진성구취 및 가성구취 환자군의 심리적 특성차이에 대한 연구

장승원,김진성,강경,김주연,손지영,백승환,최제인,류봉하,Jang, Seung-Won,Kim, Jin-Sung,Kang, Kyung,Kim, Ju-Yeon,Son, Ji-Yeong,Baek, Seung-Hwan,Choi, Jane,Ryu, Bong-Ha 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.4

Objectives : This study was designed to investigate the difference between genuine and pseudo halitosis about qi stagnation and stress. Methods : We recruited 63 halitosis patients who visited the halitosis clinic in the Kyung Hee University Korean Medicine Hospital from June 2012 to August 2013. We classified the halitosis patients into two groups, genuine and pseudo halitosis based on organoleptic assesment (OLT) score and evaluated the severity of self-reported halitosis using visual analog scale (VAS), amount of sulfide compounds using Halimeter, qi stagnation level using qi stagnation questionnaire and stress levels using heart rate variability (HRV) parameters. Results : Comparing the genuine halitosis group and the pseudo halitosis group, there was no significant difference in VAS of halitosis but significant difference in halimeter score. Distribution of qi stagnation and non-qi stagnation groups was significantly different between genuine and pseudo halitosis. Compared to the genuine halitosis group, the pseudo halitosis group showed a significant higher value of low frequency/high frequency ratio (LF/HF ratio). Conclusions : The result of this study suggest that there is significant difference about qi stagnation and stress level between genuine halitosis and pseudo halitosis patients, so when approaching pseudo halitosis patients, we should consider their psychological and emotional status.

라섹 후 하이드로겔 및 실리콘하이드로겔 치료용 렌즈 착용 시의 임상 경과 차이

장승원,정의상,정태영,Seung Won Jang,Eui Sang Chung,Tae Young Chung 대한안과학회 2007 대한안과학회지 Vol.48 No.10

Purpose: To compare the effectiveness between wearing a conventional hydrogel vifilcon A bandage contact lens (BCL) and a silicone hydrogel lotrafilcon A BCL after laser-assisted subepithelial keratomileusis (LASEK). Methods: LASEK was performed on 38 eyes of 19 patients. Each patient was fitted with a silicone hydrogel lotrafilcon A lens in one eye and a conventional hydrogel vifilcon A lens in the other eye. The patient was masked on the type of lens in each eye. General preference between the two types of lenses, subjective symptoms (pain, photophobia, tearing, dryness, and foreign body sensation; graded as 0 to 4), and the area of non-viable corneal epithelium were assessed in each eye at one and four days after surgery. Results: Patients reported preferring the lotrafilcon A lens to vifilcon A at 1 (79%) and 4 (74%) days after LASEK. The mean symptom scores of tearing and foreign body sensation at 1 day after surgery (P=0.012 and P=0.034, respectively) and foreign body sensation at 4 days after surgery (P=0.027) were significantly lower in the lotrafilcon A group. The mean area of the non-viable corneal epithelium was smaller in the lotrafilcon A lens group at 1 day and 4 days after surgery, although not statistically significant. Conclusions: Patients better tolerated the silicone hydrogel lotrafilcon A BCL compared with the conventional hydrogel vifilcon A BCL. The mean symptom scores were significantly lower in the lotrafilcon A group at both 1 and 4 days after LASEK.

구강건조증 환자에서 음허 측정 설문지 절단점 개발 및 진단능 평가

장승원,김진성,Jang, Seung-Won,Kim, Jin-Sung 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.4

