천연 탄산 온천수의 아토피 유발 쥐 모델에 대한 혈소판 응집 억제 효능 평가

장순우,박정환,곽진영,고영미,안택원,Jang, Soonwoo,Park, Junghwan,Kwak, Jinyoung,Go, Youngmi,Ahn, Taekwon 대전대학교 한의학연구소 2017 혜화의학회지 Vol.26 No.1

Objectives:Spring water is widely known to relax muscles by promoting blood circulation. This study was conducted to analyze theantithrombotic effect of naturally carbonated hot spring water (NCHW) to assess its influence on blood circulation. Methods:Atopic dermatitis was induced in the skin of the mice used in this experiment. NCHW was applied, and the antithrombotic effect was assessed and compared with that of other interventions. The positive control group was treated orally with aspirin. Results:After 3 weeks of exposure to NCHW, the experimental groupshowed a significant antithrombotic effect. NCHW also produced inhibitory responses to both collagen- and ADP-induced platelet aggregation, whereas the group given aspirin reacted only to collagen-induced platelet aggregation. Conclusions:The experiment demonstrated the intrinsic antithrombotic effects of NCHW compared with those of artificially carbonated water, tap water, and aspirin. This result suggests the possibility that NCHW can be used as a supportive and alternative treatment for vascular diseases.

Cyanoacrylate 접착제에 의한 직업성 천식 및 비염 1례

장순우,남기철,전형준,박종태,김병권 대한산업의학회 2008 대한직업환경의학회 학술대회 논문집 Vol.41 No.-

An Exploratory Research for the Development of Strategic Roadmap for Deploying Solar Technology in Developing Countries

장순우,박문수 융합연구학회 2022 융합연구학회지 Vol.6 No.3

The solar energy deployment requires cooperation by and among diverse constituents, changes in the national policies, market adoption, and the technologies appropriate for a transformation facilitated towards energy independence. While technological and financial assessments are important, the governing policies and the deployment process play a larger role, as they influence and accelerate penetration and the deployment rate of solar technology. This study introduces a multi-level and interrelated strategic roadmap which provides a perceptual model for the solar deployment. The objective is to enable policymakers to gain insights to the long-term effects of policy elements and realize long-term policy visions. It is intended to provide a holistic approach by connecting the vision with short and long-term goals and assesses different aspects of the time-changing solar technology deployment. Developing a strategic roadmap for policymakers is a novel approach. This study validates the strategic roadmap framework through elicitation of experts. The key finding suggests that six aspects, namely motivation; energy scenario; market and policy assessment; technology and product assessment; dependencies; and barriers are required for a strategic roadmap of policy recommendation.

