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T-형 $Ca^{2+}$ 채널 길항제인 Mibefradil을 첨가한 인간 정자의 첨체반응 관찰
이재호,손원영,이정하,이인선,김영찬,한징택,Lee, Jae-Ho,Son, Weon-Young,Lee, Jung-Ha,Lee, In-Sun,Kim, Young-Chan,Han, Ching-Tack 대한생식의학회 2000 Clinical and Experimental Reproductive Medicine Vol.27 No.1
Objective: The sperm acrosome reaction is a $Ca^{2+}$-dependent exocytotic event that is triggered by adhesion to the mammalian egg's zona pellucida. Previous studies suggested a role of $Ca^{2+}$ channels in acrosome reactions. This study was conducted to investigate the T-type calcium channel is operated in acrosome reaction of human spermatozoa. Method: Human semen samples were obtained from healthy donors with normal criteria. The spermatozoa were divided into five groups: Group 1 were non-treated as a control; Group 2 where spermatozoa were exposed to 5 ${\mu}M$ $Ca^{2+}$ A23187 $(Ca^{2+}i)$; Group 3 where spermatozoa were exposed 5 ${\mu}M$ $Ca^{2+}i$ and mibefradil; Group 4 where spermatozoa were exposed 5 ${\mu}M$ $Ca^{2+}i$ and nifedipine, and Group 5 where spermatozoa were treated with 5 ${\mu}M$ $Ca^{2+}i$ and both of mibefradil and nifedipine. Spermatozoa in all groups were retrieved after incubation for 15 and 30 minutes at $37^{\circ}C$. After staining with PSA-FITC, fluorescence was observed under a fluorescence microscope, and AR was evaluated on a total>100 spermatozoa/side. Result and Conclusion: We observed on acrosome reaction inhibition rate in human spermatozoa the various of concentration of mibefradil, nifedipine. Maximum response was noted with 1.0 ${\mu}M$ mibefradil and the decrease of acrosome reaction inhibition rate 45%. Nifedipine in acrosome reaction inhibition rate was only about 25%. The $Ca^{2+}i$-induced AR of spermatozoa was significantly suppressed by mibefradil. Incidence of the suppression was depending on concentration of mibefradil. Results from the present study suggest that the human spermatozoa possess T-type channel. The observation that reversible inhibitor of T channels in male germ cells provides a new mechanism of contraceptive action.
이재호,김영수,Lee, Jae-Ho,Kim, Yung-Soo 대한치과보철학회 1989 대한치과보철학회지 Vol.27 No.1
Loss of teeth causes the inevitable reduction of residual ridge. Among the various methods solving this problem, hydroxyapatite proved to be useful for correction of ridge defect and irregularity. The purpose of this study is to evaluate the tissue responses of two types Of hydroxyapatites and resin polymer. Calcitite 2040 (Calcitek Inc.), Interpore 200 (Interpore Int.), and HTR polymer (HTR Sciences) were implanted into the jaw of an adult dog. The procedure was designed to obtain the results of 1 week, 2 week, 4 week, and 12 week-intervals. And after 12 weeks from the first operation day, the dog was sacrificed and evaluated histologically by light microscope. The results were as follows : 1. The mucosa was healed after two weeks. 2. After 1 week, there were acute inflammatory cells, but diminished after 2 weeks and were not seen after 12 weeks. 3. The hydroxyapatites implanted in soft tissues were surrounded by fibrous connective tissue. And some foreign body giant cells were found. 4. Calcitite and Interpore particles implanted subperiosteally were surrounded by newly formed bone after 12 months. And direct contact between bone and particles was noted. 5. The HTR particles implanted in soft tissues were encapsulated by fibrous connective tissues. The sample where the particles contacted directly to bone could not obtained by some probable insufficiencies of surgical technique or care of the animal. And the residue of HTR particles was digested by macrophage.
