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- 저자 : Caixia Wan (검색결과 3 건)
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The NAC transcription factor OsSWN1 regulates secondary cell wall development in Oryza sativa
Maofeng Chai,Maria Bellizzi,Caixia Wan,Zhifang Cui,Yebo Li,Guo-Liang Wang 한국식물학회 2015 Journal of Plant Biology Vol.58 No.1
Rice, as a major crop in the world, produces huge agronomic biomass residues besides food, which consist of cellulose, hemicelluloses and lignin. Many master regulators of secondary wall synthesis were identified in the model plant Arabidopsis. In this study, we investigated the function of a NAC (NAM, ATAF, and CUC2) transcription factor related to secondary cell wall biosynthesis, which is highly expressed in rice sclerenchyma tissue and is named OsSWN1. Our results showed that engineering of OsSWN1 could exhibit multiple features regulated to agronomic traits and bioenergy research. Over-expression of OsSWN1 caused an erect-leaf and enclosed-flower phenotype. Secondary cell wall-related genes were actively expressed in transgenic plants with obvious ectopic lignin deposition in the leaf collar, while increased lignin content and decreased the sugar yield correspondingly. In addition, down-regulation of OsSWN1 expression levels decreased lignin content and increased the sugar yield in transgenic plants. Bioinformatics analysis revealed that OsSWN1-like genes are highly conserved in switchgrass and sorghum, suggesting a possibility of manipulating the expression level of the OsSWN1 orthologs in the bioenergy crops for biofuel production.
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Lijie Tang,Yan Ma,Caixia Yang,Enxiang Liang,Hong Yin,Qiong Wan,Jiance Zhang,Wei Wang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.118 No.-
Flexible energy storage devices are susceptible to damage, which might result in safety issues. In thispaper, a self-healing flexible P(AAPBA-co-P4-AC) gel electrolyte based on dynamic borate bond crosslinkingstrategy is reported. On the one hand, it is simple to process into complicated shapes or patterns,and on the other hand, it could rapidly return to its original state after stress damage. Even after ten timesself-healing, the gel has the same mechanical properties as the non-damaged gel. Furthermore, this gelcan also be applied in all-solid-state supercapacitors without the need of extra electrolytes. Becausethe gel has a large number of hydroxyl groups, it has a high affinity for the activated carbon electrode,and the supercapacitors can maintain 100% initial performance under various angles or strains. Afterten thousand times cycles charge–discharge, the supercapacitors using the gel after twenty times selfhealingprocess can retain 90% of its initial capacity, which is only 4% lower than the non-damagingsupercapacitors, demonstrating high self-healing ability.
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Shi Si,Gu Huijie,Xu Jinyuan,Sun Wan,Liu Caiyin,Zhu Tong,Wang Juan,Gao Furong,Zhang Jieping,Ou Qingjian,Jin Caixia,Xu Jingying,Chen Hao,Li Jiao,Xu Guotong,Tian Haibin,Lu Lixia 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Excessive osteoclast activation, which depends on dramatic changes in actin dynamics, causes osteoporosis (OP). The molecular mechanism of osteoclast activation in OP related to type 1 diabetes (T1D) remains unclear. Glia maturation factor beta (GMFB) is considered a growth and differentiation factor for both glia and neurons. Here, we demonstrated that Gmfb deficiency effectively ameliorated the phenotype of T1D-OP in rats by inhibiting osteoclast hyperactivity. In vitro assays showed that GMFB participated in osteoclast activation rather than proliferation. Gmfb deficiency did not affect osteoclast sealing zone (SZ) formation but effectively decreased the SZ area by decreasing actin depolymerization. When GMFB was overexpressed in Gmfb-deficient osteoclasts, the size of the SZ area was enlarged in a dose-dependent manner. Moreover, decreased actin depolymerization led to a decrease in nuclear G-actin, which activated MKL1/SRF-dependent gene transcription. We found that pro-osteoclastogenic factors (Mmp9 and Mmp14) were downregulated, while anti-osteoclastogenic factors (Cftr and Fhl2) were upregulated in Gmfb KO osteoclasts. A GMFB inhibitor, DS-30, targeting the binding site of GMFB and Arp2/3, was obtained. Biocore analysis revealed a high affinity between DS-30 and GMFB in a dose-dependent manner. As expected, DS-30 strongly suppressed osteoclast hyperactivity in vivo and in vitro. In conclusion, our work identified a new therapeutic strategy for T1D-OP treatment. The discovery of GMFB inhibitors will contribute to translational research on T1D-OP.
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