퇴행성 관절염에서 Interleukin-6와 Soluble Interleukin-6 Receptor

장재석 ( Jae Suk Chang ),정용갑 ( Yong Gab Jeong ),조우신 ( Woo Shin Cho ),빈성일 ( Seong Il Bin ),엄규황 ( Kyu Hwang Ym ),김정화 ( Jung Hwa Kim ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.3

Objective: Unlike other soluble receptors, the soluble interleukin-6 receptor (sIL-6R) cooperates with IL-6 to activate gp130 of effector cell. As the IL-6 and sIL-6R are important in the rheumatoid disease, this study was designed to measure concentration of IL-6 and sIL-6R in synovium and synovial fluid of the degenerative arthritis. Methods: The synovium and synovial fluid were obtained during total knee replacement arthroplasty. The synovium was taken from eleven patients, and synovial fluid taken from sixteen patients. Same patients between two groups were seven. Tissue cultures of the synovial tissues were done with 10% FBS for 72 hours. After irrigation, thery were incubated for 48 hours without FBS, and the culture media and the synovial fluid were collected after centrifuged at 2500rpm for 10 minutes. The level of IL-6 and sIL-6R were measured by quantitative sandwich enzyme immunoassay technique. Results: In the synovium, the IL-6 level was 5.1±0.12ng/ml, and the sIL-6R level was 0.41±0.25ng/ml. In the synovial fluid, the IL-6 level was 0.09± 0.15ng/ml, and the sIL-6R level was 10.37±3.28ng/ml. These results show that IL-6 concentration was measured highly in two groups, especially in synovium (sixty times), and the sIL-6R concentration was measured significantly high in synovial fluid (twenty-five times). Conclusion: The IL-6 and sIL-6R were elevated in degenerative arthrits. We confirmed the source of IL-6 was synovium (very high in synovial tissue culture media), but we need further study for the source of sIL-6R as it was remarkably elevated as IL-6 and its level was lower than serum.

Interleukin-13 Increases Podocyte Apoptosis in Cultured Human Podocytes

Lee, Keum Hwa,Oh, Ji Young,Seong, Su-Bin,Ha, Tae-Sun,Shin, Jae Il Korean Society of Pediatric Nephrology 2018 Childhood kidney diseases Vol.22 No.1

Purpose: Podocytes are important architectures that maintain the crucial roles of glomerular filtration barrier functions. Despite this structural importance, however, the mechanisms of the changes in podocytes that can be an important pathogenesis of minimal change nephrotic syndrome (MCNS) are not clear yet. The aim of this study was to investigate whether apoptosis is induced by interleukin (IL)-13 in cultured human podocytes. Methods: Human podocytes were treated with different IL-13 doses and apoptotic cells were analyzed using terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL assay) and fluorescence-activated cell sorting (FACS). Results: The IL-13 increased the number of TUNEL-positive cells in a dose-dependent manner at 6 and 18 hours (P<0.05 and P<0.05, respectively). The apoptosis rate was appeared to be increased slightly in the IL-13-stimulated podocytes (8.63%, 13.02%, and 14.46%; 3, 10 and 30 ng/mL, respectively) than in the control cells (7.66%) at 12 hours by FACS assay. Conclusion: Our study revealed that IL-13 expression may increase podocyte apoptosis. Blocking the IL-13 signal pathway can potentially play an important role in regulating the apoptosis of podocytes.

