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Urushiol Induces Growth Inhibition and Apoptosis in MCF-7 Human Breast Cancer Cells
Seaho Kim,So-Hyun Jeong,Mohammad Akbar Hossain1,Min Young Kim,김동환,Jin-Ah Kim,윤정현,나천수,김남득 대한암예방학회 2009 Journal of cancer prevention Vol.14 No.4
In this study, we investigated the effects of urushiol which was isolated from the sap of Korean lacquer tree (Rhus vernicifera Stokes), on the proliferation of MCF-7 human breast cancer cells. Forty-eight hour treatment of urushiol inhibited the growth of breast cancer cells and induced cell DNA fragmentation. This urushiol-induced apoptosis in the MCF-7 cells was closely linked with the down-regulation of Bcl-2 protein expression and the cleavage of poly (ADP-ribose) polymerase. Urushiol also caused a marked increase in the level of p21WAF1/CIP1protein in a p53-dependent manner. Based on our data, urushiol can be considered as a good candidate for an effective chemotherapeutic agent inducing apoptosis of cancer cells, although further study will be needed to confirm this.
Morin Inhibits the Growth of Murine Hepatoma Cells via Cell Cycle Arrest and Induction of Apoptosis
Mi-Na Kim,Eun-Young Ahn,Sang Eun Park,Mohammad Akbar Hossain1,Min Young Kim,문전옥,김남득,윤정현 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.3
Morin (3,5,7,2’,4’-pentahydroxyflavone) is a common dietary flavonoid that exhibits various biological activities, including anti-proliferative, anti-tumor promotion, anti-oxidative, and anti-inflammatory effects. In the present study, we investigated the effects of morin on the cell growth and the viabilities of hepa1c1c7 murine hepatoma cells. Flow cytometric analysis showed that morin-treated cells increased sub-G1 peak accompanied by DNA cleavage and phosphatidylserine externalization, indicating early apoptosis. Flow cytometric analysis also revealed that morin treatment induced G2/M arrest in the cell cycle progression. In addition, morin treatment induced alterations in expression levels of proteins which are linked to cell cycle and apoptosis, such as cyclin B1, Cdc2, Fas, Fas ligand, Bax, Bcl-2, caspase-9,caspase-3, and poly (ADP-ribose) polymerase, in a concentration-dependent manner. Taken together, these results suggest that morin inhibit cell growth and induce cytotoxicity of murine hepatoma cells through G2/M phase arrest and apoptosis.
Design and analysis of a new composite double negative metamaterial for multi-band communication
Mohammad Jakir Hossain,Mohammad Rashed Iqbal Faruque,Mohammad Tariqul Islam 한국물리학회 2017 Current Applied Physics Vol.17 No.7
In this paper, a double C-shaped structure of double negative composite metamaterial is designed and depicts in configurations that can capable in a multi-band microwave frequency band. The design has achieved relative negative permeability, relative negative permittivity and relative negative refractive index. Analysis and comparison were done by using four configurations of composite metamaterial such as horizontal 1 1 array and vertical 1 1 array structures and the horizontal 1 1 and vertical 1 1 unit-cell configurations. Multi-band operating frequencies namely, S-band, C-band and X-band have been achieved using all configurations. The proposed metamaterial size is 1.2 cm 1.2 cm 0.16 cm which includes all geometrical parameters to fit the design inside the substrate area. Computer Simulation Technology (CST) is adopted to investigate this design where an incident electromagnetic wave travelling along the positive z-axis with an E-field polarized along the y-axis. The results of the proposed metamaterial depict multi-band metamaterial response over the frequency span from 1 to 15 GHz. The effective medium ratio of the metamaterial unit-cell is 7.44. Moreover, the results clearly seen that the single-negative and double-negative metamaterial characteristics of the unit-cell and arrays over the multi-band. The dimensions and scattering parameters of the proposed double C-shaped metamaterial are suitable for the S -band, C-band and X-band applications.
Effect of Repeated Freeze-Thaw Cycles on Beef Quality and Safety
Mohammad Hafizur Rahman,Mohammad Mujaffar Hossain,Syed Mohammad Ehsanur Rahman,Mohammad Abul Hashem,오덕환 한국축산식품학회 2014 한국축산식품학회지 Vol.34 No.4
The objectives of this study were to know the effect of repeated freeze-thaw cycles of beef on the sensory, physicochem-ical quality and microbiological assessment. The effects of three successive freeze-thaw cycles on beef forelimb were inves-tigated comparing with unfrozen fresh beef for 75 d by keeping at -20±1°C. The freeze-thaw cycles were subjected to threethawing methods and carried out to know the best one. As the number of freeze-thaw cycles increased color and odor de-clined significantly before cook within the cycles and tenderness, overall acceptability also declined among the cycles aftercook by thawing methods. The thawing loss increased and dripping loss decreased significantly (p<0.05). Water holdingcapacity (WHC) increased (p<0.05) until two cycles and then decreased. Cooking loss increased in cycle 1 and 3, but dec-reased in cycle 2. pH decreased significantly (p<0.05) among the cycles. Moreover, drip loss, cooking loss and WHC wereaffected (p<0.05) by thawing methods within the cycles. 2-Thiobarbituric acid (TBARS) value increased (p<0.05) graduallywithin the cycles and among the cycles by thawing methods. Total viable bacteria, total coliform and total yeast-mould countdecreased significantly (p<0.05) within and among the cycles in comparison to the initial count in repeated freeze-thawcycles. As a result, repeated freeze-thaw cycles affected the sensory, physicochemical and microbiological qua- lity of beef,causing the deterioration of beef quality, but improved the microbiological quality. Although repeated freeze-thaw cyclesdid not affect much on beef quality and safety but it may be concluded that repeated freeze and thaw should be minimizedin terms of beef color for commercial value and WHC and tenderness/juiciness for eating quality.