Objectives: The aims of study were developing cut-off value of Yin-deficiency questionnaire (YDQ) for diagnosis of Yin-deficiency (YD) and compare diagnostic ability between YDQ and Yin-deficiency scale score (YDS) in xerostomia patients. Methods: We recruited 58 xerostomia patients. They were diagnosed YD or non-YD by 3 Korean medicine doctors (KMD). We assessed YD using YDQ and YDS. We evaluated xerostomia using VAS, Dry Mouth Symptom Questionnaire (DMSQ), Salivary Flow Rate (SFR), oral moisture on buccal mucosa and tongue surface (OMB and OMT). We surveyed tongue coatings using Winkel Tongue Coating Index (WTCI). Results: We diagnosed 23 patients YD and 35 patients non-YD. There were no significant differences of age, sex and body mass index between the YD and non-YD groups. Using receiver operating characteristic curve analysis, the optimal cut-off value of YDQ was defined as 304. Sensitivity, specificity and Youden index of YDQ were 86.96%, 71.43% and 1.5839 respectively. Using Cohen's coefficient of agreement, we found that degree of agreement between KMD and YDQ diagnosis was moderate (${\kappa}$=0.524, p<0.001). Using Pearson's correlation analysis, we found concurrent validity of YDQ and YDS were significant correlated. Using area under curve value, we found diagnostic ability between YDQ and YDS were not significantly different (p=0.505), but there were more strong correlations between DMSQ-symptoms and YDQ (r=0.731, p<0.001) than correlations between DMSQ-symptoms and YDS (r=0.418, p<0.01). Conclusions: The cut-off value of YDQ can diagnose YD in xerostomia and diagnostic ability of YDQ in xerostomia is better than YDS.

미각 장애 환자 5례를 대상으로 한 대한 한방 치료의 효과

백승환,김진성,장승원,손지영,최제인,한성준,이엄지,류봉하,Baek, Seung-Hwan,Kim, Jin-Sung,Jang, Seung-Won,Son, Ji-Yeong,Choi, Jane,Han, Seong-Jun,Lee, Eom-Jee,Ryu, Bong-Ha 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.3

Objectives: The purpose of this study was to report the effect of traditional Korean medical therapy such as acupuncture, electroacupuncture and herbal medicine in taste disorder patients. Methods: We surveyed 5 taste disorder patients visiting the Oral Diseases Clinic in the Kyung Hee University Oriental Medicine Hospital from January, 2014 to June, 2014. Before starting traditional Korean medical therapy such as acupuncture, electroacupuncture and herbal medicine, the subjects were evaluated on severity of discomfort using visual analogue scale (VAS), salivary flow rate (SFR), quality of life about oral health (based on the 14-item Oral Health Impact Profile-14) and qi-stagnation condition (based on the 23-item qi-stagnation Questionnaire). Visual analogue scale was re-evaluated during the treatment period. Results: There was no relationship between diminished SFR and severity of discomfort. Also change or loss of taste did not influence the quality of life about oral health. However, stress which refers to qi-stagnation could be one of the reasons taste disorder occurs. After receiving traditional Korean medical therapy, all 5 patients' visual analogue scale score decreased. Conclusions: Traditional Korean medical therapy may potentially be an option for taste disorder. Further evaluations including pre-post comparison with larger number of cases will be needed in the future.

구취 환자의 한방 치료 효과에 대한 전.후 비교 연구: OralChroma$^{TM}$를 이용하여

최제인,김진성,장승원,손지영,백승환,한성준,이엄지,류봉하,Choi, Jane,Kim, Jin-Sung,Jang, Seung-Won,Son, Ji-Yeong,Baek, Seung-Hwan,Han, Seong-Jun,Lee, Eom-Jee,Ryu, Bong-Ha 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.4

Objectives: The purpose of this study was to evaluate the clinical effect of Korean medical treatments such as herbal medicine, acupuncture, and electroacupuncture by using the portable gas chromatograph OralChroma$^{TM}$ (Abimedical, Japan) in halitosis patients. Methods: We surveyed 30 halitosis patients who had visited the Oral Diseases Clinic in the Korean Medical Hospital of Kyunghee University from October, 2013 to November, 2014. Before starting Korean medical treatment, the subjects were evaluated on sociodemographic characteristics, severity of discomfort using visual analogue scale (VAS), unstimulated salivary flow rate (USFR), and halitosis associated life-quality test (HALT) score. To evaluate the therapeutic effect, we measured the volatile sulfur compounds (VSCs) in breath by using OralChroma$^{TM}$ before and after 3 weeks treatment. Results: The concentration of total VSCs measured by OralChroma$^{TM}$ significantly decreased (p=0.001). Furthermore, the level of hydrogen sulfide and methyl mercaptan also significantly decreased (p<0.05). However, although the level of dimethyl sulfide decreased as well, there was no significance(p>0.05). Conclusions: Korean medical treatment was effective in treating halitosis by decreasing VSCs. Further study, with well-designed randomized controlled trials with larger number of cases will be needed in the future.