천연 탄산 온천수의 아토피 유발 쥐 모델에 대한 혈소판 응집 억제 효능 평가

장순우,박정환,곽진영,고영미,안택원 大田大學校 附屬 韓方病院 2017 惠和醫學 Vol.26 No.1

Spring water is widely known to relax muscles bypromoting blood circulation. This study was conducted to analyze theantithrombotic effect of naturally carbonated hot spring water (NCHW) to assessits influence on blood circulation. Methods:Atopic dermatitis was induced in the skin of the miceused in this experiment. NCHW was applied, and the antithrombotic effect was assessedand compared with that of other interventions. The positive control group was treatedorally with aspirin. Results:After 3 weeks of exposure to NCHW, the experimental groupshowed a significant antithrombotic effect. NCHW also produced inhibitoryresponses to both collagen- and ADP-induced platelet aggregation, whereas the groupgiven aspirin reacted only to collagen-induced platelet aggregation. Conclusions:The experimentdemonstrated the intrinsic antithrombotic effects of NCHW compared with thoseof artificially carbonated water, tap water, and aspirin. This result suggests thepossibility that NCHW can be used as a supportive and alternative treatment forvascular diseases. 고혈압, 당뇨 등의 대사증후군으로 인해 발생하는 심뇌혈관질 환은 전세계적으로 주요한 사망 원인 중 하나이다. 우리나라에서 도 10대 사망원인 중 하나로 2015년 기준 전체 사망원인의 1/5 정도(19.2%)를 차지하고 있으며, 매년 증가하는 추세로 알려져 있다1). 심뇌혈관질환의 유발 원인은 식이습관, 생활방식, 유전적 요인 등 여러 가지가 보고되고 있으나 무엇보다도 인슐린 저항 성과 관련된 대사증후군으로 인한 혈행장애가 직접적인 원인으 로 꼽힌다2). 혈액은 적혈구, 백혈구, 혈소판 등의 혈구와 혈장으로 구성되어 있으며, 신체 각 조직으로 호흡과 소화를 통해 얻은 산소와 영양분 을 공급하고, 대사에서 발생한노폐물과 이산화탄소를 제거함으로써 각 조직의 항상성 유지에 중요한 역할을 담당한다. 또한 혈장 내의 응고 인자(coagulation factors)와 혈소판은 혈관 손상 시 지혈 작 용을 촉진하여 손상 부위로부터 혈액의 손실을 최소화하고, 혈액의 정상적인 순환을 유지시키도록 해준다. 혈소판은 심혈관 질환들, 중풍, 말초혈관질환, 당뇨 등에 중요 한 역할을 한다3). 혈관의 손상시 혈관내벽의 collagen, Von Willebrand factor, fibronectin 등이 노출되면서 혈소판의 활성 을 촉진한다. 혈소판은 활성화되면서 serotonin, Ca2+, thromboxane A2 등을 유리하여 주위의 다른 혈소판의 응집을 증폭시키고, 혈장에 존재하는 응고 인자와 반응하여 혈괴를 형성 함으로써 효과적인 지혈 작용을 유도하게 된다. 지혈 작용은 손 상된 부위로부터의 혈액의 손실을 최소화하고 혈액의 정상 순환 을 유지하기 위한 방어기전으로, 정상 혈관에서는 지혈 기전의 활성화 반응과 함께 억제 반응이나 혈괴 분해 반응들이 균형을 이룸으로써 항상성이 유지되고 있다. 이 역할들이 바르게 수행되 기 위해서는 혈액내 구성 세포 및 조직의 기능이 정상적으로 유 지되어야 함은 물론이고 혈액 자체의 순환 또한 원활하게 이루 어져야 한다4). 온천은 일반적으로 ‘지하로부터 용출되는 25℃ 이상의 온수로서 그 성분이 인체에 해롭지 아니한 것’을 말하며, 성분에 따라서 여러 가지 종류로 나뉜다5). 온천은 기본적으로 말초 혈관의 순환 및 인체 의 신진대사를 촉진하여 대사증후군, 류마티스, 아토피 피부염 등에 효과가 있다고 알려져 있으며, 삼국시대부터 질병 치료에 활용되었다 고 한다6). 한의학에서는 온천이 질병치료에 사용되는 원리에 대해 인체 장부 氣機의 升降出入이 水의 濡潤작용에, 氣血津液의 흐름은 水의 滋榮작용에 의하여 비롯된다고 설명하였다. 이에 온천욕을 하게 되면 온천 자체가 성미가 辛熱하고 약간의 毒이 있어 疥癬과 瘡毒을 제거하고 溫經通絡, 活暢氣血, 化瘀舒筋의 효능이 있다고 하였다7). 최근 들어서 입욕제, 외용제 등 보조요법으로서의 온천수의 질병 치 료 효능에 대한 관심이 깊어지고 있으며, 온천수 자체의 온열 효과뿐 만 아니라 유황(sulfur), 마그네슘(magnesium), 게르마늄(germanium), 탄산(carbon dioxide) 등 각각의 온천수가 함유하고 있는 성분의 항염증, 항아토피 효과, 말초 모세혈관과 세동맥의 확장 효과 등의 약리적 효능 또한 연구가 계속되고 있다5, 8-9). 이에 본 연구에서는 천안 지역의 대표적인 온천인 테딘 워터파크의 천연 탄산 온천수의 입욕 치료를 통하여, 그것의 말초 혈관에서의 혈행개선 효과에 대해 실험적으로 입증하고자 하였다.

