향정신성약물(向精神性藥物)이 뇌(腦) amine 함량(含量) 변동(變動)에 미치는 영향(影響)(제 1 보고)(第 1 報告)

이세규,김혜성,Lee, Se-Kyu,Kim, Hei-Sung 대한약리학회 1970 대한약리학잡지 Vol.6 No.1

The present study is concerned with the demonstration of the relationship between the behavior and the brain concentration of noradrenaline resulted from pretreatment of amphetamine in isolated or aggregated rats. The experimental subjects were rats weighing from 120g to 200g housed 1, 2, and 6 in a cage. Analeptic activity of amphetamine was measured by determining the sleeping time induced by pentobarbital sod. The noradrenaline content in brain was determined with Aminco-Bowmann's spectro-photofluorometer by Lee's modification of Shore and Olin method. Results: 1) The analeptic activity of amphetamine on the sleeping time induced by pentobarbital sod. was more increased in the grouped rats than in isolated animal. 2) In being isolated and grouped rats, the sleeping time induced pentobarital sod, was markedly prolonged by pretreatment of amphetamine. 3) Means of housing rats, e.g., isolation or aggregation did not seem to affect the brain noradrenaline depleting action. 4) Repeated daily parenteral administration of amphetamine sulfate for a period 1 to 3 weeks resulted in decrement of brain noradrenaline concentration in being isolated and grouped rats. 5) The prolongation of sleeping time of the isolated or aggregated rats, when pretreated with amphetamine, compared with that of stock rats, seems to be attributable rather to the means of housing than the variation of the noradrenaline caused by amphetamine.

표면결함이 있는 복합적층 시편의 강도

이세규,홍창선 ( Sei Kyu Lee,Chang Sun Hong ) 한국복합재료학회 1989 Composites research Vol.2 No.2

오가피(五加皮) Ethanol Extract의 실험적(實驗的) 신성고혈압(腎性高血壓)에 미치는 영향(影響)

이세규,고석태,임동윤,Lee, Sae-Kyu,Ko, Suk-Tai,Lim, Dong-Yoon 한국약제학회 1978 Journal of Pharmaceutical Investigation Vol.8 No.3

This study was carried out for the purpose of observing the effect of Korean Acanthopanax Radicis Cortex on renal hypertension and to clarify the mechanism of this effect, making use of its ethanol extract. Adult male or female rats, weighing 180-250g, were divided into 3 groups; the first for normotensive control, the second for hypertensive control and the third for hypertensive Acantopanax-treatment. Rats in the normotensive and hypertensive control group were administered 0.9% saline subcutaneously only, whereas those in the Acanthopanax-treated hypertensive group were administered 50mg/kg Acanthopanax ethanol extract subcutanously once a day. Changes of original blood pressure, and responses of blood pressure to various 4gents(norepinephrine, angiotensin, acetylcholine, serotonin and histamine) were recorded for each group on the initial, 18th, 32nd and 46th days of the experiment. The results obtained in this experiment are as follows: 1) The initial blood pressure was $102.6{\pm}7.6mmHg$ on the average. The blood pressures of the normotensive control group were not observed to alter significantly at any period in the course of the experiment. 2) The mean blood pressures in the hypertensive control group were recorded at $120.3{\pm}10.4mmHg$ on the 18th day, at $134.5{\pm}9.2$ on the 32nd day and at $138.8{\pm}8.3$ on the 46th day, thus revealing significant elevation in comparison with the corresponding normotensive control group blood pressures. On the other hand, the mean blood pressures in Acanthopanax-treated hypertensive group on the 18th, 32nd and 46th days were $118.3{\pm}9.7,\;129.9{\pm}8.3\;and\;120.2{\pm}8.3mmHg$ respectively. The blood pressures of the hypertensive-Acanthopanax group recorded. on the 46th day revealed a significant difference as compared with those of the corresponding hypertensive control group. 3) On the 46th day of this experiment, the responses of blood pressure to acetylcholine in the hypertensive-Acanthopanax group were suppressed significantly as compared with those of the hypertensive control group, and in the latter group, angiotensin was decreased markedly as compared with the corresponding normotensive control group. In contrast, pressor action of norepinephrine and depressor action of serotonin and histamine did not differ significantly among the three groups. These results suggest that Acanthopanax ethanol extract suppresses the induction of renal hypertension by means of a cholinergic action such as that caused by acetylcholine.

"중국민족의학사(中國民族醫學史)에 관(關)한 연구(硏究)"

