탈명산(奪命散)의 항산화 및 항염증효과에 관한 연구

조현진,박선동,Jo, Hyeon-Jin,Park, Sun-Dong 대한한의학방제학회 2014 大韓韓醫學方劑學會誌 Vol.22 No.1

Objectives : The aim of this study was identification of the anti-oxidative and anti-inflammatory effects of Talmyung-san (TMS) in mouse macrophage, RAW264.7 cells. Methods : To identify the anti-oxidative effect of TMS, scavenging activities of DPPH radical, nitric oxide and peroxynitrite were measured in vitro. In RAW264.7 cells, DCFH-DA assay was conducted to examine the inhibitory effect of TMS on ROS production in response to lipopolysaccharide. And the productions of nitric oxide (NO), $PGE_2$ and pro-inflammatory cytokines were measured. The levels of COX-2, iNOS, nuclear NF-${\kappa}B$ p65 expression and phosphorylation of $I{\kappa}B-{\alpha}$ in cytosol were detected by western blotting analyses. Results : TMS couldn't scavenged DPPH radical, but nitric oxide and peroxynitrite were decreased. TMS decreased intracellular ROS, NO, and IL-$1{\beta}$ production effectively. However, TMS inhibited $PGE_2$ levels only in high concentration ($300{\mu}g/m{\ell}$) and TMS failed to suppress the production of IL-6 and TNF-${\alpha}$. Results from immunoblot analyses revealed that TMS decreased activation of COX-2, iNOS, phosphorylation of $I{\kappa}B-{\alpha}$ and nuclear translocation of p65. Conclusions : TMS has anti-RNS and anti-inflammatory effects via NF-${\kappa}B$ pathway and more intensive studies will be required to evaluate therapeutic potential of TMS.

황벽나무(Phellodendron amurense) 수피와 칡(Pueraria thunbergiana)의 추출성분 및 항산화 활성에 관한 연구

조현진(Hyun-Jin Jo),이상극(Sang-Kueg Lee),이학주,강하영(Ha-Young Kang),최돈하(Don-Ha Choi),이태성(Tae-Seong Lee) 한국산림바이오에너지학회 2008 산림바이오에너지 Vol.27 No.1

황벽나무(Phellodendron amurense) 수피 2 kg을 증류수로 냉수추출한 추출액과 칡(Pueraria thunbergiana) 착즙액 원액을 hexane, ethyl acetate 및 물 가용부로 분획하였다. 물 가용부를 Sephadex LH-20으로 충진한 칼럼에서 MeOH 수용액을 용출용매로 사용하여 칼럼크로마토그래피를 실시하였다. 단리된 화합물들은 TLC로 확인한 후 1H, 13CNMR, COSY, HMBC 등의 스펙트럼을 사용하여 정확한 구조를 규명하였고, MALDI- 및 EI-MS로써 분자량을 측정하였다. 황벽나무 수피에서는 ferulic acid (화합물 Ⅰ), protocatechuic acid (화합물 Ⅱ), vanillic acid (화합물 Ⅲ)가 단리되었고, 칡에서는 puerain (화합물 IV), daidzein 8-C-apiosyl-(1→6) glucoside (화합물 V)가 단리되었다. DPPH 라디칼 소거법을 이용하여 조추출물 및 각 분획물들에 대한 항산화 활성 시험을 실시하였으며 황벽나무 수피의 ethyl acetate 가용부와 칡의 조추출물에서 우수한 활성을 나타내었다. The dried barks (2 kg) of Phellodendron amurense extracted with water and the crude extractives of Pueraria thunbergiana concentrated and fractionated with a series of hexane, ethyl acetate and water on a separatory funnel. The water soluble fraction was chromatographed on a Sephadex LH-20 column using a series of aqueous methanol as eluents. The isolated compounds were identified by cellulose TLC, 1H, 13C-NMR, COSY, HMBC, MALDI- and EI-MS. The bark of Phellodendron amurense contained ferulic acid (compound Ⅰ), protocatechuic acid (compound Ⅱ), vanillic acid (compound Ⅲ) and the crude extractives of Pueraria thunbergiana contained puerain (compound Ⅳ), daidzein 8-C-apiosyl-(1→6) glucoside (compound V). The antioxidative activities of the crude extractives and each soluble fraction were tested by DPPH radical scavenging method, and the ethyl acetate soluble fraction of Phellodendron amurense and the crude extractive of Pueraria thunbergiana were very effective.

