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Cheolmin Shin(Cheolmin Shin),Sang Won Jeon(Sang Won Jeon),Seung-Hoon Lee(Seung-Hoon Lee),Chi-Un Pae(Chi-Un Pae),Narei Hong(Narei Hong),Hyun Kook Lim(Hyun Kook Lim),Ashwin A. Patkar(Ashwin A. Patkar ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Objective: Anxious depression is associated with greater chronicity, higher severity of symptoms, more severe functional impairment, and poor response to drug treatment. However, evidence for first-choice antidepressants in patients with anxious depression is limited. This study aimed to compare the efficacy and safety of escitalopram, desvenlafaxine, and vortioxetine in the acute treatment of anxious depression. Methods: Patients (n = 124) with major depressive disorder and high levels of anxiety were randomly assigned to an escitalopram treatment group (n = 42), desvenlafaxine treatment group (n = 40), or vortioxetine treatment group (n = 42) in a 6-week randomized rater-blinded head-to-head comparative trial. Changes in overall depressive and anxiety symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA), respectively. Results: Patients demonstrated similar baseline-to-endpoint improvement in scores and similar response and remission rates for HAMD and HAMA. Analysis of the individual HAMD items revealed that desvenlafaxine significantly reduced anxiety somatic scores (p = 0.013) and hypochondriasis scores (p = 0.014) compared to escitalopram. With respect to the individual HAMA items, desvenlafaxine treatment showed significantly lower scores for respiratory symptoms (p = 0.013) than escitalopram treatment and cardiovascular symptoms (p = 0.005) than vortioxetine treatment. The treatments were well tolerated, with no significant differences. Conclusion: Our results indicated no significant differences in the efficacy and tolerability of escitalopram, desvenlafaxine, and vortioxetine in this subtype of patients with anxious depression during the acute phase of treatment.
Development and Assessment of Shovel Applying Foothold
Cheolmin Lim,Kyungsuk Lee,Kyungran Kim,Hyocher Kim,Mintae Seo,Seongwoo Kim,Hyeseon Chae 대한인간공학회 2016 大韓人間工學會誌 Vol.35 No.2
Objective:The aim of this study is to develop a farming shovel to reduce workload, which helps farmers lower the risk of musculoskeletal disease. Background: Most of work using farming tools including shovels requires repetitive works and awkward postures on body parts, and it could possibly cause work-related musculoskeletal disorders. It is necessary to develop and distribute farm equipment and tools in order to reduce physical workload. Method: To improve the most uncomfortable task perceived by ten farmers during the work with a shovel, the improved shovel was designed and made as a prototype for experiment for the comparison of the existing and improved shovels. Twenty males were recruited for this experiment, and muscle activity (%MVC) of six body parts and subjective discomfort ratings by body parts while working with a shovel were measured. A paired t-test was performed to compare physical workload between the existing shovel and the developed one. Results: A shovel applying foothold tied between shaft and blade was designed, which can help workers reduce repetitive bending of back and pressures for upper limbs while digging soil. According to compared evaluation of the developed shovel and the existing shovel, the developed shovel"s %MVCs in all experimental muscles were significantly lower than those of the existing shovel. The developed shovel showed the biggest drop in perceived subjective discomfort rating of back, followed by arm and neck, compared to the existing shovel. Conclusion: It was confirmed that attaching a foothold to a shovel was an effective way of reducing workload in back and upper limbs during digging. Application: In the near future, if we put the prototype of developed shovel to practical use after making up for defects, it will help farm work environment be healthier and safer.
Development of Fruit Harvest Basket and Assessment of its Effectiveness
( Cheolmin Lim ),( Kyungsuk Lee ),( Kyungran Kim ),( Hyocher Kim ),( Sungwoo Kim ),( Mintae Seo ),( Hyeseon Chae ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-
The purpose of this study is to develop products that prevent muscular skeletal disease of farm workers, which would bring improvement for an efficient harvesting work. A pretest for product development and a survey research was carried out to inspect the problems of current harvesting work procedure. The product was developed and assessed based on ideas to supplement and improve these weak points. A total of twenty men were recruited to evaluate the effects of harvest baskets on the upper-limb muscle activities. For the usability evaluation, electromyogram of previous working method(disuse of harvest basket, one-hand carriage of the basket) and new working method with the usage of newly-developed harvest basket was examined. The whole anterior deltoid, biceps brachii and erector spinae on both sides, which makes a total of six muscle parts, were used for this experiment. The results were analyzed using ANOVA with muscle activity(%MVC) of each three forms of work and required work time from SPSS 18.0. According to the test result, all muscles did not demonstrate any statistically significant difference, with an exception of the backbone erector(right). The muscle activity of backbone erector(right) in the work method that uses harvest basket was detected to be approximately 23% less than that of the previous working method. As such, the decrease in the amount of waist muscle usage at harvesting work would enable the prevention of muscular skeletal disease and stabilization of lumbar spine.
