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설인찬 ( In Chan Seol ) 대전대학교 한의학연구소 2009 한의학연구소 논문집 Vol.18 No.2
Most of the cholesterol is synthesized by liver in the body while about one of third is taken via dietary. The main functions of cholesterol is to protect membranes in cell surface, avoid the arterial bleeding by hypertension, and prolong the life of erythrocytes, and so on. However, overload of cholesterol leads to arteriosclerosis associated with leading death cause. Lack of physical activity, emotional and environmental stress, and low intake of protein or vitamin E induce the unbalance between HDL- and LDL-cholesterol so become a basis of ischemic disorders in heart, brain and elsewhere in the body. So far, four major classes of medications for hyperlipidemia are HMG-CoA reductase inhibitors (statins), bile acid sequestrants, nicotinic acid, and fibric acids. The statins can lower LDL and levels triglyceride, but may induce myopathy and an elevation of liver enzyme levels. The bile acid sequestrants lower LDL levels and raise HDL levels with no effect on triglyceride levels but side effects of gastrointestinal (GI) distress, constipation, and a decrease in the absorption of other drugs. Nicotinic acid and fibric acids lower LDL and triglyceride levels with showing flushing, hyperglycemia, hyperuricemia, GI distress, and hepatotoxicity dyspepsia, gallstones, myopathy, and unexplained noncardiac death as adverse effects. Above western drugs lower cholesterol by 15 to 30% while all have notable adverse effects. In traditional medicine, hyperlipidemia is regarded as retention of phlegm and fluid disease. Etiology and pathogenesis of hyperlipidemia is basically based on Spleen-Deficiency and Phlegm-Stagnation, accumulation and stasis of -heat, and Qi & blood stagnation induced by Phlegm-damp, water-dampness, and blood stasis. Thereby, strengthening Spleen and dissolving Phlegm, clearing away heat and diuresis, and supplementing Qi and activating blood circulation are commonly used therapeutic methods for hyperlipidemia. The traditional herbal medicine, have been used for patients with CVA, hypertension or hyperlipidemia in Oriental hospital or Oriental clinic. The lock and key theory is used to develop most of western medicine, however many diseases are caused by mixed factors in body-complex system. We expect that Oriental pharmacological theory could be newborn as a novel drug showing high advantage of blood levels of lipidsand QOL of performance without side effects.
자액사(自縊死)와 익수사(溺水死)에 사용된 약물분석(藥物分析) 및 투여방법(投與方法)에 대(對)한 문헌적(文獻的) 효과(考察)
안정조,설인찬,An, Joung-jo,Seol, In-chan 대전대학교 한의학연구소 2001 한의학연구소 논문집 Vol.10 No.1
In the literatual study on on the herb med and the medication of Resuscitation(蘇生術) of Jayaeksa(自縊死) and Yiksusa(溺水死), the results were as follows; 1. As the single herb medication, gesim(桂心), sesin(細辛), johyub, chongyub(蔥萊)), banha(半夏), yukge(肉桂) etc. were used. 2. The $s{\breve{o}}ng$(性) of used medicines is mainly $ons{\breve{o}ng$(溫性) and $yuls{\breve{o}}ng$(熱性), the mi(味) is sinmi(辛味). 3. The $gwigy{\breve{o}}$ng(歸經) is all most $simgy{\breve{o}}gn$(心經) and $pyegy{\breve{o}}ng$(肺經). 4. The efficacy is geopung(祛風), geosub(祛濕) and geodam(祛痰) 5. On the method of herb medication, In Jayaeksa(自縊死), Chuibub(吹法), Guanbub(觀法) were most used, and In Yiksusa(溺水死), Guanbub(觀法) was most used.
과루인 및 과루인청혈플러스가 인간 탯줄 정맥 내피 세포(Human umbilicl vein endothelial cells, HUVECs)에서 염증인자 발현 억제에 미치는 영향
김해융,설인찬,유호룡,김윤식,Kim, Hae-yoong,Seol, In-chan,Yoo, Ho-ryong,Kim, Yoon-sik 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.4
Objective: To examine the effects of Trichosanthes kirilowii Maximowicz extract (TE) and Trichosanthes kirilowii Maxi mowicz Cheonghyeol Plus Phellinus linteus Cheonghyeol plus (TCP) on anti-inflammatory factor expression in human umbilical vein endothelial cells (HUVECs). Methods: HUVECs were activated with TNF-α and then treated with TE and TCP. The expression levels were then measured for intracellular genes (KLF2, eNOS, MCP-1, ICAM-1, and VCAM-1), proteins (KLF2, eNOS, MCP-1, ICAM-1, VCAM-1, ERK, and JNK, p38), and extracellular biomarkers (ICAM-1, VCAM-1, and MCP-1). Results: 1. TCP at concentrations of 100 ㎍/mL or greater significantly increased the expression of KLF2 and eNOS intracellular genes and significantly decreased the expression of ICAM-1, VCAM-1, and MCP-1 genes compared to the control group. 2. TCP at concentrations of 100 ㎍/mL or greater significantly increased the expression of KLF2, eNOS proteins compared to the control group, and significantly reduced the expression of VCAM-1, ICAM-1, MCP-1, ERK, and p38 proteins. However, JNK protein phosphorylation showed no significant change compared to the control group. 3. TCP at concentrations of 100 ㎍/mL or more significantly decreased the production of MCP-1, ICAM-1, and VCAM-1 extracellular biomarkers compared to the control group. 4. TE at a concentration of 100 ㎍/mL did not cause any significant change in the expression of intracellular genes or proteins, in the production of the extracellular biomarker MCP-1, or in the amount of JNK protein compared to the control group. Other intracellular genes, proteins, and extracellular biomarker expression showed the same trend as observed with TCP exposure. Conclusion: This study experimentally confirmed that TE and TCP could be effective in preventing or inhibiting various inflammatory vascular diseases due to their anti-inflammatory effects.
