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      • KCI등재

        임신 중기 산모혈청 삼중 표지자를 이용한 다운증후군 태아의 선별검사 결과 위양성 산모의 임신 예후

        송찬호,양영호,김재욱,김세광,김인규,조재성,김석영,최형민,임종철 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.3

        Objective: Our purpose was to study the pregnancy outcome in women whose triple marker screening [maternal serum AFP, unconjugated estriol, hCG, and maternal age] indicating an increased risk for Down syndrome [more than 1 : 270] was not confirmed by amniocentesis [false-positive result]. Methods: Between January 1995 and August 1997, 1,070 pregnant women undergoing second trimester triple marker screening for Down syndrome who gave birth at our institution were evaluated. The pregnancy outcomes of 56 women with false-positive screens for Down syndrome were compared with 1,014 screen negative controls. The pregnancy outcomes were obtained from hospital delivery records. Pregnancies with fetal chromosomal and structural anomalies were excluded from the study Results: An adverse pregnancy outcome occurred in 6 of 56 women [10.7%] with false-positive screens for Down syndrome, compared with 80 of 1,014[7.9%] in the screen negative controls [p=0.291]. The study group was not significantly different from the control group in the incidence of preterm delivery [5.4% vs. 3.5%], preeclampsia [0% vs. 1.8%], abruptio placentae [0% vs. 0.2%], intrauterine growth retardation [5.4% vs. 2.0%], and fetal death [0% vs. 0.5%]. Among six women with adverse pregnancy outcome in the study group, low uE3 level[≤ 0.75 MoM] and high hCG level [≥ 2.0 MoM] were more frequently associated with adverse pregnancy outcome than low AFP level[≤ 0.4 MoM]. Conclusion: Women with false-positive screens for Down syndrome do not appear to be associated with adverse pregnancy outcomes.

      • KCI등재

        거대 자궁내막낭종 1 예

        박충학,임병남 대한산부인과학회 1991 Obstetrics & Gynecology Science Vol.34 No.2

        저자들은 최근 대한병원 산부인과에서 난소에 발생한 거대 자궁내막낭종 1예를 치험하였기에 문헌고찰과 함께 보고하였다. Endometriosis is a disease of unknown etiology with a quite protean clinical manifestations. We have experienced one case of huge endometrial cyst in the ovary in 24-year-old woman, which is presented with a brief review of the literatures.

      • KCI등재

        난소임신 2 례

        박충학,임병남,이광준,박종하 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.4

        저자들은 최근 대한병원 산부인과에서 희귀한 난소임신 2례를 치험하였기에 간단한 문헌고찰과 함께 보고하였다. Primary ovarian pregnancy is comparatively rare in etopic pregnancy. We have experienced two cases of ovarian pregnancy, which are presented with a brief review of the literatures.

      • KCI등재

        Evidence mapping of interactions on concomitant use of Chinese medicine and platinum-based chemotherapy: a scoping review protocol

        Ai Ch’i Liew,Si Yan Chan,Ren Jye Lim,Wan Najbah Nik Nabil,Shi Min Hoo,Nai Ming Lai 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.2

        Background: The utilization of Chinese herbal medicine (CHM) has gained popularity and acceptance worldwide. Increasing use of CHM either as a stand-alone or an adjunctive treatment for cancers has given rise to increasing concern on potential herbal-drug reactions. Possible combinatory effects are important to be explored in evaluating the rationality of integrating CHM and chemotherapy in clinical practice. This study aims to update the current knowledge on herbal-drug interactions (HDI) of the commonly used platinum-based chemotherapy (PtC) in cancer patients. Methods: Systemic searches will perform on online databases (English and Chinese) to identify papers from inception until December 2019 for inclusion into the review. The search strategy will be following PRISMA Scoping Reviews Checklist as a quality assurance step. All records retrieved will be screened by 2 independent reviewers. The preclinical studies and clinical studies that involve in assessing the concurrent use of CHM and PtC will be considered. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses will be used as scoping review framework. Discussion: This scoping review will explore the compatibility or combination rule of CHM-PtC and assist in understanding HDI in CHM-PtC co-treatment. Identification of active properties in CHM’s HDI and understanding pharmacokinetics and pharmacodynamic of the CHM alone or as co-treatment are essential for patients’ safety profile. It will provide a new insight for future practice in cancer treatment. Study registration: This protocol has been registered in the Research Register (https://www.researchregistry.com/) with an unique registration number: reviewregistry790.