Development of Fruit Harvest Basket and Assessment of its Effectiveness
Cheolmin Lim,Kyungsuk Lee,Kyungran Kim,Hyocher Kim,Sungwoo Kim,Mintae Seo,Hyeseon Chae 대한인간공학회 2014 대한인간공학회 학술대회논문집 Vol.2014 No.5
The purpose of this study is to develop products that prevent muscular skeletal disease of farm workers, which would bring improvement for an efficient harvesting work. A pretest for product development and a survey research was carried out to inspect the problems of current harvesting work procedure. The product was developed and assessed based on ideas to supplement and improve these weak points. A total of twenty men were recruited to evaluate the effects of harvest baskets on the upper-limb muscle activities. For the usability evaluation, electromyogram of previous working method(disuse of harvest basket , one-hand carriage of the basket) and new working method with the usage of newly-developed harvest basket was examined. The whole anterior deltoid, biceps brachii and erector spinae on both sides, which makes a total of six muscle parts, were used for this experiment. The results were analyzed using ANOVA with muscle activity(%MVC) of each three forms of work and required work time from SPSS 18.0. According to the test result, all muscles did not demonstrate any statistically significant difference, with an exception of the backbone erector(right). The muscle activity of backbone erector(right) in the work method that uses harvest basket was detected to be approximately 23% less than that of the previous working method. As such, the decrease in the amount of waist muscle usage at harvesting work would enable the prevention of muscular skeletal disease and stabilization of lumbar spine. Which in turn would increase the effectiveness and reduce personnel expense(labor costs) while enhancing productivity with a decreased working hours.
Numerical solution of predator-prey models by the multistage differential transform method
Cheolmin Bae,Kyunghoon Kim,Donghoon Lee,Sanghyup Lee,Kanghyun Lim,Bongsoo Jang 한국산업응용수학회 2010 한국산업응용수학회 학술대회 논문집 Vol.5 No.2
In this work, we present an dynamic behavior of the predator-prey models by using efficient computational algorithm, namely the multistage differential transform method(MDTM). The standard DTM is based on the Taylor series, but it differs from the conventional Taylor series in calculating coefficients. Because of nonlinearity as wall as large size of domain, it is difficult to obtain accurate numerical approximation for many problems by the standard DTM. To overcome these difficulties, we introduce an auxiliary function to apply the DTM for solving nonlinear problems and employ domain refinement to increase accuracy of approximate solution. Several illustrated examples of Holling types predator-prey models are demonstrated and numerical results are compared with those obtained by other numerical methods such as finite-difference and RK4.
Lee, Sangwoo,Kim, Cheolmin,Kim, Jungkon,Kim, Woo-Keun,Shin, Hyun Suk,Lim, Eun-Suk,Lee, Jin Wuk,Kim, Sunmi,Kim, Ki-Tae,Lee, Sung-Kyu,Choi, Cheol Young,Choi, Kyungho D. Reidel Pub. Co ; Springer 2015 Environmental monitoring and assessment Vol.187 No.7
<P>Zacco platypus, pale chub, is an indigenous freshwater fish of East Asia including Korea and has many useful characteristics as indicator species for water pollution. While utility of Z. platypus as an experimental species has been recognized, genetic-level information is very limited and warrants extensive research. Metallothionein (MT) is widely used and well-known biomarker for heavy metal exposure in many experimental species. In the present study, we cloned MT in Z. platypus and evaluated its utility as a biomarker for metal exposure. For this purpose, we sequenced complete complementary DNA (cDNA) of MT in Z. platypus and carried out phylogenetic analysis with its sequences. The transcription-level responses of MT gene following the exposure to CdCl2 were also assessed to validate the utility of this gene as an exposure biomarker. Analysis of cDNA sequence of MT gene demonstrated high conformity with those of other fish. MT messenger RNA (mRNA) expression and enzymatic MT content significantly increased following CdCl2 exposure in a concentration-dependent manner. The level of CdCl2 that resulted in significant MT changes in Z. platypus was within the range that was reported from other fish. The MT gene of Z. platypus sequenced in the present study can be used as a useful biomarker for heavy metal exposure in the aquatic environment of Korea and other countries where this freshwater fish species represents the ecosystem.</P>