Enhancing the solubility and bioavailability of poorly water-soluble drugs using supercritical antisolvent (SAS) process

Abuzar, Sharif Md,Hyun, Sang-Min,Kim, Jun-Hee,Park, Hee Jun,Kim, Min-Soo,Park, Jeong-Sook,Hwang, Sung-Joo Elsevier 2018 International journal of pharmaceutics Vol.538 No.1

<P><B>Abstract</B></P> <P>Poor water solubility and poor bioavailability are problems with many pharmaceuticals. Increasing surface area by micronization is an effective strategy to overcome these problems, but conventional techniques often utilize solvents and harsh processing, which restricts their use. Newer, green technologies, such as supercritical fluid (SCF)-assisted particle formation, can produce solvent-free products under relatively mild conditions, offering many advantages over conventional methods. The antisolvent properties of the SCFs used for microparticle and nanoparticle formation have generated great interest in recent years, because the kinetics of the precipitation process and morphologies of the particles can be accurately controlled. The characteristics of the supercritical antisolvent (SAS) technique make it an ideal tool for enhancing the solubility and bioavailability of poorly water-soluble drugs. This review article focuses on SCFs and their properties, as well as the fundamentals of overcoming poorly water-soluble drug properties by micronization, crystal morphology control, and formation of composite solid dispersion nanoparticles with polymers and/or surfactants. This article also presents an overview of the main aspects of the SAS-assisted particle precipitation process, its mechanism, and parameters, as well as our own experiences, recent advances, and trends in development.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Effect of hybrid interface on mode-I interlaminar fracture toughness of woven Carbon/Flax hybrid composite

Abuzar Jamil,Maksym Li,Jung-il Song 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.6

탄소섬유/아마섬유 하이브리드 복합재료의 기계적 물성 향상 기구에 관한 연구

아부자르자밀 ( Jamil Abuzar ),이동우 ( Dong-woo Lee ),송정일 ( Jung-il Song ) 한국복합재료학회 2023 Composites research Vol.36 No.4

대량의 폐기물에 의한 환경오염, 세계 평균기온 상승에 의한 기후위기가 인류의 생존을 위협하는 수준에 이르고 있다. 이를 해결하기 위하여 다양한 분야에서 관련 연구가 이루어지고 있으며 재료분야에서도 친환경적이며 탄소중립적인 소재를 개발하기 위한 연구가 활발히 이루어지고 있다. 본 연구에서는 탄소섬유에 천연섬유를 조합함으로써 천연섬유의 장점인 친환경성과 탄소배출 저감을 달성하고자 하였다. 일반적으로 고강도와 저강도 소재를 조합할 경우 그 중간의 물성을 가지는 것으로 알려져 있지만, 본 연구에서는 일부 물성이 탄소섬유 복합재료의 물성을 초과하는 결과를 얻을 수 있었다. 이를 검증하기 위하여 탄소섬유복합재료와 탄소섬유/천연섬유 하이브리드 복합재료를 제조하고 다양한 기계적시험을 통하여 기계적 물성을 비교하고 우수한 물성을 보이는 시험에 대하여 강도향상 기구를 분석하였다. 시험결과 하이브리드 복합재료의 굽힘강도와 파괴인성치가 탄소섬유 복합재료에 비하여 우수하게 나타났으며 강도향상 기구를 규명하였다. 하이브리드 복합재료를 활용할 경우 더욱 우수한 강도의 구조물을 제작할 수 있을 뿐만아니라 환경오염 및 기후위기에도 도움이 될 것으로 예상된다. Environmental pollution from waste and the climate crisis, due to rising global average temperatures, are reaching critical levels threatening human survival. Research is ongoing across various fields to solve this problem, with a key focus on developing eco-friendly, carbon-neutral materials. Our study aimed to integrate natural fibers, known for their environmentally friendly properties and lower carbon emissions, with carbon fibers. In general, combining high-strength and low-strength materials results in intermediate properties. However, we found that certain properties in our study exceeded those of typical carbon fiber composite materials. To validate this, we produced both carbon fiber composite materials and carbon fiber/natural fiber hybrid composite materials. We then compared their mechanical properties using a range of specific tests. Our results revealed that the hybrid composite material exhibited superior bending strength and fracture toughness compared to the carbon fiber composite material. We also identified the underlying mechanisms contributing to this strength enhancement. This breakthrough suggests that the use of hybrid composite materials may allow the production of stronger structures. Moreover, this can play a significant role in mitigating environmental pollution and the climate crisis by reducing carbon emissions, a major contributing factor to these global challenges.

