호산구의 활성 억제 사이토카인과 억제 기작의 규명

박춘식 ( Park Chun Sig ),최은남 ( Choe Eun Nam ),이영목 ( Lee Yeong Mog ),박성우 ( Park Seong U ),장안수 ( Jang An Su ),이준혁 ( Lee Jun Hyeog ),최윤성 ( Choe Yun Seong ),정일엽 ( Jeong Il Yeob ) 대한천식알레르기학회 2003 천식 및 알레르기 Vol.23 No.4

DBA/1JCrj Mouse에 있어서 콜라젠유도관절염에 관한 면역학적 고찰

박승규,이지연,정일엽,최용경,최인성,김효준 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.3

There is growing evidence that a variety of cytokines are secreted by cells at the inflammation sites of rheumatoid arthritis (RA) and that CDS+ B cell, a minor subtype of B cell population producing natural autoantibodies, is implicated in pathogenesis of RA. In this study, we evaluated the both cytokne levels and change of CDS+ B cell population in the peripheral blood from DBA/lJCrj mice(H-2`) which are collagen-induced arthritis(CIA) susceptible strain. Surprisingly, the healthy DBA/1JCrj and MRL/Ipr/Ipr(H-2'`) mice which were autoimmune susceptible strains tested in this experiment, showed lower IL-4, IL-6 and IL-10 levels in serum by 60% than heal-thy normal mouse strains such as Balb/c(H-2d), C57BL/6(H-2') and outbred ICR mice. MRL/lpr/ 1pr mice in which onset of spontaneous autoimmune disease is dependent upon age were similar to healthy DBA/1JCrj mice in levels of the cytokines in the serum when they are young. After the CIA(for DBA/1JCrj) or the spontaneous autoimmune disease(for MRL/lpr/Ipr) had been developed in the susceptible mouse strains, the levels of IL-6 and IL-4 in the serum were increased to 1.8- and 13-fold, respectively, as compaired with those from control groups while level of IL-10 remained relatively constant. The elevated levels of IL-4- and IL-6, however, in the serum from mice with disease status were still below those of the healthy normal mouse strains. On the other hand, CDS+ B cell population in the peripheral blood, which were reported to be increased with the development of RA for human, was rather significantly decreased for the CIA-induced DBA/lJCrj mice as evidenced by FACS analysis. It could be due to the differences in the pathogenic mechanism between CIA and RA. Taken together, our results. suggest that the levels of both these cytokines and CDS+ B cells may be utilized as important diagnostic markers for arthritides.

A Comparative Study of Mathematics Curriculum between Korea and the United States

CHOE, HYO IL,CHOE, HO SEONG 한국수학교육학회 1997 수학교육연구 Vol.1 No.2

당뇨병이 폐결핵 치료 결과에 미치는 영향

최성일 ( Choe Seong Il ),이승철 ( Lee Seung Cheol ),공석준 ( Gong Seog Jun ),박주홍 ( Park Ju Hong ),손말현 ( Son Mal Hyeon ) 대한내과학회 2003 대한내과학회지 Vol.65 No.5

목적 : 당뇨병을 지닌 폐결핵 환자에서 당뇨병은 폐결핵의 치료 경과에 큰 영향을 미치지 않는 것으로 알려져 있다. 그러나 이는 pyrazinamide가 널리 사용되기 이전의 보고로 pyrazinamide가 포함된 4제의 항결핵 요법을 이용한 최근의 보고들은 드물다. 객담에서 항산균의 존재 유무는 항결핵 치료의 반응을 평가하는 가장 표준적인 방법으로 보편적으로 5개월 이후에 객담 도말 검사에서 항산균이 존재시엔 치료 실패로 간주한다. 그리하여 저자들은 당 Background : Many studies have shown that diabetes mellitus does not modify the clinical features and treatment outcomes. However, to our knowledge, those surveys for clinical features and treatment outcomes in pulmonary tuberculosis with diabetics were p

