Determinants of Exercise Capacity in Patients With Hypertrophic Cardiomyopathy

Hwang Ji-won,Lee Sang-Chol,Kim Darae,Kim Jihoon,Kim Eun Kyoung,Chang Sung-A,Park Sung-Ji,Kim Sung Mok,Choe Yeon Hyeon,Ahn Joong Hyun,Park Seung Woo 대한의학회 2022 Journal of Korean medical science Vol.37 No.8

Background: Reduced exercise capacity reflects symptom severity and clinical outcomes in patients with hypertrophic cardiomyopathy (HCM). The present study aimed to identify factors that may affect exercise capacity in patients with HCM. Methods: In 294 patients with HCM and preserved left ventricular (LV) ejection fraction, we compared peak oxygen consumption (peak VO2) evaluated by cardiopulmonary exercise testing as a representative parameter of exercise tolerance with clinical and laboratory data, including N-terminal pro-hormone of brain natriuretic peptide (NT-proBNP), diastolic parameters on echocardiography, and the grade of myocardial fibrosis on cardiac magnetic resonance imaging (CMR). Results: Median peak VO2, was 29.0 mL/kg/min (interquartile range [IQR], 25.0–34.0). Age (estimated β = −0.140, P < 0.001), female sex (β = −5.362, P < 0.001), NT-proBNP (β = −1.256, P < 0.001), and E/e′ ratio on echocardiography (β = −0.209, P = 0.019) were significantly associated with exercise capacity. Peak VO2 was not associated with the amount of myocardial fibrosis on CMR (mean of late gadolinium enhancement 12.25 ± 9.67%LV). Conclusion: Decreased exercise capacity was associated with age, female sex, increased NTproBNP level, and E/e′ ratio on echocardiography. Hemodynamic changes and increased filling pressure on echocardiography should be monitored in this population for improved outcomes.

Korean Society of Heart Failure Guidelines for the Management of Heart Failure: Management of the Underlying Etiologies and Comorbidities of Heart Failure

Sang Min Park,Soo Youn Lee,Mi-Hyang Jung,Jong-Chan Youn,Darae Kim,Jae Yeong Cho,Dong-Hyuk Cho,Junho Hyun,Hyun-Jai Cho,Seong-Mi Park,Jin-Oh Choi,Wook-Jin Chung,Seok-Min Kang,Byung-Su Yoo 대한심장학회 2023 Korean Circulation Journal Vol.53 No.7

Most patients with heart failure (HF) have multiple comorbidities, which impact their quality of life, aggravate HF, and increase mortality. Cardiovascular comorbidities include systemic and pulmonary hypertension, ischemic and valvular heart diseases, and atrial fibrillation. Non-cardiovascular comorbidities include diabetes mellitus (DM), chronic kidney and pulmonary diseases, iron deficiency and anemia, and sleep apnea. In patients with HF with hypertension and left ventricular hypertrophy, renin-angiotensin system inhibitors combined with calcium channel blockers and/or diuretics is an effective treatment regimen. Measurement of pulmonary vascular resistance via right heart catheterization is recommended for patients with HF considered suitable for implantation of mechanical circulatory support devices or as heart transplantation candidates. Coronary angiography remains the gold standard for the diagnosis and reperfusion in patients with HF and angina pectoris refractory to antianginal medications. In patients with HF and atrial fibrillation, long-term anticoagulants are recommended according to the CHA2DS2-VASc scores. Valvular heart diseases should be treated medically and/or surgically. In patients with HF and DM, metformin is relatively safer; thiazolidinediones cause fluid retention and should be avoided in patients with HF and dyspnea. In renal insufficiency, both volume status and cardiac performance are important for therapy guidance. In patients with HF and pulmonary disease, beta-blockers are underused, which may be related to increased mortality. In patients with HF and anemia, iron supplementation can help improve symptoms. In obstructive sleep apnea, continuous positive airway pressure therapy helps avoid severe nocturnal hypoxia. Appropriate management of comorbidities is important for improving clinical outcomes in patients with HF.

