새로운 Acetylcholinesterase inhibitors의 합성

최순규,김형민,조승환,최학기,박유미,이용균,정대일,김인식,한정태 동아대학교 부설 기초과학연구소 2004 基礎科學硏究論文集 Vol.21 No.1

노인성 치매의 일종인 alzheimer's disease의 효과적인 억제제를 합성하기 위해 우리는 분자 모델링에 의한 가장 적합한 물질인 m-[(N,N,N-trimethylammonio)phenyl]boronic acid를 합성하였다. 출발물질인 3-aminophenylboronic acid monohydrate의 경우 boronic acid의 작용기인 hydroxyl group을 protecting시킴으로써 반응의 안정성을 기하였다. Quarternary ammonium salt는 과량의 methyliodide와 염기 촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시켜 상당히 높은 수율을 얻을 수 있었다. 또한 과량의 methyliodide와 염기촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시킨 결과 boronic acid의 protection없이도 안정하게 반응이 진행되어짐을 확인할 수 있었다. In order to syntheisize a effective inhibotor for alzheimer's disease, we synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 which is designed by molecular modeling form. We protected the hydroxyl group of 3-aminophenylboronic acid monohydrate 1 with ethlyne glycol to remove the reactivity if hydroxyl group. To synthesize m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4, we reacted 3-aminophenylboronic acid monohydrate 1 with ezcess methyl iodide and potassium hydrogen carbonate as a base-catalyst in methanol. but On executed reaction without protection on hydroxyl group, we found out the result that the hydroxyl group of boronic acid group at 3-aminophenylboronic acid monohydrate 1 didn't react with excess methyliodide. Synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 is in progress about biological tests as a plausible acetylcholinesterase inhibitor.

우리나라 일부 석면사업장의 석면폐 유병률

백도명,백남원,최정근,손미아,임정기,이원진,문영한,박정선,최병순 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

Asbestos industry has been in operation over 60 years in Korea. However, the prevalence of asbestosis has not been yet reported. With rapid turn-over of workers, previous cross-sectional studies of current workers on the job could not find cases with exposures long enough for the development of asbestosis. This study was done to evaluate asbestosis prevalence of those worksites with operation history of more than 20 years. In total, 139 workers from 5 worksites were examined. Asbestos industries covered in the study include 2 asbestos textile, 1 brake lining, and 2 ship repairing worksites. Chest x-ray was taken from all workers and read by two experts familiar with pneumoconiosis classification according to 1980 ILO guidelines. Those with findings compatible with asbestosis were further ckecked with high resolution computerized tomography (HRCT). Pulmonary function tests were done according to ATS guidelines, and occupational and previous medical history was taken through a standardized interview. Air-borne asbestos was measured according to NIOSH method 7400. The air-borne asbestos concentrations ranged from 0.2-1.3 f/cc for asbestos textile, from 0.7-1.0 f/cc for brake lining, and from 6.3-7.8 f/cc during asbestos removal at ship repairing worksite. Of the 139 workers 25 had abnormal chest radiographic findings, and 10 of them had findings compatible with pneumoconiosis. When work history and current asbestos measurements were accounted, 9 workers who had more than 10 years of asbestos exposure history showed chest radiographic findings of pneumoconiosis with Finally, 4 workers showed finding of pulmonary fibrosis and/or pleural thickening at HRCT, and 2 of them had restrictive lung function changes. The study results showed that, among 139 subjects, there were 4(3%) definite asbestosis cases confirmed with HRCT. The prevalence of probable asbestosis was 7% for 10-14 years of exposure, 13% for 15-19 years of exposure, and 23% for 20 or more years of exposure. The prevalence of compensable asbestosis with abnormal lung function was 4-6% for those with 15 or more years of exposure.