Measurement Error Mitigation for NISQ Devices

Syed Muhammad Abuzar Rizvi,Muhammad Asad Ullah,Hyundong Shin 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.6

Quantum Optimal Control with Pulses

Syed Muhammad Abuzar Rizvi,Fakhar Zaman,Kyesan Lee,Hyundong Shin 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.11

Machine Learning for Qubit State Estimation on IBM Quantum Computer

Syed Muhammad Abuzar Rizvi,Muhammad Asad Ullah,Hyundong Shin 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.2

Quantum computing is a rapidly emerging technology, that harnesses the unprecedented resources to solve problems too complex for classical computers. Quantum computers have qubits, which are quantum mechanical analogue of classical bits. IBM uses superconducting qubits for its quantum computers which are controlled by microwave pulses. IBM provides cloud-based experimentalist level access to its superconducting quantum computers equipping end-user with the ability to calibrate pulse parameters and implement customized error mitigation techniques. In this paper we apply multiple machine learning algorithms to estimate the qubit state using the pulse level control and compare their performance in terms of median and interquartile range of accuracy.

Lactobacillus probiotics improves dysbiotic vaginal microbiota through gut-vagina-axis in Korean women

( Sunwha Park ),( Abuzar Ansari ),( Doo Heon Son ),( Young Min Hur ),( Young-ah You ),( Soo-min Kim ),( Gain Lee ),( Seungbeom Kang ),( Sang Hyeon Lim ),( Young-ju Kim ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: The objective of the study is to determine whether Lactobacillus probiotics improves dysbiotic vaginal microbiota through gut-vagina-axis in Korean women. Methods: This clinical trial was conducted on 57 women who visited at Ewha Womans University Hospital in 2021 for routine gynecological examination. We gave probiotics for total 6 weeks to subjects and their cervicovaginal fluid (CVF) samples were collected with 3 times (before, after 3, and 6 weeks from taking probiotics). The Lactobacillus probiotics were contained of L. reuteri, L. rhamnosus, and L. acidophilus. We checked STD PCR and gram stain for calculating Nugent score and analyzed microbiome by NGS. Raw sequencing data were processed by 16s rRNA sequencing using Quantitative Insight into Microbial Ecology software package 2 (QIIME 2, v2021.11). Data visualization was performed using the ggplot2 package of R (v4.1.3), and statistical analysis was performed through Wilcoxon Rank-Sum Test, Kruskal-Wallis Rank Sum Test and PERMANOVA using the vegan package. P values <0.05 were considered statistically significant. Results: The subjects with normal group were 26 women and the abnormal group was 10 women according to the Nugent score and NGS analysis. The 26 women were represented of eubiosis state that Lactobacillus accounted for more than 90% and the 10 women showed dysbiosis state with high alpha-diversity according to NGS. There was a significant correlation between Nugent score and alpha-diversity (R=0.37 for OTUs, p<0.001; R=0.45 for Shannon diversity, p<0.001; R=0.41 for Evenness, p<0.001, respectively). Among the abnormal group, 60% of women was significantly changed to normal vaginal environment after taking Lactobacillus probiotics by oral route for 6 weeks (p<0.05). After taking probiotics, their alpha-diversity was decreased and beta-diversity was improved to the normal condition. Conclusion: This study suggests that Lactobacillus probiotics by oral route could improve the vaginal environment and change the microbiome composition.

