Validity of the Korean Version of the Fear of Alzheimer’s Disease Scale for the Assessment of Anticipatory Dementia

문연실,김희진,최호진,오성일,한설희 대한의학회 2014 Journal of Korean medical science Vol.29 No.3

Anticipatory dementia is related to anxiety, which is a clinical predictor of early conversionto Alzheimer’s disease. The Fear of Alzheimer’s Disease Scale (FADS) is a reliable and validinstrument to address anticipatory dementia. The aim of the present investigation was todevelop the Korean version of the Fear of Alzheimer’s Disease Scale (K-FADS) and to verifyits reliability and validity. We developed the K-FADS to consist of 30 items with total scoresranging from 0 to 120, as in the original FADS. One hundred eight healthy volunteerparticipants, drawn from 3 different university hospitals, were evaluated. The K-FADSrevealed good reliability (Cronbach α = 0.96) and good validity as compared to the Koreanversion of the State-Trait Anxiety Inventory Form (r = 0.242, P = 0.013). Test-retestreliability was excellent, as the intra-class correlation coefficient comparing the retest totest was 0.98 (95% confidence interval, 0.96-0.99). Our results show that the K-FADS is asuitable and valuable scale to assess anticipatory dementia in elderly Koreans.

Which Stratum of Urban Elderly Is Most Vulnerable for Dementia?

문연실,이희영,남궁옥경,한설희 대한의학회 2016 Journal of Korean medical science Vol.31 No.10

Many factors associated with a patient’s lifestyle may disrupt timely access to dementia diagnosis and management. The aim of this study was to compare characteristics of lifestyle factors at the time of initial evaluation for dementia across degrees of dementia, and to identify risk factors relating to late detection of dementia, in order to understand the various lifestyle barriers to timely recognition of the disease. We reviewed medical records of 1,409 subjects who were diagnosed as dementia among 35,723 inhabitants of Gwangjin-gu. Dementia severity was divided into three degrees. Age, sex, education, income, smoking, heavy drinking, physical activity, religion, and living conditions were evaluated. There was a significantly greater proportion of individuals who were old age, female, less educated, who had never smoked or drank heavily, without physical activity, with no religious activity and living with family other than spouse in the severe dementia group. The lifestyle risks of late detection were old age, lower education, less social interactions, less physical activity or living with family. We can define this group of patients as the vulnerable stratum to dementia evaluation. Health policy or community health services might find ways to better engage patients in this vulnerable stratum to dementia.

임상 추론: 점차 진행하는 기억장애로 내원한 79세 여자

문연실,김은주 대한신경과학회 2019 대한신경과학회지 Vol.37 No.2

비특이적 만성 어지럼증을 보인 기립성빈맥증후군 1예

문연실,김영진,이준화,오지영 대한임상신경생리학회 2011 Annals of Clinical Neurophysiology Vol.13 No.1

Postural orthostatic tachycardia syndrome (POTS) is characterized by increased heart rate with preserved blood pressure on orthostatic stress. Many patients with postural orthostatic tachycardia syndrome can be misdiagnosed as neurosis, chronic fatigue or anxiety disorder. We report a patient with POTS who presented chronic dizziness and fatigue. In approaching to a patient with orthostatic or nonspecific chronic dizziness, the postural heart rate as well as blood pressure should be checked not to miss the diagnosis.

성관계 중 발생한 뇌경색

문연실,김한영,오지영,김동욱,강현석,조현지,김숙희,김영진,이준화,한설희 대한신경과학회 2010 대한신경과학회지 Vol.28 No.1

Paradoxical embolism after the Valsalva maneuver can cause ischemic stroke in patients with patent foramen ovale (PFO). A 27-year-old woman presented with abnormal movement of the right arm and aphasia. Brain imaging showed acute infarction in the left frontal lobe and segmental steno-occlusion in the left middle cerebral artery. A PFO study demonstrated air embolic signals in the middle cerebral artery. This case of embolic stroke occurred during sexual intercourse, probably related to the Valsalva maneuver, in a patient with PFO.