중학교 가정과 '인간발달과 가족관계' 영역에서 Gordon의 창의적 문제 해결법의 적용

최기옥,채정현 한국 가정과 교육 학회 2000 한국가정과교육학회지 Vol.12 No.3

The purpose of this research was to apply and conduct a class with Cordon's Creative Problem Solving Method(Synectics) to the area of 'human development and family relations'among male students in a jr. high school. Subject matters which were appropriate for applying Cordon's Creative Problem Solving method were selected from 'human development and family relations 'area. With problem circumstances set to reflect to the highest degree the interests of individuals and families. An 8 hour teaching instructional guide was constructed with 「strategyl」 of Gordon's Creative Problem Solving method in order to solve creatively the established problem. This was practically implied to 70 students (each class had 34 and 36 students respectively) in K middle school located in Seoul. The period of this application was for 3 months during March through May of 1999. The perception of this method was examined by the teachers and students through open-ended questions. The record of perception showed that 56 students out of 70(with no response from 5 students) thought that the class done by the creativity problem solving method was good. The majority of reasons mentioned for the Positive answers were 'being able to express thoughts freely in a familiar environment which improves thought process', 'enhancement of Presentational skills and concentration', 'being exposed to various ideas was interesting'and'rewarding to be able to receive different thoughts which were unusual of daily life'. In addition the students who participated in the class were able to fester a joint experience which improved their understanding of relationships and sense of community. Moreover students who did not do well in the class, or were diffident were encouraged to participate, which in result showed that there was even an internal effect.

로드셀을 이용한 직물의 신축성 측정에 관한 연구

최정수,김은석,주기세,왕지남 한국경영과학회 2002 한국경영과학회 학술대회논문집 Vol.- No.1(1)

So far, the common elasticity data of textile fabrics has not been present because the method depends on the knowledge of measurement operators. In this paper, the new measurement equipment using road cell is presented to measure the coefficient of textile fabrics in real time. The measurement method is based on the volt: among textile fabrics. The textiles with strong elasticity are high voltage produced from others are low. The presented method can be applied to visualize the textile, sew the cloth, contrc textile fabrics. Also, these measurement datum are used to B2B electronic trading system.

지각된 스트레스와 스트레스 대처방식이 직장인의 우울과 불안에 미치는 영향

최영민,이정호,이기철 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

Objectives : We attempted to clarify the relationship of perceived stress and the ways of coping to depression and anxiety in the white-collar workers. Methods : Fine Humded forty-five white-collar workers in a large enterprise were studied using a questionnaire package composed of demographic data, job stress questionnaire, global assessment of recent stress, the ways of coping checklist, Beck depression inventory, and state-trait anxiety inventory. And self reports of the subjects were statistically analyzed with the method of path analysis. Results & Conclusions : Perceived stress(job stress plus life stress) and the coping(problem-focused plus emotion-focused) determined 28.2% of the depression, 39.1% of the state-anxiety, and 35.4% of the trait-anxiety. These findings suggest that perceived stress and the coping have significant effects on the depression and state-trait anxiety of the white-collar workers. Although seemingly similar, problem-focused and emotion-focused copings, were contrary to each other in effects. Problem-focused coping reduced depression, anxiety and perceived life stress. However, emotion-focused coping didn't reduce the depression and anxiety. Furthermore, emotion-focused coping tended to increase perceived life stress. From these findings the authors inferred that emotion-focused coping interpreted the perceived stress as threatening and consequently became ineffectively defensive. On the other hand, problem-focused coping appeared to interpret the perceived stress as challenge and this challenge-appraisal mobilized effective coping resources. Applying path analysis, the aurhors could make the interactional stress model in the white-collar workers comprised of perceived job stress, perceived life stress, problem-focused coping, emotion-focused coping, depression, and state-trait anxiety.

