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Bae, Won-Jung,Park, Jae Suh,Kang, Soo-Kyung,Kwon, Il-Keun,Kim, Eun-Cheol MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.6
<P>The present study evaluated the protective effects of melatonin in ethanol (EtOH)-induced senescence and osteoclastic differentiation in human periodontal ligament cells (HPDLCs) and cementoblasts and the underlying mechanism. EtOH increased senescence activity, levels of reactive oxygen species (ROS) and the expression of cell cycle regulators (p53, p21 and p16) and senescence-associated secretory phenotype (<I>SASP</I>) genes (interleukin [IL]-1β, IL-6, IL-8 and tumor necrosis factor-α) in HPDLCs and cementoblasts. Melatonin inhibited EtOH-induced senescence and the production of ROS as well as the increased expression of cell cycle regulators and SASP genes. However, it recovered EtOH-suppressed osteoblastic/cementoblastic differentiation, as evidenced by alkaline phosphatase activity, alizarin staining and mRNA expression levels of Runt-related transcription factor 2 (Runx2) and osteoblastic and cementoblastic markers (glucose transporter 1 and cementum-derived protein-32) in HPDLCs and cementoblasts. Moreover, it inhibited EtOH-induced osteoclastic differentiation in mouse bone marrow–derived macrophages (BMMs). Inhibition of protein never in mitosis gene A interacting-1 (PIN1) by juglone or small interfering RNA reversed the effects of melatonin on EtOH-mediated senescence as well as osteoblastic and osteoclastic differentiation. Melatonin blocked EtOH-induced activation of mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK) and Nuclear factor of activated T-cells (NFAT) c-1 pathways, which was reversed by inhibition of PIN1. This is the first study to show the protective effects of melatonin on senescence-like phenotypes and osteoclastic differentiation induced by oxidative stress in HPDLCs and cementoblasts through the PIN1 pathway.</P>
채진욱,김일희,권우성,이근미,정승필,문용 영남대학교 의과대학 2003 Yeungnam University Journal of Medicine Vol.20 No.1
Background: Body weight is an important factor that influence the bone density in postmenopausal women except estrogen dificiency. However, different results are reported about the relationship between body composition and bone density in the postmenopausal women. We have studied the relationship between age, body weight, body mass index (BMI), waist hip ratio (WHR), muscle mass, fat mass, fat free mass and bone density. Materials and Methods: We have studied 127 persons of postmenopausal women who visited university medical center and examined the inbody 3.0 and Dual Energy X-ray Absorptiometry (DEXA) from Jan, 2001 to Jun, 2002. they didn't have any disease and didn't received homone therapy, osteoprosis therapy or other medication that influence the bone density. Results: The numbers of study subjects is total 127 persons. Mean age is 56.9±5.14, mean weight is 59.3±8.7 kg, mean BMI is 25.37±3.16 (kg/㎡), mean fat mass is 20.02±5.05 kg, mean muscle mass is 37.49±4.50 kg, mean fat free mass is 39.80±4.70, mean BMD is 0.828±0.148 (g/㎠). In the result of linear regression analysis, age, height, weight, muscle mass, fat free mass, fat mass, BMI are significant determinants of BMD. In stepwise multiple regression analysis, age is the most significant determinant of BMD and besides age, fat mass is the most significant determinant of BMD among body composition. Conclusion: In postmenopausal women, age, height, weight, BMI, muscle mass, fat free mass, fat mass are significant determinants of BMD and besides age, fat free mass is the most significant determinant of BMD among the body composition. So, diet and exercise that increase fat free mass will contribute to bone density increment.