코돈 최적화된 유전자를 이용한 재조합 대장균으로부터 인간 인터페론 베타 발현

김종석(Jong-Seok Kim),장승원(Seung-Won Jang),박재범(Jae-Bum Park),권덕호(Deok-Ho Kwon),장영준(Young-Jun Chang),정형무(Hyung-Moo Jung),한상인(Sang-In Han),홍억기(Eock-Kee Hong),하석진(Suk-Jin Ha) 한국생물공학회 2017 KSBB Journal Vol.32 No.1

The multiple sclerosis caused by multiple inflammatory disease or immune system disorder, is usually treated by interferon β through adjusting the abnormal immune reactions. For high production of human interferon β using recombinant E. coli, codon optimized and wild type genes were synthesized. When pET-15b or pET-21a vector was used as an expression vector with each gene, there was no target protein expression. When pQE30 vector was used as an expression vector, human interferon β was expressed by recombinant E. coli XL1-blue and E. coli JM109. Using the codon optimized gene, the expression of human interferon β was slightly increased as compared to that from wild type gene. However, most of expressed human interferon β was insoluble form.

재발성 아프타성 구내염 환자에 대한 가미육미지황탕의 효능

김주연,김진성,손지희,선종기,강경,장승원,손지영,류봉하,Kim, Ju-Yeon,Kim, Jin-Sung,Son, Ji-Hee,Seon, Jong-Ki,Kang, Kyung,Jang, Seung-Won,Son, Ji-Young,Ryu, Bong-Ha 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.2

Objectives : This study was designed to investigate the Efficacy of Gamiyukmijihwang-tang on Recurrent Aphthous Stomatitis. Methods : We surveyed 10 recurrent aphthous stomatitis patients visited the oral diseases clinic in the Kyung Hee University Oriental Medicine Hospital from September, 2011 to March, 2012. Before and 2 weeks after taking Gamiyukmijihwang-tang, the subjects were evaluated on clinical characteristics of recurrent aphthous stomatitis, severity of pain using visual analogue scale (VAS), quality of life about oral health (based on the 14-item Oral Health Impact Profile-14) and yin-deficiency condition (based on the 10-item Yin-deficiency Questionnaire). Then, 5 patients who had already finished treatment were assessed about recurrence of recurrent aphthous stomatitis by telephone survey 6 weeks later. Results : After 2 weeks taking Gamiyukmijihwang-tang, clinical characteristics of 10 patients of recurrent aphthous stomatitis improved; their severity of pain, quality of life about oral health and yin-deficiency condition improved significantly. After 6 weeks, 3 of 5 patients who had already finished treatment didn't experience recurrence of recurrent aphthous stomatitis. The other 2 patients experienced a recurrence, but their clinical characteristics of recurrent aphthous stomatitis improved significantly. Conclusions : Gamiyukmijihwang-tang is effective on recurrent aphthous stomatitis. Studies with a larger number of cases and longer follow-up will be needed in the future.

