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Choi, Jae-Sung,Kwak, Kyung-A,Park, Min-Ju,Kim, Young-Hee,Gil, Hyo-Wook,Song, Ho-yeon,Hong, Sae-yong International Scientific Literature, Inc. 2013 Medical science monitor Vol.19 No.-
<P><B>Background</B></P><P>To determine whether initial reactive oxygen species (ROS)-induced endothelial cell injury is involved in early death after paraquat intoxication and concentrations of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and von Willebrand factor (VWF) reflecting endothelial cell injury, we investigated the initial endothelial cell injury marker involved in the pathogenesis of death within 5 days after paraquat ingestion.</P><P><B>Material/Methods</B></P><P>Sixty patients with paraquat poisoning were prospectively enrolled. Plasma samples were collected at admission. Plasma concentrations of Ang-1, Ang-2, and VWF were measured by enzyme-linked immunosorbent assay. The patients were classified into 3 categories: survivors, early death (died within 5 days after ingestion), and late death (died more than 5 days after ingestion).</P><P><B>Results</B></P><P>The baseline concentration of Ang-2 and the Ang-2: Ang-1 ratio were significantly higher in patients who died (Ang-2 [pg/mL], 1012.75±468.02 <I>vs.</I> 1986.07±1675.37 [p=0.002]; Ang-2: Ang-1, 0.90±0.49 <I>vs.</I> 2.16±2.28 [p=0.002]). The Ang-2: Ang-1 ratio was significantly higher in the early death group (2.41±2.54) than in the survivors (0.90±0.49) and the late death group (1.33±0.64). The Ang-2: Ang-1 ratio was significantly associated with early death (OR, 2.602; 95% CI, 1.106–6.117; p=0.028) after adjusting for plasma levels of paraquat, age, PCO<SUB>2</SUB>, and creatinine. VWF did not predict mortality.</P><P><B>Conclusions</B></P><P>Endothelial cell damage could be involved in the pathogenesis of early death following paraquat ingestion.</P>
Choi, Hyunmo,Jeong, Suyeong,Kim, Dong Su,Na, Hyung Jin,Ryu, Jong Sang,Lee, Seung Sik,Nam, Hong Gil,Lim, Pyung Ok,Woo, Hye Ryun Blackwell Publishing Ltd 2014 Physiologia plantarum Vol.150 No.2
<P>Phytochromes are red (R)/far-red (FR) photoreceptors that are central to the regulation of plant growth and development. Although it is well known that photoactivated phytochromes are translocated into the nucleus where they interact with a variety of nuclear proteins and ultimately regulate genome-wide transcription, the mechanisms by which these photoreceptors function are not completely understood. In an effort to enhance our understanding of phytochrome-mediated light signaling networks, we attempted to identify novel proteins interacting with phytochrome B (phyB). Using affinity purification in ArabidopsisphyB overexpressor, coupled with mass spectrometry analysis, 16 proteins that interact with phyB in vivo were identified. Interactions between phyB and six putative phyB-interacting proteins were confirmed by bimolecular fluorescence complementation (BiFC) analysis. Involvement of these proteins in phyB-mediated signaling pathways was also revealed by physiological analysis of the mutants defective in each phyB-interacting protein. We further characterized the athb23 mutant impaired in the homeobox protein 23 (ATHB23) gene. The athb23 mutant displayed altered hypocotyl growth under R light, as well as defects in phyB-dependent seed germination and phyB-mediated cotyledon expansion. Taken together, these results suggest that the ATHB23 transcription factor is a novel component of the phyB-mediated R light signaling pathway.</P>
Acute and Subchronic Inhalation Toxicity of n-Octane in Rats
Sung, Jae-Hyuck,Choi, Byung-Gil,Kim, Hyeon-Yeong,Baek, Min-Won,Ryu, Hyun-Youl,Kim, Yong-Soon,Choi, Young-Kuk,Yu, Il-Je,Song, Kyung-Seuk Occupational Safety and Health Research Institute 2010 Safety and health at work Vol.1 No.2
Objectives: We have investigated the toxic effects of the inhalation of subchronic and acute levels of n-octane. Methods: The rats were exposed to n-octane of 0, 2.34, 11.68 and 23.36 mg/L (n = 5 rats/group/gender) in an acute inhalation test (Organization for Economic Co-operation and Development (OECD) TG 403), or to 0, 0.93, 2.62 and 7.48 mg/L (n = 10 rats/group/gender) for a subchronic inhalation test (OECE TG 413), to establish a national chemical management system consistent with the Globally Harmonized Classification System (GHS). Results: Acutely-exposed rats became lethargic but recovered following discontinuation of inhalation. Other clinical symptoms such as change of body weight and autopsy finds were absent. The LC50 for the acute inhalation toxicity of n-octane was determined to exceed 23.36 mg/L and the GHS category was 'not grouping'. Subchronically-treated rats displayed no significant clinical and histopathological differences from untreated controls; also, target organs were affected hematologically, biochemically and pathologically. Therefore, the no observable adverse effect level was indicated as exceeding 7.48 mg/L and the GHS category was 'not grouping' for the specific target organ toxicity upon repeated exposure. Conclusion: However, n-octane exposure should be controlled to be below the American Conference of Industrial Hygienists recommendation (300 ppm) to prevent inhalation-related adverse health effects of workers.