자오가피(刺五加皮) 약침액(藥針液)의 항(抗)알러지 효과(效果)에 대한 실험적(實驗的) 연구(硏究)
윤종태,설인찬,김동희,김성훈,김한성,Yoon, Jong-Tae,Seol, In-Chan,Kim, Dong-Hee,Kim, Sung-Hoon,Kim, Han-Sung 대한침구의학회 2001 대한침구의학회지 Vol.18 No.2
Objetives : This study was done to evaluate the antiallegic effect of medicinal acupuncture solution of Acanthopanax senticosus(Rupr. et Maxim;abbreviated as ASMA), studies were done experimentally. Methods : For this aim MTT assay, anaphylaxis reaction, DTH, histamine release, IgE production and vascular permability was evaluated. Results : ASMA didn't show an effective cytotoxicity on the mouse lung fibroblast. It insignifcantly suppressed histamine release from mast cells induced by compound 48/80, while it significantly reduced IgE production and SRBC-challenged DTH(Delayed type hypersensitivity). ASMA effectively suppressed anaphylactic reaction induced by compound 48/80. However, it didn't inhibit vascular permeability and contact dermatitis significantly. Conclusion:Medicinal acupucture solution had antialletgic effects. Acanthopanax senticosus medical acupuncture depress the allergy reaction. Especially in anaphylactic type, the effect was good.
수면중 이갈이에 의해 발생한 턱관절 통증 환자에 대한 FCST 활용 1예 보고
엄태민,김윤식,설인찬,유호룡,Eom, Tae-Min,Kim, Yoon-Sik,Seol, In-Chan,Yoo, Ho-Ryong 턱관절균형의학회 2014 턱관절균형의학회지 Vol.4 No.1
본 증례에서는 수면 중 이갈이에 의해 발생한 턱관절 통증에 대하여 FCST를 포함한 침치료를 통해 양호한 치료효과가 있는 것을 관찰하였다. 상기 환자는 FCST의 균형측정지 검사상 TMJ의 경미한 불균형 외에 방사선 소견상 구조적인 큰 이상이 없었음에도 이갈이에 따른 심한 근육긴장으로 통증이 발생한 경우였다. 이것을 통해 FCST가 턱관절의 구조적인 문제에만 국한되어 적용되는 것이 아니라 턱관절 주위 근육 긴장의 빠른 회복에도 상당한 효과가 있음을 볼 수 있었다. 또한 야간에 TBA를 착용한 상태로 잠을 자게 되면 그 자체로 이갈이에 대한 예방효과가 있어 현재 턱관절통증 등의 증상이 없는 이갈이 환자에게도 예방적인 목적으로 TBA의 처방이 가능할 것으로 사료된다. A 27 year-old male patient with sleep bruxism-induced temporomandibular pain was managed by appliance of FCST with 3 weeks of duration, combined with acupuncture. After being treats for 3 weeks, the patient's pain was improved. Assessment was made by self assessment (Numerical Rating Scale, NRS; Korean Oral Health Impact Profile, KOHIP) and clinical observation. An impressive effect was observed and further clinical and biological research on FCST is expected.
간양상항방(肝陽上亢方)이 고혈압(高血壓)에 미치는 영향
한덕희,오영선,설인찬,김윤식,Han, Deok-Hee,Oh, Young-Seon,Seol, In-Chan,Kim, Yoon-Sik 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.6
This study was done to investigate the effect of Ganyangsanghang-bang(GYSHB) on hypertension. After administering GYSHB extract to SHR for 5 weeks, changes in blood pressure, pulse rate, aldosterone and catecholamine levels in plasma were examined, and immunohistochemical changes were observed, and liver function test was done. The following results were obtained; blood presure decreased significantly as well as levels of aldosterone and norepinephrine in SHR. But levels of dopamine were unaffected. No capillary vessel dilation in adrenal cortex was observed. Safety against hepatic toxicity was showed. These results support a role for GYSHB might be usefully applied in treatment of hypertension.
가미계혈등탕(加味鷄血藤湯)이 고혈압(高血壓)에 미치는 영향(影響)
오영선,김윤식,설인찬,유병찬,Oh, Young-Seon,Kim, Yoon-Sik,Seol, In-Chan,Yu, Byeong-Chan 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4
Objectives : This study was done to investigate the effect of Gamigehyuldeung-tang on hypertension. Methods : After administering Gamigehyuldeung-tang extract to SHR(Spontaneous Hypertensive Rats) for 5 weeks, changes in blood pressure, pulse rate, aldosterone and catecholamine levels in plasma were examined, and immunohistochemical changes and scanning electron microscopic changes were observed. Results : The following results were obtained; blood presure decreased significantly as well as levels of aldosterone, dopamine and epinephrine in SHR. But levels of norepinephrine were unaffected. No capillary vessel dilation was observed. A decrease in cell damage was seen in microscope investigation. Conclusions : These results support a role for Gamigehyuldeung-tang might be usefully applied in treatment of hypertension.