골수강내 경골 절골 지침자를 이용한 슬관절 전치환술

빈성일,최준원,남태석 대한슬관절학회 2003 대한슬관절학회지 Vol.15 No.1

목적 : 골수강내 경골 절골 지침자를 사용하여 시행하여 슬관절 전치환술에서 경골 절골각 및 하지 정열의 정확도를 알아보고자 하였다. 대상 및 방법 : 1998년 11월부터 2001년 8월까지 골수강내 경골 절골 지침자를 이용하여 시행한 슬관절 전치환술 343예 중 술후 1년 이내에 기립상 전하지 방사선 촬영을 시행한 160예를 대상으로 하였다. 술후 방사선 사진상 경골의 해부학적 축과 경골 삽입물이 이루는 각도 및 대퇴골의 해부학적 축과 경골의 해부학적 축이 이루는 각도를 계측하였다. 결과 : 경골의 해부학적 축과 경골 삽입물이 이루는 각도는 평균 89.5°, 범위는 84°~94°였고, 90°±2°에 133예(83.1%)가 해당되었고, 그 중 66예(41.3%)는 90°였다. 대퇴골의 해부학적 축과 경골의 해부학적 축이 이루는 각도는 평균 5.6°였고, 범위는 0°~11°였다. 결론 : 슬관절 전치환술에서 경골 절골의 지침자로, 골수강내 지침자를 정확한 술식대로 사용할 경우 만족할 만한 경골 절골각 및 하지 정열을 얻을 것으로 사료된다. Purpose: To evaluate the tibia osteotome angle and whole leg alignment in total knee replacement arthroplasty using intramedullary tibia guide. Methods & Materials : Amongst 343 cases of TKA using an intramedullary tibial cutting guide from November 1998 to August 2001, 160 cases who took a standing whole leg AP simple roentgenography within 1 year were selected. Post-operatively, the angle formed by the tibial anatomical axis anbd tibial component, along with the angle with the angle formed between the femoral anatomical axis and tibial anatomical axis and tibial anatomical axis were measured. Results : The average angle between the tibial anatomical axis and tibial component was 89.5°(84°~94°), 133 cases (83.1%) were within the range of 90°±2° and amongst these 66 cases(41.3%) were 90°. The average angle formed between the femoral anatomical axis and tibial anatomical axis was 5.6°(0°~11°). Conclusion : When used properly, and intramedullary tibial cutting guide in TKA result in satisfactory tibial osteotome angle and whole leg alignment in TKA.

슬관절에 생긴 관절근접의 점액종 : 1예 보고 A Case Report

이상민,신명진,김성문,이상훈,강병성,빈성일 최신의학사 2003 最新醫學 Vol.46 No.11-12

Correlation between Tear of Lateral Discoid Meniscus and Cartilage Damage in Patients Under 40 Years Old

Seong-Il Bin(빈성일),Tae-Seok Nam(남태석),Ji-Hyun Ahn(안지현),Se-Kwan Oh(오세관) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.8

