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Aluminium에 의한 알츠하임병 유발 및 항산화제의 발병 억제 효과
최성돈,박동기 건국대학교 자연과학연구소 1998 建國自然科學硏究誌 Vol.9 No.1
The in vitro effects of Aluminium on lipid peroxidation were studied in rat brain homogenates and PC liposome. We used 0.01mM AINH₄(SO₄)₂/0.25mM ascorbic acid as a initiator of oxidation and used TBA-method for secondary products of lipid hydroperoxides and HPLC with chemiluminesence detector for PC-OOH. At the initial reaction, we can see the steady increase of TBARS formation/PC-OOH content for incubation time after oxidation of brain homogenate /PC liposome with initiator. In vivo study, we were performed to investigate the effect of serum and microsomal enzyme activities in rat after administration of Aluminium and the effect of Aluminium on histological change in brain tissue. Aluminium, at a dose of 10㎎/㎏ of body weight/day for 4 weeks, has a deleterious effect on the activities of hydrolytic enzymes (acetylcholin- esterase) of the neurotransmitter acetylcholine. Acetylcholinesterase(AChE) activity and PC-OOH content increased in administration of Aluminium group. In addition to, microsomal enzyme (NADPH cytochrome c reductase) activity of Aluminium Control group is lower than any other antioxidant treatment group. And, the brain tissue histological change of Aluminium administration group is obviously different from any other group.
아로마 에센셜 오일의 항스트레스효과에 대한 연구 - 뇌파 검사를 중심으로
최진영,오홍근,전겸구,이준석,박동기,최성돈,전태일,김미경,김석범 대한임상신경생리학회 2000 Annals of Clinical Neurophysiology Vol.2 No.2
Purpose : This study was performed to evaluate the antistress effects of two aromatic blends being composed of synergic essential oils and also to differentiate its effectiveness between two. Methods : The subject were 20(10 for men, 10 for women) for vital factors and another 20(10 for men, 10 for women) for serum catecholamine. Vital factors(blood pressure, pulse), electroencephalography, psychological tests(SACL, STAI) and serum catecholaminewere applied to the subjects. Results : 1. All two aromatic synergic blends revealed no significant difference of vital factors after inhalation but stable conditions generally by lowering pulse and blood pressure after inhalation. 2. Both blends were significantly valuable in antianxiety and antistress effects statistically. There were no statistically difference between two blends. 3. There were no significant difference in all brain waves after inhalation of two blends but generally stable brain waves were seen in all areas. 4. There were antistress effects of both blends in accordance of decreased serum catecholamines after inhalation of both blends. There were no significantly difference between two blends statistically. Conclustion : Both two aromatic synergic blends reached effective antistress and antianxiety states after inhalation of each blends. There were no significant difference between two blends. Further studies be considered. Also clinical applications of these two aromatic synergic blending oils to develop the aromatic products would be affordable in the future.
브랜딩 아로마 에센셜오일의 항스트레스효과에 대한 실험연구
오홍근,최진영,전겸구,이준석,박동기,최성돈,전태일,김미경,김석범 한국정신과학학회 2001 한국정신과학회 학술대회 논문집 Vol.14 No.-
Objectives: This study was performed to evaluate the antistress effects of two aromatic blends being composed of synergic essential oils and also to differentiate its effectiveness between two. Methods: The subject were 20(10 for men, 10 for women) for vital factors and another 20(10 for mem, 10 for women) for serum catecholamine. Vital factors(blood pressure, pulse), electroencephalograpy, psychological tests(SACL, STAI) and serum catecholamine were applied to the subjects. Results: 1. All two aromatic synergic blends revealed no significant differnce of vital factors after inhalation but stable conditions generally by lowering pulse and blood pressure after inhalation. 2. Both blends were significantly valuable in antianxiety and antistress effects statistically. There were no statistically difference between two blends. 3. There were no significant difference in all brain waves after inhalation of two blends but generally stable brain waves were seen in all areas. 4. There were antistress effects of both blends in accordance of decreased serum catecholamines after inhalation of both blends. There were no significantly difference between two blends statistically. Conclusion: Both two aromatic synergic blends reached effective antistress and antianxiety states after inhalation of each blends. There were no siginificant difference between two blends. Further studies about the effectiveness between the amount of aromatic essential oils and the duration of inhalation should be considered. Also clinical applications of these two aromatic synergic blending oils to develop the aromatic products would be affordable in the future.