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Cytokine Induction by a Polysaccharide-protein Complex Isolated from Agaricus blazei Murill
Hyun-Ok Ku,In-Cheon Kim,Young-Hwa Sim,Sang-Hee Jeong,Chang-Hee Kweon,Shin-Ja Park,Yun-Bae Kim,Han-Sang Yoo,Yong-Soon Lee 한국독성학회 1999 Toxicological Research Vol.15 No.3
A polysaccharide-protein (74.1 : 12.8%) complex was extracted from Agaricus blazei Murill, and its cytokine-inducing potency was investigated in vitro and in vivo. In peritoneal macrophage cultures, the polysaccharide-protein complex induced a high level of interleukin-1α and interleukin-6 production in a dose-dependent manner. In contrast, tumor necrosis factor-α was not detected in the culture supernatant of macrophages stimulated with the polysaccharide-protein complex. Such an increased production of interleukin-6 was also observed in splenocyte cultures, while interleukin-2, interleukin-4, tumor necrosis factor-α and inteljeron-y were not significantly increased following stimulation. Such a pattern in cytokine induction by polysaccharide-protein complex was observed in mice, though it was transient 1-2 hr after intraperitoneal challenge. High levels (5,000-7,500 pg/ml) of interleukin-6 were achieved 1 hr after administration of 5-20 mg/kg of stimulus. Serum interleukin-1α, tumor necrosis factor-α and interferon-y levels were also increased to some extent, while interleukin-2 and interleukin-4 were not responsive. Taken together, it is suggested that interleukin-6 is the most responsive cytokine to stimulation with polysaccharide-protein complex from Agaricus blazei Murill.
( Hyun Ok Ku ) 한국동물실험대체법학회 2009 한국동물실험대체법학회 학술대회집 Vol.2009 No.3
Given animal welfare considerations, local lymph node assays (LLNAs) or LLNA-type assays have been extensively utilized to evaluate sensitizing chemicals. The LLNA endpoint is determined by the incorporation of 3H-thymidine or 5-bromo-2`-deoxyuridine into lymphocytes or by cell counting. However, there have been some concerns that certain non-sensitizing irritants may yield false positive results or that its use to discriminate between classes of chemicals is minimal. It is thus desirable to identify additional endpoints with in LLNA itself. More information than that currently available from LLNAs can provide more insightful data than the assay itself. Through several studies, to refine the LLNA for the differentiation and characterization of chemical-induced allergic responses, we investigated the protein and/or mRNA levels of various gene transcripts and cytokines in ear skin-draining auricular LNs of mice exposed to known sensitizers and irritants and examined their availability as supportive indicators for LLNA. For this, CBA/N mice were topically treated daily with a well known chemical sensitizer such as a strong contact sensitizer 1-chloro-2,4-dinitrobenzene (DNCB), a skin contact sensitizer 2-phenyl-4-ethoxymethylene-5-oxazolone (OXA), and a skin or respiratory sensitizer toluene 2,4-diisocyanate (TDI), and the non-sensitizing irritants, croton oil (CRO) and nonanoic acid (NA), for 3 consecutive days. The mRNA levels in auricular lymph nodes draining the ear skin were then analyzed by gene expression microarrays or real time RT-PCR and immunoassay. Sensitizer-induced changes in parameters such as ear thickness, lymph node weight, and cell count also occurred in irritant-treated mouse tissues. However, gene transcripts such as Ifi27, Il12rb1 and Zbp1 and several cytokines, which are related to T-cell activation, were shown to be up-regulated in auricular lymph nodes by sensitizers exclusively. Significantly, different sensitizers evoked different cytokine patterns of IL-4 and IFN-γ, as DNCB strongly up-regulated both IFN-γ and IL-4, OXA up-regulated IFN-γ strongly but IL-4 weakly, and TDI up-regulated IL-4 highly but IFN-γ weakly. The sensitizers also strongly up-regulated GzmB mRNA, while the irritants had a much weaker effect. Thus, these differential gene expressions and cytokines may be useful as additional endpoints for discriminating between irritants and sensitizers or contact and respiratory sensitizers in the LLNA itself.
Prediction of skin penetration of Bifenthrin using in vitro micro-pig skin model
Ji-Hyun Bang(Ji-Hyun Bang),Hyun-Ok Ku(Hyun-Ok Ku),Byung-Suk Jeon(Byung-Suk Jeon),Hyobi Kim(Hyobi Kim),Kwang-Jick Lee(Kwang-Jick Lee),Yong-Sang Kim(Yong-Sang Kim),Hee Yi(Hee Yi) 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-
(Ki Ok Han),(Chang Hoon Yim),(Ho Yeon Jung),(Hak Chul Jang),(Hyun Ku Yoon),(Dong Hee Cho),(Hyun Ho Shin),(In Kwon Han),(Hyun Suk Choi),(Jeong Bae Park) 대한내과학회 2002 The Korean Journal of Internal Medicine Vol.17 No.2
N/A Background: Plasma cholesteryl ester transfer protein (CETP) functions to transfer cholesteryl ester from HDL to triglyceride-rich lipoproteins and regulates plasma HDL cholesterol level. A common mutation, the exon 15 A to G substitution at codon 442 (D442G) results in reduced plasma CETP activity and increased plasma HDL cholesterol level. Meanwhile, hormone replacement therapy (HRT) in postmenopausal women increases plasma HDL cholesterol level. Methods: We investigated the frequency of D442G mutation and its effect on plasma HDL cholesterol level in Korean women. We also examined if the mutation has any effect on an increase in plasma HDL cholesterol level during HRT. Results: Two hundred and twenty eight women aged over 40 years were recruited in this study. Of 228 women, 22 (9.6%) were identified as having the D442G mutation; 21 heterozygotes and 1 homozygote. The subjects with the mutation had higher plasma HDL cholesterol levels than those without the mutation (61.6 ±17.3 vs. 55.1 ±14.0 mg/dL, p<0.05). After 12 month HRT, HDL cholesterol increased by 6.4% (3.6 ±13.2 mg/dL, p<0.05) and D442G mutation did not have any significant effect on the change of plasma HDL cholesterol level. Conclusion: D442G mutation is common in Korean postmenopausal women and it is associated with increased plasma HDL cholesterol level. HRT for postmenopausal women increased plasma HDL cholesterol level in similar amounts regardless of the presence or absence of D442G mutation.
최근 2년간 Journal of Korean Academy of Nursing 게재논문 분석-연구 동향, 실험중재, 연구의 근거등급을 중심으로
신현숙(Shin, Hyun-Sook),현명선(Hyun, Myung-Sun),구미옥(Ku, Mi-Ok),조명옥(Cho, Myung-Ok),김숙영(Kim, Sook-Young),정재심(Jeong, Jea-Sim),정금희(Jeong, Geum-Hee),서문경애(Seomoon, Gyeong-Ae),손연정(Son, Youn-Jung) 한국간호과학회 2010 Journal of Korean Academy of Nursing Vol.40 No.1