Hydrazine-selective chromogenic and fluorogenic probe based on levulinated coumarin.
Choi, Myung Gil,Hwang, Jiyoung,Moon, Jung Ok,Sung, Jaeyoung,Chang, Suk-Kyu American Chemical Society 2011 Organic letters Vol.13 No.19
<P>Chemosignaling of hydrazine by selective deprotection of levulinated coumarin was investigated. In the presence of hydrazine, levulinated coumarin was selectively deprotected, resulting in chromogenic and fluorescent turn-on type signaling. The selective naked-eye detectable signaling of hydrazine was possible in the presence of representative metal ions and common anions in an aqueous environment.</P>
Zeatin Prevents Amyloid $\beta$-Induced Neurotoxicit and Scopolamine-Induced Cognitive Deficits
Choi, Soo-Jung,Jeong, Chang-Ho,Choi, Sung-Gil,Chun, Ji-Yeon,Kim, Young-Jun,Lee, Jeong-Min,Shin, Dong-Hoon,Heo, Ho-Jin The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.2
The antioxidative and protective effects of zeatin against amyloid $\beta$-protein ($A{\beta}$)-induced neurotoxicity were investigated using PC12 cells. Zeatin showed antioxidative and cell protective effects against $A{\beta}$-induced neurotoxicity. In this study, we also evaluated the effect of zeatin on learning and memory capacity in vivo using ICR mice with amnesia induced by scopolamine (1 mg/kg of body weight). Zeatin, when administered to mice at 4.5 mg/kg of body weight, significantly ameliorated scopolamine-induced amnesia as measured in both the passive avoidance test and Y-maze test. Injecting mice with scopolamine impaired performance on the passive avoidance test ($48\;{\pm}\;4.5%$ decrease) and on the Y-maze test ($12\;{\pm}\;13%$ decrease). In contrast, mice treated with zeatin before scopolamine injections were protected from these changes (5-34% decrease in step-through latency; 1-4% decrease in alternation behavior). The present results suggest a possible chemopreventive role of zeatin in Alzheimer's disease.
( Gil-chun Park ),( Shin Hwang ),( Dong-hwan Jung ),( Tae-yong Ha ),( Gi-won Song ),( Chul-soo Ahn ),( Deok-bog Moon ),( Ki-hun Kim ),( Young-in Yoon ),( Hwui-dong Cho ),( Jin-uk Choi ),( Sung-gyu Lee 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: A cryopreserved iliac artery homograft (IAH) has not been considered suitable for middle hepatic vein (MHV) reconstruction during living donor liver transplantation (LDLT), primarily due to the low patency from its small diameter. We revised our surgical techniques for MHV reconstruction using an IAH to improve its patency. Methods: This study analyzed the causes of early conduit occlusion and developed revised techniques to address this that had clinical application. Results: The potential risk factors for early conduit occlusion were the small IAH size, small graft V5/V8 opening, and small recipient MHV-left hepatic vein stump. These factors were reflected to our revised surgical methods which included endarterectomy of the atherosclerotic plaque, unification of the internal and external iliac artery branches for large V5, and branch-patch arterioplasty for large V8. IAH endarterectomy was applied to 8 patients and resulted in a 1-month occlusion rate of 37.5%. Branch unification technique was applied to 5 patients and a 1-month occlusion rate of 20.0% was obtained. Branch-patch arterioplasty was applied to 5 patients leading to a 1-month occlusion rate of 40.0%. The overall patency rates of the IAH-MHV conduits in our 18 patients were 66.7% at 1 month, 38.9% at 3 months, and 33.3% at 1 year. Conclusions: Our refined MHV reconstruction using an IAH improved short-term MHV conduit patency, but did not effectively prevent early conduit occlusion, particularly with a small- or medium-sized IAH. Individualized reconstruction designs during LDLT operation are needed when an IAH is used for a modified right liver graft.