구강작열감증후군 환자에서 기울과 전중($CV_{17}$)압통의 상관성 - Algometer를 이용한 전중압통의 정량화 측면에서 -

강경,김진성,선종기,손지희,김주연,장승원,손지영,이현주,류봉하,Kang, Kyung,Kim, Jin-Sung,Seon, Jong-Ki,Son, Ji-Hee,Kim, Ju-Yeon,Jang, Seung-Won,Son, Ji-Young,Lee, Hyun-Ju,Ryu, Bong-Ha 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.4

Objectives : This study was designed to find out whether there is a correlation between qi-stagnation score and pressure pain threshold (PPT) on acupuncture point $CV_{17}$ in burning mouth syndrome (BMS) patients. Methods : Thirty BMS patients who newly visited Oral Disease Clinic at the Kyung Hee University Korean Medicine Hospital were surveyed. The subjects were evaluated on age, illness duration, sex, self-assessed severity of BMS, qi-stagnation score, and PPT on 3 acupuncture points ($CV_{17}$, Rt. $SP_9$, Lt. $SP_9$). Results : There was significant correlation between age and PPT on $CV_{17}$ (p=0.005). Therefore, partial correlation analysis with age as control variable was done, and the result showed significant correlation between qi-stagnation score and PPT on $CV_{17}$ (p=0.001). Qi-stagnation diagnostic point by PPT on $CV_{17}$ was suggested as 3.8056 $kg/cm^2$ based on the fact that diagnostic score is 28.50 in the qi-stagnation questionnaire. Furthermore, considering that PPT is effected by age, we could attain qi-stagnation diagnostic equation of PPT on $CV_{17}$, that is suggested as $0.047{\times}(age)+0.848kg/cm^2$. PPT of 3 acupuncture points ($CV_{17}$, Rt. $SP_9$, Lt. $SP_9$) was compared, and the result showed that PPT was significantly lower on $CV_{17}$ (w/Rt $SP_9$: p=0.022, w/Lt. $SP_9$: p=0.012). Also, significance and correlation coefficient with qi-stagnation were higher on $CV_{17}$ (p<0.001, r=-0.620) than Rt. $SP_9$ (p=0.023, r=-0.413) or Lt. $SP_9$ (p=0.014, r=-0.444). Conclusions : The result of this study suggested that PPT on $CV_{17}$, measured quantitatively by algometer, had a strong correlation with qi-stagnation score in BMS patients. Therefore, the study showed that $CV_{17}$ can be a useful acupuncture point in diagnosing qi-stagnation by measuring PPT in BMS patients.

구강작열감 증후군 환자의 구강내 통증에 대한 한방치료의 효과: 전.후 비교 연구

손지영,김주연,강경,백승환,최제인,장승원,류봉하,김진성,Son, Ji-Young,Kim, Ju-Yeon,Kang, Kyung,Baek, Seung-Hwan,Choi, Jane,Jang, Seung-Won,Ryu, Bong-Ha,Kim, Jin-Sung 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.2

Objectives : Burning mouth syndrome (BMS) is characterized by chronic pain or a burning sensation in the mouth. There is limited evidence available to provide clear guidelines for treating BMS patients and a variety of different treatments have been used. This study was designed to investigate the Effects of Korean medicine therapies on oral pain in patients with BMS. Methods : We surveyed 30 BMS patients who newly visited the Oral Diseases Clinic in the Kyung Hee University Korean Medicine Hospital from February 2012 to March 2013. When the patients visited the clinic for the first time, they were evaluated on sociodemographic characteristics, BMS questionnaire, severity of pain using visual analogue scale (VAS) and pressure pain threshold (PPT) of the acupuncture point CV17. After 3 weeks of Korean medicine therapies (acupuncture, electroacupuncture, pharmacopuncture and herbal medicine), they were re-evaluated with the VAS and the PPT. Results : After 3 weeks of Korean medicine therapies, 30 patients' oral pain improved and the PPT score on CV17 rose, which means decrease of qi-stagnation score. Conclusions : Korean medicine therapies were effective on oral pain in patients with BMS. To confirm the additional curative effect and evaluate the efficacy of each treatment, well-designed randomized controlled trials will be needed in the future.

BCG 골수염

유홍재(Hong Jae Yoo),강재도(Jae Do Kang),장승원(Sung Won Jang),류만규(Man Ku Yon) 대한정형외과학회 1984 대한정형외과학회지 Vol.19 No.4