출산후 여성의 우울성향과 영아 기질, 양육 스트레스 및 대처방식과의 연관성

최영민,이승휘,김영미,이정호,전성일,이기철 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

목 적 : 산후우울증의 발생은 출산 직후부터 1년까지 지속될 수 있고 출산 이후에도 오랜 기간동안 발생 가능성이 있으며, 산후우울증을 단순히 선행하는 감정적 문제, 통제 소재, 사회적지지, 출산과 동반된 생리적 변인만으로 설명할 수 없다. 그러므로 산후우울증은 출산후 산모-영아 상호관계에서 겪게되는 어려운 영아의 기질, 산모가 영아를 양육하면서 겪게되는 양육 스트레스, 그리고 산모의 대처 방식과 연관이 있을 것이다. 본 연구는 산후우울증과 영아 기질, 양육 스트레스, 대처방식을 변인으로 하여 산후우울증과의 연관성을 평가하기위해 산후의 우울성향과 각 변인의 관계를 연구하였다. 방 법 : 연구의 대상은 1996년 7월 16일부터 8월 27일까지 인제 대학교 의과대학 부속 상계백병원 소아과 외래에 예방 접종을 위해 내원한 4개월에서 12개월 사이의 영아를 둔 산모 105명을 대상으로 하였다. Beck우울척도(BDI), 영아기질척도(EAS), 부모 양육스트레스 목록표(PSI), 대처방식척도(WCC)를 사용하여 산후의 우울성향과 이들 변인과의 연관성을 평가하여 다음과 같은 결과를 얻었다. 결 과 : 1) 어머니의 우울성향 점수는 영아의 기질중 부정적 정서성(r=.26 p<0.05), 과도한 활동성(r=.22 p<0.05)과 유의미한 상관 관계를 보였다. 영아의 사회성 척도와는 부적 상관이 있었으나 통계적으로 유의미하지는 않았다. 2) 어머니의 우울성향 점수는 양육 스트레스와는 정적 상관관계가 있었다(r=.44 p<0.001). 3) 어머니의 우울성향 점수와 대처방식과 유의미한 상관관계를 보이지 않았다. 4) 영아의 부정적 정서성과 양육 스트레스는 정적 상관관계가 있었으나(r=.49 p<0.001) 사회성, 활동성과의 상관관계는 유의미하지 않았다. 양육 스트레스와 대처방식과도 통계적으로 유의미한 상관관계를 보이지 않았다. 결 론 : 본 연구 결과, 산모의 산후 우울성향과 첫째, 영아 기질 중 정서성과 활동성이 연관관계가 있고 둘째, 양육스트레스와 연관이 있으나 세째, 대처방식과는 연관이 없었다. 이런 결과는 산후의 우울성향과 각 요인과의 연관성을 살펴볼 때 산후우울증에 더 중요한 영향을 미치는 것은 산모의 대처 방식이라는 어머니 측의 변인보다는 출산과 동반된 양육 스트레스 혹은 영아의 어려운 기질일 것이라고 추론할 수 있다. Objectives : This Study examined the relationship of depressive tendency in postpartum women with psychosocial factors such as infant temperament, parental stress and coping style. Methods : The subjects consisted of 05 postpartum women, each of whom had an infant aged 4 to 12 months. They were assessed on demographic variables and on measures of the depressive symptomatology, infant temperament, parental stress and the coping style using Beck Depression Inventory(BDI), the EAS temperamental survey, Parenting Stress Index(PSI), the Way of Coping Checklist(WCC). And then we assessed the relationship of depressive tendency in postpartum women with psychosocial factors. Results : The results were as follows : 1) Depressive tendency in postpartum women had significant relationship with emotionality(r=.26 p<0.05) and activity(r=.22 p<0.05) of infant temperament. 2) Depressive tendency in postpartum women had significant relationship with parenting stress(r=.44 p<0.001). 3) Depressive tendency in postpartum women had no significant relationship with coping style. 4) Parental stress had significant relationship with emotionality(r=.49 p<0.001) but did not have any relationship with sociability and activity of infant temperament. Parenting stress had no significant relationship with coping style. Conclusion : These results suggest that depressive tendency in postpartum women correlated with emotionality and activity of infant temperament correlated with parenting stress but not correlated with coping style. Infant temperament and parenting stress to child rearing are more significantly correlated with depressive tendency in postpartum women than coping style of postpartum women.

Genetic 알고리즘을 이용한 능선회귀 상수의 결정에 관한 연구

최이선,염준근,정기문 조선대학교 통계연구소 2000 統計硏究所論文誌 Vol.2 No.1

We use biased estimators to detect multicollinerity and ridge regression estimator among biased estimators. Important problem here is determination of ridge constant in ridge regression estimator. To determine ridge constant there is method using variance inflation factor and ridge trace, scree diagram in graphic method. With method using ridge trace and scree diagram it is not easy to find ridge constant. Method using variance inflation factor determine ridge constant when expectation of variance inflation factor is to approximate "1" applying all possible ridge constant between zero and one. In this thesis we propose determination of ridge constant to detect multicollinerity using genetic algorithm. Ridge constant is converged quickly through experiment.

