文山 李載毅의 삶과 交遊

李鍾虎(Lee Jong-Ho) 한국인물사연구소 2010 한국인물사연구 Vol.13 No.-

Moonsan is Lee Jae-ui(1772~1839)'s pen name. He is born the eldest grandson of the Jeonju Lee's Dukchun family line. Jeonju Lee's family is a prince of the blood in Chosun dynasty.. His noble birth make him a proud person. His birthplace was Seoul, but he have lived in Yongin, Kyunggi province. Especially he is a great-grandson of chief general, Lee Ju-guk who loved by king Jungjoe. Lee Jae-ui should carry out a duty of descendant offering sacrifice to his ancestors. That is a devout and unavoidable fate for him. Because he has a strong consciousness of offering sacrifice to his ancestors. He didn't go into government service at all. Instead of it, he made an effort to cultivate his morals and manage the family. Lee Jae-ui was taught chinese literature by Nam, you-do and the confucian scriptures by Ryu, Jung-mo in early years. During adult ages, he was a disciple of Park, yoon-won and Song, hwan-ki who are prominent scholars of confucianism. And then he promoted a friendship with lung, Jaw-meun Ann, ho Kim, young Sim, Ryu Song, Myung-hee lung, Yak-yong etc., they are his senior scholars. Whang, Gi-chun and Hong, Jik-pil, Lee, Man-jung and Sim, Du-young are Lee Jae-ui's best friends, First of all, he was known by lung, Yak-yong's argument parter of human nature. We hope that Lee Jae-ui's literature and thought is studied deeply sooner or later.

현와 이도의 삶과 문학

이종호(Lee, Jong-ho) 대동한문학회 2014 大東漢文學 Vol.40 No.-

이 글은 17세기 고령의 선비, 현와 이도의 삶과 문학을 조명한 것이다. 현와는 임란 직후 서울에서 양녕대군의 6세손으로 태어나 평탄한 소년기를 보내다가 광해조 대북정권의 난정에 가담한 백형 이심이 인조반정으로 처형되면서 집안형편이 어렵게 되었다. 그즈음 현와는 영남의 선비 이대기의 딸과 혼인하면서 초계로 낙남했고, 그 이후로 점차 영남사인으로 정착하게 된다. 소과에는 입격했으나 대과에 매번 불리하여 일정 시기에 와서 과거를 그만두었고, 고령으로 거처를 옮긴 뒤 60세를 전후하여 음직으로 종묘서 직장, 안기도 찰방 등을 역임했다. 현와의 문학세계를 개괄적으로 검토했는 바, 현와의 시 중에서 척화파 대신 정온과 성주의 병졸 이사룡의 절의정신을 노래한 작품이 수작으로 꼽히는데 모두가 병자호란이 낳은 문예적 분비물인 셈이다. 장편 산문작품은 가야산을 유람하면서 견문한 내용과 느낌을 기록한 유람기로 묘사의 사실성이 돋보이는데, 그가 초계 지역사회에서 주도적 인물이었음을 알게 해준다. 단편으로는 안동의 기녀 당아와 나눈 로맨스를 담담하게 묘사한 송별 서문과 문생 전형의 서재 이름을 풀이한 두암팔경시 서문이 평가할 만하다. 현와는 선진양한 고문을 전범으로 삼아 학습한 어우 유몽인에게서 고문을 배웠기에 장자의 문장을 전범으로 삼고 장자적 상상력에 기초하여 문장구법을 구사하려 했다. 그러나 그의 문법이 전고의 활용 등과 같은 부분에서 다소 의미전달력이 떨어져 문체가 통창하지 못한 결함이 간혹 엿보인다. 이 글에서는 지역한문학의 활성화라는 의도 아래, 새로운 작가의 발굴이라는 면에 중점을 두고, 현와의 삶과 교유를 구체적으로 살펴 향후 심화될 그의 문학세계 검토에 토대를 마련하고자 힘썼다. 아울러 이 글을 통해 17세기 병자호란 이후 나타난 蹈海의식과 忠憤정신의 형상화가 고령지역 한문학의 주된 주제였음도 확인하였다. This paper studied on the literature of Hyunwa Lee Do(1593~1668) who has lived in 17th century. Hyunwa, his literary name, was born on 1593 right after Japanese Yimjin Invasion of Korea for the 6th descendant from Yanneong-Daegoon. Eventually Gwanghae's misgovernment committed by Daebuk regime caused Yinjo Banjung(coup). As soon as his oldest brother who get involved in a misgovernment died by execution, his family was broken up. He was married Lee Daegi's daughter, and then he moved to Chogea of Youngnan Province from Seoul. Hyunwa was gradually settled immigrants in Yeungnam as a provincial Sunbi. Until then he passed Samasi but still failed Mungwa. By the way, before long he moved to Goryung, and took up a public office as a Jongmyouseo Jikjang, Angido Chalbang. We can summarize a literary world of Hyunwa as follows. Poems that vividly described Jong-on and Lee sa-ryong's faithful mind was loved to recite, and prose writings as a diary of Gayasan sight-seeing, farewell preface about pure love with gisaeng Dang-a, reading expressed his thoughts on Duarm which was a Joan-hyong's studying room are his major work. In short, he was one of the talented provincial intelligentsia in 17th century of Choson dynasty, used Jangja's imagination to write prose. To conclude, I believe that his literary works based on Byungja-horan which broke out in 1636. Also his Dohae mind and Chungboon sprit stemmed from the bitter experience forced to give in to Chung, Manchurian empire treated as a Barbarian.

