http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
加味鷄血藤湯이 Glutamate receptor와 Free radical 및 뇌손상 보호에 미치는 영향
안종석,김동희,김윤식,이용구,박종오,남궁욱,설인찬 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3
This study was investigated to prove the effect of GMGHT on the gultamate receptor, free radical and brain damage in rats sujected to Brain Ischemia The results were as follows ; 1. GMGHT showed significant inhibitory effect of GMGHT on LDH release induced by NMDA, AMPA, and kinate. 2. GMGHT showed significant inhibitory effect of GMGHT on LDH release induced by BSO and Fe^2+. 3. GMGHT decreased coma duration time in a infatal dose of KCN and showed 30% of survival rate in a fatal dose. 4. GMGHT decreased ischemic area and edema incited by the MCA blood flow block. 5. GMGHT showed improvement of forelimb test after MCA occulusion in neurological exemination. 6. GMGHT showed no significant change after MCA occulusion in pathological observation as normal group. These results indicate that GMGHT can be used in the brain damage sujected to Brain Ischemia. Further study will be needed about the functional mechanism and etc.
류마티스 : 전신홍반루푸스로 오인된 혈관내B대세포림프종 1예
박찬걸 ( Chan Keol Park ),이정찬 ( Jeong Chan Lee ),강성욱 ( Seong Wook Kang ),심승철 ( Seung Cheol Shim ),윤환중 ( Hwan Jung Yun ),김진만 ( Jin Man Kim ),유인설 ( In Seol Yoo ) 대한내과학회 2015 대한내과학회지 Vol.89 No.6
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of non-Hodgkin’s lymphoma (NHL) and that progresses rapidly and is usually fatal. Because it usually presents with nonspecific symptoms, such as fever, the early diagnosis of IVLBCL is very difficult and it is often misdiagnosed as another disease. Systemic lupus erythematosus (SLE) is an autoimmune disease that affects various organs. The clinical manifestation of SLE ranges from rash and arthritis through anemia and thrombocytopenia to serositis, nephritis, seizures, and psychosis. Thus, it can be easily confused with many other disorders. We report a case of IVLBCL mimicking SLE in the initial diagnosis. (Korean J Med 2015;89:746-751)
설효찬(Hyo Chan Seol),최준식(Jun Shik Choi) 대한약학회 2005 약학회지 Vol.49 No.5
The aim of this study is to investigate the effects of verapamil on the pharmacokinetics of tamoxifen follwing oral administration of tamoxifen with verapamil to rats. Tamoxifen (10mg/kg) was administered orally in the presence or absence of verapamil (1, 3 or 6 mg/kg). Compared to the control group (given tamoxifen alone), the presence of verapamil significantly (p〈 0.05 by 1mg/kg, p〈 0.01 by 3 and 6 mg/kg) increased the areas under the plasma concentration-time curve (AUC) and the peak concentrations (CMAX) of tamoxifen. Consequently, the relative bioavailability (RB%) of tamoxifen with verapamil was 1.6-2.1 fold highter than that of the control. But the time to reach peak concentration (TMAX) and the terminal half-life(t1/2) of tamoxifen were not altered significantly in the presence of verapamil. The increased AUC and CMAX of tamoxifen in the presence of verapamil might be associated with inhibition by verapamil of the P-glycoprotein and the firstpass metabolizing enzyme CYP3A4 in small intestinal mucosa. The drug interaction should be taken into consideration when tamoxifen is used to the patient with verapamil in the clinical setting.
Kim, Ki Chan,Go, Hyo Sang,Bak, Hae Rang,Choi, Chang Soon,Choi, Inha,Kim, Pitna,Han, Seol-Heui,Han, So Min,Shin, Chan Young,Ko, Kwang Ho BioMed Central 2010 JOURNAL OF BIOMEDICAL SCIENCE -BASEL- Vol.17 No.1
<P><B>Background</B></P><P>Prenatal ethanol exposure during pregnancy induces a spectrum of mental and physical disorders called fetal alcohol spectrum disorder (FASD). The central nervous system is the main organ influenced by FASD, and neurological symptoms include mental retardation, learning abnormalities, hyperactivity and seizure susceptibility in childhood along with the microcephaly. In this study, we examined whether ethanol exposure adversely affects the proliferation of NPC and de-regulates the normal ratio between glutamatergic and GABAergic neuronal differentiation using primary neural progenitor culture (NPC) and <I>in vivo </I>FASD models.</P><P><B>Methods</B></P><P>Neural progenitor cells were cultured from E14 embryo brain of Sprague-Dawley rat. Pregnant mice and rats were treated with ethanol (2 or 4 g/kg/day) diluted with normal saline from E7 to E16 for <I>in vivo </I>FASD animal models. Expression level of proteins was investigated by western blot analysis and immunocytochemical assays. MTT was used for cell viability. Proliferative activity of NPCs was identified by BrdU incorporation, immunocytochemistry and FACS analysis.</P><P><B>Results</B></P><P>Reduced proliferation of NPCs by ethanol was demonstrated using BrdU incorporation, immunocytochemistry and FACS analysis. In addition, ethanol induced the imbalance between glutamatergic and GABAergic neuronal differentiation <I>via </I>transient increase in the expression of Pax6, Ngn2 and NeuroD with concomitant decrease in the expression of Mash1. Similar pattern of expression of those transcription factors was observed using an <I>in vivo </I>model of FASD as well as the increased expression of PSD-95 and decreased expression of GAD67.</P><P><B>Conclusions</B></P><P>These results suggest that ethanol induces hyper-differentiation of glutamatergic neuron through Pax6 pathway, which may underlie the hyper-excitability phenotype such as hyperactivity or seizure susceptibility in FASD patients.</P>