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Curved-quartic-function elements with end-springs in series for direct analysis of steel frames
Si-Wei Liu,Jake Lok Yan Chan,Rui Bai,Siu-Lai Chan 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.29 No.5
A robust element is essential for successful design of steel frames with Direct analysis (DA) method. To this end, an innovative and efficient curved-quartic-function (CQF) beam-column element using the fourth-order polynomial shape function with end-springs in series is proposed for practical applications of DA. The member initial imperfection is explicitly integrated into the element formulation, and, therefore, the <i>P</i>-<i>δ</i> effect can be directly captured in the analysis. The series of zero-length springs are placed at the element ends to model the effects of semi-rigid joints and material yielding. One-element-per-member model is adopted for design bringing considerable savings in computer expense. The incremental secant stiffness method allowing for large deflections is used to describe the kinematic motion. Finally, several problems are studied in this paper for examining and validating the accuracy of the present formulations. The proposed element is believed to make DA simpler to use than existing elements, which is essential for its successful and widespread adoption by engineers.
연구노트 : 포도 추출물로부터 C/EBP 전사인자 활성 비교
이시림 ( Si Rim Lee ),박철홍 ( Chul Hong Park ),권은영 ( Eun Young Kuan ),루옌칭 ( Yan Qing Lu ),김홍 ( Hong Kim ),김기찬 ( Ki Chan Kim ),손형우 ( Hyeong U Son ),이현진 ( Hyun Jin Lee ),허진철 ( Jin Chul Heo ),이상한 ( Sang Han L 한국식품저장유통학회(구 한국농산물저장유통학회) 2011 한국식품저장유통학회지 Vol.18 No.1
In order to compare what kinds of transcription factors are associated with the inhibition of preadipocyte cell proliferation, we prepared several grape extracts and tested the expression patterns by reverse transcription-polymerase chain reaction. As a result, 50% ethanol extract of Campbell early seed inhibited adipogenesis derived from the MDI solution. Extract of Campbell early seed was significantly inhibited lipid droplet formation and expression of molecular factors C/EBP-alpha and delta in 3T3-L1 cells. It is suggested that grape extracts of fractions would be a good candidate for the development of regional skin fat modulator.
Ai Ch’i Liew,Si Yan Chan,Ren Jye Lim,Wan Najbah Nik Nabil,Shi Min Hoo,Nai Ming Lai 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.2
Background: The utilization of Chinese herbal medicine (CHM) has gained popularity and acceptance worldwide. Increasing use of CHM either as a stand-alone or an adjunctive treatment for cancers has given rise to increasing concern on potential herbal-drug reactions. Possible combinatory effects are important to be explored in evaluating the rationality of integrating CHM and chemotherapy in clinical practice. This study aims to update the current knowledge on herbal-drug interactions (HDI) of the commonly used platinum-based chemotherapy (PtC) in cancer patients. Methods: Systemic searches will perform on online databases (English and Chinese) to identify papers from inception until December 2019 for inclusion into the review. The search strategy will be following PRISMA Scoping Reviews Checklist as a quality assurance step. All records retrieved will be screened by 2 independent reviewers. The preclinical studies and clinical studies that involve in assessing the concurrent use of CHM and PtC will be considered. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses will be used as scoping review framework. Discussion: This scoping review will explore the compatibility or combination rule of CHM-PtC and assist in understanding HDI in CHM-PtC co-treatment. Identification of active properties in CHM’s HDI and understanding pharmacokinetics and pharmacodynamic of the CHM alone or as co-treatment are essential for patients’ safety profile. It will provide a new insight for future practice in cancer treatment. Study registration: This protocol has been registered in the Research Register (https://www.researchregistry.com/) with an unique registration number: reviewregistry790.