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한국에서의 학령전기 소아 중독 실태에 관한 국, 내외 비교 연구
이수훈 ( Soo Hoon Lee ) 대한보건협회 2013 대한보건연구 Vol.39 No.1
연구목적: 국내뿐만 아니라 한국을 포함한 동북아시아에서 소아 중독 현황에 대한 정보는 거의 알려진바 없다. 이에 저자들은 서울 응급의료정보센터에 의뢰된 소아 중 독환아에 대한 인구학적인 통계 및 중독 실태 조사를 통해 소아 중독 관리 능력을 향상시키고, 소아 중독 예방을 위한 계획 및 제도를 수립하는데 도움을 주고자 이 연구를 시행하였다. 연구방법: 본 연구는 2010년에 후향적으로 서울 응급의료정보센터로 의뢰된 학령전기 중독 환아에 대한 상담 기록을 분석하였다. 중독 물질을 의약품과 비의약품으로 나누어 비교 분석하고 두 그룹간의 특징 및 차이점들을 알아보았다. 연구결과: 연구 대상은 1352명으로, 이중 94.6%가 36개월 이하였다. 13-24개월에서 소아 중독이 가장 많이 일어났으며 연령이 증가할수록 빈도가 줄어들다가 61-72개월에서 다시 빈도가 증가하는 양봉(bimodal distribution) 형태를 보였다. 남아가 여아보다 많았으며, 봄에 소아 중독이 가장 호발하였다. 개인 위생 용품과 감기약에 의한 중독이 가장 많았으며, 실리카겔을 포함한 방습제에 의한 중독이 다른 나라의 연구 결과에 비해 많았다. 다른 나라 중독 센터보다 즉시 병원을 방문하라고 의료지도된 경우가 많았다. 비의약품에 의한 중독이 의약품보다 많았으며 두 그룹 간에는 여러 차이들이 존재하였다. 비의약품 중독군의 경우 의약품 중독군에 비해 평균 연령이 어리고 중독 경과 시간이 짧고 현장에서의 응급 처치가 많았지만, 즉시 응급실을 방문하도록 의료 지도받은 경우는 상대적으로 적었다. 결론: 우리는 서울 응급의료정보센터의 자료를 토대로 한국의 6세 미만 소아 중독의 특징들에 대해 알아보고 국, 내외연구들과 비교 분석을 해보았다. 이처럼 지역별, 국가별로 소아 중독의 특성이 다른 이유는 지역이나 국가마다 다른 제도와 문화적 관습 및 생활 양식을 가지고 있기 때문이라고 생각된다. 따라서 소아 중독 사고 예방 방법도 나라 및 지역, 시기에 따라 다르게 정해져야 할 필요가 있다. 또한 이러한 결과를 바탕으로 국가 중독 관리 센터의 설립을 통한 소아 중독 예방프로그램이나 정책 등이 적극적으로 도입되기를 기대해본다. Objectives: Little information has been published regarding the status of pediatric poisonings in Asia, particularly in northeast Asia including South Korea. We studied the epidemiology of accidental poisonings among children younger than 6 years in South Korea through emergency medical information center data. Methods: We retrospectively reviewed the records about poisonings of children younger than 6 years who consulted by the Seoul Emergency Medical Information Center in 2010. The demographic data and detailed information about the poisonings was investigated. The substances causing the poisonings were divided into pharmaceuticals and non-pharmaceuticals, and their characteristics and the difference between the two groups were investigated. Results: A total of 1352 cases were collected, of which 94.6% occurred in children younger than 3 years. There is a bimodal distribution of age with two peaks, highest in 1 year and increasing again between 61 and 72 months. Boys (51.8%) were involved more than girls. The incidence of pediatric poisoning was higher in spring. Personal care products and cold medications were the most common causative substances. Desiccants were distinctively more common than in other countries. Referral to hospitals was more frequent than reports of other poison control centers. The exposure to non-pharmaceuticals (58.9%) was more common than pharmaceuticals. There were several differences between non-pharmaceutical and pharmaceutical group. Conclusion: We demonstrated the characteristics of pediatric poisoning in South Korea using the data from emergency medical information center. Through those data, we may be able to implement preventive strategies and educational programs in South Korea.
베라파밀 중독의 쥐 모델에서 지방에멀젼 정맥주사의 효과
하대명,김동훈,김태윤,이수훈,정진희,이상봉,임대성,강창우,Ha, Dae-Myung,Kim, Dong Hoon,Kim, Taeyun,Lee, Soo Hoon,Jeong, Jin Hee,Lee, Sang Bong,Lim, Daesung,Kang, Changwoo 대한임상독성학회 2018 대한임상독성학회지 Vol.16 No.1
Purpose: Intravenous lipid emulsion (ILE) has been shown to have significant therapeutic effects on calcium channel blocker overdose in animal studies and clinical cases. In this preliminary experiment, we investigated the hemodynamic changes and survival in a rat model of verapamil intoxication. Methods: Fourteen male Sprague-Dawley rats were sedated and treated with ILE or normal saline (control), followed by continuous intravenous infusion of verapamil (20 mg/kg/h). Mean arterial pressure and heart rate of rats were monitored during the infusion. In addition, the total dose of infused verapamil and the duration of survival were measured. Results: Survival was prolonged in the ILE group ($32.43{\pm}5.8min$) relative to the control group ($24.14{\pm}4.3min$) (p=0.01). The cumulative mean lethal dose of verapamil was higher in the ILE group ($4.3{\pm}0.7mg/kg$) than in the control group ($3.2{\pm}0.5mg/kg$; p=0.017). Conclusion: ILE pretreatment prolonged survival and increased the lethal dose in a rat model of verapamil poisoning.
