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( Gyeol Seong ),( Dong Hyun Sinn ),( Wonseok Kang ),( Geum-youn Gwak ),( Yong-han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Hepatitis e antigen-positive patients with high serum hepatitis B virus (HBV) DNA but normal alanine aminotransferase (ALT) are presumed in immune-tolerant phase, and their risk of developing complication is still debatable. Recent guideline suggested to use ALT levels, liver biopsy, elastography or liver fibrosis biomarker (eg, FIB-4) to stratify risk of complication for patients presumed in immune-tolerant phase. Methods: We analyzed of 651 HBeAg positive patients with high serum HBV DNA levels (=7 log IU/mL) but normal or mildly elevated ALT levels (<80 U/L), age more than 18 years (male = 404) who were monitored for at least 1 year from 1998 to 2006. Normal ALT was defined as 35 U/L for men and 25 U/ L for women. The risk of developing hepatocellular carcinoma (HCC) was assessed. Results: During a median 11.2 years of follow-up (range: 1.1- 18.0 years), 42 patients (6.5%) developed HCC. Age, sex, ALT and FIB-4 levels were independent factors associated with HCC development. Those with mildly elevated ALT levels showed significantly higher risk of developing HCC than normal ALT levels (3.4% vs. 9.4% at 10 years for normal ALT vs. mildly elevated ALT, P=0.001). Among patients with normal ALT level (n = 301), FIB-4 level was independent factor associated with HCC development (hazard ratio 2.35; 95% confidence interval 1.54-3.58, P<0.001). Among 301 patients with normal ALT levels, 51 patients (16.9%) had FIB-4 = 1.453. The HCC risk at 10 years was significantly higher for those with high FIB-4 levels (1.3% vs. 13.6% for FIB-4 <1.453 vs. =1.453, P<0.001). Conclusions: Among patients presumed in immune tolerant phase, HCC risk was generally low but was not null. Among patients with normal ALT levels, some showed high FIB-4 levels, and their risk of developing HCC was high. Our data indicate that FIB-4 can be an useful non-invasive marker for stratifying HCC risk among patients presumed in immune tolerant phase, and those with high FIB-4 levels warrants close attention.
Ko, Gyeol,Seo, Yongwon American Chemical Society 2019 Environmental science & technology Vol.53 No.21
<P>SF<SUB>6</SUB> hydrate formation behaviors in various reaction media, such as bulk water, porous silica gel, and hollow silica, were investigated for hydrate-based SF<SUB>6</SUB> separation with a primary focus on thermodynamic stability and formation kinetics. The measured three-phase (H-L<SUB>W</SUB>-V) equilibria demonstrated that the types of reaction media used in this study had no effect on the thermodynamic stability of SF<SUB>6</SUB> hydrates. The dissociation enthalpy (Δ<I>H</I><SUB>d</SUB>) of SF<SUB>6</SUB> hydrate was measured using a high-pressure micro-differential scanning calorimeter, and it corresponded well with estimates from the Clausius-Clapeyron equation. The unstirred porous silica gel system showed a larger gas uptake and a higher growth rate at the early stage of SF<SUB>6</SUB> hydrate formation. However, the gas uptake and growth rate of SF<SUB>6</SUB> hydrates in stirred bulk water and unstirred hollow silica were significantly increased at a larger temperature driving force or in the presence of sodium dodecyl sulfate. The experimental results obtained in this study will be very helpful for a better understanding of the thermodynamic and kinetic characteristics of SF<SUB>6</SUB> hydrate formed in various reaction media and in surfactant-added solution, and are expected to contribute to further development of the hydrate-based SF<SUB>6</SUB> separation process.</P> [FIG OMISSION]</BR>
Han Gyeol Kim,Joonho Lee,Guy Makov 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.5
Bi–Sn alloy phase diagram under pressure was re-calculated using the CALculation of PHAse Diagrams method by applyingnew density data. Theoretically, alloy phase diagram under pressure can be calculated with bulk thermodynamic databaseand thermophysical property data such as density and sonic velocity. In the recent study by Emuna et al. (J Alloys Compd687:360–369, 2016), thermodynamic parameters were determined from literature values with additional modification tofit experimental data of phase boundaries. In this study, density of liquid Bi–Sn alloys was re-evaluated with an advanceddensity measurement technique: the constrained drop method. By applying the new density data, the Bi–Sn phase diagramunder pressure could be calculated successfully without any modification of thermodynamic parameters.
Yoo Gyeol,Su Ram Kim,Kim Jae Won,이준용 대한창상학회 2024 Journal of Wound Management and Research Vol.20 No.1
Background: Recent advances in three-dimensional (3D) reconstruction of tomographic imaging have rarely been applied to wound management and soft tissue-related diseases due to the nature of imaging modality hindering automatic segmentation of the region of interest (ROI). The authors created 3D images of soft tissue lesions using open-source software and evaluated their usefulness through four clinical cases.Methods: Patients with wounds or soft tissue lesions underwent enhanced tomography. The surgeon manually segmented the ROIs and reconstructed them using 3D Slicer. The reconstructed images were overlaid on an anatomy plate or clinical pictures for clinical application. The authors conducted hands-on training and surveyed the participants before and after the course to evaluate clinical applicability and efficacy.Results: Nine plastic surgeons were enrolled. After training, their perception of applying 3D imaging on deep pus pocket drainage, foreign body removal, and deep-located lesion biopsy remained unchanged. However, their response significantly changed from likely to very likely in whether 3D reconstruction imaging of deep soft tissue lesions would help improve the surgical outcome. They answered positively in their recommendation of 3D reconstruction and its application to clinical practice. However, they responded neutrally to whether it was easy to learn. This method was found most useful for deep lesion excision planning, followed by drainage of deep concealed pus pockets, foreign body removal, and biopsies of lesions difficult to localize.Conclusion: Surgeon-generated 3D reconstruction of wounds and soft tissue lesions using open-source software can aid clinical practice, significantly improving surgical outcomes in deep soft tissue lesions.