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1. 06㎛ Nd : YAG Laser를 이용한 요추간판탈출증의 경피적 수핵감압술
이흥선,변박장,최순관,신원한,권귀향,이인수,이경석,김범태 순천향대학교 1994 논문집 Vol.17 No.4
The 1.06㎛ Neodymium-YAG Laser(800 micron hemisherical) is revealed a useful tool for percutaneous laser disc decompression(PLDD). Especially PLDD would be applied to the management of lumbar disc herniation with minimal intervention. Total irradiated energy to one level of disc space was bout 1000 to 2000 joules. We performed this method at 10 levels, in 7 cases of patients, consisting of 4 males and 3 females with an average age of 37.7 years. Five cases showed excellent and good results, were observed. In two cases, open surgery was required because of unsatisfactory results. The best results were obtained in the protrusion type of disc herniation. We have summarized some advantages of PLDD: a) safe and simple procedure in an outpatient setting, b) avoiding general anesthesia, late spinal instability, c) possibility of repetitive use.
Effect of Gamma Irradiation on the Structural and Physiological Properties of Silk Fibroin
Nak-Yun Sung,Eui-Baek Byun,Sun-Kyu Kwon,Jae-Hun Kim,Beom-Seok Song,Jong-il Choi,Jin-Kyu Kim,Yohan Yoon,Myung-Woo Byun,Mee-Ree Kim,Hong-Sun Yook,Ju-Woon Lee 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.1
This study was conducted to examine the changes in the molecular structure and physiological activities of silk fibroin by gamma irradiation. The results of gel permeation chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that the molecular weight of fibroin was increased depending upon the irradiation dose. Secondary structure of fibroin determined by using circular dichroism revealed that the ratio of α-helix was increased up to 10 kGy and then decreased depending upon the irradiation dose. Whereas, the ratio of β-sheet, β-turn, and random coil were decreased and then increased with an alteration in the α-helix secondary conformation. The 2.2-diphenyl-1-picryl-hydrazil (DPPH) radical scavenging activity of fibroin was increased by gamma irradiation at 5 kGy, but was decreased above 10 kGy depending upon the irradiation dose. Also, the inhibition activities of tyrosinase and melanin synthesis of fibroin were increased by gamma irradiation. These results indicated that gamma irradiation could be used as an efficient method to make fibroin more suitable for the development of functional foods and cosmetics.
Byun, Hee Sun,Zhou, Wei,Park, InWha,Kang, Kidong,Lee, So-Ra,Piao, Xuezhe,Park, Jin Bong,Kwon, Taeg Kyu,Na, MinKyun,Hur, Gang Min Elsevier 2018 Biochemical pharmacology Vol.158 No.-
<P><B>Abstract</B></P> <P>Despite recent tremendous progress, targeting of TNF-related apoptosis-inducing ligand (TRAIL) as a cancer therapy has limited success in many clinical trials, in part due to inactivation of death inducing signaling complex (DISC)-mediated caspase-8 signaling cascade in highly malignant tumors such as glioblastoma. In this study, screening of constituents derived from <I>Astilbe rivularis</I> for TRAIL-sensitizing activity identified C-27-carboxylated oleanolic acid derivatives (C27OAs) including 3β-hydroxyolean-12-en-27-oic acid (C27OA-1), 3β,6β,7α-trihydroxyolean-12-en-27-oic acid (C27OA-2), and 3β-<I>trans</I>-<I>p</I>-coumaroyloxy-olean-12-en-27-oic acid (C27OA-3) as novel TRAIL sensitizers. Interestingly, these C27OAs did not affect apoptotic cell death induced by either ligation of other death receptor (DR) types, such as TNF and Fas or DNA damaging agents, which suggests that C27OAs effectively and selectively sensitize TRAIL-mediated caspase-8 activation. Mechanistically, C27OAs