성애진 ( Ae Jin Sung ),이수훈 ( Soo Hoon Lee ),신현탁 ( Hyuntack Shin ),임대성 ( Daesung Lim ) 대한응급의학회 2021 대한응급의학회지 Vol.32 No.6
Fat embolism syndrome is a rare disease associated with long bone fractures and plastic surgery. In previous studies of cerebral fat embolism, no reports of cardiac arrest occurred by cerebral fat embolism. Therefore, we aimed to report the first case of cardiac arrest by cerebral fat embolism after scalp lipoma removal.
글루포시네이트 암모늄 제초제 중독환자에서 혈중 암모니아 농도와 사망률과의 연관성에 대한 연구
고은나래 ( Eun Na Lae Ko ),김동훈 ( Dong Hoon Kim ),이수훈 ( Soo Hoon Lee ),정진희 ( Jin Hee Jeong ),이상봉 ( Sang Bong Lee ),성애진 ( Aejin Sung ),서자현 ( Ja Hyoen Suh ),강창우 ( Changwoo Kang ) 대한임상독성학회 2020 대한임상독성학회지 Vol.18 No.2
Purpose: The association of the initial serum ammonia level with in-hospital mortality in patients with acute glufosinate-ammonium herbicide poisoning was studied. Methods: This retrospective cohort study was conducted between March 2012 and August 2019 in the emergency department after glufosinate-ammonium herbicide poisoning. Survivors and non-survivors were analyzed using a Mann-Whitney U test and Fisher’s exact test. Multivariate logistic regression analysis was performed to determine the independent risk factors for mortality. Results: One hundred and six patients were enrolled; 11 died, yielding a mortality of 10.4%. The serum bicarbonate level was significantly lower in the non-survival group than the survival group. Age, serum ammonia, blood urea nitrogen, creatinine levels, SOFA score, and APACHE II score were significantly higher in the non-survival group than the survival group. Age, serum ammonia, and creatinine level were independent risk factors for mortality in multivariate logistic regression analysis. Conclusion: The initial serum ammonia level is associated with mortality in patients with acute glufosinate herbicide poisoning.
장귀상 ( Gui Sang Jang ),이재혁 ( Jae Hyuk Lee ),김규석 ( Kyu Seok Kim ),조유환 ( You Hwan Jo ),이중의 ( Joong Eui Rhee ),이경분 ( Kyoung Bun Lee ),박찬종 ( Chan Jong Park ),강창우 ( Chang Woo Kang ),이수훈 ( Soo Hoon Lee ),김중희 대한외상학회 2013 大韓外傷學會誌 Vol.26 No.1
Purpose: Sulforaphane is a naturally-occurring isothiocyanate abundant in broccoli. It has been suggested as a promising antioxidant. In this study, the therapeutic effect of sulforaphane in paraquat intoxication was investigated. Methods: Paraquat was administered via the tail vein, after which sulforaphane or a vehicle (4% DMSO) was administered intraperitoneally 15 minutes after paraquat administration. Histological injury, lipid peroxidation, plasma cytokine (IL-6, IL-10), and nitric oxide were measured. In addition, the effect of sulforaphane on survival in paraquat-intoxication was observed. Results: Regarding histological injury, lipid peroxidation, and plasma cytokine and nitric-oxide response, sulforaphane administration showed no protective effects in paraquat-intoxicated rats. Rather, it increased mortality (log rank p=0.03) and caused lipid peroxidation, as well as plasma cytokine and nitric-oxide production, to be increased. Conclusion: Sulforaphane had no therapeutic effect on paraquat-intoxicated rats; rather, it increased mortality.
박상호(Sangho Park),정영상(Young Sang Jung),송준엽(Jun Yeob Song),이승우(Seung Woo Lee),김동훈(Dong Hoon Kim),이수훈(Soo Hoon Lee),박종권(Jong Kweon Park) 한국생산제조학회 2005 한국생산제조시스템학회 학술발표대회 논문집 Vol.2005 No.5
Existing manufacturing system has consumed too much energy, space and resource in micro parts manufacturing. To improve this, micro factory system is suggested. But it is difficult to get the high reliability in the assembly, production and inspection of the minute parts because the construction of the micro factory has been started just before. In this study, we will build the digital manufacturing simulation on the micro factory's process and verify the production and assembly process using this simulation.