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FBW7 Upregulation Enhances Cisplatin Cytotoxicity in Non-small Cell Lung Cancer Cells
Yu, Hao-Gang,Wei, Wei,Xia, Li-Hong,Han, Wei-Li,Zhao, Peng,Wu, Sheng-Jun,Li, Wei-Dong,Chen, Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Introduction: Lung cancer is extremely harmful to human health and has one of the highest worldwide incidences of all malignant tumors. Approximately 80% of lung cancers are classified as non-small cell lung cancers (NSCLCs). Cisplatin-based multidrug chemotherapy regimen is standard for such lesions, but drug resistance is an increasing problem. F-box/WD repeat-containing protein 7 (FBW7) is a member of the F-box protein family that regulates cell cycle progression, and cell growth and differentiation. FBW7 also functions as a tumor suppressor. Methods: We used cell viability assays, Western blotting, and immunofluorescence combined with siRNA interference or plasmid transfection to investigate the underlying mechanism of cisplatin resistance in NSCLC cells. Results: We found that FBW7 upregulation significantly increased cisplatin chemosensitivity and that cells expressing low levels of FBW7, such as NCI-H1299 cells, have a mesenchymal phenotype. Furthermore, siRNA-mediated silencing or plasmid-mediated upregulation of FBW7 resulted in altered epithelial-mesenchymal transition (EMT) patterns in NSCLC cells. These data support a role for FBW7 in regulating the EMT in NSCLC cells. Conclusion: FBW7 is a potential drug target for combating drug resistance and regulating the EMT in NSCLC cells.
Multidisciplinary Perspectives in Understanding Slow-moving Landslide
( Wei-an Chao ),( Ming-chien Chung ),( Keng-hao Kang ),( Chih-pin Lin ),( Tung-lin Tai ),( Hao-wen Yang ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
Landslides have caused extensive infrastructure damage and threatened the human fatalities through the centuries. Among all triggered factors, massive precipitation and large earthquakes are considered to be the two key activators for pushing landslide moving, particularly for catastrophic landslides. The most acceptable mechanism resulting the landslide movement is liquefaction due to increasing water pore pressure. In this study, a landslide site has been well understood by hydrological, geophysical, geological, geodetic, geotechnical and seismological (H4GS) perspectives. Our seismic monitoring of daily relative velocity changes (dv/v) in sliding material decreased coinciding with first-half rainy period yet increased observing in post-half raining event. Geodetic survey (real-time kinematic, RTK; total station) before and after rainy period presents the vertical subsidence without any horizontal movement. The results from multidisciplinary investigation allow us to draw the conceptual model of landslide healing process caused by the water loading. Under the stability condition (F > 1.0) for each sliding materials, unconsolidated landslide colluvium and impermeable sliding surface could trap the seepage water to be as water pool, provided compact force acting on the materials below the sliding boundary. The vertical force of compaction facilitates to increasing the cohesion and strength of materials, tending the landslide material to be much stability. We demonstrated that healing process is periodically occurred but only for prolonged and intense precipitation combined with stability condition.
Slight vapor deficit accelerates graft union healing of tomato plug seedling
Wei, Hao,Muneer, Sowbiya,Manivannan, Abinaya,Liu, Ya,Park, Ji Eun,Jeong, Byoung Ryong PWN-Polish Scientific Publishers 2018 Acta physiologiae plantarum Vol.40 No.8
<P>The application of grafting in tomato production has substantially improved tomato quality and yields. It has been demonstrated that humidity plays an important role in the graft healing of seedlings. This study focuses on the optimum relative humidity (RH) conditions for scion and rootstock healing of grafted tomato (Solanum lycopersicum L.) seedlings. Two tomato cultivars, 'Super Sunload' and 'Super Dotaerang', grafted onto 'B-Blocking' rootstock were subjected to one of three RH regimens: 70-80, 80-90, or 90-100%. The results showed that the scions of both cultivars showed apparent wilting under the 70-80 and 80-90% RH treatments. On this basis, the 90-100% RH treatment was subdivided into 95-96, 97-98, and 99-100% RH treatments, which were then applied. Among these subdivided RH treatments, the fresh weights of the scions and rootstocks significantly increased in response to the treatments of 97-98 and 99-100% RH, and the graft union connection of both cultivars was also enhanced after two days of healing. Furthermore, lower levels of endogenous H2O2 and less activity of antioxidant enzymes were observed in both cultivars in response to treatment with 95-96 or 97-98% RH, which indicated that less oxidative stress occurred. Overall, it is suggested that 97-98% is the optimal RH level for the graft healing of tomato seedlings.</P>
Control of thermoacoustic instability of liquid-spray flame with porous sound absorber
Hao Zhou,Hao Fang,Dongliang Wei,Zihua Liu,Zhaowen Wang,Hanxiao Meng 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.8
A kind of porous sound absorber was studied to control the thermoacoustic oscillation of liquid mist flame, which combined natural fibrous materials and perforated plate. It could optimize the sound absorption characteristics of fibrous materials by adding perforated plate and air cavity. The influences of the interlayer and back cavity depth of two kinds of fibrous materials with the mass of 20, 30, 40 g were investigated experimentally in an impedance tube and applied to control the oscillating ethanol flame. The results showed that the best depth of interlayer and back cavity were 20 cm and 30 cm, respectively. The addition of two kinds of fiber sandwich structures could reduce the amplitude of the sound pressure oscillation in the combustion chamber by 89.2 % and 92.6 %, as well as 88.0 % and 91.2 % in the plenum chamber, meanwhile, restrained the flame heat release fluctuation by 73 %. It was proved that the porous sound absorber could act as a damp in the acoustic transmission path and suppress the sound source.