고지방식이로 유도된 비만 생쥐모델에서 저령차전자탕의 항비만 효과

장순우,고영미,곽진영,안택원,Jang, SoonWoo,Kho, Young-mee,Kwak, Jin-young,Ahn, Taek-won 사상체질의학회 2018 사상체질의학회지 Vol.30 No.2

Objective This study investigated the effects of Jeoreongchajeonja-tang in a high-fat diet-induced obesity mouse model. Methods The study examined 9-week-old male mice (C57bl/6J) divided into four groups: the normal(C57bl/6J-Nr), control (high-fat diet only; HFD-CTL), positive-control (high-fat diet with Garcinia cambogia), and experimental (high-fat diet with Jeoreongchajeonja-tang; HFD-JCT) groups. After 7 weeks, the body weight, food efficiency ratio, organ weight, and visceral fat weight of the mice were measured. Blood serum tests, mRNA, liver histopathology, and epididymis adipocytes were also examined. Results Compared with the Control(HFD-CTL) group, the Experimental(HFD-JCT) group given Jeoreongchajeonja-tang showed significant reductions in absolute body weight and food efficiency ratio. The serum alanine aminotransferase, total-cholesterol, triglyceride, low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, insulin-like growth factor-1, and leptin levels were significantly lower in the experimental group than in the control group. The serum adiponectin levels were significantly higher in the experimental group than in the control group. Compared with the control group, the experimental group showed significant reductions in absolute abdominal subcutaneous fat, epididymal adipose tissue, kidney adipose tissue, intestine adipose tissue, and liver, kidney and spleen adipose tissue weights. The C/EBP-${\beta}$, leptin, and SREBP1c/ADD1 mRNA expression were significantly lower in the experimental group than in the control group, while the UCP-2 and adiponectin mRNA expression were significantly higher. Compared with the control group, the experimental group showed a significant reduction in the absolute adipocyte area in the liver and epididymal adipose tissue. Conclusion Jeoreongchajeonja-tang has an anti-obesity effect. Additional clinical studies are expected.

에틸 시아노아크릴레이트에 의해 유발된 것으로 추정되는 직업성 천식 및 비염 1예

장순우(Soon Woo Jang),남기철(Ki Chul Nam),전형준(Hyung Joon Jhun),김병권(Byoung Gwon Kim),박종태(Jong Tae Park) 대한직업환경의학회 2009 대한직업환경의학회지 Vol.21 No.3

비만 생쥐모델의 폐약(肺弱)을 유발하기 위한 Bleomycin의 농도 결정 연구.

고영미,장순우,안택원 大田大學校 附屬 韓方病院 2020 惠和醫學 Vol.29 No.1

Objectives : The objectives of this study is to develop a mouse model similar to Taeeum-type by inducing Lung fibrosis with bleomycin, and to determine adequate concentration of bleomycin. Methods : The subjects were divided into six groups: normal, obesity induced group, and bleomycin administered 0.015U, 0.03U, 0.06U, and 0.09U(U/100g bw) concentrations respectively. Each concentration of bleomycin was dissolved in distilled water, and administered through Intra-Nazal-Trachea injection method. Food intake and body weight were measured at regular time weekly. At the end of the experiment, blood was gathered by cardiac puncture for biochemical examinations, organs were removed for histological examinations, and weigh and mRNA genes was analyzed. Result : Mice administered with bleomycin at 0.015U and 0.03U showed body and fat weight gain, and increased blood total cholesterol, LDL-cholesterol, glucose, and free fatty acid level. Fat related genes also showed higher level than the control group. Obesity was most strongly induced in the mice administered with 0.03U of bleomycin. On the other hand, when bleomycin was administered at concentrations above 0.06U, a model of obesity mouse was not created due to rapid emphysema inflammation and weakness. Conclusions : Mice were most vulnerable to obesity when bleomycin was administered at a concentration of 0.3 to cause liver damage. Bleomycin concentration over 0.06U did not cause obesity-induced mice, due to severe damage in liver.