upregulate the expression of cell surface DR5 and DISC formation without affecting downstream intracellular apoptosis-related proteins. The upregulation of DR5 expression by C27OAs strictly depends on transactivation of C/EBP homology protein, which is regulated through the p38 MAPK pathway, rather than p53 and intracellular reactive oxygen species status. Taken together, our results identify the novel C27OAs as TRAIL sensitizers targeting the upstream DISC assembly of DR5, and provide a rationale for further development of C27OAs for facilitating TRAIL-based chemotherapy in glioblastoma patients.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Kyu Kwang Whang ),( Eun Sun Choi ),( Rosa Kim ),( Ji Yeon Byun ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Since all superficial, interconnecting and deep vessels of nevus flammeus, hemangioma and AV malformation proliferate at the dermis and the subcutaneous fat layer, treatment by laser only is demanding, especially for adult patients. To treat hemangiomas located on lips is challenging because of blood pumping during surgery and of difficulty in shaping of lips. Objectives: To treat recalcitrant hemangioma, nevus flammeus and AV malformation for adults more effectively. Methods: 97 cases (male 32, female 65) of nevus flammeus, hemangioma and AV malformation (mostly on the lip) for 10 years are included and investigated. Aforementioned cases were treated using CO<sub>2</sub> laser partial excision with subdermal dissection, coagulation and/or removal of primary, deep vessels by radiofrequency, and pulsed dye laser with long pulse Nd:YAG (Cynergy multiplex), which could penetrate deeper level than 595nm only. Results: These cases of recalcitrant hemangiomas were treated effectively, preserving anatomical shape as much as possible, with the combination treatment concept. Conclusion: By combining CO<sub>2</sub> laser surgery and multiplex laser, hemangiomas and nevus flammeus, that had been known to be difficult to treat, were removed successfully.
Byun, Hayoung,Cho, Yang-Sun,Jang, Jeon Yeob,Chung, Kyu Whan,Hwang, Soojin,Chung, Won-Ho,Hong, Sung Hwa Triological Foundation [etc.] 2013 The Laryngoscope Vol.123 No.10
<P>To evaluate the prognostic and predictive value of electroneuronography (ENoG) in acute severe inflammatory facial paralysis, including Bell's palsy and Ramsay Hunt syndrome (RHS).</P>
Compact Six-Port Transceiver for Time-Division Duplex Systems
Hyung-Sun Lim,Wan-Kyu Kim,Jong-Won Yu,Hyung-Chul Park,Woo-Jin Byun,Myung-Sun song THE INSTITUTE OF ELECTRICAL ENGINEERS 2007 IEEE Microwave and Wireless Components Letters Vol. No.
<P>A compact six-port transceiver for time-division duplex systems is proposed. The proposed transceiver only uses a single six-port junction for the Tx and Rx mode. Also, we propose the new radio frequency (RF) and baseband interface component, which consists of switch, reflection coefficient generator, and the power detector. The prototype circuits are fabricated to validate the new transceiver with 15-Mbps quadrature phase shift keying (QPSK) digital modulator and 10-Mbps QPSK demodulator at the carrier frequency of 2.4GHz. The proposed six-port transceiver can provide a simple, low-cost, low-power, and reconfigurable RF design platform</P>
Bacillus natto와 B. licheniformis의 혼합 Starter로 제조된 청국장의 품질특성
연규춘(Kyu-Chun Youn),김동호(Dong-Ho Kim),김정옥(Jung-Ok Kim),박병준(Byung-Jun Park),육홍선(Hong-Sun Yook),조재민(Jae-Min Cho),변명우(Myung-Woo Byun) 한국식품영양과학회 2002 한국식품영양과학회지 Vol.31 No.2
