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Hassan Ahmed Hassan Ahmed Ismail,강병훈,김재수,이재형,최인욱,차광호,육재민,이영하 대한기생충학ㆍ열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.6
IL-12 and IL-23 are closely related in structure, and have been shown to play crucial roles in regulation of immune responses. However, little is known about the regulation of these cytokines in T cells. Here, we investigated the roles of PI3K and MAPK pathways in IL-12 and IL-23 production in human Jurkat T cells in response to Toxoplasma gondii and LPS. IL-12 and IL-23 production was significantly increased in T cells after stimulation with T. gondii or LPS. T. gondii and LPS increased the phosphorylation of AKT, ERK1/2, p38 MAPK, and JNK1/2 in T cells from 10 min post-stimulation, and peaked at 30-60 min. Inhibition of the PI3K pathway reduced IL-12 and IL-23 production in T. gondii-infected cells, but increased in LPS-stimulated cells. IL-12 and IL-23 production was significantly reduced by ERK1/2 and p38 MAPK inhibitors in T. gondii- and LPS-stimulated cells, but not in cells treated with a JNK1/2 inhibitor. Collectively, IL-12 and IL-23 production was positively regulated by PI3K and JNK1/2 in T. gondii-infected Jurkat cells, but negatively regulated in LPS-stimulated cells. And ERK1/2 and p38 MAPK positively regulated IL-12 and IL-23 production in Jurkat T cells. These data indicate that T. gondii and LPS induced IL-12 and IL-23 production in Jurkat T cells through the regulation of the PI3K and MAPK pathways; however, the mechanism underlying the stimulation of IL-12 and IL-23 production by T. gondii in Jurkat T cells is different from that of LPS.
Ismail Hassan Ahmed Hassan Ahmed,차승만,김연,홍성태 대한기생충학ㆍ열대의학회 2023 The Korean Journal of Parasitology Vol.61 No.2
In several schistosomiasis-endemic countries, the prevalence has remained high in some areas owing to reinfection despite repeated mass drug administration (MDA) interventions; these areas are referred to as persistent hot spots. Identifying hotspots is critical for interrupting transmission. This study aimed to determine an effective means of identifying persistent hot spots. First, we investigated the differences between Schistosoma haematobium and Schistosoma mansoni prevalence among school-aged children (SAC) estimated by a community-based survey, for which local key informants purposively selected communities, and a randomly sampled school-based survey. A total of 6,225 individuals residing in 60 villages in 8 districts of North Kordofan, Blue Nile, or Sennar States, Sudan participated in a community-based survey in March 2018. Additionally, the data of 3,959 students attending 71 schools in the same 8 districts were extracted from a nationwide school-based survey conducted in January 2017. The community-based survey identified 3 districts wherein the prevalence of S. haematobium or S. mansoni infection among SAC was significantly higher than that determined by the randomly sampled school survey (e.g., S. haematobium in the Sennar district: 10.8% vs. 1.1%, P<0.001). At the state level, the prevalence of schistosomiasis among SAC, as determined by the community-based survey, was consistently significantly higher than that determined by the school-based survey. Purposeful selection of villages or schools based on a history of MDA, latrine coverage, open defecation, and the prevalence of bloody urine improved the ability for identifying persistent hot spots.