전통주 주박의 항혈전 활성 평가

김미선(Mi-Sun Kim),이예슬(Ye-Seul Lee),김종식(Jong Sik Kim),신우창(Woo-Chang Shin),손호용(Ho-Yong Sohn) 한국생명과학회 2014 생명과학회지 Vol.24 No.8

전통주 주박을 이용한 고부가가치 식품소재 개발을 위해, 상업적 시설에서 생산된 3종 약주(J-B, J-S, J-Y) 및 2종 탁주(J-H, J-W) 주박의 ethanol 추출물 및 열수 추출물을 조제하고 이들의 혈액응고 저해활성, 혈소판 응집저해 활성 및 인간 적혈구 용혈활성을 평가하였다. 5종 주박의 pH는 3.90~4.29로 유사하였으나, brix는 5.0~27.0으로 다양하게 나타났으며, 수분 및 알코올 함량에서도 시료에 따라 1.8배의 차이를 나타내었다. 주박의 색차와 성분은 첨가된 부재료 및 사용누룩에 좌우되었으며, J-W 주박의 경우 수분함량이 80.3%, brix 13, 알코올 함량 1.8%를 함유하여 다른 주박에 비해 다양한 식품제조에 용이하게 이용 가능하리라 판단되었다. Ethanol 추출효율은 J-H, J-W, J-B, J-S, J-Y의 순, 열수 추출효율은 J-S, J-B, J-W, J-H, J-Y의 순으로 높았으며, 총폴리페놀 및 총플라보노이드함량은 ethanol 추출물 중에서는 J-H, 열수 추출물 중에서는 J-Y 주박에서 가장 높았다. 5종 주박의 10종 추출물은 모두 5 mg/ml 농도까지 인간 적혈구에 대한 용혈활성이 나타나지 않았으며, J-B, J-S, J-Y의 약주 주박의 ethanol 추출물에서 유의적인 혈액응고저해 활성이 나타났으며, J-W 탁주 주박의 열수 추출물에서 thrombin 저해 활성과 J-B, J-S 및 J-H 주박 열수 추출물에서 혈액 응고인자 저해활성을 확인하였다. 혈소판 응집저해 활성평가의 경우 J-W 탁주 주박의 ethanol 및 열수 추출물에서만 아스피린에 필적하는 우수한 활성이 확인되었다. 본 연구결과는 다양한 약주 및 탁주 주박이 항혈전 활성을 가지고 있으며, 주박으로부터 항혈전제 개발이 가능함을 제시하고 있다. In this study, ethanol and hot water extracts of lees from Korean traditional wine (J-B, J-S, J-Y, J-H, and J-W) were prepared, and their effects on blood coagulation, platelet aggregation, and hemolysis of human red blood cells (hRBCs) were investigated to develop functional food ingredients from lees. The pH and brix of the lees ranged from 3.90 to 4.29 and 5.0 to 27.0o, respectively, and there was a huge difference in the water and ethanol content among the lees. The nuruk and additives used affected the color and physicochemical properties of lees. The J-W takju made from only rice and traditional nuruk, which has 13o brix and 1.8% of alcohol, has potential as functional food ingredient. With regard to the extraction yields of lees, higher yields were obtained from J-H, which contains different medicinal plants, in ethanol, followed by J-W, J-B, J-S, and J-Y. Higher extraction yields of lees were obtained from J-S in hot water, followed by J-B, J-W, J-H, and J-Y, respectively. The ethanol extract of J-H and the hot water extract of J-Y had the highest contents of total polyphenol and total flavonoids among the lees extracts. The 10 lees extracts did not show hemolysis activity against hRBCs up to 5 mg/ml. In an anticoagulation activity assay, the ethanol extracts of three yakju lees (J-B, J-S, and J-Y) and the hot water extract of J-W inhibited thrombin activity, whereas the hot water extract of J-B, J-S, and J-H inhibited blood coagulation factors. In an antiplatelet aggregation activity assay, only the J-W takju lees showed significant inhibition activity. Our results suggest that lees from traditional wine had high potential as a novel antithrombosis agent.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