비타민 D 결핍과 인지장애

문연실,한설희 대한치매학회 2012 Dementia and Neurocognitive Disorders Vol.11 No.4

Vitamin D is not a true vitamin but a fat-soluble steroid prohormone that has long been known for its important and diverse role in the biological system. Many studies have revealed that vitamin D deficiency is linked with an increased risk of autoimmune diseases, cardiovascular diseases, cancers, type II diabetes and infectious diseases. Vitamin D3 is transformed to its active form, 1, 25-dihydroxyvitamin D3, through metabolisms in the liver and kidney. 1, 25-dihydroxyvitamin D3 interacts with its vitamin D receptor, and the brain is now known to have vitamin D receptors and 1α-hydroxylase. Several lines of evidences suggest vitamin D deficiency is associated with cognitive impairment and dementia, however, its position in cognitive function is still in its infancy. Vitamin D deficiency is a reversible condition and can be easily treated with supplements. Randomized controlled trials of vitamin D supplementation in patients with neurodegenerative conditions are needed.

Vulnerable Strata to Non-Adherence and Overuse in Treatment for Patients with Cognitive Impairment

문연실,Lim Jae-Sung,Lee Chan-Nyoung,최호진 대한치매학회 2020 Dementia and Neurocognitive Disorders Vol.19 No.4

Background and purpose: Appropriate medication treatment could enable both cognitively impaired patients and caregivers to hold on their cognitive functioning and quality of life. Thus, medication management and the factors influencing how management for this condition is carried out must be identified. In this study we aimed to evaluate the frequency of medication nonadherence (MNA) or drug overuse for cognitive impairment (DOC) and to extract significant variables, including the demographic and social characteristics, vascular risk factors, and cognitive status, for the diagnosis of MNA and DOC in Korean patients. Methods: We investigated patients aged over 50 years between March 2019 and June 2019 via the cognitive enHancement of patIents with acQuired cognitive impairment (HIQ) campaign. MNA was defined as a participant who was classified as having cognitive impairment but did not take any cognition-related drugs, whereas DOC was defined as a participant who had normal cognition but was taking cognition-related drugs. Results: We included 10,767 patients. The MNA group consisted of 337 participants, whereas the DOC group comprised 1,107 participants. The factors that could differentiate the MNA group from the normal-behavior group were age, education, sex, and the total Korean version of Mini-Mental State Examination (K-MMSE) score. The factors that could differentiate the DOC group from the normal medication-behavior group were age, sex, residential distinction, experience of a dementia screening test, and the total K-MMSE score. Conclusions: The underlying factors contributing to inadequate dementia-medication management must be understood, and intervention or support is needed to enable safe medication management.

근감소증의 진단과 신경학적 견해

문연실,한설희 대한신경과학회 2017 대한신경과학회지 Vol.35 No.4/SUP

Sarcopenia (Greek ‘sarx’ or flesh+‘penia’ or loss) originally is proposed as the term to describe age-related decrease of muscle mass. These days, sarcopenia is defined as a syndrome characterized by progressive loss of skeletal muscle mass and strength with a risk of adverse outcomes such as poor quality of life, physical disability, and death. In the recent decade, there are a few of consensus; European, international, and Asian consensus panels have published definitions. Additionally, measurement techniques that can be used for research and clinical practice settings according to their suitability are suggested. Many studies are reported about the association with sarcopenia and neurologic diseases, however, the results are heterogenous due to lack of sufficient studies. Some pharmacologic and non-pharmacologic methods are suggested as the intervention of sarcopenia, although there are not enough studies, yet. In this review, we summarize current understanding of the diagnostic sarcopenia and neurological point of view of sarcopenia.

Vertebral artery dissection presenting as transient global amnesia: a case report and review of literature

문연실,한설희 대한치매학회 2014 Dementia and Neurocognitive Disorders Vol.13 No.2

Vertebral artery dissection is one of the most common causes of stroke in young adults. The course of the vertebral artery dissection is usually benign, and pure transient amnesia as an initial symptom has been rarely reported. We describe a patient with vertebral artery dissection who presented with acute transient amnesia, and review the medical literatures about the pathophysiological mechanism of transient global amenesia (TGA). This case could be a one of evidence which supports the cerebrovascular mechanism of TGA.

경찰특공대(SWAT) 작전복(BDU)의 기능성 향상을 위한 패턴개발 - 작전복 개발 및 착의평가를 중심으로 -

문연실 ( Yeon Sil Moon ),김선희 ( Son Hee Kim ),김은경 ( Eun Kyong Kim ) 대한가정학회 2005 Human Ecology Research(HER) Vol.43 No.5