided into two groups of different time periods, one before 2009 (surgical period group) and the other from 2009 onward (endovascular period group). We analyzed the type and location of surgery as well as clinical characteristics of patients and treatment results. Results: Fifty-three cases were for the surgical period group and 59 cases for the endovascular group. No difference in the demographic characteristics and the distribution of major atherosclerosis risk factors was found between the two groups. Additionally, the technical and functional success rate was similar in both groups. However, it is found that there were more acute cases in the endovascular period group than in the surgical period group. The number of cases in need of suprainguinal or below knee exposure was similar in both groups. In hybrid cases, suprainguinal or below knee exposures were more frequently needed during the former period than the latter period. Conclusion: The role of surgical treatment is currently in the process of changing. Surgical treatment seems to be a complementary alternative to endovascular treatment for chronic limb ischemia. However, it still seems to play a major role for acute limb ischemia.