Association of Guanosine Triphosphate Cyclohydrolase 1 Gene Polymorphisms with Fibromyalgia Syndrome in a Korean Population

KIM, SEONG-KYU,KIM, SEONG-HO,NAH, SEONG-SU,LEE, JI HYUN,HONG, SEUNG-JAE,KIM, HYUN-SOOK,LEE, HYE-SOON,KIM, HYOUN AH,JOUNG, CHUNG-IL,BAE, JISUK,CHOE, JUNG-YOON,LEE, SHIN-SEOK Journal of Rheumatology 2013 The Journal of rheumatology Vol.40 No.3

<P><B>Objective.</B></P><P>Guanosine triphosphate cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the synthesis of tetrahydrobiopterin, which is an essential cofactor in nitric oxide (NO) production. Polymorphisms in the <I>GCH1</I> gene have been implicated in protection against pain sensitivity. The aim of our study was to determine whether single-nucleotide polymorphisms (SNP) in the <I>GCH1</I> gene affect susceptibility and/or pain sensitivity in fibromyalgia syndrome (FM).</P><P><B>Methods.</B></P><P>A total of 409 patients with FM and 422 controls were enrolled. The alleles and genotypes at 4 positions [rs3783641(T>A), rs841(C>T), rs752688(C>T), and rs4411417(T>C)] in the <I>GCH1</I> gene were analyzed. The associations of the <I>GCH1</I> SNP with susceptibility and clinical measures in patients with FM were assessed.</P><P><B>Results.</B></P><P>The frequencies of alleles and genotypes of the 4 SNP did not differ between patients with FM and healthy controls. Among 13 constructed haplotypes, we further examined 4 (CCTT, TTCT, TTCA, and CCTA) with > 1% frequency in both FM and controls. No associations of <I>GCH1</I> polymorphisms with FM-related activity or severity indexes were found, although the number and total score of tender points in patients with FM differed among the 4 haplotypes (p = 0.03 and p = 0.01, respectively). The CCTA haplotype of <I>GCH1</I> was associated with significantly lower pain sensitivity and occurred less frequently than the CCTT haplotype in patients with FM (p = 0.04, OR 0.45, 95% CI 0.21–0.96).</P><P><B>Conclusion.</B></P><P>Our study provides evidence that certain <I>GCH1</I> haplotypes may be protective against susceptibility and pain sensitivity in FM. Our data suggest that NO is responsible for pain sensitivity in the pathogenesis of FM.</P>

심포지움,특별강연 및 일반연제 발표 : 고칼륨혈증의 치료 예후 인자로서 임상 양상과 심전도 양상과와 관련성에 대한 조사

최성일 ( Choe Seong Il ),한상웅 ( Han Sang Ung ),김호중 ( Kim Ho Jung ) 대한신장학회 2000 춘계학술대회 초록집 Vol.19 No.2

4 Dipyridamole (99m)Tc-MIBI SPECT의 육안 분석과 정량적 분석

최진현 ( Choe Jin Hyeon ),도문홍 ( Do Mun Hong ),이근우 ( Lee Geun U ),신원호 ( Sin Won Ho ),최성란 ( Choe Seong Lan ),함종열 ( Ham Jong Yeol ),최동주 ( Choe Dong Ju ),염명걸 ( Yeom Myeong Geol ),정순일 ( Jeong Sun Il ),최진학 ( C 대한내과학회 1993 대한내과학회지 Vol.44 No.4

