Distribution, side involvement, phenotype and associated anomalies of Korean patients with craniofacial clefts from single university hospitalbased data obtained during 1998-2018

Jee Hyeok Chung,Sunjin Yim,Il-Sik Cho,Seung-Weon Lim,Il-Hyung Yang,Jeong Hyun Ha,Sukwha Kim,Seung-Hak Baek 대한치과교정학회 2020 대한치과교정학회지 Vol.50 No.6

Objective: To investigate the distribution, side involvement, phenotype, and associated anomalies of Korean patients with craniofacial clefts (CFC). Methods: The samples consisted of 38 CFC patients, who were treated at Seoul National University Dental Hospital during 1998–2018. The Tessier cleft type, sex, side involvement, phenotype, and associated anomalies were investigated using nonparametric statistical analysis. Results: The three most common types were #7 cleft, followed by #0 cleft and #14 cleft. There was no difference between the frequency of male and female. Patients with #0 cleft exhibited nasal deformity, bony defect, and missing teeth in the premaxilla, midline cleft lip, and eye problems. A patient with #3 cleft (unilateral type) exhibited bilateral cleft lip and alveolus. All patients with #4 cleft were the bilateral type, including a combination of #3 and #4 clefts, and had multiple missing teeth. A patient with #5 cleft (unilateral type) had a posterior openbite. In patients with #7 cleft, the unilateral type was more prevalent than the bilateral type (87.0% vs. 13.0%, p < 0.001). Sixteen patients showed hemifacial microsomia (HFM), Goldenhar syndrome, and unilateral cleft lip and palate (UCLP). There was a significant match in the side involvement of #7 cleft and HFM (87.5%, p < 0.01). Patients with #14 cleft had plagiocephaly, UCLP, or hyperterorbitism. A patient with #30 cleft exhibited tongue tie and missing tooth. Conclusions: Due to the diverse associated craniofacial anomalies in patients with CFC, a multidisciplinary approach involving a well-experienced cooperative team is mandatory for these patients.

양측 부신 거대종양의 형태를 보인 악성 임파종 2예

한지숙,정상수,정혜원,정재호,허갑범,이현철,임승길,김경래,송영득,남재현,안철우,김진석,김명수,한승혁,구영석 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.1

Adrenal gland is a common site of metastatic tumors such as breast cancer, lung cancer, and colon cancer. When adrenal mass is found incidentally, adenoma is the most common among single adrenal masses. But in the case of bilateral adrenal masses, infection, bilateral metastases and hemorrhage are common. Secondary involvement of the adrenal gland is found in 25% of autopsy cases of non-Hodgkin's lymphoma. However, adrenal insufficiency is rare because it becomes apparent only when approximately 90% of adrenal cortex is destructed. We exprienced two cases of malignant lymphoma which involved the adrenal glands bilaterally. One case in which adrenal insufficiency was suspicious, was accompanied by hypovolemic shock and sepsis at the initial presentation. He died of sepsis combined with DIC even though hydrocortisone, intravenous saline infusion, and antibiotics therapy were started immediately. The other one was found incidentally, in which adrenal infiltraion was confirmed by CT scan. Hormonal level was normal and adrenal masses disappeared after chemotherapy(J Kor Soc Endocrinol 15:121-127, 2000).

고속 확장된 작업공간을 가진 병렬 로봇을 위한 경량 3-DOF 손목 메커니즘의 ANSYS 기반 응력해석

박상혁(Sang Hyeok Park),정원지(Won Jee Chung),황희건(Hui Geon Hwang),김홍록(Hong Rok Kim),최세웅(Se Woong Choi),지명준(Myeong Jun Jee),홍우철(Woo Cheol Hong) 한국기계가공학회 2022 한국기계가공학회지 Vol.21 No.2

This study proposed a method of testing the stability when selecting gears to reduce the weight of a 3-DOF wrist mechanism for a pick-and-place 3-DOF parallel robot with an increased workspace by using an additional straight axis at its top. We performed SolidWorks<SUP>Ⓡ</SUP> modeling- and ANSYS<SUP>Ⓡ</SUP>-based structural analysis of a pinion gear, which is most vulnerable to the force from a 3-DOF wrist mechanism, to lighten the robot weight for performing various tasks. When the initial analysis results considerably differed from the theoretical values calculated in advance, we checked and identified the errors in the contact conditions or input values. Ultimately, it is believed that the methodology presented in this paper will help in mitigating errors during analysis and determine the accurate values for a lightweight 3-DOF wrist mechanism for a parallel robot with an expanded workspace.