Hassan, Gul,Bae, Jinho,Hassan, Arshad,Ali, Shawkat,Lee, Chong Hyun,Choi, Yohan Elsevier 2018 Composites. Part A, Applied science and manufactur Vol.107 No.-
<P><B>Abstract</B></P> <P>Strain sensors based on graphene are attracting a lot of attention for electronic applications due to its outstanding electrical and mechanical properties. In this paper, we propose a high stretchable strain sensor based on graphene flakes/ZnO composite, which is deposited on micro-random ridged type PDMS substrate. To connect between graphene flake to flake, ZnO nano particles are applied and best graphene flakes and ZnO nano particles blending ratio is 1:0.5. Using this ink, an active layer is fabricated on the micro-random ridged PDMS substrate at ambient conditions through commercialized inkjet printer DMP-3000. Especially, utilizing the micro-random ridged 1.06 mm thick PDMS substrate with surface roughness of 0.34, its stretchability is achieved up to 30%. The flexibility of the fabricated strain sensor is demonstrated down to 10 mm bending diameter. These results reveal that the proposed strain sensor has potential in diverse wearable electronic applications and diverse human motions.</P>
Clinical Findings of Sydenham Chorea in Pediatric Patients: A Single-Center Retrospective Study
Hassan Mottaghi Mohaddam Shahri,Ehsan Hassan Nejad,Mehran Beiraghi Toosi,Abdolreza Malek,Asma Payandeh 대한소아신경학회 2023 대한소아신경학회지 Vol.31 No.3
Purpose: Sydenham chorea is known for its rapid, irregular, and aimless involuntary movements and is considered a benign and self-limiting condition among the major manifestations of rheumatic fever. The current study reviewed the demographic, clinical, and paraclinical findings of pediatric patients with Sydenham chorea. Methods: This cross-sectional study was conducted among 22 patients with Sydenham chorea who were admitted to the pediatric wards of Mashhad Imam Reza and Ghaem Hospitals between 2006 and 2016. Data from these patients’ medical records were extracted, organized using checklist forms, and analyzed. Results: Eight patients were male and 14 were female. The average age was 10.09±3.53 years. In 31.8% of patients, chorea was the only sign of rheumatic fever. Chorea was unilateral in 21.1% of patients. The most common clinical findings were, in descending order, jerky movements, facial grimacing, gait disorders, mental disorders, speech disorders, muscle weakness, and milkmaid’s grip. Cardiac auscultation was normal in 76.2% of patients, while a holosystolic murmur was heard in 23.8%. In laboratory exams, 50% of patients were erythrocyte sedimentation rate (ESR)-positive, 31.2% were C-reactive protein (CRP)-positive, and 53.3% were anti-streptolysin O (ASO)-positive. Echocardiography showed the prevalence of mitral regurgitation (63.6%), aortic regurgitation (45.5%), tricuspid regurgitation (22.7%), pulmonary regurgitation (4.5%), and pericardial effusion (4.5%). Conclusion: This study showed that Sydenham chorea can be the only sign of rheumatic fever. This disease typically occurs in children between the ages of 7 and 12. ESR, CRP, and ASO can be the most effective laboratory tests for diagnosis.
A flat-panel-shaped hybrid piezo/triboelectric nanogenerator for ambient energy harvesting
Hassan, Gul,Khan, Fasihullah,Hassan, Arshad,Ali, Shawkat,Bae, Jinho,Lee, Chong Hyun IOP 2017 Nanotechnology Vol.28 No.17
<P>Recently, many researchers have been paying attention to nanogenerators (NGs) as energy sources for self-powered mirco-nano systems, and studying how to achieve their higher power generation. Hence, we propose a hybrid-type NG for harvesting both the piezoelectric and triboelectric effect simultaneously. In the proposed hybrid NG, the piezoelectric NG (PNG) and triboelectric NG (TENG) are fabricated using polydimethylsiloxane (PDMS) and perovskite zinc stannite (ZnSnO<SUB>3</SUB>) nanocubes with a high charge polarization of 59 uC cm<SUP>−2</SUP> composite (PDMS?+?ZnSnO<SUB>3</SUB>) and UV surface-treated PDMS, respectively. To effectively combine a high output current of PNG and a high voltage of TENG, these two NGs are stacked upon each other, and separated by sponge spacers providing a uniform air gap for the triboelectric effect. In particular, this fabricated structure has a low Young’s modulus for piezoelectricity. The proposed hybrid NG device effectively achieves a combined peak voltage of 300 V on an open circuit, a power density of 10.41 mW cm<SUP>−2</SUP> at 1 MΩ load, and a maximum short circuit current density of 16 mA cm<SUP>−2</SUP> at 50 Ω load. It is feasible that the proposed NG can be utilized as a source for various self-powered systems.</P>
Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells
Hassan, Zeinab Korany,Elamin, Maha Hussein,Omer, Sawsan Ali,Daghestani, Maha Hassan,Al-Olayan, Ebtesam Salah,Elobeid, Mai AbdelRahman,Virk, Promy Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: Breast cancer is a major health problem worldwide. Olive oil induces apoptosis in some cancer cells due to phenolic compounds like oleuropein. Although oleuropein has anticancer activity, the underlying mechanisms of action remain unknown. The study aimed to assess the mechanism of oleuropin-induced breast cancer cell apoptosis. Materials and Methods: p53, Bcl-2 and Bax gene expression was evaluated by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in luminal MCF-7 cells. Results: Oleuropein-induced apoptosis was accompanied by up-regulation of both p53 and Bax gene expression levels and down-regulation in Bcl2. Conclusions: Oleuropein induces apoptosis in breast tumour cells via a p53-dependent pathway mediated by Bax and Bcl2 genes. Therefore, oleuropein may have therapeutic potential in breast cancer patients by inducing apoptosis via activation of the p53 pathway.