Immunobiotics Beneficially Modulate TLR4 Signaling Triggered by Lipopolysaccharide and Reduce Hepatic Steatosis In Vitro

Kanmani, Paulraj,Ansari, AbuZar,Villena, Julio,Kim, Hojun Hindawi 2019 Journal of immunology research Vol.2019 No.-

<P>Hepatic inflammation and injury may result from the translocation of pathological bacteria and their proinflammatory mediators. Probiotics attenuate hepatic diseases related to inflammation by exhibiting immunoregulatory effects. Therefore, this study was conducted to evaluate lipid reduction and immunoregulatory potentials of probiotic bacteria in vitro. HepG2 cells treated with total cellular fluid (TCF) of LABs reduced lipid accumulation. Moreover, cells responded to lipopolysaccharide (LPS) by producing higher levels of IL-6, IL-8, MCP-1, and TNF-<I>α</I>. TCF of LABs treatment showed remarkably diminished levels of the expression of these cytokines via modulation of the expression of TLR-negative regulators, as well as MAPK and NF-<I>κ</I>B pathways. Moreover, heat-killed LABs were able to diminish TGF-<I>β</I>, IL-1<I>β</I>, and IL-6 and to increase IL-10 and TLR4 levels in THP-1 cells. LABs also decreased the protein level of TNF-<I>α</I>. These results demonstrated that immunobiotics exhibit potent immunoregulatory activity and may be used as effective therapeutic agents to alleviate inflammatory response.</P>

Synthesis and characterization of graphene oxide-doped nano-hydroxyapatite and its adsorption performance of toxic diazo dyes from aqueous solution

Prabhu, Subbaiah Muthu,Khan, Abuzar,Hasmath Farzana, M.,Hwang, Gil Chan,Lee, Woojin,Lee, Giehyeon Elsevier 2018 Journal of molecular liquids Vol.269 No.-

<P>In this study, graphene oxide-doped nano-hydroxyapatite (nHAp@GO) composite was synthesized via a simple in-situ one-pot method and was used as an adsorbent for the removal of toxic diazo dyes, Congo Red (CR) and Trypan Blue (TB), in water. A remarkable adsorption capacity for CR (48.5 mg/g) and TB (41.0 mg/g) were shown on the surface of nHAp@GO (2 g/L), respectively, and was much higher than those of bare nHAp or GO. After doping of GO on nHAp, the specific surface area of nHAp was increased by 2.5 times. The presence of sulphur peak in EDX spectrum and S-O stretching vibration peak in FTIR confirmed the adsorption of dyes on the surface of nHAp@GO composite. After the adsorption process, the shifting of d((100)) spacing of nHAp confirmed the loading of bulky organic moieties on nHAp@GO composite. Maximum CR and TB dyes adsorption occurred in a wide range of initial pH between 3.0 and 10.0. The adsorption of both CR and TB dyes are due mainly to the electrostatic interaction, pi - pi stacking interaction, hydrophobic interaction, and hydrogen bonds between dyes and nHAp@GO composite. The nHAp@GO nanocomposite was recycled up to three times at the sustained efficiency after washing with ethanol solution. We believe that such multifunctional material developed in this study will be effectively used for the depollution of toxic diazo dyes in practical applications. (C) 2018 Elsevier B.V. All rights reserved.</P>

Latest Transformations of XP Process Model: A Systematic Literature Review

Khan, Sadia,Fahiem, Muhammad Abuzar,Bakhtawar, Birra,Aftab, Shabib,Ahmad, Munir,Aziz, Nauman,Almotilag, Abdullah,Elmitwally, Nouh Sabri International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.6

Process model is an integral part of software industry. Different process models are used now a days in the industry for different software projects. Process models need to be tailored to address some specific project needs. Agile models are considered as the most widely used process models nowadays. They have distinctive features and the ability to address the dynamic needs of today's software development. Extreme programming (XP) is one of the extensively used agile process model especially for small projects. Many researchers have tried to mold XP to overcome its shortcomings and for better working in specific scenarios. Therefore, many customized versions of XP process model are available today. In this paper, we are going to analyze the latest customizations of XP. For this purpose, a systematic literature review is conducted on studies published from 2012 till 2018 in renowned online search libraries. This comprehensive review highlights the purpose of customizations, along with the areas in which customizations are made, and phases & practices which are being customized. This work will serve the researchers to discover the modern versions of XP process model as well as will provide a baseline for future directions for customizations.