영문법 구조에 대한 한국인 성인 영어학습자의 명시적 지식과 암시적 지식 비교

조현진(Jo, Hyeon-jin),임현우(Lim, Hyun-Woo) 한국응용언어학회 2013 응용 언어학 Vol.29 No.4

The study investigates Korean English learners’ explicit and implicit knowledge of 17 grammatical structures. Participants consisted of 100 undergraduate and graduate school students. Their explicit and implicit knowledge was measured using the Untimed Grammatical Judgment Test, the Metalinguistic Knowledge Test, and the Ellicited Oral Imitation Test, all of which were developed by Ellis (2005, 2006). The study also examines the relationships between multiple learner variables and the two types of knowledge. The study results show that the Korean English learners possessed more developed explicit grammar knowledge compared to their implicit knowledge. The verb complement, past tense, and third person singular -s were the top three highest scored structures in explicit knowledge, while the verb complement, possessive’s and adverb position were the highest for implicit knowledge. The past tense, third person singular -s, and since/for were highly scored for explicit knowledge but lower for implicit knowledge, while the possessive ’s, adverb position, and embedded question were high for implicit knowledge but low for explicit knowledge. Among the learner variables, previous experience living abroad showed a significant impact on both types of knowledge. The starting age of learning English and prior experience learning English grammar influenced only implicit knowledge. The pedagogical implications are provided along with suggestions for future study.

천연염료자원 탐색 및 염색특성(Ⅱ)

조현진(Hyun-Jin Jo),이상극(Sang-Kueg Lee),강하영(Ha-Young Kang),최돈하(Don-Ha Choi),최인규(In-Gyu Choi) 한국산림바이오에너지학회 2006 산림바이오에너지 Vol.25 No.2

거북꼬리의 적정염색 조건을 구명하기 위하여 열수 및 알칼리추출물을 사용하여 염색조건에 따른 염착량(K/S) 및 Munsell의 색상(Hue), 명도(Value), 채도(Chroma)의 변화에 대하여 조사하였다. 면, 한지, 실크에 대한 열수 및 알칼리추출물 처리 염색물의 최대흡수파장(λmax)은 400 ㎚였다. 염색조건에 따른 염착량은 온도와 시간 조건에서 실크 염색물이 높은 수치를 나타내었고, 80 ℃와 40분을 전후로 큰 변화를 보이지 않았다. 농도조건에서는 농도가 높을수록 급격히 증가하는 경향을 나타내었다. Munsell의 색상은 온도와 시간조건에서 알칼리추출물 처리 염색물은 YR (Yellow Red) 계열의 색상을, 열수추출물 처리 염색물은 R (Red) 계열의 색상을 나타내었으며 온도는 80 ℃, 시간은 40분을 전후로 큰 변화가 없었다. 명도 및 채도는 뚜렷한 변화를 보이지 않았고 염색조건에는 큰 영향을 미치지 않는 것으로 사료된다. 따라서 거북꼬리추출물로 염색할 경우 최적 염색조건은 온도 80 ℃, 시간 40분, 농도 100% (추출원액)로 조절하는 것이 바람직할 것으로 생각된다. K/S values, Hue, Value, and Chroma changes of the hot-water and alkali extract of Boehmeria tricuspis have investigated to obtain an optimum dyeing conditions. Maximum optical absorption of the cotton, Hanji, and silk dyed with the extract were observed at 400 ㎚. The K/S value of the dyed silk was higher than those of other materials in the treatments with the temperature and time condition and there was not much changes in the treatments near 80 ℃ and 40 minutes. Also, the K/S value of the dyed silk was drastically increased as the concentration of the dye was increased. In the treatments with temperature and time condition, Hue of the materials dyed with alkali extracts resulted in YR color, whereas materials dyed with hot-water extracts provided R color. In the time and temperature condition of treatment, there were no significant changes in the samples treated near 80 ℃ and 40 minutes. The Value and Chroma of the dyed materials were not significantly changed. As a result, it is suggested that the optimum temperature, time, and concentration of dye would be 80 ℃, 40 minutes, and 100%, respectively, when cotton, Hanji, and silk are dyed with Boehmeria tricuspis extract.

