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- 저자 : Chung Jieun (검색결과 85 건)
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Jieun Chung,김하영,문연실,문원진 대한자기공명의과학회 2020 Investigative Magnetic Resonance Imaging Vol.24 No.2
Background: Determination of inter-method differences between clinically available volumetry methods are essential for the clinical application of brain volumetry in a wider context. Purpose: The purpose of this study was to examine the inter-method reliability and differences between the Siemens morphometry (SM) software and the NeuroQuant (NQ) software. Materials and Methods: MR images of 86 subjects with subjective or objective cognitive impairment were included in this retrospective study. For this study, 3D T1 volume images were obtained in all subjects using a 3T MR scanner (Skyra 3T, Siemens). Volumetric analysis of the 3D T1 volume images was performed using SM and NQ. To analyze the inter-method difference, correlation, and reliability, we used the paired t-test, Bland-Altman plot, Pearson’s correlation coefficient, intraclass correlation coefficient (ICC), and effect size (ES) using the MedCalc and SPSS software. Results: SM and NQ showed excellent reliability for cortical gray matter, cerebral white matter, and cerebrospinal fluid; and good reliability for intracranial volume, whole brain volume, both thalami, and both hippocampi. In contrast, poor reliability was observed for both basal ganglia including the caudate nucleus, putamen, and pallidum. Paired comparison revealed that while the mean volume of the right hippocampus was not different between the two software, the mean difference in the left hippocampus volume between the two methods was 0.17 ml (P < 0.001). The other brain regions showed significant differences in terms of measured volumes between the two software. Conclusion: SM and NQ provided good-to-excellent reliability in evaluating most brain structures, except for the basal ganglia in patients with cognitive impairment. Researchers and clinicians should be aware of the potential differences in the measured volumes when using these two different software interchangeably.
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( Jieun Kang ),( Jisun Park ),( Dawn Chung ),( San Hui Lee ),( Eun Young Park ),( Kyung-hee Han ),( Seoung Jin Choi ),( In-bai Chung ),( Hyuck Dong Han ),( Yeon Soo Jung ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.4
Objective To describe the clinical outcomes of frozen-thawed embryo transfer (FET) with artificial preparation of the endometrium, using a combination of estrogen (E2) and progesterone (P4) with or without a gonadotropin-releasing hormone agonist (GnRHa), and the modified natural cycle (MNC) with human chorionic gonadotropin (hCG) trigger. Methods In this retrospective study, we evaluated 187 patients during 3 years (February 2012-April 2015). The patients were allocated to the following treatment groups: group A, comprising 113 patients (181 cycles) who received GnRHa+E2+P4; group B, comprising 49 patients (88 cycles) who received E2+P4; and group C, comprising 25 patients (42 cycles) who received hCG+P4. The inclusion criteria were regular menstrual cycles (length 24-35 days) and age 21-45 years. Results The primary outcome of the study ― implantation rate (IR) per embryo transferred ― was not statistically different among the 3 groups. Similar results were found for the IRs with fetal heartbeat per embryo transferred (68/181 [37.6%] in group A vs. 22/88 [25.0%] in group B vs. 14/42 [33.3%] in group C) and for the live birth rates (LBRs) per embryo transferred (56/181 [30.9%] in group A vs. 18/88 [20.5%] in group B vs. 11/42 [26.2%] in group C). Conclusion Although the pregnancy outcomes were better in the hormone therapy with GnRHa group, hormone therapy FET with GnRHa for pituitary suppression did not result in significantly improved IRs and LBRs when compared with hormone therapy FET without GnRHa or MNC FET.
