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Dong Zhao,Ming-Yao Gu,Jiu Liang Xu,Li Jun Zhang,Shi Yong Ryu,양현옥 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.1
Ginger, one of worldwide consumed dietary spice, is not only famous as food supplements, but also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this study, a ginger constituent, 12-dehydrogingerdione (DHGD) was proven that has comparable anti-inflammatory activity with positive control 6-shogaol in inhibiting LPS-induced interleukin (IL)-6, tumor necrosis factor (TNF)-α, prostaglandin (PG) E2, nitric oxide (NO), inducible NO synthase (iNOS) and cyclooxygenase (COX)-2, without interfering with COX-1 in cultured microglial cells. Subsequent mechanistic studies indicate that 12-DHGD may inhibit neuro-inflammation through suppressing the LPS-activated Akt/IKK/NF-κB pathway. Furthermore, 12-DHGD markedly promoted the activation of NF-E2-related factor (Nrf)-2 and heme oxygenase (HO)-1, and we demonstrated that the involvement of HO-1 on the production of pro-inflammatory mediators such as NO and TNF-α by using a HO-1 inhibitor, Zinc protoporphyrin (Znpp). These results indicate that 12-DHGD may protect against neuro-inflammation by inhibiting Akt/IKK/IκB/NF-κB pathway and promoting Nrf-2/HO-1 pathway.
Dong-Xia Zhao,Jun-Min Wang,Ya-Ping Guo 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.1
This paper addresses the exponential stability for an interconnected system of an nth-order ODE systemwith the input governed by the Dirichlet boundary of a heat equation, and conversely, the output of the ODE isfluxed into the heat equation. The semigroup approach is adopted to show that the system operator is well-posed. We establish the exponential stability of the system by Riesz basis method. Furthermore, with MATLAB software,some numerical simulations are presented to show the effectiveness of the interconnection between the heat PDEand ODE systems.
Zhao Dong,Liu Lei,Yu Fanhua,Heidari Ali Asghar,Wang Maofa,Chen Huiling,무함마드칸 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.3
The ant colony optimization algorithm is a classical swarm intelligence algorithm, but it cannot be used for continuous class optimization problems. A continuous ant colony optimization algorithm (ACOR) is proposed to overcome this difficulty. Still, some problems exist, such as quickly falling into local optimum, slow convergence speed, and low convergence accuracy. To solve these problems, this paper proposes a modified version of ACOR called ADNOLACO. There is an opposition-based learning mechanism introduced into ACOR to effectively improve the convergence speed of ACOR. All-dimension neighborhood mechanism is also introduced into ACOR to further enhance the ability of ACOR to avoid getting trapped in the local optimum. To strongly demonstrate these core advantages of ADNOLACO, with the 30 benchmark functions of IEEE CEC2017 as the basis, a detailed analysis of ADNOLACO and ACOR is not only qualitatively performed, but also a comparison experiment is conducted between ADNOLACO and its peers. The results fully proved that ADNOLACO has accelerated the convergence speed and improved the convergence accuracy. The ability to find a balance between local and globally optimal solutions is improved. Also, to show that ADNOLACO has some practical value in real applications, it deals with four engineering problems. The simulation results also illustrate that ADNOLACO can improve the accuracy of the computational results. Therefore, it can be demonstrated that the proposed ADNOLACO is a promising and excellent algorithm based on the results.
Dong, Xiao-Peng,Xiao, Tian-Hui,Dong, Hong,Jiang, Ning,Zhao, Xiao-Gang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Objective: To investigate the effects of endostar, a recombined humanized endostatin, plus cisplatin on the growth, lymphangiogenesis and lymphatic metastasis of the Lewis lung carcinoma (LLC) in mice. Methods: A tumor model were established in C57BL/6 mice by intravenious transplantation of LLC cells. Then the mice were randomized to receive administration with NS, endostar, cisplatin, or endostar plus cisplatin. After the mice were sacrificed, tumor multiplicity, tumor size and lymph node metastasis were assessed. Then the expression of vascular endothelial growth factor-c (VEGF-C) and podoplanin were determined by immunohistochemical staining. Results: Endostar plus cisplatin significantly suppressed tumor growth. lymphatic metastasis and prolonged survival time of the mice without obvious toxicity. The inhibition of lymphatic metastasis was associated with decreased microlymphatic vessel density (MLVD) and expression of VEGF-C. Conclusions: Endostar combined with cisplatin was more effective to suppress tumor growth and lymphatic metastasis than either agent alone. Thus this may provide a rational alternative for lung carcinoma treatment.