Treatment modalities for Korean patients with unilateral hemifacial microsomia according to Pruzansky-Kaban types and growth stages

Il-Hyung Yang,Jee Hyeok Chung,Sunjin Yim,Il-Sik Cho,Sukwha Kim,Jin-Young Choi,Jong-Ho Lee,Myung-Jin Kim,Seung-Hak Baek 대한치과교정학회 2020 대한치과교정학회지 Vol.50 No.5

Objective: To investigate the treatment modalities (Tx-Mods) for patients with unilateral hemifacial microsomia (UHFM) according to Pruzansky–Kaban types and growth stages. Methods: The samples consisted of 82 Korean UHFM patients. Tx-Mods were defined as follows: Tx-Mod-1, growth observation due to mild facial asymmetry; Tx-Mod-2, unilateral functional appliance; Tx-Mod-3, fixed orthodontic treatment; Tx-Mod-4, growth observation due to a definite need for surgical intervention; Tx-Mod-5, unilateral mandibular or bimaxillary distraction osteogenesis (DO); Tx-Mod-6, maxillary fixation using LeFort I osteotomy and mandibular DO/sagittal split ramus osteotomy; Tx-Mod-7, orthognathic surgery; and Tx-Mod-8, costochondral grafting. The type and frequency of Tx-Mod, the number of patients who underwent surgical procedures, and the number of surgeries that each patient underwent, were investigated. Results: The degree of invasiveness and complexity of Tx-Mod increased, with an increase in treatment stage and Pruzan ky–Kaban type (initial < final; [I, IIa] < [IIb, III], all p < 0.001). The percentage of patients who underwent surgical procedures increased up to 4.2 times, with an increase in the Pruzansky–Kaban type (I, 24.1%; IIa, 47.1%; IIb, 84.4%; III, 100%; p < 0.001). However, the mean number of surgical procedures that each patient underwent showed a tendency of increase according to the Pruzansky–Kaban types (I, n = 1.1; IIa, n = 1.5; IIb, n = 1.6; III, n = 2.3; p > 0.05). Conclusions: These findings might be used as basic guidelines for successful treatment planning and prognosis prediction in UHFM patients.

Post-translational modification of OCT4 in breast cancer tumorigenesis

Cho, Yunhee,Kang, Hyeok Gu,Kim, Seok-Jun,Lee, Seul,Jee, Sujin,Ahn, Sung Gwe,Kang, Min Jueng,Song, Joon Seon,Chung, Joon-Yong,Yi, Eugene C.,Chun, Kyung-Hee Nature Publishing Group 2018 CELL DEATH AND DIFFERENTIATION Vol. No.

<P>Recurrence and drug resistance of breast cancer are still the main reasons for breast cancer-associated deaths. Cancer stem cell (CSC) model has been proposed as a hypothesis for the lethality of breast cancer. Molecular mechanisms underlying CSC maintenance are still unclear. In this study, we generated mammospheres derived from breast cancer MDA-MB231 cells and MCF7 cells to enrich CSCs and performed DNA microarray analysis. We found that the expression of carboxy terminus of HSP70-interacting protein (CHIP) E3 ubiquitin ligase was significantly downregulated in breast CSCs. CHIP depletion increased mammosphere formation, whereas CHIP overexpression reversed this effect. We identified interactomes by mass spectrometry and detected CHIP directly interacted with OCT4, a stemness factor. CHIP overexpression decreased OCT4 stability through proteasomal degradation. CHIP induced OCT4 ubiquitination, whereas H260Q, a catalytic CHIP mutant, did not. Interestingly, we determined that OCT4 was ubiquitinated at lysine 284, and CHIP overexpression did not degrade K284R mutant OCT4. CHIP overexpression decreased the proliferation and side population of breast cancer cells, but these were not occurred in K284R mutant OCT4 overexpressed cells. Only 1000 cells showing CHIP depletion or OCT4 overexpression sufficiently generated breast tumors and lung metastases in xenografted mice. Ubiquitination-defective mutant of OCT4(K284R) overexpressed cells drastically generated tumor burdens in mice. Patients with breast cancer who showed low CHIP expression had poor survival probability. Taken together, we suggest that CHIP-induced OCT4 ubiquitination is important in breast CSCs. Regulation of CHIP expression and OCT4 protein stability is a considerable approach for breast cancer therapy.</P>

Le Fort I osteotomy as treatment for traumatic class III malocclusion caused by Le Fort III fracture: A case report

Han Byeol Jin,Jee Hyeok Chung,Kyung Sik Kim,Seung Hong Kim,최준,Jeong Yeol Yang 대한미용성형외과학회 2019 Archives of Aesthetic Plastic Surgery Vol.25 No.1

Trauma in the modern society is characterized by multiple injuries, and the several comorbidities are often accompanied by facial bone fracture. The types of multiple facial bone fractures vary from Le Fort to panfacial fracture. Le Fort fracture, which can cause problems, such as facial disfigurement, functional impairment of mastication, malocclusion and speech abnormalities, is a challenging case for plastic surgeons. The purpose of treatment for patients with malocclusion due to Le Fort fracture is to maintain and restore both function and aesthetics. The author reports a case of Le Fort I osteotomy as a surgical correction of traumatic class III malocclusion due to Le Fort III fracture.