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Chung, Jieun,Kim, Hayoung,Moon, Yeonsil,Moon, Won-Jin Korean Society of Magnetic Resonance in Medicine 2020 Investigative Magnetic Resonance Imaging Vol.24 No.2
Background: Determination of inter-method differences between clinically available volumetry methods are essential for the clinical application of brain volumetry in a wider context. Purpose: The purpose of this study was to examine the inter-method reliability and differences between the Siemens morphometry (SM) software and the NeuroQuant (NQ) software. Materials and Methods: MR images of 86 subjects with subjective or objective cognitive impairment were included in this retrospective study. For this study, 3D T1 volume images were obtained in all subjects using a 3T MR scanner (Skyra 3T, Siemens). Volumetric analysis of the 3D T1 volume images was performed using SM and NQ. To analyze the inter-method difference, correlation, and reliability, we used the paired t-test, Bland-Altman plot, Pearson's correlation coefficient, intraclass correlation coefficient (ICC), and effect size (ES) using the MedCalc and SPSS software. Results: SM and NQ showed excellent reliability for cortical gray matter, cerebral white matter, and cerebrospinal fluid; and good reliability for intracranial volume, whole brain volume, both thalami, and both hippocampi. In contrast, poor reliability was observed for both basal ganglia including the caudate nucleus, putamen, and pallidum. Paired comparison revealed that while the mean volume of the right hippocampus was not different between the two software, the mean difference in the left hippocampus volume between the two methods was 0.17 ml (P < 0.001). The other brain regions showed significant differences in terms of measured volumes between the two software. Conclusion: SM and NQ provided good-to-excellent reliability in evaluating most brain structures, except for the basal ganglia in patients with cognitive impairment. Researchers and clinicians should be aware of the potential differences in the measured volumes when using these two different software interchangeably.
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Jieun Lee,Jung Han Lee,In-Young Chung,Chang-Joon Kim,Byung-Gook Park,Dong Myong Kim,Dae Hwan Kim IEEE 2011 IEEE TRANSACTIONS ON NANOTECHNOLOGY Vol.10 No.5
<P>Performances and energy efficiencies of various single-electron transistor-based (SET-based) binary full adders (FAs) are comparatively investigated with optimization of device parameters by means of simulation program with integrated circuit emphasis models including nonideal effects commonly observed in really implemented SETs. The proposed binary decision diagram (BDD) cell-based 1-bit FA is the most promising in terms of energy efficiency (τ=0.3 aJ/state), power dissipation (P = 1.2 nW), delay (τ=20 ps), and immunity to process variations (background charge noise ΔQ<SUB>0</SUB> <; ±0.112q and control gate capacitance mismatch ΔC<SUB>cg</SUB> <; 0.5 × C<SUB>cg</SUB>) at the expense of hardware burden, compared with majority gate-based SET FAs (3.988 aJ/state, P = 15.95nW, τ=52 ps, ΔQ<SUB>0</SUB> <; ±0.0392q, ΔC<SUB>cg</SUB> <; 0.35 × C<SUB>cg</SUB>) and SET threshold logic gate-based FAs (3.845 aJ/state, P=15.38nW, τ=107 ps, ΔQ<SUB>0</SUB> <; ±0.028q, ΔC<SUB>cg</SUB> <; 0.2 × C<SUB>cg</SUB>). It is also found that the SET itself dominates the power dissipation in SET-based FAs and the static dc power plays a significant role in power consumption in SET-based FAs, compared with the dynamic power, regardless of the FA type. In addition, SET-based BDD FAs are compared with their CMOS counterparts.</P>
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Chung, In-Young,Jang, Hyeri,Lee, Jieun,Moon, Hyunggeun,Seo, Sung Min,Kim, Dae Hwan IOP Pub 2012 Nanotechnology Vol.23 No.6
<P>We introduce a simulation method for the biosensor environment which treats the semiconductor and the electrolyte region together, using the well-established semiconductor 3D TCAD simulator tool. Using this simulation method, we conduct electrostatic simulations of SiNW biosensors with a more realistic target charge model where the target is described as a charged cube, randomly located across the nanowire surface, and analyze the Coulomb effect on the SiNW FET according to the position and distribution of the target charges. The simulation results show the considerable variation in the SiNW current according to the bound target positions, and also the dependence of conductance modulation on the polarity of target charges. This simulation method and the results can be utilized for analysis of the properties and behavior of the biosensor device, such as the sensing limit or the sensing resolution.</P>
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Jieun Lee,Suk-Hwan Kang,Hyo-Sik Kim,Dong-Hwan Jeon,Seung Jong Lee,Seok Woo Chung,Jin Wook Lee,Yongseung Yun,Ho-Jung Ryu,Jeom-In Baek 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.9
Experimental research on coal gasification with a filtration and desulfurization system for the development of an integrated gasification combined cycle (IGCC) was performed with Indonesian LG, KPU and Canadian Arch coals. A dry-feeding entrained-bed type gasifier was operated below the fusion temperature of the coal and at 20 bar of pressure. The filtration system was designed for continuous capture and subsequent removal of the fly ash and the unreacted coal residue via a specialty metal filter. The hot fuel gas desulfurization unit (HGD) consisted of a transport desulfurizer, a bubbling regenerator and a multi-cyclone. The research objective was to investigate the feasibility of applying a partial slagging coal gasifier to attain high carbon conversion and cold gas efficiencies as well as to attain an operational capability for combining with filtration and HGD. A Pilot-scale test demonstrated that the coal fines were effectively removed and the overall sulfur removal efficiency of the hot fuel gas desulfurization unit was higher than 95.3%.