과학교육 개선을 위한 실험모델 제작에 관한 연구(Ⅰ)

이기종,이광호,이종철,김자홍 全北大學校 基礎科學硏究所 1991 基礎科學 Vol.14 No.1

A curriculum for teaching materials in Science Education was studied as a model for modified xperiment on fundamental courses. Coscious effort can be made to desingn experiments that require minimum apparatus, that require low-cost equipment that can be made to from cheap locally available materials. Computer-aided instruction programs at high school, freshman course level have been developed. The software package was consist of five programs: The program contains explanation and problems for the calculation of resonance energy, molecular structure, mole concept, Rutherford's experiment, thermodynamic processes. Special course equipment package explanation mole concept, Rutheford's experiment, thermo dynamic processes. Special course were designed in Science Education with the understanding that to a certain extent science values would be covered in all of the modified experiments and program models.

Regulatory Effect of Matcha Green Tea on Fine Dust-Exposed Cytotoxicity in Respiratory System

Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hyo Lim Lee,Hye Rin Jeong,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Jong Cheol Kim,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

This study was performed to evaluate the protective effect of matcha green tea on particulate matter (PM)2.5-indued nasal and pulmonary cytotoxicity. The matcha green tea increased the cell viability and inhibited the ROS production in PM2.5-induced cytotoxicity in nasal RPMI2650 and pulmonary A549 cells. The matcha green tea regulated the expression of apoptosis, such as p-Akt, BCl-2, caspase-3, caspase-1 and HO-1, and inflammation, such as TLR4, TLR4 and Nrf2, in PM2.5-indued RPMI2650 cells. In addition, the matcha green tea showed regulatory effect of the apoptosis and inflammatory effect by increasing the BCl-2 and suppressing the caspase-3, TLR4, TNF-α and COX-2 in A549 cells. In addition, the matcha green tea suppressed antioxidant deficits by regulating the reduced GSH contents, SOD activities and MDA levels, and ameliorated the mitochondrial dysfunction by regulating the mitochondrial ROS production, mitochondrial membrane potential and ATP contents in pulmonary tissue. Ultimately, consumption of matcha green tea down-regulated the inflammatory proteins such as TNF-α, p-JNK, p-IκB-α, p-NF-κB and COX-2 in lung tissue.