칡뿌리 섬유의 펄프화 및 쉬트 표면 특성

조현진(Hyun-Jin Jo),윤승락(Seung-Lak Yoon),황병호(Byung-Ho Hwang) 한국펄프·종이공학회 2011 한국펄프·종이공학회 학술발표논문집 Vol.2011 No.4

번역 대비를 통한 『번역소학(飜譯小學)』 과 『소학언해(小學諺解)』 의 의역(意譯)과 직역(直譯) 연구 -명사유(名詞類)의 의역(意譯)과 직역(直譯)을 중심으로-

조현진 ( Hyun Jin Jo ) 한국외국어대학교 언어연구소 2015 언어와 언어학 Vol.0 No.67

This article aims to review the translation difference between Beonyeoksohak and Sohakeonhae, which show distinctive features of liberal vs. literal translation styles out of the 16th century literature in Korea. In this paper, based on the translation of Sohakeonhae, the translations of the Chinese words or phrases in the original text are compared from the perspectives of liberal and literal styles, after divided categories such as nouns. These two writings carry the translation of the same original Chinese text. Beonyeoksohak has a tendency of liberal translation style and some Chinese characters are not translated to make the sentences natural. On the contrast, in Sohakeonhae, every single Chinese character is translated. As a result, Beonyeoksohak is easier to understand as its translation is smooth and closer to the spoken Korean language, while in Sohakeonhae, the translated sentences are not natural and thus, make it difficult to understand them.

칡뿌리의 섬유 자원화에 관한 연구(제 1보) : 칡뿌리의 해부학적 및 화학적 특성

조현진(Hyun-Jin Jo),윤승락(Seung-Lak Yoon),황병호(Byung-Ho Hwang) 한국펄프·종이공학회 2011 펄프.종이기술 Vol.43 No.1

옻칠한지의 제조 및 특성

조현진(Hyun-Jin Jo),이상극(Sang-Kueg Lee),노정관(Jeong-Kwan Roh) 한국펄프·종이공학회 2007 한국펄프·종이공학회 학술발표논문집 Vol.- No.-

호혜성에 근거한 기본소득 비판에 대한 반론과 한국 사회에서의 그 함축

조현진(Jo, Hyun Jin) 건국대학교 인문학연구원 2015 통일인문학 Vol.62 No.-

노동의무나 자산보유 여부와 무관하게 누구에게나 개인단위로 정기적으로 일정액을 지급하자는 기본소득제는 불안정한 저임금 일자리를 감내할 유인과 복지사각지대를 줄일 수 있다는 이유로 그 도입이 활발히 논의되고 있다. 하지만 기본소득은 누구에게나 지급된다는 이유 때문에 일하는 자에 대한 일하지 않는 자의 착취나 무임승차를 정당화한다는 비판을 받았다. 이 글은 주로 판 파레이스의 논의에 의거해 이런 비판들에 대해 답하고 기본소득론의 분배정의론을 명료화하는 것을 목표로 삼는다. 먼저, 생산적 기여를 하지 않는 자발적인 여가 선호자에게는 기본소득의 수급자격을 박탈해야 한다는 비판에 대해 그런 주장이 암묵적으로 노동선호자를 우대하고 여가선호자를 차별하는 정책을 지지하는 것이라고 답했다. 기본소득이 일하지 않는 사람이 일하는 사람으로부터 부당한 이익을 취득하는 착취라는 비판에 대해 자연자원과 같은 자산을 재원으로 지급되는 기본소득은 착취가 아니며 기본소득은 분배정의를 구현함으로써 호혜적 관계가 제대로 기능할 수 있는 여건을 마련해 준다고 반론했다. 또, 기본소득이 불공정한 여타의 관계들을 시정하는 역할을 할 수 있기 때문에 일면적으로 착취로 해석될 수 없음을 보여주었다. 기본소득이 일하지 않는 자의 무임승차를 정당화한다는 비판에 대해 차등의 원리와 무임승차자의 비무임승차자화에 근거해 기본소득 지급의 정당성을 옹호했다. 마지막으로, 더 높은 보장성과 더 나은 실질적 자유의 확보를 가능하게 하기 때문에 사회적 지분급여보다 기본소득이 더 우수한 지원 방안임을 보여주었다. 또, 모두가 일자리 자산의 가치에 대해 1인당 몫과 자격을 동등하게 가지고 있기 때문에 일자리 자산의 가치를 노동의향이 있는 사람에게만 분배하는 것은 부당하다는 점을 보여주었다. 이상의 논의로부터 근로연계복지의 기능과 현실에 대한 우리의 발상이 전환될 필요가 있다는 점과 함께 통일 후 기본소득의 가능성에 대해 사고할 필요가 있음을 환기시켰다. The idea of Basic income is planned as a salary paid to regularly all individuals by central or local government, regardless of the obligation to work and means-test. This idea is hotly debated even in progressive groups. The opponents claim that it could weaken the motivation of labour and make people avoid the hard and low-waged works. They also claim that the basic income scheme can cause the risk of abuse as well as increase the free-riding tendency of the benefited by its unconditionality. The aim of this article is to reply these objections and to elucidate the conception of distributive justice mainly based on Van Parijs’ theory of basic income. In reply to the first objection that basic income should not be given to the leisure-lover who seems not to contribute to society, I answered that such an objection would privilege the labour-lover and discriminate against the leisure-lover. In reply to the second objection that basic income includes the exploitation, which consists in taking unfair advantage of the labour-lover, I responded that basic income had nothing to do with the unfair advantage for the leisure-lovers, because its source of revenue would be financed by taxes on natural resources, and that basic income could provide adequate conditions for distributive justice. Furthermore, I showed that basic income couldn’t be only interpreted as an exploitation in one direction since it could rectify other unfair relations. In reply to the third objection that basic income will increase the free-ride on the labor-lover, I showed that the legitimacy of basic income could be assured by means of the ‘Principle of Difference’ and being a non-free-rider. Finally, I made clear that basic income would be much superior to Stakeholder grants, since it could give us more real freedom and provide the higher level of security. Moreover, I showed that the exclusive redistribution to the future worker would be unfair since it would amount to favour the labour-lover. This article emphasized that we should change our way of thinking on the function of workfare and its reality and that we ought to need to rethink of the possibility of basic income after the Reunification of Korean Peninsula.