청국장의 산업적인 대량생산 system에 B. subtilis, B. natto, B. licheniformis 그리고 B. natto와 B. licheniformis의 혼합균주를 starter로 하여 45시간 동안 청국장을 발효시키면서 각 시험제품의 미생물 생장, 일반성분, 효소활성, 향기성분 등을 분석하고 관능을 평가하였다. 청국장의 수분은 점질물의 형성이 많은 B. subtilis와 B. natto 시험구에서 다소 높았으며 pH는 B. licheniformis에서 8.68로 가장 높았고 B. subtilis에서 8.13으로 가장 낮았다. 미생물의 생장정도는 B. subtilis가 10^9 CFU/g까지, B. licheniformis는 10^8 CFU/g까지 생장하였으며 단백질분해효소의 활성은 B. subtilis에서 1.35unit/g으로 가장 높았고 B. licheniformis에서 0.45 unit/g으로 가장 낮았다. 아미노태질소와 암모니아태 질소의 함량은 미생물의 생장률 및 단백질분해 효소의 활성에 비례하여 B. subtilis > B. natto > B. licheniformis의 순으로 높은 함량을 나타내었다. 한편, B. natto와 B. licheniformis의 혼합균주를 starter로 하여 제조한 청국장의 일반 품질은 B. natto와 B. licheniformis를 단독 접종한 제품의 평균치에 해당하는 특성을 보였다. 검출된 향기성분의 화학적 구성은 ketones 9종, alcohols 11종, aldehyde 6종, heterocyclic compounds 4종, ester 6종, acids 4종, hydrocarbons 4종, 기타 14종이었으며 균주별로는 B. subtilis에서 25종, B. natto에서 30종, B. licheniformis에서 28종, B. natto와 B. licheniformis를 혼합하여 접종한 청국장에서는 41종의 향기성분이 검출되었다. 유기산의 총량은 B. subtilis를 접종한 청국장에서 3.98%로 가장 높았고 B. natto는 2.24%, B. licheniformis는 1.53%이었으며 B. natto와 B. licheniformis의 혼합 시험구에서는 1.67%의 함량을 보였다. 분석된 향기성분과 유기산은 starter로 접종된 Bacillus의 종류에 따라 각각 특징적인 조성을 나타내었다. 관능평가 결과 색, 향, 맛 그리고 전체적인 선호도의 모든 항목에서 B. natto와 B. licheniformis의 혼합 시료가 가장 높은 선호도를 보였고 B. subtilis를 starter로 한 시료의 선호도가 가장 낮았다. The quality characteristics and sensory evaluation of chungkookjang were investigated. The samples were prepared and fermented by the inoculation of Bacillus strains; B. subtilis, B. natto and B. licheniformis as a single starter, and mixed culture of B. natto and B. licheniformis on the industrialized model system. It was shown that microbial growth, protease activity, contents of amino- and ammonia-nitrogen and contents of organic acid were higher in B. subtilis inoculated sample, and were lower in B. licheniformis inoculated one. General quality characteristics of sample inoculated by mixed culture of B. natto and B. licheniformis took a middle position between each B. natto and B. licheniformis inoculated one. Fifty eight species of odor components were identified. Ethanol, 3-methyl-1-butanol, acetic acid, benzaldehyde and alkyl pyrazines were identified in all samples and most of other flavor components were strain specific. The contents of unpleasant smell components, alkyl pyrazines and benzaldehyde, were lower in B. licheniformis inoculated sample. The sensory evaluations showed that chungkookjang manufactured from mixed culture of B. natto and B. licheniformis was most acceptable. Therefore, results indicated that chungkookjang manufactured from mixed culture of B. natto and B. licheniformis induced better sensory quality than that of the control.
10세 수준 인공지능의 도덕성 판단 적용 기준에 관한 연구
변순용 ( Byun Sun-young ),정진규 ( Jeong Jin-kyu ),김은수 ( Kim Eun-soo ),박보람 ( Park Bo-ram ) 한국윤리교육학회 2018 윤리교육연구 Vol.0 No.50
본 논문은 10세 아동과 동일한 수준의 도덕성을 지닌 인공지능을 만들기 위한 프로젝트의 일환으로 인공지능의 도덕성을 판단할 수 있는 기준을 제시하는 것에 목적이 있다. 우리는 이와 같은 목적을 달성하기 위해 콜버그의 도덕발달 이론을 활용하여 AMA의 도덕발달 3단계를 만들었으며, 그 단계별 특징을 나타낼 수 있는 시나리오를 고안하였다. 본 논문은 우리가 고안한 시나리오를 바탕으로 10세 아동의 도덕 판단과 행동 근거를 설문을 통해 알아보고, 그것을 근간으로 인공지능 로봇의 도덕성 측정 기준을 제시하고자 한다. The purpose of this paper is to present the criteria of moral judgment of artificial intelligence that can do the same thing as 10-years-old child. In order to achieve this purpose, we have established the moral developmental theory of AMA which is based on Kohlberg's theory of moral reasoning in previous research, and explained the moral characteristics that AMA can do at each stage. This paper is based on the scenario that we have developed. This scenario can make a moral assessment of human behavior. We survey the scenarios to see how actually 10-years-old behave, and based on them, what are the criteria for measuring the morality of artificial intelligence.