이재호,조현우,김도형,이형석,윤석진,류철,조창식,Lee, J.H.,Cho, H.W.,Kim, D.H.,Lee, H.S.,Yoon, S.J.,Ryu, C.,Cho, C.S. 한국전자통신연구원 2016 전자통신동향분석 Vol.31 No.4
특정 제조사의 단말 또는 운영체제에 의존성이 없는 플랫폼 독립적인 웹은 높은 이식성, 소프트웨어의 재활용, 개발 생산성, 풍부한 개발자 존재, 유지 보수 면에서 장점을 가지나, 화려한 UI/UX를 제공하는 네이티브 응용에 비해 낮은 성능으로 웹 기반의 응용 개발 및 보급이 크게 활성화되지 못했다. 한편 데스크톱은 물론 모바일 단말의 멀티코어 기반 Graphic Processing Unit(GPU), CPU 탑재 등 HW 고사양화와 웹 응용에서도 HW 가속 기능을 활용할 수 있는 표준 제공으로 성능 제약을 극복할 수 있게 되었다. 본고에서는 GPU 발전동향을 살펴보고, 고속 렌더링 및 병렬 연산처리를 요구하는 웹 응용이 GPU기반 HW 가속 기능을 활용할 수 있는 크로노스 그룹의 그래픽 가속(Web Graphics Library: WebGL) 및 컴퓨팅(Web Computing Language: WebCL) 지원 표준 규격을 정리한다. 또한, 최근 차세대 GPU Application Programming Interface(API)로 발표된 Vulkan에 대해 알아보고, 웹 고속화 기술에 적용 가능성에 대해 전망한다.
AI 메이커 코딩 교육이 컴퓨팅 사고력 향상에 미치는 영향 분석
이재호,김대현,이승훈,Lee, Jaeho,Kim, Daehyun,Lee, Seunghun 한국정보교육학회 2021 정보교육학회논문지 Vol.25 No.5
This study analyzed the effect of AI maker coding education on improving students' computational thinking. The subjects of the study were 10 students at H Elementary School in Ansan, and a total of 8 AI maker coding education using the Instructional Model for Maker Education based on SW Coding was applied to students to find out the degree of improvement of computational thinking. Students who participated in the class performed a process of solving real-life problems through coding and making activities, measured the degree of improvement in computing thinking before and after education through a computing thinking test paper, and observed students' thinking processes related to computing thinking components through interviews. As a result, it was confirmed that the average score of all students' computational thinking skills was improved, and the deviation of scores between students decreased. Through the interview, it was found that students actively utilize their thinking skills related to computational thinking skills in the problem-solving process. Through this, it was confirmed that AI maker coding education can have a positive effect on improving students' computing thinking skills. 본 연구에서는 AI 메이커 코딩 교육이 초등학생의 컴퓨팅 사고력 향상에 미치는 영향을 분석하였다. 연구 대상은 안산시 H 초등학교에 재학 중인 10명의 학생이며, 소프트웨어 코딩 기반 메이커교육용 교수학습모형을 활용한 총 8차시의 AI 메이커 코딩 교육을 학생들에게 적용하여 컴퓨팅 사고력의 향상 정도를 분석하였다. 수업에 참여한 학생들은 실생활의 문제를 코딩과 메이킹 활동을 통해 해결하는 과정을 수행하였고, 컴퓨팅 사고력 검사지를 통해 교육 전·후의 컴퓨팅 사고력 향상 정도를 측정하는 한편, 면담을 통해 컴퓨팅 사고력 구성요소와 관련된 학생들의 사고 과정을 관찰하였다. 연구 결과 모든 학생의 컴퓨팅 사고력 평균 점수가 향상되었으며, 학생 간 점수의 편차가 감소함을 확인하였다. 면담을 통해서는 문제해결 과정에서 학생들이 컴퓨팅 사고력과 관련된 사고 능력을 적극적으로 활용함을 알 수 있었다. 이를 통해 AI 메이커 코딩 교육은 학생의 컴퓨팅 사고력 향상에 긍정적인 영향을 줄 수 있음을 확인하였다.
이재호,박충범,류철,김영훈,방승찬,Lee, J.H.,Park, C.B.,Ryu, C.,Kim, Y.H.,Bang, S.C. 한국전자통신연구원 2013 전자통신동향분석 Vol.28 No.2
본고에서는 무선랜 기반 근접인식(proximity awareness) 모바일 서비스 제공에 필요한 관련 기술 동향 및 표준현황을 정리한다. 특히 수많은 기기들이 산재하는 모바일 D2D(Device to Device) 통신환경에서 인접 장치 및 서비스 발견 과정에 사용자 개입을 최소화할 수 있도록 접속 대상을 보고 선택하는 방식의 시선통신(look-and-link)과 네트워크 계층의 접속 이전에 주변 디바이스에서 제공되는 서비스를 미리 파악하거나 간단한 정보를 송수신할 수 있는 무결합 메시징(preassociation messaging) 연구동향을 소개한다. 이러한 기술은 셀룰러 중심의 기존 모바일 서비스들과 차별성을 가지며 무선랜 기술을 활용하는 D2D 환경에서 근접인식 모바일 서비스를 활성화할 수 있는 핵심 요소기술로 이용될 것이다.