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음식물 폐기물류로 제조된 퇴비의 고형연료 가치 평가 연구
이경섭,장한별,정은지,도아름,하진욱 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2
In 2019, the daily generation of food waste in Korea was 14,314 tons, which is a steady increase compared to the past. To efficiently use food waste as an effective resource, composting and feeding are carried out. In Korea, attention is gradually focused on a sustainable resource circulation society. Compost made of food waste has problems with foreign substances, heavy metals, and salt content, and solid fuelization research is being actively conducted to compensate for this. In this study, infrared spectroscopy(FT-IR), organic content measurement(TGA), and chemical composition were measured to compare the fuel characteristics with wood pellets, which are major solid fuels, in order to examine the physical and chemical properties of food waste compost.
Han Byeol Jin,Jee Hyeok Chung,Kyung Sik Kim,Seung Hong Kim,최준,Jeong Yeol Yang 대한미용성형외과학회 2019 Archives of Aesthetic Plastic Surgery Vol.25 No.1
Trauma in the modern society is characterized by multiple injuries, and the several comorbidities are often accompanied by facial bone fracture. The types of multiple facial bone fractures vary from Le Fort to panfacial fracture. Le Fort fracture, which can cause problems, such as facial disfigurement, functional impairment of mastication, malocclusion and speech abnormalities, is a challenging case for plastic surgeons. The purpose of treatment for patients with malocclusion due to Le Fort fracture is to maintain and restore both function and aesthetics. The author reports a case of Le Fort I osteotomy as a surgical correction of traumatic class III malocclusion due to Le Fort III fracture.
Han Byeol Jin,Jee Hyeok Chung,Kyung Sik Kim,Seung Hong Kim,최준,Jeong Yeol Yang 대한미용성형외과학회 2019 Archives of Aesthetic Plastic Surgery Vol.25 No.1
Temporal hollowing is a contour deformity that results in a concavity or hollowing of the temporal region, causing significant cosmetic problems that affect patients both physically and psychologically. For these patients, cranioplasty is needed for protective coverage of the brain and to restore a pleasing aesthetic contour to the cranium. We report a case in which titanium mesh was used as a customized craniofacial implant for a bony defect and a silicone implant was used for soft tissue augmentation of muscle and to address temporal fat pad atrophy. The procedure resulted in high patient satisfaction from an aesthetic standpoint and, importantly, restored a functional barrier resistant to trauma.
Park Jung-Jin,Oh Kwangseok,Lee Gun-Wu,Bang Geul,Park Jin-Hee,Kim Han-Byeol,Kim Jin Young,Shin Eun-Young,Kim Eung-Gook 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Senescence, a hallmark of aging, is a factor in age-related diseases (ARDs). Therefore, targeting senescence is widely regarded as a practicable method for modulating the effects of aging and ARDs. Here, we report the identification of regorafenib, an inhibitor of multiple receptor tyrosine kinases, as a senescence-attenuating drug. We identified regorafenib by screening an FDA-approved drug library. Treatment with regorafenib at a sublethal dose resulted in effective attenuation of the phenotypes of βPIX knockdown- and doxorubicin-induced senescence and replicative senescence in IMR-90 cells; cell cycle arrest, and increased SA-β-Gal staining and senescence-associated secretory phenotypes, particularly increasing the secretion of interleukin 6 (IL-6) and IL-8. Consistent with this result, slower progression of βPIX depletion-induced senescence was observed in the lungs of mice after treatment with regorafenib. Mechanistically, the results of proteomics analysis in diverse types of senescence indicated that growth differentiation factor 15 and plasminogen activator inhibitor-1 are shared targets of regorafenib. Analysis of arrays for phospho-receptors and kinases identified several receptor tyrosine kinases, including platelet-derived growth factor receptor α and discoidin domain receptor 2, as additional targets of regorafenib and revealed AKT/mTOR, ERK/RSK, and JAK/STAT3 signaling as the major effector pathways. Finally, treatment with regorafenib resulted in attenuation of senescence and amelioration of porcine pancreatic elastase-induced emphysema in mice. Based on these results, regorafenib can be defined as a novel senomorphic drug, suggesting its therapeutic potential in pulmonary emphysema.