HBV : PO-04 ; Antiviral efficacy of entecavir and adefovir combination therapy in chronic hepatitis B patients with previous nucleos(t)ide analogues failures

( Darae Kim ),( Young Eun Chon ),( Sang Hoon Ahn ),( Hana Park ),( Seung Up Kim ),( Do Young Kim ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Jun Yong Park ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Entecavir (ETV) and adefovir (ADV) combination can be used as a rescue therapy for patients who had failed nucleos(t)ide analogues where tenofovir has not been introduced. We evaluated the efficacy of ETV and ADV combination therapy in patients who had failed to previous nucleos(t)ide analogue (NA). Methods: This study included consecutive 66 compensated chronic hepatitis B (CHB) patients who have failed to previous NAs. All patients received ETV and ADV combination therapy for at least 6 months. While all of the patients had experienced lamivudine (LAM), 48 (72.7%) had experienced ADV and 53 (80.3%) had been treated with ETV. Genetic resistance to LAM, ADV, and ETV at baseline were detected in 65 (98.5%), 12 (18.2%), and 36 (54.5%), respectively. Results: Median HBV DNA level was 5.63 (1.86∼8.23) log IU/mL and fifty nine patients had HBeAg positivity. During a median of 15 (6-38) months of ETV and ADV combination therapy, virological response (VR, < 60 IU/mL by PCR assay) was achieved in 18 of 66 (27.3%) patients. Cumulative VR rates were 21.5%, 28.4%, 36.6% and 36.6% at 6, 12, 24 and 36 months, respectively. When we investigated predictors for VR, baseline ADV resistance along with low baseline ALT level (p=0.027) were significantly associated with decreased VR from multivariate analysis. Conclusions: ETV and ADV combination rescue therapy showed limited efficacy for CHB patients who had failed to previous NAs, however, it can be considered as a rescue therapy in patients who do not have resistance to ADV and high baseline ALT level.

AN OPERATOR SPLITTING METHOD FOR PRICING THE ELS OPTION

Sung-Ki KIM,In-Suk WEE,Darae JEONG,Junseok KIM 한국산업응용수학회 2012 한국산업응용수학회 학술대회 논문집 Vol.7 No.2

L-type amino acid transporter SLC43A2 in ovarian cancer regulate accumulation and suppressive function of MDSC in TME

( Darae Lee ),( Iseul Kim ),( Eun-jeong Park ),( Boram Lee ),( Chorong Kim ),( Yoon Hyeon Hu ),( Heejoo Hong ),( Se Jin Lee ),( Tae Gyu Ahn ),( Hyang Ah Lee ),( Sung Hun Na ),( Jong Yoon Hwang ),( Yun 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: Ovarian cancer is the most lethal malignant cancer in women. Myeloid-derived suppressor cells (MDSCs) accumulation in tumor microenvironment (TME) contribute poor prognosis of ovarian cancer patients. Tumor cells consume high amount of nutrition to meet their bioenergetics/biosynthetic demands. High nutrition demand of tumor cells leads to deprivation of several nutrition in TME, making that tumor-infiltrating immune cells compete with cancer cells for nutrition to maintain their own function. SLC43A2 is a type of L-type amino acid transporter found in various cancers, resulting in methionine deprivation in TME. Methods: The TCGA data sets were used for analyzing the correlation of SLC43A2 mRNA, MDSC markers, and overall survival of ovarian cancer patients. Whole blood was collected from fifteen patients who underwent debulking surgery in Kangwon National University Hospital. PBMC and serum was isolated from the whole blood. Immune cells in PBMC were analyzed with flowcytometry. Methionine was measured with LC/MS method. Results: We found that SLC43A2 mRNA negatively correlates with overall survival and mRNA of MDSC markers including CD33, CD14, CD15 and PD-L1 from ovarian cancer patients as assessed with TCGA data sets. Additionally, serum methionine concentration showed negative correlation with percent of CD11b+ CD33+ cells (represented as MDSC phenotype) in PBMCs donated from ovarian cancer patient cohort. We also found that tumor growth was delayed and tumor-infiltrating granulocytic MDSCs was reduced in SLC43A2 KO melanoma-bearing mice as compared to WT-bearing mice. Gr-1+ MDSCs isolated from SLC43A2 KO melanoma-bearing mice revealed reduced T cell suppression activity than MDSCs isolated from WT melanoma-bearing mice. Conclusion: These findings suggested that alteration of TME metabolism due to high level of SLC43A2 expression in cancer cells resulting in methionine deprivation can affect MDSC physiology and anti-cancer immunity.

The Korean Organ Transplant Registry (KOTRY): Second Official Adult Heart Transplant Report

Darae Kim,Jin-Oh Choi,Jaewon Oh,Hyun Jai Cho,Sung-Ho Jung,Hae-Young Lee,Seok-Min Kang,Jae-Joong Kim,Eun-Seok Jeon 대한심장학회 2019 Korean Circulation Journal Vol.49 No.8