      • KCI등재

        복강경 난관불임시술후 발생한 자궁외임신에 관한 임상적 연구

        박충학,임병남,이광준,박종하 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.10

        1987년 1월 1일부터 1990년 6월 30일까지 대한병원 산부인과병동에 입원한 총 64예의 자궁외임신중 복강경 불임시술후 발생한 자궁외임신 19예를 분석, 고찰하여 다음과 같은 결론을 얻었다. 1. 복강경 난관불임시술 후 발생한 자궁외임신은 전 자궁외임신 64예중 19예로 29.7%이었다. 2. 연령분포는 23세부터 42세까지였으며, 호발연령군은 31∼35세였다. 3. 최다 임신횟수는 13회, 최소 임신횟수는 2회로서, 평균 임신횟수는 3.6회였다. 최다 생존아 수는 3명이었고, 최소 생존아 수는 1명으로 평균 생존아 수는 2.2 명이었다. 4. 인공유산횟수는 1회가 11예(57.9%)로 가장 많았으며, 평균 인공유산횟수는 1.2회였다. 5. 대부분의 경우 하복부 동통, 이상질출혈, 무월경, 오심 및 구토, 현기증 등의 증상이 복합적으로 나타났으며 심한 경우는 쇼크상태를 보였다. 입원당시 혈색소치 농도는 최저 8.3gm/dl에서 최고 13.3gm/dl까지의 분포를 보였으며, 평균농도는 10.4gm/dl이었다. 6. 뇨임신반응검사의 양성율은 76.5%이었으며, 더글라스와 천자 소견에서는 94.7%의 양성반응율을 보였다. 7. 최종월경 제 1일부터 증상 발생시까지의 기간은 최저 4주에서 최고 11주까지의 분포를 보였으며 평균 임신기간은 6.7주였다. 8. 복강경 불임시술후 자궁외임신 치료까지의 기간은 최소 5개월에서 최고 12년까지의 분포를 보였으며, 평균기간은 58.6개월이었다. 9. 복강경 불임시술 방법은 18예가 전기소작법에 의한 것이고, 1예가 silastic band에 의한 것이었다. 난관불임시술을 받은 의료기관은 가족계획협회 의원 9예, 산부인과 전문의원 7예, 종합병원 3예이었다. 10. 자궁외임신이 발생된 부위는 난관원위부 10예, 난관근위부 7예, 자궁각부 2예였으며, 최다 호발부위는 난관팽대부로서 9예의 빈도를 나타냈다. 11. 복강내 출혈량은 1,000∼ 1,500cc가 31.6%로 가장 많았고, 2,000cc 이상 출혈한 경우도 21.0%나 있었다. 수혈하지 않은 경우도 4예가 있었으나 평균 2.1pints를 수혈하였다. 12. 수술방법에서는 양측 난관절제술이 52.6%로서 가장 많이 시행하였으며 환측 난관 난소절제술을 시행한 경우가 15.8%였고, 자궁각절제술을 시행한 경우는 10.5%였다. The incidence of ectopic pregnancy was reported to be increased recently. This study was taken to evaluate the clinical and statistical nature of ectopic pregnancy following laparoscopic tubal sterilization. An analysis of 19 patients of ectopic pregnancy following laparoscopic tubal sterilization which were treated at Dae Han General Hospital during the period from January 1987 to June 1990 was done. Followings were the results summarized: 1. Among the 64 cases of ectopic pregnancy during the period, 19 cases(29.7%) were found to occur after laparoscopic tubal sterilization. 2. The mean age was 32.7 years (range from 23 to 42) and the most prevalent age group was 31 to 35 years. 3. The mean number of gravidity and living children were 3.6 and 2.2 respectively. 4. Lower abdominal pain was the single most common presenting symptom (94.7%), with abnormal vaginal bleeding (78.9%). 5. The mean gestational period was about 6.7 weeks. 6. The mean interval between laparoscopic tubal sterilization and treatment was 58.6 months, with the shortest interval being 5 months and the longest 144 months. 7. The methods of sterilization were mostly electrical cauterization (18 cases) and the rest was silastic band application (1 case). 8. The location of ectopic pregnancy were in the fimbrial portion (5.3%), ampullary portion (47.4%), isthmic portion (15.8%), interstitial portion (21.0%), and uterine cornual portion(10.5%). 9. The mean intraperitoneal blood loss was 1300 CC and mean blood transfusion volume was 2.1 pints. 10. The operation methods were bilateral salpingectomy in 10 patients, unilateral salpingo-oophorectomy with contralateral salpingectomy in 3 patients, unilateral salpingo-oophorectomy in 2 patients, cornual wedge resection in 2 patients, unilateral salpingectomy in 1 patient, and unilateral salpingectomy with contralateral tubal ligation in 1 patient.

