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산청목(山靑木)이 간섬유화 진행 억제에 미치는 효과에 대한 연구
이승보,우홍정,Lee, Seung-Bo,Woo, Hong-Jung 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.2
Objectives : This study was performed in order to investigate the anti-fibrogenic effect of Acer tegmentosum Maxim. on r at hepatic stellate cell line T6. Materials and Methods : Hepatic stellate Cells (T6) were treated with various concentrations of distilled water Acer teg mentosum Maxim. extract for 24, 48, 72 hours. After the treatment, cell viability, proliferation, procollagen levels, mRNA of AS MA, MMP-2, collagen type 1a2 and IL-6 production were measured using MTT assay, BrdU assay, RT-PCR, procollagen typ e 1 C-peptide EIA kit and murine IL-6 ELISA development kit. Results : Cell viability of HSC-T6 decreased significantly in both 24 hours and 48 hours groups in a dose-dependant man ner. Proliferation of HSC also decreased in the same way. In the RT-PCR, mRNA expression of collagen type 1a2 and ASMA decreased in the groups which were treated with Acer tegmentosum Maxim. for 24 hours. The production of procollagen tended to decrease in a dose-dependant manner in the 24 hours treated group. IL-6 production increased under Acer tegmentosum trea tment in a dose-dependant manner in both 24 and 48 hours groups. Conclusion : These results show the possibility that Acer tegmentosum Maxim. can be an effective remedy for liver fibrosi s and liver cirrhosis.
시뮬레이션을 통한 강제배기 시스템의 굴삭기 실내 공기조화 영향 연구
이정환(Jung-Hwan Lee),오충현(Choong-Hyun oh),이승보(Seung-bo Lee),정헌술(Heon-Sul Jeong) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.11
In this paper, possible energy saving strategy of ventilating system in excavator cabin was investigated. Through the computer simulation by AMESim package, effect of air-conditioning and forced exhaust system in the excavator cabin is studied on the temperature and energy consumption. Especially, effect of intake temperature, exhaust flow rate, and air-conditioning setting was studied on the temperature inside Cabin. For this purpose, AMESim model for system performance analysis of passenger thermal comfort in the excavator cabin was constructed. For the validity of the model, simulation results were compared with the test results in the literature first. Then, the AMESim model was used for the analysis of the effect of the each variable on the internal temperature change. The simulation was also done on for case of several different outside temperature. Through this study, possible energy saving strategy of ventilating system in excavator was identified.
피로를 주소로 내원한 환자의 생활섭생, 허손 및 피로의 상관성에 대한 고찰
김세훈,이장훈,이승보,최미영,김영철,우홍정,Kim, Se-Hoon,Lee, Jang-Hoon,Lee, Seung-Bo,Choi, Mi-Young,Kim, Young-Chul,Woo, Hong-Jung 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.1
Objectives : Consumption is a chronic wasting disease, in oriental medicine concept. Fatigue is a common symptom experienced by many people who have consumption. However, there has been little study about the relationship between consumption and fatigue in the Oriental medicine. For this reason, we attempted to investigate the present status of fatigue of outpatients, and its relation with consumption index, public health practice index, Chalder fatigue scale and Subjective Symptoms of Fatigue Test. Methods : The subjects were 149 outpatients who complain fatigue between Nov. 1, 2006 and Oct. 31, 2007. We measured degree of consumption by consumption index. We measured degree of fatigue by Chalder fatigue scale and Subjective Symptoms of Fatigue Test. Public health practice were investigated by "Breslow's 7 health practice". Results : Studies have shown that a group who disregard public health practices have higher numerical value, in part of $q\grave{i}-x\bar{u}$, $xu\grave{e}-x\bar{u}$, and Physical symptoms than a group more concerned with public health practice. A group who has fatigue for a period over 6 months are more likely to be $q\grave{i}-x\bar{u}$, $y\bar{i}n-x\bar{u}$, Chalder fatigue scale, neuro-sensory symptoms than a group fatigued for less than 6 months. Among the subjects, 81 (55.5%) were considered as 'fatigue patients' by the Chalder scale. Chalder fatigue scale, according to the Subjective Symptoms of Fatigue Test, consumption also, The more increase of Subjective symptoms of fatigue test, the more of consumption scale. Conclusions : This study has shown that there is a link between consumption and fatigue. Moreover, oriental medicine's consumption is more concrete than fatigue scale, so consumption index will have wide application to the study of fatigue.
기혈음양허손(氣血陰陽虛損) 변증(辨證) 분석을 위한 설문문항 개발
우홍정,김세훈,이승보,최미영,김영철,이장훈,Woo, Hong-Jung,Kim, Se-Hoon,Lee, Seung-Bo,Choi, Mi-Young,Kim, Young-Chul,Lee, Jang-Hoon 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.4
Objectives : Consumption is a chronic wasting disease and major portion of Oriental Medicine's therapy. However, there is no standard diagnostic method for consumption that is $q{\grave{i}}-x{\bar{u}}$, $xu{\grave{e}}-x{\bar{u}}$, $yang-x{\bar{u}}$, $y{\bar{i}}n-x{\bar{u}}$. Methods : A questionnaire which includes symptoms and signs for diagnosis of $q{\grave{i}}-x{\bar{u}}$, $xu{\grave{e}}-x{\bar{u}}$, $yang-x{\bar{u}}$, $y{\bar{i}}n-x{\bar{u}}$ was evaluated by Delphi technique. Each question was valuated by interviewing 27 oriental medicine doctors. Then. we choose questions given over 5 points and reorganized some items according to the recommendations by interviewed-doctors. We then accessed the value of re-organized questions composing of the questionnaires. Conclusion : We finally chose each 9 items of $q{\grave{i}}-x{\bar{u}}$, $xu{\grave{e}}-x{\bar{u}}$, $yang-x{\bar{u}}$, $y{\bar{i}}n-x{\bar{u}}$'s questionnaire. Further study is necessary for modification of questionnaire by statistics and certification by clinical trial.
사행유로를 갖는 고분자연료전지내부에서 가스확산층을 통과하는 반응가스 우회유동에 대한 연구
조중원(Choong-Won Cho),안은진(Eun-Jin Ahn),이승보(Seungbo Lee),윤영기(Young-Gi Yoon),이원용(Won-Yong Lee) 대한기계학회 2009 大韓機械學會論文集B Vol.33 No.4
A serpentine channel geometry often used in a fuel cell has a strong pressure gradient between adjacent channels in specific regions. The pressure gradient helps some amount of reactant gas penetrate through a gas diffusion layer(GDL). As a result, the overall serpentine flow structure is slightly different from the intention of a designer. The purpose of this paper is to examine the effect of serpentine flow structure on current density distribution. By using a commercial code, STAR-CD, a numerical simulation is performed to analyze the fuel cell with high aspect ratio of active area. To increase the accuracy of the numerical simulation, GDL permeabilities are measured with various compressive forces. Three-dimensional flow field and current density distribution are calculated. For the verification of the numerical simulation results, water condensation process in the cathode channel is observed through a transparent bipolar plate. The result of this study shows that the region of relatively low current density corresponds that of dropwise condensation in cathode channels.