http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
문철웅,정종훈,박천국,이승일,배학연,장경식,김만우,정춘해,홍순표,이병래,김호중 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1
Renal ischemia is one of the most common causes of acute renal failure. Four factors related to the pathogenesis of acute renal failure are vasoconstriction, decreased glomerular filtration rate, tubular back leak of filtrate, and intratubular obstruction. The cellular response to renal ischemic insults include decreased content of adenosine trihosphate, lipid peroxidation induced membrane degradation, alteration in cellular pH, and calcium or phospholipase induced mitochondrial dysfunction. Much attention has been given to the role of increased cellular calcium as a pathogenetic contributor to cell injury during ischemia. Author studied the protective effects of calcium antagonists on cellular injury during renal ischemia in rat. To investigate the protective role of these agents, author measured the amount of malondialdehyde(MDA) and the enzyme activities of free radical scarvengers-superoxide dismutase(SOD), catalase and glutathione peroxidase from non-pretreated group and calcium antagonists pretreated groups in control, ischemia and reflow subgroups. The results were summerized as follows: 1) The amount of MDA in non-pretreated group was higher in the reflow compared with the control(<p<0.01). But, in all pretreated groups, there was no statistically difference in the amount of MDA. 2) The SOD activity in non-pretreated group was lower in both the ischemia and the reflow compared with the control (P<0.05). But, in both verapamil and trifluoperazine-pretreated groups, there was no statistically difference in the SOD activity. 3) Both catalase and glutathione peroxidase activities in non-pretreated group were lower in both the ischemia and the reflow compared with the control (P<0.05). But in all pretreated groups, there was no statically difference in both catalase and glutathione peroxidase activities. These results suggest that free radical mediated ischemic injury by renal artery clamp in rat can be protected by intraperitoneal pretreatment with calcium antagonists. As trifluoperazine has a protective effect in renal ischemia, the calcium activated calmodulin dependent enzyme may play a role in renal ischemic injury.
인슐린 비의존형 당뇨병 환자에서 24시간 혈압 변동 및 요중 알부민 배설량에 관한 연구
주기산,안기완,정종훈,배학연,홍순표 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1
Recently, blood pressure(BP) starts to increase in close relationship to development of persistent microalbuminuria in diabetes. Thus, author studied 24-hour BP changes in diabetics compared to the those in nondiabetics and the changes of urinary albumin excretion (UAE) according to 24-hour BP changes in diabetics with microalbuminuria. Twenty-four-hour ambulatory blood pressure monitoring(ABPPM) was performed in 38 NIDDM patients(18 normotensives and 20 hypertensives) and in 37 control subjects without diabetes(18 normotensives and 19 hypertensives) . Also 24-hour ABPM was performed in 38 diabetics (20 microalbuminurit and 18 normoalbuminuric). The analysis of individual recordings allowed us to detect an impaired circadian pattern(the disappearance of the nocturnal BP decrease or a paradoxical BP increase) in 30% of the normotensive and 31% of the hypertensive diabetics. Twenty-four-hour ABPM(night systolic/diastolic ±SD mmHg) was significantly higher in microabluminuric(124.2 ±11.4/75.1±8.2 mmHg) than in normoalbuminuric subject, (114.0±7.6/64.6±6.6 mmHg, p<0.05). This study suggests that not only awaking BP but also especially day-night minimum SBP decrease are highly responsible for the renal impairment in NIDDM patients, unrelation to hypertension. Thus. ABPM reflects the association between UAE and blood pressure in diabetics more precisely than clinical measurements. and a significant correlation exists between rate of increase in Urinary albumin excretion and blood pressure in diabetics.
Bae, Jung-Hoon,Kim, Hyun-Jin,Kim, Mi-Jin,Sung, Bong Hyun,Jeon, Jae-Heung,Kim, Hyun-Soon,Jin, Yong-Su,Kweon, Dae-Hyuk,Sohn, Jung-Hoon Elsevier 2018 Journal of biotechnology Vol.266 No.-
<P>An efficient production system for optically pure L-and D-lactic acid (LA) from Jerusalem artichoke tuber powder (JAP) was developed by metabolic engineering of Kluyveromyces marxianus. To construct LA-producing strains, the ethanol fermentation pathway of K. marxianus was redirected to LA production by disruption of KmPDC1 and expression of L-and D-lactate dehydrogenase (LDH) genes derived from Lactobacillus plantarum under the control of the K. marxianus translation elongation factor 1 alpha promoter. To further increase the LA titer, the L-LA and D-LA consumption pathway of host strains was blocked by deletion of the oxidative LDH genes KmCYB2 and KmDLD1. The recombinant strains produced 130 g/L L-LA and 122 g/L D-LA by direct fermentation from 230 g/L JAP containing 140 g/L inulin, without pretreatment or nutrient supplementation. The conversion efficiency and optical purity were >> > 95% and >> >99%, respectively. This system using JAP and the inulin-assimilating yeast K. marxianus could lead to a cost-effective process for the production of LA.</P>
Hoon Seonwoo,Won-Gyu Bae,Sunho Park,Hong-Nam Kim,Kyoung Soon Choi,Ki Taek Lim,Hoon Hyun,Jin-Woo Kim,Jangho Kim,Jong Hoon Chung IEEE 2016 IEEE transactions on nanobioscience Vol.15 No.8
<P>Living cells receive biochemical and physical information from the surrounding microenvironment and respond to this information. Multiscale hierarchical substrates with micro- and nanogrooves have been shown to mimic the native extracellular matrix (ECM) better than conventional nanopatterned substrates; therefore, substrates with hierarchical topographical cues are considered suitable for investigating the role of physical factors in tissue functions. In this study, precisely controllable, multiscale hierarchical substrates that could mimic the micro- and nanotopography of complex ECMs were fabricated and used to culture various cell types, including fibroblasts, endothelial cells, osteoblasts, and human mesenchymal stem cells. These substrates had both microscale wrinkles and nanoscale patterns and enhanced the alignment and elongation of all the cells tested. In particular, the nanotopography on the microscale wrinkles promoted not only the adhesion, but also the functions of the cells. These findings suggest that the hierarchical multiscale substrates effectively regulated cellular structure and functions and that they can be used as a platform for tissue engineering and regenerative medicine.</P>
裵鍾淳,權正烈,沈勇勳,盧潤炅 경상대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.16 No.-
Vertical deformation and lateral flow can occur as a result of the construction of nearby embankments on a soft ground. This paper considered the behavior from a model test that situated pressure berms on the soft ground by trapezodial load., as varied the height and width of the pressure berm and height(H) of the load. But width(B) of the load is equal to all tests. The test results are as follows : 1. Maximum settlement occur at the center of the embankment and ending settlement is to the depth about 1.8B from the ground surface. 2. Maximum uplift location is about 0.3B ∼ 0.4B from the toe of the pressure berm and maximum uplift deformation occur with its height at H/2 without any influence from its width. 3. The width and height of the pressure berm for mimimum uplift deformation is 2H and H/3. 4. Maximum lateral flow occur to the depth at D/3 from the ground surface without any influence from its height and width.