PREPARATION AND CHARACTERIZATION OF ELECTRIC ZAO NANOPARTICLES
HAO-WEI SHI,HONG-ZHEN XIE,JIN-KU LIU,YAN WANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2010 NANO Vol.5 No.4
The white good dispersion zinc aluminium oxide (ZAO) nanoparticles were efficiently prepared by solid phase synthesis method. The morphologies, structures, photoelectricity of the ZAO nanoparticles and the thermochemistry behavior of the precursor were analyzed by TEM, XRD, UV-vis and TG, etc. The phytotoxicity properties of the ZAO nanoparticles were researched for the first time. The results show that the ZAO nanoparticles have a strong inhibition of seed germination and root growth. The biological toxicity of ZAO nanoparticle reduces along with the enlargement of nanoparticle size.
Hao Luo,Mingyao Lin,Yang Cao,Wei Guo,Li Hao,Peng Wang 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.5
The ride-through control of a doubly-fed induction generator (DFIG) for the voltage sags on wind farms utilizing crowbar circuits by which the rotor side converter (RSC) is disabled has being reported in many literatures. An analysis and calculation of the transient current when the RSC is switched off are of significance for carrying out the low voltage ride through (LVRT) of a DFIG. The mathematical derivation is highlighted in this paper. The zero-state and zero-input responses of the transient current in the frequency domain through a Laplace transformation are investigated, and the transient components in the time domain are achieved. With the characteristics worked out from the linear resolving without modeling simplification, the selection of the resistance in the linear crowbar circuit and the value conversion from a linear circuit to a nonlinear one is proposed to setup the attenuation rate. In terms of grid code requirements, the theoretical analysis for the time constant of the transient components attenuation insures the controllability when the excitation of the RSC is resumed and it guarantees the reserved time for the response of the reactive power compensation. Simulations are executed in MATLAB/SIMPOWER and experiments are carried out to validate the theoretical analysis. They indicate that the calculation method is effective for selection of the resistance in a crowbar circuit for LVRT operations.
Hao Wei,박지은,Yoo Gyeong Park,ByoungRyongJeong 한국원예학회 2019 Horticulture, Environment, and Biotechnology Vol.60 No.3
Seedling production is the basis of most agricultural, especially horticultural, cultivation and is important for crop cultivation. The quality of seedlings directly aff ects the quality and yield of crops after transplanting. The scale of seedling production inthe Republic of Korea has increased gradually and signifi cantly, and the proportion of grafted seedlings of fruit vegetableshas become increasingly important. The quality of grafted vegetable seedlings is valued by farmers more than before; thus,the quality of grafted seedlings of fruit vegetables has become an important area of study. To determine the direction of thisresearch, we surveyed several representative seedling production growers in diff erent provinces of the Republic of Korea. Weinvestigated the graft healing methods used by Korean growers of fruit vegetable plug seedlings, including the light intensity,air temperature, and relative humidity in plug seedling cultivation greenhouses, graft healing tunnels, and closed-type grafthealing factories in summer and winter seasons. It was found that the graft healing methods used by diff erent growers varied. There were vast diff erences in air temperature and relative humidity between graft healing tunnels and closed-type healingfactories. In greenhouses, the temperature in winter was low and the light intensity was insuffi cient, while the temperature insummer was high and relative humidity was too low to be optimal for grafted seedlings. Due to the diff erences in coveringmaterials, the light spectrum in cultivation greenhouses and the graft healing spaces also varied among growers. In general,there were no standardized production models or environmental conditions for grafted plug seedling cultivation. Therefore,follow-up studies will be needed for the development of the grafted plug seedling industry in Republic of Korea.