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( Hye Sung Won ),( Lee So Maeng ),( Hiun Suk Chae ),( Hyung Keun Kim ),( Young Suk Cho ),( Jin Hyoung Kang ),( Hong Seok Jang ),( Mi Ryeong Ryu ) 대한소화기학회 2012 Gut and Liver Vol.6 No.2
Background/Aims: The purpose of this study was to investigate the malignant potential of aberrant crypt foci (ACF) by measuring the multiplicity of crypts and lectin expression in the early and late stages of 1,2-dimethylhydrazine (DMH)- induced colon carcinogenesis. Methods: Six-week-old Wistar rats were injected subcutaneously with DMH for 27 weeks. We classified ACF according to the number of crypts per ACF as a few crypts (≤3 crypts, FC ACF) or numerous crypts (≥4 crypts, NC ACF). Immunohistochemistry was used to evaluate lectin expression. Results: In the early stage, FC ACF (590/1,902, 31.0%) occurred more frequently than NC ACF (35/449, 7.8%); whereas in the late stage, NC ACF (176/449, 39.2%) occurred more frequently than FC ACF (324/1,902, 17.0%). The number of ACF peaked at 15 to 20 weeks. The ratio of NC/FC ACF increased gradually during carcinogenesis. The expression of both UEA1 and PNA was higher in NC ACF than FC ACF. Lectin expression increased in the late stage compared with the early stage. Conclusions: The expression of lectin was higher in NC ACF and ACF in the late stage. Therefore, ACF with higher multiplicities in the late stage may have more malignant potential in DMH-induced colon carcinogenesis. (Gut Liver 2012;6:229-234)
( Won Ki Hong ),( Moon Young Kim ),( Soon Koo Baik ),( Youn Zoo Cho ),( Hye Won Hwang ),( Jin Hyung Lee ),( Myeong Hun Chae ),( Seung Yong Shin ),( Jung Min Kim ),( Mee Yon Cho ),( Sang Ok Kwon ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: A reliable non-invasive assessment of the severity is essential in the management of chronic liver disease. The hepatic vein arrival time (HVAT) as assessed by microbubble contrast-enhanced ultrasonography (CEUS) has been known to show good correlation with histological grade in HCV related liver disease. However, little has been known about the relationship with alcoholic liver disease. We investigated the utility of HVAT in prediction of histological grade of alcohol related chronic liver disease. Methods: One-hundred twenty seven patients with biopsy proven alcohol related chronic liver disease were studied prospectively. Histological grades were estimated by METAVIR fibrosis scoring system (F0-F4). After an overnight fast, a bolus of contrast agent (SonoVue) was injected into an antecubital vein and signals were recorded from the right or middle hepatic veins for analysis. HVATs were calculated as the time from injection to a sustained rise in Doppler signal 10% above baseline. Results: Mean HVAT from F0 to F4 cirrhosis showed a significant progressive shortening of 26.1±5.5 (F0, 7), 20.3±1.4 (F1, 9), 17.4±0.6 (F2, 12), 15.1±1.4 (F3, 34) and 12.7±1.8 (F4, 65) seconds, respectively (P<0.001). The area under the receiver operating characteristic curve (AUROC) was 0.924 for F4 cirrhosis and the sensitivity, specificity for F4 cirrhosis for an HVAT cutoff value of 14.8 sec were 87.7%, 82.3%, respectively. In addition, HVAT also showed significant correlation with Child- Pugh`s score (P<0.001, r2=0.406), the presence of large esophageal varices (P=0.002), ascites (P<0.001) and the history of esophageal variceal hemorrhage (P=0.036). Conclusions: HVAT using a microbubble CEUS could be effective noninvasive method in assessment of the histological severity and disease severity in alcohol related chronic liver disease.