니코틴 대체요법군과 니코틴 대체제 및 부프로피온 병용투여군 간의 금연 6주 후 체중변화의 차이

조현진(Hyun Jin Jo),이정규(Jeong Gyu Lee),정동욱(Dong Wook Jeong),김민석(Min Seok Kim),김영주(Young Joo Kim),이상엽(Sangyeop Lee),김윤진(Yun Jin Kim) 대한임상노인의학회 2008 대한임상노인의학회지 Vol.9 No.2

연구배경: 부프로피온(Bupropion)의 금연 후 체중증가 억제효과는 이미 알려져 있지만, 니코틴 대체요법과 부프로피온의 병용요법 시에도, 니코틴 대체요법만 적용한 군보다 유의한 효과를 보이는지에 대한 연구는 드물었다. 국내 보건소 금연클리닉 사업을 통하여 이에 대해 알아보고자 하였다. 방법: 2007년 1월 부산의 일개 보건소 금연클리닉을 방문하여 5개월간 금연에 성공한 70명의 남성을 대상으로 니코틴 대체요법을 시행 받은 군 32명과 니코틴 대체요법과 부프로피온을 함께 시행 받은 군 38명에서 금연 전후의 체중, 체질량지수, 호기 일산화탄소량, 혈압을 조사하였다. 결과: 양 군의 비교에서 니코틴 대체제 단독요법군과 부프로피온과의 병용요법군의 체중증가의 기울기 및 체질량지수 증가의 기울기에는 유의한 차이가 없었다. 금연 후 6주째의 체중은 연령(r=−0.536, P<0.001), 흡연기간(r=−0.505, P<0.001)과는 유의한 음의 상관관계를 나타내었고, 하루 평균 흡연량(r=0.312, P<0.01) 및 첫 방문시 체중(r=0.985, P<0.001)과는 양의 상관관계를 보였다. 결론: 니코틴 대체제 단독요법군 및 니코틴 대체제와 부프로피온의 병용요법군의 금연 6주 후 체중 증가율에는 유의한 차이가 없었다. Background: The suppressive effect of bupropion for weight gain after smoking cessation was already known, but studies about whether the combination therapy of nicotine replacement therapy and bupropion has better suppressive effect for weight gain after smoking cessation than nicotine replacement therapy alone have been rare. The purpose of this study was to evaluate this subject along with a domestic project for smoking cessation in Republic of Korea. Methods: 70 males had started smoking cessation from January in 2007, and succeeded in ceasing smoking for 5 months by visiting a smoking clinic of a health center in Pusan. The patients were divided into two groups which are the group of nicotine replacement therapy alone and nicotine replacement therapy with bupropion therapy. Weight, body mass index, expiratory carbon monoxide amount and blood pressure of two groups were compared and analyzed. Results: The rates of increment of weight of two groups had no significant differences. Negative correlation was represented between the average of weight at the 6th week and the averages of age and duration of smoking. Positive correlation was represented between the average of number of cigarettes and baseline weight. Conclusion: Nicotine replacement therapy alone and nicotine replacement therapy with bupropion therapy have the similar rate of increment of weight after 6 weeks of smoking cessation.