15세 이상 40세 이하의 활동기 연령에서 외측 원판형 반월상 연골 파열과 동반된 연골 손상 정도의 상관 관계에 대해서 알아 보고하고자 하였다. 1998년 10월에서 2004년 7월까지 외측 원판형 반월상 연골 파열로 관절경하 반월상 연골 절제술을 받은 144예 중 외측 원판형 반월상 연골에 단독 손상을 보인 15세 이상 40세 이하의 환자 56명, 65예에서 나이, 증상 기간, 관절경하 반월상 연골 파열 형태, 하지 정열 상태와 동반된 연골 손상의 정도를 조사, 분석하였다. 수술 전 가장 흔한 증상은 동통(89.2%)이었다. 관절경 검사에서 완전 원판형 반월상 연골 파열은 22예였으며, 파열 양상은 선형(longitudinal) 파열이 11예로 가장 많았다. 불완전형 원판형 반월상 연골 파열은 43예로, 이중 방사형(radial) 파열이 18예로 가장 많았다. 선형 파열로 분류된 전례에서 양동이 손잡이형(bucket-handle) 파열의 형태를 보였다. 65예 중 33예(47%)에서 경골 혹은 대퇴골 외과의 연골이 Outerbridge 분류상 3, 4등급의 소견을 보였으며, 21예의 선형 파열 중 15예(65%)에서 다른 형태의 파열에 비해 많은 비율에서 관절 연골의 손상이 관찰되었다. 증상 기간은 연골 손상 정도와 의미 있는 상관 관계를 보였으나, 나이, 방사선 검사상 하지 정열 상태는 동반된 연골 손상의 정도와는 상관 관계가 없었다. 15세 이상 40세 이하의 활동기 연령에서의 외측 원판형 반월상 연골 파열 중 선형 파열(양동이 손잡이형)에서 외측 경골 및 대퇴골 연골의 손상이 비교적 많았으며, 증상 기간과 연골 손상 정도가 상관 관계가 있어, 이 경우 비교적 조기에 적절한 외과적 치료를 시행하는 것이 바람직할 것으로 사료된다. Purpose: To report the correlation between tears in the lateral discoid menisci and cartilage damage in patients under 40 years old. Materials and Methods: Arthroscopic meniscectomy was performed on 144 cases of tears in lateral discoid menisci from September 1998 to July 2004, of which 65 cases were in 56 patients aged 15 to 40 year old and showed isolated tears of lateral discoid menisci. For these 65 cases, we inspected clinical symptoms and tear patterns and analyzed the relationships among age, duration of clinical symptoms, tear pattern of the meniscus on arthroscopic findings, the alignment of the lower extremities on X-rays and the severity of associated cartilage damage. Results: The most common pre-operative symptom was pain (89.2%), followed by locking (32.3%), a clicking sound (16.9%), and giving way (16.9%). Arthroscopic findings showed, 22 cases of complete type-discoid meniscus, consisting of 11 longitudinal tears, 5 simple horizontal tears, 5 complicated horizontal tears, 1 radial tear and no complex or degenerative tears. There were 43 cases of incomplete type-discoid meniscus, consisting of 18 radial tears, 10 longitudinal tears, 8 complicated horizontal tears, 3 simple horizontal tears, 3 complex tears and 1 degenerative tear. All longitudinal tears showed a pattern of bucket-handle tears. Associated cartilage damage greater than grade 3 according to the Outerbridge classification was observed in 33 cases, 11 complete and 22 incomplete discoid-type, on the lateral femoral condyle or tibial plateau. Of the 21 cases of longitudinal tear, 15 had associated cartilage damage significantly increased rate in comparison with other types of clinical tear pattern. Of the 15 cases of grade 4 cartilage damage, 9 had longitudinal tears. The duration of clinical symptoms was correlated with cartilage damage, but there was no significant associated between cartilage damage and age or the alignment of the lower extremities on X-rays. Conclusion: Longitudinal (bucket-handle) tears of the lateral discoid meniscus inpatients 15 to 40 years old, showed significant associated with cartilage, damage. The duration of symptoms was also correlated with cartilage damage, indicating that prompt initiation of appropriate surgical treatment should be considered in these cases.

Have Evolving Surgical Methods Improved Clinical Outcomes after Anterior Cruciate Ligament Reconstruction?

( Seong-il Bin ) 대한슬관절학회 2017 대한슬관절학회지 Vol.29 No.1

Graft extrusion after medial and lateral MAT differs according to surgical technique: a meta-analysis

Bin, Seong-Il,Kim, Hyun-Jung,Lee, Dae-Hee Springer-Verlag 2018 Archives of orthopaedic and trauma surgery Vol.138 No.6

관절경적 전방십자인대 재건술의 재시술

빈성일(Seong Il Bin),정의룡(Ewy Ryong Chung) 대한정형외과학회 1995 대한정형외과학회지 Vol.30 No.6

외측 원판형 연골판의 유형과 파열 양상간의 상관관계

빈성일 ( Bin Seong Il ),김지철 ( Kim Ji Cheol ),김종민 ( Kim Jong Min ),주동만 ( Ju Dong Man ) 대한슬관절학회 2003 제21차 정기학술대회 초록집 Vol.- No.-

슬관절 전치환술후 보행분석을 이용한 평가

빈성일 ( Bin Seong Il ),유종윤 ( Yu Jong Yun ),최준원 ( Choe Jun Won ),주동만 ( Ju Dong Man ) 대한슬관절학회 2003 제21차 정기학술대회 초록집 Vol.- No.-