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유비쿼터스 환경을 위한 임베디드 정보표시 장치 시스템 구현
이병권,김석일,전중남 충북대학교 컴퓨터정보통신 연구소 2004 컴퓨터정보통신연구 Vol.12 No.1
가전제품 및 생활도구에 운영체제가 내장됨으로써 네트워크 및 파일시스템을 사용할 수 있게 되었고, 그 결과로 제품이 지능화되고 소형화되고 있다. 본 논문에서는 ARM, x86, 그리고 XScale기반으로 임베디드 플랫폼에서 동작하는 임베디드형 정보표시장치를 설계하고 구현 과정을 설명한다. 각 플랫폼에 대한 커널 포팅, 파일시스템 구성 과정을 설명하고, 서버 클라이언트 환경에서 동작하는 정보 표시 소프트웨어에 대하여 설명한다. 서버는 화면에 여러 종류의 데이터와 및 제어정보를 클라이언트에게 보내고, 클라이언트는 수신된 데이터를 재조립하여 지정된 영역에 표시한다. With the help of embedded operating system, the electric home appliances have been able to access the network and file system, and become intelligent and miniaturized. In this paper, we explain an information display system operating on three embedded platforms: ARM, x86, and XScale. For each platform, we describe the process of kernel porting and file system construction. And we also explain the information display software based on the server-client environment. The server sends various kinds of display data and control data to the clients. A client reassembles the received data and displays them in the appropriate location of its screen
거대 점오염원이 주변 대기질에 미치는 영향에 관한 연구
김유근,이화운,전병일,장은숙,홍정혜,문윤섭,원경미,송정희 부산대학교 환경문제연구소 1996 環境硏究報 Vol.14 No.1
In order to show the effect of a vast point pollutant source on air quality of Pusan Thermoeletric Power Plant and its surrounding area, air quality around Pusan Thermoeletric Power Plant was simulated by ISCLT-2 which was supplied by EPA. For this purpose the emission amount of SO_2, NO_2 and TSP was calculated and atmospheric stability was classified for a recent decade(1985~1994) in Pusan. A result of the emission amount showed that much amount of NO_2, NO_2 and TSP are emitted from industrial area. It was clear that NO_2 is much emitted from line source and industrial area. And as a result of classification of atmospheric stability, neutral, stable and unstable state were 58%, 24.1% and 17.9%, respectivly. The result of ai quality simulation by ISCLT-2 showed that Pusan Thermoeletric Power Plant is affecting on the increse of 2.0ppb, 3.0ppb and 5.0㎍/㎥, SO_2, NO_2, and TSP respectively at its surrounding area, site A-3 which was located westward 2.2㎞ distance from Plant
How useful are liver function tests in vitro in human hepatoma cell line (HepG2)?
Byung-Suk Jeon,Seong-Yun Hwang,So-Ryeon Hwang,Nam-Ju Kim,Hee Yi,Ji-Hyun Bang,Moon Her,Hyun-Ok Ku 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
In preclinical hepatotoxicity testing cell based are frequently relevant. However, prediction of drug induced liver injury remains a major challenge. Here we addressed the usefulness of frequently relevant markers of hepatocellular injury in human hepatocarcinoma cell line (HepG2) in response to treatment with either acetaminophen, amiodarone, etoposide, orphenadrine and/or lovastatin. The change in the cellular injury (AST, ALT and LDH) were determined toxicity and above drug concentrations as to evaluate the utility of these markers in vitro systems. Initially, treatment of HepG2 with any of the drugs caused a statistically significant reduction in enzyme activities to suggest a switch from basic amino acid metabolism towards induced detoxification. However, treatment for prolonged periods of time caused cytolysis, as evidenced by the significant rise in extracellular LDH and the concomitant increase in ALT and AST activity. Notably, among the various endpoints studied, LDH was best to determined dose dependent cytotoxicity, while other markers of hepatocellular injury were variable. Taken collectively, LDH measurement proofed to be robust in predicting hepatocellular toxicity; therefore, it should be included in preclinical testing strategies for an improved prediction of hepatotoxicity.
Cytochrome P450 enzyme levels in HepG2 cells and iPSC-derived hepatocytes
Byung-Suk Jeon,Nam-Ju Kim,Hee Yi,Ji-Hyun Bang,Moon Her,Hyun-Ok Ku 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Hepatocyte cell systems for in vitro assessment include hepatoma cell lines and normal hepatocyte cultures used in toxicity and metabolism of drugs. However, each cell line has its own characteristics. Induced pluripotent stem cells(iPSC), which can be differentiated to hepatocytes and providing a limitless supply of cells with hepatocyte characteristics that can mimic the physiology of liver, has been one of the best ways to portray the in vivo system. Thus, the objective of the present study was to compare between HepG2 cell line and iPSC-derived hepatocytes to conclude which is the good model for preclinical in vitro drug screening studies. We evaluated cytotoxicity and induction of CYP1A2 and 3A4 with treated acetaminophen, aminodarone, orphenadrine or lovastatin. The levels of CYPs was measured with luminometric assay. The cytotoxicity and induction of CYPs was increased in a concentration-dependent manner, and the CYPs level was higher in iPSC-derived hepatocytes than in HepG2. The results showed that in vitro studies on cytotoxicity and drug metabolism using iPSC-derived hepatocytes can be potential application as cost effective substitutes in drug screening. We will cover how iPSC technology is being used to develop predictive models and how information gained from in vitro screening experiments using this model.
Byung-Suk Jeon,이희,구현옥 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.1
Stem cell-based products (SCPs) are an emerging field of veterinary medicine that focuses on the regeneration, repair, or replacement of damaged tissues or organs. However, there are some issues in applying the traditional regulatory guideline for the approval of SCPs as veterinary medicinal products. This article describes the positions of Korea, US, and EU regarding SCPs, and compares the regulatory guidelines of each country for their safety evaluation. Although there are some differences in the regulatory guidelines, similar considerations in identifying the quality of SCPs and their safety has adopted. Overall, these guidelines need to be harmonized among countries.