農村地域 改新敎會의 多目的 空間 活用 方案

남윤철,장순우,한규영 한국농촌건축학회 1999 농촌건축 : 한국농촌건축학회논문집 Vol.1 No.2

대학 및 연구기관의 지원역량 촉진을 위한 제도 개편 연구 - 연구지원체계평가의 지표 개편을 중심으로 -

박문수,장순우 충북대학교 국가미래기술경영연구소 2022 기술경영 Vol.7 No.4

This study is based on the government policy to create an enabling environment for effective research. This policy was established to provide better research support services in higher education and research institutions, as researchers have insufficient support. Researchers are in a situation where their research commitment is hindered by research support activities, such as R&D administration and research fund management; therefore, the administrative burden is increasing for researchers. The Korean government integrated the Ministry of Education's Research Fund Management Fact-Finding Survey and the Ministry of Science and ICT's Certificate of Excellence for Research Support Services in 2015 to evaluate the support service in research institutions. As a result, the most recent evaluation was conducted in 2020. However, due to amendments in the National Research And Development Innovation Act, there is a need to reorganize the evaluation system to strengthen the research support service of research institutions and increase the satisfaction of administrative support for researchers. Therefore, the study assessed the 2020 evaluation results using the SMART evaluation principle to provide improvement directions.

직무스트레스와 감정표현불능 성향과의 상관성

유성진,김자현,장순우,전형준,김병권,박종태 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.4

목적 근로자를 대상으로 직무스트레스와 감정표현불능성향과의 상관성에 대하여 연구하였다 방법 서울과 경기도 안산지역의 2개 대학병원에 건강검진을 위해 내원한 근로자중 생산직 근로자521명을 대상으로 하였다 한글판 Karasek 직무스트레스 설문(Korean version of the Karasek's Job Content Questionnaire JCQ)을 통해 직무스트레스를 평가하고 한글판 토론토 감정표현불능증 적도 설문(Korean Version of Toronto Alexithymia Scale TAS-20K)으로 감정표현불능 성향을 조사하였다 개별 JCQ 척도의 중앙값을 기준으로 이분하였고 직무긴장도 (Karasek 직무 긴장모델에 의해 정신적 직무요구와 직무재량도로 직무긴장도 평가 높음/중간/낮음) 직업불안정성 (높음/낮음) 직무불만족도(높음/낮음) 3가지 척도로 직무스트레스를 평가하였다 JCQ 척도와 감정표현불능 성향(total TAS score ≥52)과의 상관성을 알아보기 위해 보정하지 않은 비차비(crude odds ratios)와 보정비차비(adjusted odds ratios)를 계산하였다 결과 보정하지 않은 비차비 계산시 직무긴장도가 낮은 집단보다 높은 집단(crude OR 3.05 95% CI 1.35-6.87)에서 직업불안정성이 높은 집단(2.98 1.69-5.27)에서 직무불만족도가 높은 집단(2.93 1.69-5.09)에서 감정표현불능 성향이 유의하게 높게 나타났다 다중로지스틱회귀모형에 의한 보정비차비 계산시 직무긴장도가 낮은 집단보다 높은 집단(adjusted OR 2.26 95% CI 0.93-5.44)에서 감정표현불능 성향이 크게 나타났으나 유의하지는 않았고 직업불안정성이 높은 집단(2.26 1.21-4.22)에서 직무불만족도가 높은 집단(1.99 1.06-3.74)에서 감정표현불능 성향이 유의하게 높게 나타났다 결론 직무스트레스와 감정표현불능 성향 사이에 유의한 상관성이 있는 것으로 나타났다 Objectives We evaluated the association between job stress and alexithymic traits in Korean workers Methods Workers(n=521) who visited two university hospitals for medical check-ups were recruited for this study Job stress was evaluated using the Korean version of Karasek's Job Content Questionnaire(JCQ) and alexithymic traits were assessed using the Korean version of the Toronto Alexithymia Scale(TAS-20K) Crude and adjusted odds ratios(ORs) of job stress scales (job strain, job insecurity and job dissatisfaction) with alexithymic traits(total TAS score ≥ 52) were calculated Results High job strain compared with low strain had a high but insignificant association with alexithymic traits(adjusted OR, 2.26 95% CI, 0.93-5.44) High job insecurity(adjusted OR 2.26, 95% CI 1.21-4.22) and high job dissatisfaction (adjusted OR 1.99 95% CI 1.06-3.74) had significant associations with alexithymic traits Conclusions This study suggests that job stress is associated with alexithymic traits in workers.