Dong, Liang,Li, Feng,Piao, Yongzhe,Sun, Dong,Zhao, Rui,Li, Cheng,Cong, Lina,Zhao, Changxin The Korean Society for Applied Biological Chemistr 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.2
High sugar concentration culturing was commonly used in modern fermentation industry. However, it leads to the reduction of the foam stability in beer brewing due to the excess secretion of proteinase A. To better understand the characterization of proteinase A excretion from Saccharomyces cerevisiae in high sugar stress conditions, the cultures were grown by using YNB medium with a high concentration of glucose. Pro-PrA isolated from the medium was purified by gel exclusion chromatography, and the PrA activity was detected using fluorescent substrate analysis. The relative molecular weight of the purified PrA and pro-PrA was estimated at 42 and 54 kDa, respectively, by SDS-PAGE. It indicated that the metabolic behavior of PrA in the high glucose culturing was quite different from the normal conditions, and glucose concentration may have a big influence on its secreted process. Further study showed that PrA was released at the logarithmic growth phase of the culturing, and the amount of PrA was 11 times higher compared with the normal culturing. PrA was considered to be activated by itself under acidic conditions. And it was also confirmed in this work that the step-wise pathway for the autoactivation known as a pseudo-PrA has a major contribution to the autoactivation process of PrA zymogen outside the cell.
Fluorescent Nanoparticles for Observing Primo Vascular System Along Sciatic Nerve
Zhao-Feng Jia,Ki-Hoon Eom,Jin-Myung Cha,Jin-Kyu Lee,Zhen-Dong Su,Wen-Hui Yu,Pan Dong Ryu,소광섭,Byung-Cheon Lee 사단법인약침학회 2010 Journal of Acupuncture & Meridian Studies Vol.3 No.3
The primo vascular system was found in the epineurium along the rat sciatic nerve following subcutaneous injection of fluorescent nanoparticles at the Zusanli acupoint (ST-36). Nanoparticles were injected into the primo-vessel near ST-36 and flowed along the sciatic nerve. Fluorescence revealed a structure in the epineurium that was hardly detectable. Images of the isolated sample stained with 4’,6-diamidino-2-phenylindole were captured using confocal microscopy. These images showed the distinctive nuclei distribution and multi-lumen structure of primo-vessels that differentiate them from lymphatic vessels, blood capillaries and nerves. This study demonstrates a new use for nanoparticles in fluorescence reflectance imaging techniques during in vivo imaging of primo-vessels.
Zhao, Zheng Lin,Zhao, Guang Wen,Li, Li,Li, Meng Quan,Guan, Li Xin,Yang, Xu Dong,Li, Hou Zhong,Lin, Feng,Lee, Jong-Rok,Zhao, Rong Jie Korean Society of ToxicologyKorea Environmental Mu 2009 Toxicological Research Vol.26 No.1
The effects of aqueous extract of Schizandra Chinensis Fruit (AESC) on cadmium-induced changes of monoamine neurotransmitters in the different brain regions of adult rats were investigated. Male rats were received intraperitoneal (i.p.) administration of CdCl2 (0.6 mg/kg/d) for 21 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA) in striatum and serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in cortex were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Cd intoxicated rats (P < 0.05), while pretreatment with AESC (20 mg/kg/d or 60 mg/kg/d, p.o., 30 min before $CdCl_2$) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC significantly increased the reduction of glutathione contents and superoxide dismutase activities in cortex induced by $CdCl_2$. These results suggest that AESC ameliorates Cd-induced depletion of monoamine neurotransmitters in brain through its antioxidant activity.
Study on fatigue life and mechanical properties of BRBs with viscoelastic filler
Zhao-Dong Xu,Jun Dai,Qian-Wei Jiang 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.26 No.2
In this paper, two kinds of buckling restrained braces (BRBs) are designed to improve the mechanical properties and fatigue life, the reserved gap and viscoelastic filler with high energy dissipation capacity are employed as the sliding element, respectively. The fatigue life of BRBs considering the effect of sliding element is predicted based on Manson-Coffin model. The property tests under different displacement amplitudes are carried out to evaluate the mechanical properties and fatigue life of BRBs. At last, the finite element analysis is performed to study the effects of the gap and viscoelastic filler on mechanical properties BRBs. Experimental and simulation results indicate that BRB employed with viscoelastic filler has a higher fatigue life and more stable mechanical property compared to BRB employed with gap, and the smaller reserved gap can more effectively improve the energy dissipation capacity of BRB.
Dong-xia Zhao,Dong-xia Fan,Ya-ping Guo 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.8
In this paper, the well-posedness and stability of a 1-d 2×2 hyperbolic system under proportional feedback control is addressed. The semigroup approach and norm equivalence theorem is adopted to obtain the explicit dissipative condition for control parameters. The asymptotic spectral analysis of the system is presented. It is shown that the real part of the eigenvalues goes to some negative constant as the modulus of eigenvalues goes to +∞. Moreover, we find that there is a group of generalized eigenfunctions which forms a Riesz basis of the Hilbert state space. Hence, the spectrum determined growth condition holds, and then the exponential stability is established.