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Inhibitory mechanism of Korean Red Ginseng on GM-CSF expression in UVB-irradiated keratinocytes
Chung, Ira,Lee, Jieun,Park, Young Sun,Lim, Yeji,Chang, Do Hyeon,Park, Jongil,Hwang, Jae Sung The Korean Society of Ginseng 2015 Journal of Ginseng Research Vol.39 No.4
Background: UV-irradiated keratinocytes secrete various proinflammatory cytokines. UV-induced skin damage is mediated by growth factors and proinflammatory cytokines such as granulocyte macrophage colony stimulating factor (GM-CSF). In a previous study, we found that the saponin of Korean Red Ginseng (SKRG) decreased the expression of GM-CSF in UVB-irradiated SP-1 keratinocytes. In this study, we attempted to find the inhibitory mechanism of SKRG on UVB-induced GM-CSF expression in SP-1 keratinocytes. Methods: We investigated the inhibitory mechanism of SKRG and ginsenosides from Panax ginseng on UVB-induced GM-CSF expression in SP-1 keratinocytes. Results: Treatment with SKRG decreased the expression of GM-CSF mRNA and protein induced by irradiation of UVB in SP-1 keratinocytes. The phosphorylation of ERK was induced by UVB at 10 min, and decreased with SKRG treatment in SP-1 keratinocytes. In addition, treatment with SKRG inhibited the UVB-induced phosphorylation of epidermal growth factor receptor (EGFR), which is known to be an upstream signal of ERK. From these results, we found that the inhibition of GM-CSF expression by SKRG was derived from the decreased phosphorylation of EGFR. To identify the specific compound composing SKRG, we tested fifteen kinds of ginsenosides. Among these compounds, ginsenoside-Rh3 decreased the expression of GM-CSF protein and mRNA in SP-1 keratinocytes. Conclusion: Taken together, we found that treatment with SKRG decreased the phosphorylation of EGFR and ERK in UVB-irradiated SP-1 keratinocytes and subsequently inhibited the expression of GM-CSF. Furthermore, we identified ginsenoside-Rh3 as the active saponin in Korean Red Ginseng.
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Clinical Outcomes of Dose Modification During Pirfenidone Treatment in Patients with IPF
( Jieun Kang ),( Man Pyo Chung ),( Moo Suk Park ),( In Jae Oh ),( Heung Bum Lee ),( Young Whan Kim ),( Jong Sun Park ),( Soo Taek Uh ),( Yun Seong Kim ),( Yangjin Jegal ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Pirfenidone is an antifibrotic medication proven to slow down the progression of idiopathic pulmonary fibrosis (IPF). However, its adverse effects frequently prevent patients from taking the full recommended dose and consequent dose modifications often follow. In this study, we evaluated whether dose modifications during treatment have any impact on clinical outcomes. Methods We used the data of a prospective post-marketing study of pirfenidone conducted at 10 hospitals in South Korea from 2014 to 2017. Patients were included in the current analysis if they received pirfenidone for more than 3 months and had lung function data at baseline and at least once during follow-up. We classified the study patients into three groups based on the dose received for the longest period during follow-up (1800mg, 1200mg, and less than 1200mg/day). The following clinical outcomes were compared between the groups: death, hospitalization, acute exacerbation, pulmonary function decline, changes in symptom, and adverse events. Results There were 53, 45, and 45 patients in the 1800mg, 1200mg, and less than 1200mg/day group, respectively. The median followup duration in all patients was 11 months (interquartile range, 9-12 months). Baseline patients treated with pirfenidone 1800mg/day tended to be younger and had the lowest diffusing capacity of the lung for carbon monoxide (DLCO). During follow-up, the three groups were not different in the number of deaths, hospitalizations, and acute exacerbations. Annual declines in forced vital capacity and DLCO were not significantly different. The proportion of patients who experienced FVC decline ≥10% was also not significantly different between the groups. The symptom changes were similar between the groups. Photosensitivity and anorexia were the most frequently developed adverse events found in a dose-dependent manner. Conclusions Dose modifications to improve drug compliance resulted in similar outcomes compared with full dose pirfenidone in patients with IPF.
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