Background and Objectives: This second adult heart transplantation (HTx) report is based on Korean Organ Transplant Registry data submitted on 400 HTxs in recipients of all ages. Methods: From March 2014 to December 2017, a total of 400 HTxs were performed at 4 major centers in Korea. We analyzed demographics and characteristics according to transplant years. Patterns of immunosuppression, allograft rejection, and survival after HTx were analyzed. Donor and recipient age were highlighted. Results: Some distinct differences in HTx statistics were noted. Mean donor age increased significantly in the most recent years compared to 2014–2015, while mean recipient age did not change. The proportion of patients on pre-transplant extracorporeal membrane oxygenation (ECMO) increased over time. One-year and intermediate-term survival was significantly worse in patients on pre-transplant ECMO compared to those without mechanical support. Over the years, tacrolimus has increased to become the most frequently used calcineurin inhibitor over cyclosporine, while the number of patients using steroids both at discharge and 1-year follow-up has declined. Age did not affect 1-year survival, but significantly affected intermediate-term survival. Conclusions: From 2014 to 2017, centers were willing to accept older donors to address increasing organ shortages and more patients received transplant under ECMO care. Increasing age was a strong independent factor for intermediate-term survival, however, post-transplant comorbidities did not differ among age groups. Further studies with longer follow-up duration are needed to better understand age-related post-transplant prognosis.

Landsat 8 위성 기반 고해상도 지표면 광대역 알베도 산출

이다래 ( Darae Lee ),서민지 ( Minji Seo ),이경상 ( Kyeong-sang Lee ),최성원 ( Sungwon Choi ),성노훈 ( Noh-hun Sung ),김홍희 ( Honghee Kim ),진동현 ( Donghyun Jin ),권채영 ( Chaeyoung Kwon ),허모랑 ( Morang Huh ),한경수 ( Kyung-soo 대한원격탐사학회 2016 大韓遠隔探査學會誌 Vol.32 No.6

알베도는 태양에너지의 흡수량을 결정하는 주요 기후 변수 중 하나로서, 이러한 알베도를 산출하는 것은 기후 변화 연구에 있어 중요한 과정이다. 이 때, 산출된 알베도 자료를 효율적으로 사용하기 위해서는 높은 공간해상도와 장기간의 일관성 있는 산출이 중요하게 고려된다. 따라서 본 연구에서는 Landsat 8을 기반으로 Landsat 7과의 일관성을 유지한 고해상도 지표면 광대역 알베도를 산출하였다. 먼저, Landsat 7과 Landsat 8의 채널 별 일관성을 분석한 결과, 상관계수(R)가 평균 0.96으로 높은 상관성을 보였다. 이러한 결과를 바탕으로 Landsat 7 알베도와 Landsat 8 반사도 채널 자료를 다중회귀분석에 적용하여 Landsat 8 광대역 알베도 전환 식을 도출하였다. 도출된 식을 통해 Landsat 8 지표면 광대역 알베도를 산출하고, Landsat 7 알베도 자료와 비교하여 검증하였다. 그 결과 R-square(R²)가 0.89, Root Mean Square Error (RMSE)가 0.003의 높은 정확도를 보였다. Albedo is one of the climate variables that modulate absorption of solar energy, and its retrieval is important process for climate change study. High spatial resolution and long-term consistent periods are important considerations in order to efficiently use the retrieved albedo data. This study retrieved surface broadband albedo based on Landsat 8 as high resolution which is consistent with Landsat 7. First of all, we analyzed consistency of Landsat 7 channel and Landsat 8 channel. As a result, correlation coefficient(R) on all channels is average 0.96. Based on this analysis, we used multiple linear regression model using Landsat 7 albedo, which is being used in many studies, and Landsat 8 reflectance channel data. The regression coefficients of each channel calculated by regression analysis were used to derive a formula for converting the Landsat 8 reflectance channel data to broadband albedo. After Landsat 8 albedo calculated using the derived formula is compared with Landsat 7 albedo data, we confirmed consistency of two satellite using Root Mean Square Error (RMSE), R-square (R²) and bias. As a result, R² is 0.89 and RMSE is 0.003 between Landsat 7 albedo and Landsat 8 albedo.

Efficient 3D Volume Reconstruction from a Point Cloud Using a Phase-Field Method

Jeong, Darae,Li, Yibao,Lee, Heon Ju,Lee, Sang Min,Yang, Junxiang,Park, Seungwoo,Kim, Hyundong,Choi, Yongho,Kim, Junseok Hindawi Limited 2018 Mathematical problems in engineering Vol.2018 No.-

<P>We propose an explicit hybrid numerical method for the efficient 3D volume reconstruction from unorganized point clouds using a phase-field method. The proposed three-dimensional volume reconstruction algorithm is based on the 3D binary image segmentation method. First, we define a narrow band domain embedding the unorganized point cloud and an edge indicating function. Second, we define a good initial phase-field function which speeds up the computation significantly. Third, we use a recently developed explicit hybrid numerical method for solving the three-dimensional image segmentation model to obtain efficient volume reconstruction from point cloud data. In order to demonstrate the practical applicability of the proposed method, we perform various numerical experiments.</P>