위암 환자에서 세포성 면역 기능에 관한 연구

이재익,윤일국,이종선,김종완,장준,안정기,송민호,정현용,이헌영,김삼용,김영건 충남대학교 암연구소 1991 癌共同硏究所 硏究誌 Vol.1 No.1

We performed a variety of lymphocyte stimulation tests, delayed hypersensitivity skin tests, and enumeration of several lymphocyte subpopulations in 21 patients with gastric cancer who did not receive any form of anticancer therapy, and in 20 healthy controls. The gastric cancer patients had significantly decreased number and total score of positive reactions in delayed hypersensitivity skin tests compared with the healthy controls. The percent of CD_(4) positive lymphocytes in the gastric cancer patients was significantly decreased compared to the normal control subjects, but it had no correlation with the total score of delayed cutaneous hypersensitivity reactions. The ratio of helper to suppressor cells was lower in the cancer group. The uptake of 3H-thymidine was markedly depressed in cancer patients when stimulated with various mitogens. There was little correlation between any of the stimulation tests and any of the lymphocyte subpopulation proportions to delayed hypersensitivity cutaneous reactions. Optimal proliferative response was found in lymphocytes stimulated with 10 micrograms of concanavalin-A and 10 microgram of phytohemagglutinin. Advanced stage patients had greatly depressed delayed hypersensitivity skin reactions and proliferative responses to mitogens compared with localized diseases. These results suggest that gastric cancer patients have depressed cellular immune functions, which mainly result from the decreased helper cells and defects in functional proliferative response to mitogens. Interleukin-2 and interferon-gamma restored the in vitro proliferative response of lymphocyte in patients with gastric cancer.

톨루엔을 포함한 유기용제의 직업적 폭로로 인한 신경내분비계 영향

이채언,이종태,정의화,손혜숙,문덕환,전진호,강정학,이창희,김휘동,김종한,정귀옥 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2

Long term occupational exposure to solvent mixtures may cause adverse effects to the central nervous system with neurobehavioral symptoms. And some organic slovents have been suggested to cause impairment of tuberoinfundibular dopaminergic activity and neurochemical mechanisms controlling pituitary secretion. For the purpose of assessing neuroendocrine effects in occupational solvents exposure, hormonal study settings (shoes-manufacturing industry & fishing products industry) and compared with nonexposed controls(33 men, 85 women). Male workers exposed to solvent mixtures had significantly lower plasma level of follicle-stimulating hormone(FSH) than nonexposed male controls. While female workers exposed to solvent mixtures had significantly lower plasma levels of growth hormone(GH), and thyroid-stimulating hormone(TSH) than nonexposed female controls. The results of significant decrease in plasma concentrations of pituitary hormones(FSH, GH, and TSH) in workers exposed solvent mixtures indicate that occupational exposure to solvent mixtures may induce neuroendocrine effects through an effect on hypothalamic pituitary axis.

위장관을 침범한 Henoch-Soho¨nlein purpura 1예

이승곤,김채규,서종옥,이호영,이호준,정회상,박유환,정춘해 조선의대 1996 The Medical Journal of Chosun University Vol.21 No.2

일방성 GFRP 복합재료에서 음향방출 신호의 위치표정

이종오,원순호,윤운하,이종규,소철호 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.3

General source location method that use an arrival time differences among sensor is restricted to the composite material and the complex-shaped material. In this study, a bundle-type acoustic sensor composed of 6 pinducers was utilized to determine wave propagation direction and then to estimate source location of the unidirectional GFRP. For the purpose of the study, slowness curve for the material was obtained and made an assumption that the incident waves on pinducers are propagated as a plane wave. According to the results, measured propagation directions of the wave was coincide with theoretical background, however, it was a hassle to determine the source location exactly. But, it is expected that bundle-type sensor gives more accurate results for zone location than generally used acoustic sensors.