이배익,정일호,권만근 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4
Recently, the diet of middle aged Korean men is changing. Instead of eating Korean foods exclusively, they are consuming more Western foods which are often unhealthy. In addition, they are exercising less. These factors are leading to a rise in lifestyle related disease, such as diabetes, and dangerous medical conditions like hypertension. As a result, some middle aged men have taken up light exercise, such as hiking, walking, swimming etc. However, they don't know how to set up an exercise program, i.e. frequency of exercise, intensity, duration, etc. A 15 week exercise class was set up 36 middle aged men. Before the class began, a physical fitness and blood test were administered to each subject. The same tests were repeated after the 15th week. Based on the initial results, individual programs were prepared for each participant. A step calorie counter was supplied to measure their exercise activity. The step count results were checked everday, and based on the results, the subjects were divided into three groups for analytical purposes. The firts group, sixteen subjects(44%), averaged a little over 8,000 steps per day. The second group, eight subjects(22%), averaged between 8-10,000 steps per day. The third group, twelve subjects(33%), averaged a little over 10,000 steps per day. After fifteen weeks, the total cholesterol, HDL cholesterol and LDL cholesterol of all subjects showed no significant change. The second and third group showing an especially marked decrease in blood sugar. Also, physical fitness improved for the second and third groups. In conclusion, both groups doing the most exercise showed improvement in their TG and blood sugar results. Blood pressure also decreased for these two groups, which was not true for the first group, also, physical fitness improved in the second and third groups, while the first group showed no significant change. It appears that exceeding a certain minimum level of exercise is required to achieve good results. What would happen if group 1 did the same exercise for longer than is weeks.
Yeong-Min Park,Kyung Tae Noh,Young-Il Jeong,정인덕,강현규,Gil Sun Cha,Su Jung Lee,Jong Keun Seo,Dae Hwan Kang,황태호,이은경,Byungsuk Kwon,박영민 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.2
We evaluated the effectiveness of rhamnogalacturonan II (RG-II)-stimulated bone marrow-derived dendritic cells (BMDCs)vaccination on the induction of antitumor immunity in a mouse lymphoma model using EG7-lymphoma cells expressing ovalbumin (OVA). BMDCs treated with RG-II had an activated phenotype. RG-II induced interleukin (IL)-12, IL-1b, tumor necrosis factor-a (TNF-a) and interferon-c (IFN-c) production during dendritic cell (DC) maturation. BMDCs stimulated with RG-II facilitate the proliferation of CD8þ T cells. Using BMDCs from the mice deficient in Toll-like receptors (TLRs), we revealed that RG-II activity is dependent on TLR4. RG-II showed a preventive effect of immunization with OVA-pulsed BMDCs against EG7 lymphoma. These results suggested that RG-II expedites the DC-based immune response through the TLR4signaling pathway.
Optically Switchable Smart Windows with Integrated Photovoltaic Devices
Kwon, Hyun-Keun,Lee, Kyu-Tae,Hur, Kahyun,Moon, Sung Hwan,Quasim, Malik M.,Wilkinson, Timothy D.,Han, Ji-Young,Ko, Hyungduk,Han, Il-Ki,Park, Byoungnam,Min, Byoung Koun,Ju, Byeong-Kwon,Morris, Stephen M Wiley Blackwell (John Wiley Sons) 2015 Advanced energy materials Vol.5 No.3
Il-Keun Kwon,Nan-Sim Pang,Bock-Young Jung,Jin-Sun Jeong,Hee-Jung Yun 대한치과보철학회 2014 The Journal of Advanced Prosthodontics Vol.6 No.3
PURPOSE The aim of this study was to determine the absolute value of the root/crown ratio (R/C ratio) using panoramic radiographs (PRGs) in a healthy Korean population. MATERIALS AND METHODS In total, 99 patient radiographs (of 50 males and 49 females subjects; aged 16 to 24 years old) were examined, and 2,770 teeth were analyzed. Crown lengths and root lengths were measured with modified Lind's measurements using PACS tools by two examiners in two separate sessions two months apart. All data were analyzed using SPSS. The independent t-test was used to assess for gender differences, and the paired t-test was used to compare both arches with a significance level of P<.05. RESULTS The mean R/C ratios varied from 1.29 to 1.89 (male: 1.28-1.84; females: 1.31-1.94). The highest R/C ratios were recorded for the mandibular canines (1.89), followed by the maxillary canines (1.79). The lowest R/C ratios were recorded for the maxillary second molars (1.31). In comparison with the maxillary teeth (1.29-1.78), the mandibular teeth yielded the higher R/C ratio (1.47-1.89), and this difference was significant in the females (P<.05). The difference between the genders was not statistically significant, except for the maxillary central incisors, mandibular canines and mandibular first premolars. CONCLUSION These data may enhance the understanding of the clinical R/C ratio as a useful guideline for determining the status of teeth and the ethnic difference.