An Experimental Study on the Functional Assessment of End-to-side Neurorrhaphy Using Walking Track Analysis in Rats

Minn, Kyung Won,Chung, Jee Hyeok 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.2

The purpose of this study was to investigate the functional recovery of end-to-side neurorrhaphy in rats. There have been several studies about the results of end-to-side neurorrhaphy from a histologic or eletrophysiologic view point. However, histologic or electrophysiologic parameters may not correlate with the actual nerve function. In this study we assessed the results of end-to-side neurorrhaphy functionally using walking track analysis. Forty-eight male Sprague-Dawley rats were randomly divided into 4 group, with 12 rats in each group. Group 1 was the sham-operation group. Group 2 was the peroneal nerve transection group. In group 3, the peroneal nerve was severed and end-to-end neurorrhaphy was carried out. In group 4, the peroneal nerve was severed and coapted end-to-side to the lateral face of the tibial nerve after removal of the epineurium arid perineurium. Walking track analysis was done every 2 weeks up to 16 weeks. Group 3 recovered 80.4% in peroneal function at postoperative 16 weeks, whereas group 4 recovered only 46.0%. In group 2, it was impossible to measure the peroneal function by walking track analysis because of plantar flexion contracture after 6 weeks. We concluded that the end-to-side neurorrhaphy group showed better results compared with the nerve transection group. However, the end-to-end neurorrhaphy group showed still better results in the walking track analysis of rats.

Reconstruction of temporal hollowing using two alloplastic materials simultaneously with titanium mesh and a silicone implant

Han Byeol Jin,Jee Hyeok Chung,Kyung Sik Kim,Seung Hong Kim,최준,Jeong Yeol Yang 대한미용성형외과학회 2019 Archives of Aesthetic Plastic Surgery Vol.25 No.1

Temporal hollowing is a contour deformity that results in a concavity or hollowing of the temporal region, causing significant cosmetic problems that affect patients both physically and psychologically. For these patients, cranioplasty is needed for protective coverage of the brain and to restore a pleasing aesthetic contour to the cranium. We report a case in which titanium mesh was used as a customized craniofacial implant for a bony defect and a silicone implant was used for soft tissue augmentation of muscle and to address temporal fat pad atrophy. The procedure resulted in high patient satisfaction from an aesthetic standpoint and, importantly, restored a functional barrier resistant to trauma.

Acquired Palatal Fistula in Patients with Submucous and Incomplete Cleft Palate before Surgery

Park, Ie Hyon,Chung, Jee Hyeok,Choi, Tae Hyun,Han, Jihyeon,Kim, Suk Wha Korean Society of Plastic and Reconstructive Surge 2016 Archives of Plastic Surgery Vol.43 No.6

It is uncommon for a palatal fistula to be detected in individuals who have not undergone surgery, and only sporadic cases have been reported. It is even more difficult to find cases of acquired palatal fistula in patients with submucous or incomplete cleft palate. Herein, we present 2 rare cases of this phenomenon. Case 1 was a patient with submucous cleft palate who acquired a palatal fistula after suffering from oral candidiasis at the age of 5 months. Case 2 was a patient with incomplete cleft palate who spontaneously, without trauma or infection, presented with a palatal fistula at the age of 9 months.

Characterization of phenotypes and predominant skeletodental patterns in pre-adolescent patients with Pierre–Robin sequence

Il-Hyung Yang,Jee Hyeok Chung,Hyeok Joon Lee,Il-Sik Cho,Jin-Young Choi,Jong-Ho Lee,Sukwha Kim,Seung-Hak Baek 대한치과교정학회 2021 대한치과교정학회지 Vol.51 No.5

Objective: To investigate the phenotypes and predominant skeletodental pattern in pre-adolescent patients with Pierre–Robin sequence (PRS). Methods: The samples consisted of 26 Korean pre-adolescent PRS patients (11 boys and 15 girls; mean age at the investigation, 9.20 years) treated at the Department of Orthodontics, Seoul National University Dental Hospital between 1998 and 2019. Dental phenotypes, oral manifestation, cephalometric variables, and associated anomalies were investigated and statistically analyzed. Results: Congenitally missing teeth (CMT) were found in 34.6% of the patients (n = 9/26, 20 teeth, 2.22 teeth per patient) with 55.5% (n = 5/9) exhibiting bilaterally symmetric missing pattern. The mandibular incisors were the most common CMT (n = 11/20). Predominant skeletodental patterns included Class II relationship (57.7%), posteriorly positioned maxilla (76.9%) and mandible (92.3%), hyper-divergent pattern (92.3%), high gonial angle (65.4%), small mandibular body length to anterior cranial base ratio (65.4%), linguoversion of the maxillary incisors (76.9%), and linguoversion of the mandibular incisors (80.8%). Incomplete cleft palate (CP) of hard palate with complete CP of soft palate (61.5%) was the most frequently observed, followed by complete CP of hard and soft palate (19.2%) and CP of soft palate (19.2%) (p < 0.05). However, CP severity did not show a significant correlation with any cephalometric variables except incisor mandibular plane angle (p < 0.05). Five craniofacial and 15 extra-craniofacial anomalies were observed (53.8% patients); this implicated the need of routine screening. Conclusions: The results might provide primary data for individualized diagnosis and treatment planning for pre-adolescent PRS patients despite a single institution-based data.