The Effectiveness of Acupuncture Treatment for Patients with Alzheimer’s disease
Jin Hyeon Shin,신혜정,Eui Byeol Kim,안윤영,Tae Han Yook,최유민,송범용,김종욱 대한침구의학회 2020 대한침구의학회지 Vol.37 No.4
The purpose of this study was to evaluate the effectiveness of acupuncture treatment for the symptoms of Alzheimer’s disease (AD). There were 11 databases searched for randomized controlled trials using acupuncture treatment for AD. The risk-of-bias assessment tool of the Cochrane Library was used to evaluate the quality of each study. Using the Review Manager (RevMan), a meta-analysis was performed using risk ratio, mean difference, 95% confidence interval, and random effect model. There were 32 studies selected, all of which were conducted in China. There were 16 studies where acupuncture was used as the intervention, and 23 studies used Donepezil as the control group. Acupoint GV20 was most frequently selected during the treatment. The Mini Mental State Examination (MMSE) was the most frequently used outcome variable. A period of 12 weeks was the most common treatment duration. As a result of meta-analysis (n = 25), acupuncture improved the MMSE and activities of daily living scores. Electroacupuncture improved the Alzheimer Disease Assessment Scale-Cognitive Subscale, and scalp acupuncture improved the MMSE score for AD. Acupuncture alleviates the symptoms of AD. However, further research is necessary to provide a better level of evidence.
O-GlcNAc modification of Mef2c regulates C2C12 myoblast differentiation
Han Byeol Kim,Jung Hwa Seo,Hyun Gyu Seo,Hyeonjin Choi,Byung Gyu Kim,Sang Yoon Park,Sunghoon Kim,Jaeyoung Pai,Injae Shin,Jin Won Cho 한국당과학회 2016 한국당과학회 학술대회 Vol.2016 No.07
O-GlcNAc modification is glycosylation that occurs on Serine and Threonine residues of proteins located in nucleus and cytoplasm. O-GlcNAcylation regulates various cellular events including transcription, translation, cell death and cell proliferation as cellular nutrient sensor. It also has important roles in development processes such as neurogenesis, osteogenesis, adipogenesis and myogenesis. Although some roles and molecular mechanism of O-GlcNAcylation in various development process has been studied, the relationship between O-GlcNAcylation and muscle differentiation is not clearly established. We confirm that physiological conditions to regulate cellular O-GlcNAc level as well as O-GlcNAcase inhibitor treatment influenced the myogenin expression and myogenesis. We also confirm that this results was shown in mouse model system. We demonstrate that these phenomenons result from O-GlcNAc of Mef2c. Furthermore, we identify the 3 O-GlcNAc sites in Mef2c and find that one of these site has role regulating the DNA binding affinity with promoter of myogenin. Our results suggest that one specific O-GlcNAc site of Mef2c is closely associated with muscle differentiation through the regulation of myogenin transcription.
For Better Fat Graft Outcome in Soft Tissue Augmentation: Systematic Review and Meta-Analysis
Jin Bin Kim,Han Byeol Jin,Ji Hwan Son,Jee Hyeok Chung 대한미용성형외과학회 2018 Archives of Aesthetic Plastic Surgery Vol.24 No.3
Background Autologous fat grafts are widely used in plastic surgery, but they have the disadvantage of unpredictability due to variable resorption. This meta-analysis examined the literature on the survival rate of autologous fat grafts using objective markers, and investigated the factors that affected the survival rate. Methods The reviewers searched the PubMed, EMBASE, and Cochrane Library databases from January 2001 to December 2017. A meta-analysis was performed to estimate fat graft survival and to identify variables that influenced the survival rate. Results A total of 27 studies (1,066 cases) were included in the meta-analysis. The mean survival rate of grafted fat was 56.5%. The survival rate was significantly higher for cell-assisted lipotransfer (CAL) than for non-CAL (62% vs. 53.4%; P=0.015). The survival rate for procedures performed to correct lipoatrophy was higher than that of procedures performed for other purposes (64.6%; P=0.014), and was significantly higher in patients who underwent breast pre-expansion using the BRAVA device (66.2% vs. 50.35%; P=0.001). There were no significant differences in the survival rate according to the recipient site, harvesting method, or refinement method. Conclusions Fat transplantation showed a varying survival rate, with an average of 56%. In patients who underwent CAL or breast pre-expansion with the BRAVA device, the survival rate of transplanted fat was higher than in their counterparts, supporting the use of these techniques in fat transplantation.