      • KCI등재

        조기폐경 환자의 난소조직에 대한 면역조직화학적 연구

        송찬호,박기현,이병석,임경호 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.8

        본 연세대학교 의과대학 산부인과학교실에 내원한 조기폐경 환자 15명을 대상으로 난소조직에 대한 조직학 및 면역화학조직학적 검사를 통하여 4명에서 난포가 관찰되었으며 9명에서common leukocyte, 7명에서 T-임파구, 4명에서 B임파구, 5명에서 macrophage의 침착이 관찰되었고 5명에서 자가항체가 관찰되었다. 따라서 조기폐경 환자의 병리기전은 면역학적 요인에 의해 초래되며 난소파괴는 근본적으로 자가면역성 난소염에 병리기전에 의한 것으로 사료되는 바이다. The ovaries from a patient with premature ovarian failure were evaluated by conventional H-E staining and immunohistological staining. Ovarian primordial follicles were found in 4 out of 15 patients. In the immunohistologic analysis using monoclonal antibody of the inflammatory cells, including common leukocytes, T cell, B cell and macrophage. Common leukocytes were positive in 9 patients, T cell, B cell and macrophage were 7, 4, and 5 out of total 15 patients, And, autonatibody was detected in 5 out of 15 patients. On the basis of our study, ovarian destruction may be caused by the pathogenetic mechanism of autoimmune oophoritis.

      • 광주지역 황룡강 수계의 식물상

        조원철,임동옥 호남대학교산업기술연구소 2011 산업기술연구논문집 Vol.17 No.2

        본 논문은 2008년 3월부터 10월까지 황룡강 수계 중 광주광역시에 포함된 총 7개 조사지역에서 식물상과 수생식물의 분포를 분석하였다. 조사 결과 전체 식물상은 81과 220속 279종 37변종 1품종으로 총 317종류가 확인되었다. 수생식물은 30과 55속 67종 8변종으로 총 75종류가 나타났으며, 생육환경별 조건에 따라 수생식물 중 정수식물 22종, 부엽식물 7종, 침수식물 7종, 부유식물 2종 및 습생식물 37종이 각각 확인되었고, 환경부 지정 멸종위기종은 나타나지 않았으며, 산림청지정 희귀 및 멸종위기식물로는 자라풀 1종이 확인되었다. 각 조사지역에서 조사된 귀화식물은 14과 40속 46종 3변종으로 총 49종류가 확인 되었으며, 평균 도시화지수는 18.4%, 귀화율은 15.5%였다. 주요어: 황룡강, 수생식물, 멸종위기종, 귀화식물 This study was identified on the flora and distribution of hydrophytes of the 7 sites selected in Hwang-Yong River through Gwangju from March to October, 2008. In this survey, flora were identified as 317 taxa; belonging to 81 families, 220 genera, 279 species, 37 varieties and 1 forms. Rare and endangered plants selected by Forest Ministry were appeared Hydrocharis dubia. The hydrophytes were classified 75 taxa; 30 families, 55 genera, 67 species and 8 varieties. Among the hydrophytes emerged plants were 22, floating-leaved plants were 7, submerged plants were 7, free floating plants were 2 and swamp hydrophytes were 37 species respectively in Hwang-Yong River. The Ministry of Environment help protect Endangered Species has not been verified, Specify the rare and endangered plants, the Forest Service check out a piece of paper was Hydrocharis dubia. Naturalized plants were identified 49 taxa;14 families, 40 genera, 46 species and 3 varieties. The urbanization index(UI) was 18.4% and the urbanization rate(NR) was 15.5% of which were investigated 7 each sites. Key words: Hwang-Yong River, Hydrophytes, Endangered Species, Naturalized Plants

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