쑥갓의 생리활성 연구(Ⅱ)-STZ에 유도된 흰쥐에서의 과산화지질 생성계에 미치는 영향

정운용,천현욱,최종원,이용범,황기욱 慶星大學校 環境問題硏究所 1998 環境硏報 Vol.8 No.1

Chrysanthemum coronarium L. has long been used the appetite and constipation in oriental countries. We was investigated the effect on changes in serum and hepatic free radical generatin enzymes and free radical scavenging enzymes as well as detoxification mechanism of each fraction from Chrysanthemum coronarium by examining the induction of streptozotocin.(STZ) Male Sprague-Dawley rats(190∼210g), with free access to commercial rat chow (Cheil Foods & Chemical Inc.) and water, were divided into six groups : Group 1 served as normal; Group 4 received ethyl acetate fraction in STZ animal; Group 5 received butanol fraction in STZ animal; Group 6 received water fraction in STZ-induced rat. In the STZ-induced diabetic group, the serum superoxide dismutase activity decreased and formation of hydroxyl radical increased when dompared to normal. STZ caused increase hepatic lipid peroxide content was inhibited by treatment with Chrysanthemum coronarium butanol fraction and STZ decreased the hepatic glutathione compared to normal, but this was inhibited Chrysanthemum coronarium butanol fraction treatment.STZ induced change in hepatic microsomal cytochrome P-450 activity was inhibited by treatment with Chrysanthemum coronarium butanol fraction. STZ caused a significant rise in hepatic aniline hydroxylase and xanthine oxidase, decrease in aminopyrine N-demethylase when compared to normal. Activities of hepatic superoxide dismutase, catalase and glutathione peroxidase were significant rised by treatment with Chrysanthemum coronarium butanol fraction when compated to STZ. These results suggest that Chrysanthemum coronarium butanol fraction treatment suppressed STZ induced changes in serum and hepatic metabolizing enzymes system.

OFDM에서 Bitloading 알고리즘의 성능평가

최정식,이성신,김기표,변건식 東亞大學校附設 情報技術硏究所 2005 情報技術硏究所論文誌 Vol.13 No.1

OFDM technique which the available bandwidth is split into several narrowband subchannels at different frequencies is particularly suited for transmission over frequency selective channels. But if the states of some subchannel are bad, the performance of system become to decrease. The principle of bitloading is to adjust the date rate on the individual subchannels based on the current SNR. A subchannel with high SNR is then assigned more bits than a subchannels with lower SNR. As a results, we confirmed the superior performance if we used bitloading algorithm in OFDM system.

치과병원에서 사용되는 진단영상에 대한 JPEG 2000 압축률에 대한 평가

정기훈,한원정,유동수,최순철,김은경 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.3

Purpose : To find out the proper compression ratios without degrading image quality and affecting lesion detectability on diagnostic images used in dentistry compressed with JPEG 2000 algorithm. Materials and Methods : Sixty Digora periapical images, sixty panoramic computed radiographic (CR) images, sixty computed tomographic (CT) images, and sixty magnetic resonance (MR) images were compressed into JPEG 2000 with ratios of 10 levels from 5 : 1 to 50 : 1. To evaluate the lesion detectability, the images were graded with 5 levels (1: definitely absent; 2: probably absent; 3: equivocal; 4: probably present; 5: definitely present), and then receiver operating characteristic analysis was performed using the original image as a gold standard. Also to evaluate subjectively the image quality, the images were graded with 5 levels (1: definitely unacceptable; 2: probably unacceptable; 3: equivocal; 4: probably acceptable; 5: definitely acceptable), and then paired t-test was performed. Results : In Digora, CR panoramic and CT images, compressed images up to ratios of 15 : 1 showed nearly the same lesion detectability as original images, and in MR images, compressed images did up to ratios of 25 : 1. In Digora and CR panoramic images, compressed images up to ratios of 5 : 1 showed little difference between the original and reconstructed images in subjective assessment of image quality. In CT images, compressed images did up to ratios of 10 : 1 and in MR images up to ratios of 15 : 1. Conclusion : We considered compression ratios up to 5 : 1 in Digora and CR panoramic images, up to 10 : 1 in CT images, up to 15 : 1 in MR images as clinically applicable compression ratios.