가강수량의 변화패턴과 기후인자와의 상관성 분석

이다래 ( Darae Lee ),한경수 ( Kyung Soo Han ),권채영 ( Chaeyoung Kwon ),이경상 ( Kyeong Sang Lee ),서민지 ( Minji Seo ),최성원 ( Sungwon Choi ),성노훈 ( Noh Hun Seong ),이창석 ( Chang Suk Lee ) 대한원격탐사학회 2016 大韓遠隔探査學會誌 Vol.32 No.3

수증기는 지구 장파 복사에너지의 주요 흡수인자이다. 따라서 수증기량의 변화를 모니터링하고 변화의 원인을 세밀하게 조사하는 것은 필수적이다. 본 연구에서는 위성관측에 의해 얻어지는 Total Precipitable Water (TPW)자료를 사용하여 가강수량의 변화패턴을 모니터링 하고자 한다. 또한 기후인자들 중 수증기를 통해 생성되어 수증기의 변화패턴을 분석하는데 있어 중요한 역할을 하는 강수량과 다른 기후인 자들에 비해 비교적 주기적으로 나타나는 엘니뇨를 통해 가강수량의 변화패턴과 기후인자와의 상관성분석을 실시하고자 한다. 본 연구에서는 TERRA/AQUA 위성의 Moderate-Resolution Imaging Spectroadiometer (MODIS) 센서를 통해 관측된 TPW의 장기적인 변화와 한반도 중남부지방의 강수량변화를 정량적으로 분석 하고, 이들의 관계를 엘니뇨와 함께 비교하였다. 이를 통해 엘니뇨의 발생이 한반도 중남부지방의 강수량과 TPW의 변화에 영향을 주고 있는 지에 대해 조사하고자 한다. 먼저, 시계열 분석을 통해 TPW와 중남부지방 강수량의 변화를 정량적으로 산출하고 anomaly분석을 통해 이들의 변화를 세밀하게 분석한 결과 서로 반대 의 양상을 띠는 부분이 발견되어 엘니뇨의 anomaly분석결과와 비교하였다. 그 결과 대부분 같은 양상을 띠고 있던 TPW와 강수량이 엘니뇨가 발생한 후 서로 반대의 양상을 띠는 것을 확인하였다. Water vapor is main absorption factor of outgoing longwave radiation. So, it is essential to monitoring the changes in the amount of water vapor and to understanding the causes of such changes. In this study, we monitor temporal variability of Total Precipitable Water (TPW) which observed by satellite. Among climate variables, precipitation play an important part to analyze temporal variability of water vapor because it is produced by water vapor. And El Nino is one of climate variables which appear regularly in comparison with the others. Through them, we analyze relationship between temporal variability of TPW and climate variable. In this study, we analyzed long-term change of TPW from Moderate-Resolution Imaging Spectroadiometer (MODIS) data and change of precipitation in middle area of Korea peninsula quantitatively. After these analysis, we compared relation of TPW and precipitation with El Nino. The aim of study is to research El Nino has an impact on TPW and precipitation change in middle area of Korea peninsula. First of all, we calculated TPW and precipitation from time series analysis quantitatively, and anomaly analysis is performed to analyze their correlation. As a result, TPW and precipitation has correlation mostly but the part had inverse correlation was found. This was compared with El Nino of anomaly results. As a result, TPW and precipitation had inverse correlation after El Nino occurred. It was found that El Nino have a decisive effect on change of TPW and precipitation.

The fabrication of highly uniform ZnO/CdS core/shell structures using a spin-coating-based successive ion layer adsorption and reaction method

Joo, Jinmyoung,Kim, Darae,Yun, Dong-Jin,Jun, Hwichan,Rhee, Shi-Woo,Lee, Jae Sung,Yong, Kijung,Kim, Sungjee,Jeon, Sangmin IOP Pub 2010 Nanotechnology Vol.21 No.32

<P>We developed a successive ion layer adsorption and reaction method based on spin-coating (spin-SILAR) and applied the method to the fabrication of highly uniform ZnO/CdS core/shell nanowire arrays. Because the adsorption, reaction, and rinsing steps occur simultaneously during spin-coating, the spin-SILAR method does not require rinsing steps between the alternating ion adsorption steps, making the growth process simpler and faster than conventional SILAR methods based on dip-coating (dip-SILAR). The ZnO/CdS core/shell nanowire arrays prepared by spin-SILAR had a denser and more uniform structure than those prepared by dip-SILAR, resulting in the higher power efficiency for use in photoelectrochemical cells.</P>