연구배경 : 관상동맥 질환을 진단하고 병소의 위치를 결정하거나 그 기능적 의의를 평가하는 비관혈적인 검사법으로 심근 SPECT의 유용성이 널리 인정되고 있다. 저자들은 심근 SPECT의 육안 분석과 정량적 분석방법의 진단적 우위를 비교하기 위하여 본 연구를 시행하였다. 방법 : 허혈성 심장 질환을 의심하여 심근 SPECT와 관상동맥 조영술을 모두 실시한 126명의 환자를 연구 대상으로 하였다. Dipyrdamole 0.56mg/kg을 정주하고 ^(99m)Tc-MIBI 15mCi를 투여한 후 rotating gamma camera를 이용하여 부하 스캔을 구하였고, 4시간 후 ^(99m)Tc-MIBI 25mCi를 다시 투여한 후 재분포 스캔을 시행하였다. 단층 영상을 3방향으로 재배치하여 육안적으로 분석하였다. Technetium 흡수의 분포도로부터 전체 좌심실을 대표하는 2차원의 극지도를 그리고, CSMC에 의해 개발된 정상치와 비교함으로써 최종적인 병변 극지도를 구하여 정량적으로 분석하였다. 관류 결손의 재관류 여부를 육안분석으로 완전 재관류, 부분 재관류, 무 재관류군으로 구분하였고, 각 군에서의 정량적 관류 정도를 비교하였다. 결과 : 관상동맥 질환 진단의 전체적인 민감도는 육안 분석으로 91%, 정량적 분석으로는 94%로서 유의한 차이가 없었으며, 특이도는 각각 76% 및 71%로 역시 유의한 차이가 없었다. 개개의 관상동맥 분지의 병변을 육안 및 정량적 분석으로 발견할 수 있는 민감도는 좌전하행지가 각각 89% 및 92%, 우관상 동맥이 84% 및 93%, 좌회선지가 71% 및 77%로 모든 혈관에서 육안 분석보다 정량적 분석이 높았으나 유의한 차이는 없었다. 육안 및 정량적 분석의 특이도는 좌전하행지가 각각 79% 및 70%, 우관상 동맥이 77% 및 82%, 좌회선지가 96% 및 92%로 유의한 차이는 없었다. 육안 분석에 관류 결손의 완전 재관류는 협심증군에서 심근경색증군보다 유의하게 높았다. 육안분석에 의하여 분류된 각 군의 정량적 분포 정도는 완전 재관류군과 무재관류군 사이나, 부분재관류군과 무재관류군 사이에서는 유의한 차이가 있었으나, 완전 재관류군과 부분재관류군 사이에서는 유의한 차이가 없었다. 결론 : Dipyridamole 정주 후 ^(99m)Tc-MIBI SPECT검사의 정량적 분석이 육안 분석보다 더욱 정확한 분석 방법은 아닌 것으로 생각되며, 재관류 평가의 임상적 중요성에 비추어 볼 때 병변의 심한 정도와 재관류의 정도를 정량화 하는 방법에 대한 연구가 더욱 진행되어야 할 것으로 사료된다. Background: The usefulness of myocardial SPECT in diagnosing coronary artery disease, & assessing the functional significance of the coronary stenosis is confirmed by many investigators. To determine the superiority of the quantitative analysis method over the visual analysis method in assessing myocardial SPECT this study was performed. Methods: One hundred & twenty six patients with suspicious coronary artery disease had both intravenous dipyridamole ^(99m)Tc-MIBI SPECT and coronary angiougraphy within an interval of 5 days. The scintigraphic findings were assessed visually and quantitatively using two dimensional polar map. The results of visual and quantitative assessments were compared to the coronary angiographic findings. In 85 patients who showed perfusion defect on stress scintigraphy, the reversibility of the defect was evaluated by visual analysis. Results: For detection of coronary artery disease, the overall sensitivity of the visual and quantitative analyses was 91% & 94% respectively (p>0.05). The overall specificity was 76% by visual and 71% by quantitative analyses(p>0.05). For detection of individual coronary branch diseases, the quantitative analysis was higher than visual analysis in the sensitivity(LAD: 89% vs. 92%, RCAl 84% vs.93%, LCx: 71% vs. 77%), but the differences were not statistically significant. The specificities of both visual and quantitative analyses were similary high(LAD: 79% vs. 70%, RCA: 77% vs. 82%, LCx: 96% vs. 92%), but there were no significant differences also. The reversibility of perfusion defect was assessed by visual analysis. Of the 144 abnormal vascular territories in 85 patients, 49 vascular territories showed complete redistribution and 30 territories showed partial redistribution. The patients with angina had significantly higher percentage of complete redistribution (angina: 50% vs. MI: 15%, P<0.05). Conclusion: Our results showed that quantitative analysis of ^(99m)Tc-MIBI tomography may not be more accurate technique than visual analysis for detection of coronary artery disease and for localization of individual coronary stenoses.