Effect of Repeated Freeze-Thaw Cycles on Beef Quality and Safety
Rahman, Mohammad Hafizur,Hossain, Mohammad Mujaffar,Rahman, Syed Mohammad Ehsanur,Hashem, Mohammad Abul,Oh, Deog-Hwan Korean Society for Food Science of Animal Resource 2014 한국축산식품학회지 Vol.34 No.4
The objectives of this study were to know the effect of repeated freeze-thaw cycles of beef on the sensory, physicochemical quality and microbiological assessment. The effects of three successive freeze-thaw cycles on beef forelimb were investigated comparing with unfrozen fresh beef for 75 d by keeping at $-20{\pm}1^{\circ}C$. The freeze-thaw cycles were subjected to three thawing methods and carried out to know the best one. As the number of freeze-thaw cycles increased color and odor declined significantly before cook within the cycles and tenderness, overall acceptability also declined among the cycles after cook by thawing methods. The thawing loss increased and dripping loss decreased significantly (p<0.05). Water holding capacity (WHC) increased (p<0.05) until two cycles and then decreased. Cooking loss increased in cycle 1 and 3, but decreased in cycle 2. pH decreased significantly (p<0.05) among the cycles. Moreover, drip loss, cooking loss and WHC were affected (p<0.05) by thawing methods within the cycles. 2-Thiobarbituric acid (TBARS) value increased (p<0.05) gradually within the cycles and among the cycles by thawing methods. Total viable bacteria, total coliform and total yeast-mould count decreased significantly (p<0.05) within and among the cycles in comparison to the initial count in repeated freeze-thaw cycles. As a result, repeated freeze-thaw cycles affected the sensory, physicochemical and microbiological quality of beef, causing the deterioration of beef quality, but improved the microbiological quality. Although repeated freeze-thaw cycles did not affect much on beef quality and safety but it may be concluded that repeated freeze and thaw should be minimized in terms of beef color for commercial value and WHC and tenderness/juiciness for eating quality.
Mechanisms and Prospects of Ischemic Tolerance Induced by Cerebral Preconditioning
Mohammad Iqbal Hossain Bhuiyan,김연정 대한배뇨장애요실금학회 2010 International Neurourology Journal Vol.14 No.4
In the brain, brief episodes of ischemia induce tolerance against a subsequent severe episode of ischemia. This phenomenon of endogenous neuroprotection is known as preconditioning-induced ischemic tolerance. The purpose of this review is to summarize the current state of knowledge about mechanisms and potential applications of cerebral preconditioning and ischemic tolerance. Articles related to the terms ischemic preconditioning and ischemic tolerance were systematically searched via MEDLINE/ PubMed, and articles published in English related to the nervous system were selected and analyzed. The past two decades have provided interesting insights into the molecular mechanisms of this neuroprotective phenomenon. Although both rapid and delayed types of tolerance have been documented in experimental settings, the delayed type has been found to be more prominent in the case of neuronal ischemic tolerance. Many intracellular signaling pathways have been implicated regarding ischemic preconditioning. Most of these are associated with membrane receptors, kinase cascades, and transcription factors. Moreover, ischemic tolerance can be induced by exposing animals or cells to diverse types of endogenous and exogenous stimuli that are not necessarily hypoxic or ischemic in nature. These cross-tolerances raise the hope that, in the future, it will be possible to pharmacologically activate or mimic ischemic tolerance in the human brain. Another promising approach is remote preconditioning in which preconditioning of one organ or system leads to the protection of a different (remote) organ that is difficult to target, such as the brain. The preconditioning strategy and related interventions can confer neuroprotection in experimental ischemia, and, thus, have promise for practical applications in cases of vascular neurosurgery and endo-vascular therapy.
Design, Simulation and Characteristics Analysis of Wideband Metamaterial Absorber Based on Titanium
Mohammad Belal Hossain,A B M Hasan Talukder 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.9
Wide range absorption is specially needed for different microtechnological applications along with microbolometers, photodetectors and coherent thermal emitters. Here we report, design of a wideband metamaterial absorber based on Titanium (Ti) and the analysis of its absorption and reflection characteristics. The structure of the absorber consists of two titanium layers spaced by a dielectric layer of refractive index 2. The simulation is done for analyzing its characteristics using finite difference time domain method (FDTD). The results show that the absorption occurs above 90 percent in the range 750 nm to 1200 nm while the reflection occurs below 10 percent. Overall absorption over the range (400 nm to 1500 nm) is found to be almost above 80 percent.