P148 : A clinical study of skin diseases on vulvar
( Hye Rim Ko ),( So Min Kim ),( Chae Young Won ),( Hyung Jin Hahn ),( Young Bok Lee ),( Jin Wou Kim ),( Dong Soo Yu ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Vulvar diseases are not rare in dermatology, however the clinical investigations of the vulvar lesions are insufficient. Objectives: The purpose of this study was to investigate the epidemiological aspects of the vulvar diseases, and to highlight the clinical features of dermatoses of the vulvar with the brief review of the common vulvar diseases. Methods: The retrospective clinical study was performed by reviewing charts, pathologic slide, and clinical photographs of 37 patients who had received skin biopsy for vulvar lesions at Uijeongbu St. Mary’s Hospital between February 2009 and September 2013. Results: The mean age was 47.3 years. The most frequent vulvar diseases were epidermal cyst, lichen sclerosus, lichen simplex chronicus, herpes simplex infection and condyloma accuminatum in the decreasing order of frequency. Except for the 11 asymptomatic patients, the rest of the patients complained of various symptoms such as a pain, prickling sensation, tenderness and pruritus. Of the 37 cases, 14 had patches or plaques, 11 had papules or nodules, 6 had erosions or ulcers and 6 had vulvar mass. Conclusion: We retrospectively studied 37 cases of vulvar diseases. The results of this study are similar to previousreports on the clinical features of vulvar diseases. This study suggests that various conditions can affect the vulvar. Further investigation with a larger group of patients is necessary to better understand the epidemiology of vulvar diseases.
Development of A Hybrid Medical Decision Support System for Diagnosing Nasal Allergy
Chae, Young Moon,Chung, Seung Kyu,Hong, Se Won,Kang, Eun Hye,Park, In Yong 한국경영과학회 1992 經營 科學 Vol.9 No.2
This paper deals with problem of improving the capability of the medical decision support system (MDSS) for diagnosing nasal allergy by integrating the previously developed expert system with the neural network approach and the case-based reasoning (CBR) approach. Three knowledge acquisition methods were used to develop the expert system : statistical, rule-based, and the mixed approach. Among the three, the mixed approach showed the best prediction rate based on discriminant analysis. The neural network was developed using back-propagation method and then a series of sensitivity analysis were performed to improve a performance of the model. While the expert system produced the best overall matching-rate, the CBR system performed better for the problem cases, as expected, and therefore the hybrid MDSS comprising of the three knowledge acquisition approaches was suggested to further improve a performance of the MDSS.
Effect of Ion-Pair Formation with Bile Salts on the In Vitro Cellular Transport of Berberine
Chae, Hye-Won,Kim, In-Wha,Jin, Hyo-Eon,Kim, Dae-Duk,Chung, Suk-Jae,Shim, Chang-Koo 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1
The objective of this study was to examine the effect of ion-pair complexation with endogenous bile salts on the transport of a quarternary ammonium organic cationic (OC) drug, berberine, across the Caco-2 and LLC-PK1 cell monolayers. The basolateral-to-apical (BL-AP) transport of berberine in Caco-2 cells was temperature dependent and 10-fold higher than that of the apical-to-basolateral (AP-BL) transport. Similar results were observed for the transport of berberine across the LLC-PK1 cells. Moreover, the BL-AP transport in the Caco-2 cells was significantly reduced by the cis-presence of P-glycoprotein (P-gp) inhibitors such as cyclosporine A, verapamil, and digoxin. These results suggest that an efflux transporter, probably P-gp, is involved in the Caco-2 cell transport. The $K_m$ and $V_{max}$ values for the carrier-mediated transport were estimated to be 83.4 mM and 7640 pmole/h/$cm^2$, respectively. The apparent partition coefficient (APC) of berberine between n-octanol and a phosphate buffer (pH 7.4) was increased by the presence of an organic anion (OA), taurodeoxycholate (TDC, a bile salt), suggesting the formation of a lipophilic ion-pair complex between an OC (berberine) and an OA (TDC). Despite the ion-pair complexation, however, the BL-AP transport of berberine across the Caco-2 and LLC-PK1 cells was not altered by the cis-presence of bile salts or the rat bile juice. This is consistent with the reportedly unaltered secretory transport of a quarternary ammonium compound, tributylmethylammonium (TBuMA), across the Caco-2 cell monolayers in the cis-presence of bile salts or the rat bile juice, but not with our previous report in which the secretory transport of TBuMA across the LLC-PK1 cell was increased in the cis-presence of TDC. Therefore, the effect of ion-pair formation with the bile components or bile salts on the secretory transport of OCs appears to depend on the molecular properties of OCs (e.g., molecular weight, lipophilicity and affinity to relevant transporters) and the characteristics of cell strains (e.g., expression and contribution of responsible transporters to the transport).