Case Reports : A Case of Relapsing Polychondritis Associated with Myelodysplastic Syndrome with Erythroid Hypoplasia/Aplasia

Seong Wook Heo,Kyu Hyun Cho,Jung Il Ryu,Seung Hie Chung,Chae Gi Kim,Sang Gyung Kim,Jung Yoon Choe 대한내과학회 2003 The Korean Journal of Internal Medicine Vol.18 No.4

Primary Hyperoxaluria in Korean Pediatric Patients

Choe, Yunsoo,Lee, Jiwon M.,Kim, Ji Hyun,Cho, Myung Hyun,Kim, Seong Heon,Lee, Joo Hoon,Park, Young Seo,Kang, Hee Gyung,Ha, Il Soo,Cheong, Hae Il Korean Society of Pediatric Nephrology 2019 Childhood kidney diseases Vol.23 No.2

Background: Primary hyperoxaluria (PH), a rare inborn error of glyoxylate meta bolism causing overproduction of oxalate, is classified into three genetic subgroups: type 1-3 (PH1-PH3) caused by AGXT, GRHPR, and HOGA1 gene mutations, respectively. We performed a retrospective case series study of Korean pediatric patients with PH. Methods: In total, 11 unrelated pediatric patients were recruited and their phenotypes and genotypes were analyzed by a retrospective review of their medical records. Results: Mutational analyses revealed biallelic AGXT mutations (PH1) in nine patients and a single heterozygous GRHPR and HOGA1 mutation in one patient each. The c.33dupC was the most common AGXT mutation with an allelic frequency of 44%. The median age of onset was 3 months (range, 2 months-3 years), and eight patients with PH1 presented with end stage renal disease (ESRD). Patients with two truncating mutations showed an earlier age of onset and more frequent retinal involvement than patients with one truncating mutation. Among eight PH1 patients presenting with ESRD, five patients were treated with intensive dialysis followed by liver transplantation (n=5) with/without subsequent kidney transplantation (n=3). Conclusion: Most patients presented with severe infantile forms of PH. Patients with two truncating mutations displayed more severe phenotypes than those of patients with one truncating mutation. Sequential liver and kidney transplantation was adopted for PH1 patients presenting with ESRD. A larger nation-wide multicenter study is needed to confirm the genotype-phenotype correlations and outcomes of organ transplantation.

뇌동맥류에 대한 3차원 전산화단층촬영 혈관조영술의 진단적 가치

최일승,김영수,고용,오성훈,오석전,김남규,김광명,이승로 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.9

The authors have evaluated the efficacy of three dimensional computed tomographic angiography(3-DCTA) in diagnosing intracranial aneurysm. This literature studied thirty five patients harboring forty intracranial aneurysms using dynamic CT scan with intravenous contrast enhancement. After injection of 2㎎/㎏ of nonionic contrast material(Rayvist^(R)) intravenously, rapid dynamic CT scanning with thin section was performed. Three dimensional reconstruction was performed using the GE 9800 HR suface-rendering method with a threshold of about 100 Hounsfield units(HU). The authors comparatively analysed this 3-DCTA with conventional to surrounding vessels. While 3-DCTA clearly detected 38 aneurysms, conventional angiography did 37 ones. There was no significant difference between 3-DCTA and conventional angiography in demonstrating aneurysmal direction, but 3-DCTA was superior to conventional angiography in demonstrating aneurysmal shape, its neck and surrounding vascular structures. 3-DCTA showed deliberate anatomy of aneurysm and adjacent vessels through 3 dimensional image, and its operative view is helpful in surgical planning 3-DCTA might be expected to substitute for conventional angiography in the near future.