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Oh, Jaewon,Lee, Beom Seob,Lim, Gibbeum,Lim, Heejung,Lee, Chan Joo,Park, Sungha,Lee, Sang-Hak,Chung, Ji Hyung,Kang, Seok-Min Academic Press 2020 Journal of molecular and cellular cardiology Vol.138 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Survivin has an anti-apoptotic effect against anthracycline-induced cardiotoxicity. Clinically, statin use is associated with a lower risk for heart failure in breast cancer patients with anthracycline chemotherapy. So, the purpose of our study was to investigate whether survivin mediates the protective effect of statin against anthracycline-induced cardiotoxicity.</P> <P><B>Methods</B></P> <P>Mice were treated once a week with 5 mg/kg doxorubicin for 4 weeks with or without atorvastatin 20 mg/kg every day then heart tissues were analyzed. Molecular and cellular biology analyses were performed with H9c2 cell lysates.</P> <P><B>Results</B></P> <P>Doxorubicin suppressed survivin expression via activation of FOXO1 in H9c2 cardiomyocytes. Whereas, atorvastatin inhibited FOXO1 by increasing phosphorylation and inhibiting nuclear localization. Doxorubicin induced FOXO1 binding to STAT3 and prevented STAT3 from interacting with Sp1. However, atorvastatin inhibited these interactions and stabilized STAT3/Sp1 transcription complex. Chromatin immunoprecipitation analysis demonstrated that doxorubicin decreased STAT3/Sp1 complex binding to survivin promoter, whereas atorvastatin stabilized this binding. In mouse model, atorvastatin rescued doxorubicin-induced reduction of survivin expression and of heart function measured by cardiac magnetic resonance imaging.</P> <P><B>Conclusions</B></P> <P>Our study suggested a new pathophysiologic mechanism that survivin mediated protective effect of atorvastatin against doxorubicin-induced cardiotoxicity via FOXO1/STAT3/Sp1 transcriptional network.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Statin use is associated with a lower risk for heart failure in cancer patients. </LI> <LI> Survivin had an anti-apoptotic effect against doxorubicin-induced cardiotoxicity. </LI> <LI> Statin inhibited FOXO1 binding to STAT3 and restored STAT3 binding to Sp1. </LI> <LI> Transcriptional regulation of survivin was mediated via FOXO1/STAT3/Sp1 network. </LI> </UL> </P>
Sodium-glucose Co-transporter 2 Inhibitors: a New Path for Heart Failure Treatment
Jaewon Oh,이승현,Chan Joo Lee,Seok-Min Kang 대한심장학회 2021 Korean Circulation Journal Vol.51 No.5
Results from cardiovascular outcome trials (CVOT) with 5 different sodium-glucose co-transporter 2 inhibitors (SGLT2i; empagliflozin, canagliflozin, dapagliflozin, ertugliflozin, sotagliflozin), initially developed for their glucose-lowering effect by blocking tubular glucose reabsorption in kidney, have been shown to decrease the risk of heart failure hospitalization (HFH) across a range of patients with and without atherosclerotic cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). Following these CVOT results, SGLT2i (dapagliflozin, empagliflozin, sotagliflozin) also were reported to reduce HFH and cardiovascular death in patients with heart failure with reduced ejection fraction (HFrEF), regardless of existence or absence of T2DM. Ongoing studies have been conducted to evaluate the clinical benefit of SGLT2i (empagliflozin, dapagliflozin) in patients with heart failure with preserved ejection fraction (HFpEF). Although SGLT2i brought us to the entrance of a new era for prevention of HF incidence and worsening of HF, the search for pivotal mechanism of SGLT2i to improve our pharmacological armamentarium should continue in order to protect every HF patient from fatal progression of HF disease. In this review, we summarized the updated clinical evidences on SGLT2i (rather than basic and translational evidence) for reduction of HF risk in T2DM patients and favorable clinical outcomes in both HFrEF and HFpEF patients.
Antisolvent treatment of reproducible MAPbI3 perovskite solar cells in ambient atmosphere
Oh Jaewon,Shin Woojin,Lee Hyunbok,Ryu Mee-Yi 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.79 No.8
High sensitivity to external environments such as moisture, heat, oxygen, and ultraviolet light is an obstacle that must be overcome for the successful large-scale commercialization of organometallic hybrid perovskite solar cells. In particular, sufficiently high humidity resistance is essential for the synthesis of reproducible high-quality perovskite films in ambient atmosphere. In this study, we used ethyl acetate as an antisolvent during the film fabrication process to protect the moisturesensitive perovskite intermediate phase. As a result, a very high-power conversion efficiency (PCE) of 13.71% with a small standard deviation was achieved in a manufacturing environment with a 50% relative humidity, which was more than three times larger than the PCE of cells treated with diethyl ether under the same conditions. The findings of this work will allow fabricate efficient and reproducible perovskite solar cells in ambient atmosphere.
Oh, Jaewon,Lee, Chan Joo,Kim, Doo Il,Rhee, Moo-Yong,Lee, Byoung-Kwon,Ahn, Youngkeun,Cho, Byung Ryul,Woo, Jeong-Taek,Hur, Seung-Ho,Jeong, Jin-Ok,Jang, Yangsoo,Lee, Sang-Hak Wiley (John WileySons) 2017 Clinical cardiology Vol.40 No.12
<P>Conclusions: The target achievement of LDL-C < 100 mg/dL was low, and 50% LDL-C reduction was moderately achieved in Korean patients with FH receiving maximal statin-based LLT. Pretreatment LDL-C levels and diabetes mellitus were associated with target achievement. Our results provide rare and informative data on FH treatment in Asian patients.</P>
Influence of Crystallization Temperature on the Optical Properties of MAPbBr₃ Single Crystals
Jaewon Oh,Won Yeob Jeong,Seo Yun Lee,Bom Lee,Mee-Yi Ryu 한국진공학회(ASCT) 2020 Applied Science and Convergence Technology Vol.29 No.1
Optical properties of methylammonium lead bromide (MAPbBr₃) perovskite single crystals grown using a seed-induced inverse temperature crystallization method were studied using photoluminescence (PL) and time-resolved PL measurements. Crystallization rate was observed to be faster with an increasing crystallization temperature. The highest crystal quality was recorded for a sample crystallized at 85°C, and it exhibited the strongest X-ray diffraction peaks and PL intensity. The PL spectra for all samples crystallized at room temperature showed an asymmetric shape with a shoulder in the low energy side; this can be attributed to a photon recycling effect caused by re-emission inside the single crystal. We confirmed that the structural and optical properties of MAPbBr₃ single crystals can be manipulated by modifying the crystallization temperature.
Oh, Jaewon,Ahn, Woo Hyun,Kim, Taegong The Korea Institute of Information and Commucation 2019 Journal of information and communication convergen Vol.17 No.2
Web applications typically interact with databases. Therefore, it is very crucial to understand which web components access which database resources when maintaining web apps. Existing research identifies interactions between Java web components, such as JavaServer Pages and servlets but does not extract dependencies between the web components and database resources, such as tables and attributes. This paper proposes a dynamic analysis of Java web apps, which extracts such dependencies from a Java web app and represents them as a graph. The key responsibility of our analysis method is to identify when web components access database resources. To fulfill this responsibility, our method dynamically observes the database-related objects provided in the Java standard library using the proxy pattern, which can be applied to control access to a desired object. This study also experiments with open source web apps to verify the feasibility of the proposed method.