이세규,신순식,Lee, Se-Gyu,Sin, Sun-Sik 대한한방내과학회 1994 大韓韓方內科學會誌 Vol.15 No.1

유시티 개발에 대한 지역주민 충성도의 영향요인에 관한 연구

이세규(Se-Kyu Lee),이재수(Jae-Su Lee) 서울연구원 2011 서울도시연구 Vol.12 No.2

도시재생과정에서 쇠퇴지역의 물리·사회환경이 주민의 신체 및 심리 건강에 미치는 영향연구: 지방대도시 「도시재생 선도지역」을 중심으로

이세규 ( Se Kyu Lee ) 중앙대학교 국가정책연구소 2018 국가정책연구 Vol.32 No.3

본 연구의 목적은 도시재생과정에서 쇠퇴지역의 물리·사회 환경과 주민건강 간의 영향관계를 검증하여 건강친화형 도시재생정책의 판단근거를 마련하는 데 있다. 이론과 선행연구 고찰에 따르면, 쇠퇴지역의 도시재생은 물리환경을 개선하고, 사회적 자본을 향상시키면서 주민들의 신체건강과 심리건강에 긍정적인 영향을 미치고 있었다. 본 연구에서는 국가통계자료인「지역사회 건강조사」를 활용하여 지방대도시 「도시재생 선도지역」을 사례연구지역으로 물리·사회 환경과 주민건강 간의 영향관계를 규명하고자 한다. 검증결과, 쇠퇴지역의 물리환경은 주민들의 신체건강에 부(-)의 영향을, 심리건강에 정(+)의 영향을 통계적으로 유의미하게 미치고 있었다. 반면, 사회환경은 신체건강과 심리건강에 부(-)의 영향을 미치고 있었다. 본 연구의 정책적 시사점은 향후 도시재생지역에 점진적이며 효과적인 건강친화형 재생정책과 프로그램을 도입해야 한다는 것이다. 이를 위해, 앞으로 주민건강의 다양한 도시재생사업을 성공적으로 운용하기 위해 정부 부처의 컨트롤타워를 만들어 주민의 삶의 질과 건강을 함께 향상시킬 수 있는 제도마련이 필요하다. The purpose of this study is to make preparation for a basis for the judgment of the health friendly urban regeneration policy by verifying the impact between the physical and social environment of the decline area and the health of the residents during the urban regeneration process. According to the theory and preceding research, urban regeneration in the declining area had positive effects on the physical health and mental health of residents by improving the physical environment, reforming the social capital, and increasing economic stability. In this study, we intend to examine the impact between the physical and social environment of the urban regeneration area designated as the local metropolitan by using the national statistical data, "Community Health Survey". As a result of the verification, the physical environments in the affected areas was statistically significant in the effect on physical health and on metal health. On the other hand, the social environment was affecting both physical and mental health. The policy implications of the study are to introduce a gradual and effective health friendly regeneration policies and programs to urban regeneration areas in the future. In addition, the government should establish a control tower to improve the quality of life and health of residents in order to successfully operate variety urban regeneration projects form now on.

유비쿼터스 도시개발에 대한 만족도와 사회적 유대관계

이세규(Lee, Se-Kyu),이재수(Lee, Jae-Su) 한국도시행정학회 2011 도시 행정 학보 Vol.24 No.3

The intends of this study is to examine the causal relationships among the satisfaction and social relationship of the u-City residents and to find policy implications on successful u-City development. To achieve the purpose, this study reviews the existing literatures about u-City, Place Attachment, Creative City, Customer Satisfaction Index and Social Capital theories. This study uses a field survey data about ‘Eun-pyeong’ residents who live this area and the sample size is 338. The main results of this study are as follows. 1) u-City Residents Satisfaction has a negative effect on Social Relationship. 2) However, Residents Satisfaction has a positive effect on Social Relationship by the u-City Loyalty and Place Attachment. The policy implications of theses findings are as follow. To make successful development of the u-City, local government should prepare to set the monitoring system for perceived u-City’s loyalty and place attachment of residents. In order words, the u-City development should be focused residents who are recognized the u-city’loyalty and the place attachment strongly.

도시 고령자의 거주환경과 에이징 인 플레이스 간의 인과성 연구

이세규(Lee, Se-kyu),박동욱(Park, Dongwook) 한국도시행정학회 2015 도시 행정 학보 Vol.28 No.2

본 연구는 도시 고령자를 대상으로 거주환경 지각과 AIP(Aging In Place)조성의 인과성을 규명하고자 한다. 특히, 매개변수로 고령자의 신체적 또는 심리적 건강상태를 설정했을 때 불편한 거주환경과 AIP 조성 필요성 간의 상관성 및 영향력을 밝히고자 한다. 이를 위해 본 연구에서는 거주환경, 노인건강, AIP에 관한 설문문항을 구성하여 도시 노인들을 대상으로 설문조사를 실시하여 양자 간의 영향관계를 검증하고자 한다. 본 연구의 분석결과는 고령친화형 거주환경의 조성과 지원에 적합한 정책제언과 제도마련에 필요한 기초자료로 활용할 수 있다. 이 같은 연구의 목적을 달성하기 위해서 거주환경, 노인의 건강상태, 에이징 인 플레이스(AIP)에 관한 이론 및 선행연구를 고찰하여 관측변수를 선정하고 연구모형을 설정한다. 구조모형의 분석결과, 도시 고령자는 거주환경의 불편함이 클수록 AIP의 필요성에 더 적극적이었다. 거주환경의 불편함은 노인의 신체 및 심리적 건강을 악화시키는데 영향을 미쳤다. 또한 신체 및 심리적 건강을 변수로 분석한 결과, AIP 조성의 필요성이 드러났다. 더욱이 신체적 저하는 심리적 건강의 악화에 영향을 미치고 있으며, 이로 인해 AIP 조성의 필요성은 더욱 증가하는 것으로 나타났다. 본 연구의 정책적 시사점은 다음과 같다. 최근 자택에서 노후를 보내기를 원하는 노인이 증가하는 추세이다. 따라서 정부에서는 비용이 적게 들고 효율적인 노인정책을 마련하기 위해 AIP정책을 적극적으로 검토해야 한다. 또한, 활기찬 노후생활을 위해 고령친화형 설계기법을 활용하여 현 거주환경을 개선해야 한다. 무엇보다도 단순한 물리적 개선에 그치기보다는 AIP를 위한 지원서비스 및 프로그램을 함께 운영해야 한다. 특히, 현재 거주환경의 불편 요인은 노인의 건강에 직접적인 영향을 미치는 동시에 AIP조성 필요성에 영향을 미치고 있으므로, 신체적·심리적 건강요소를 고려한 거주환경 개선을 통하여 노후생활을 지속할 수 있는 프로그램을 개발해야 한다. The objective of this study is to investigate the causality between the elderly"s residential environment and the necessity of the Aging in Place(AIP) preparation by the elderly"s health to find policy implications on the successful AIP policy strategies. Therefore, we reviews the existing literatures about the residential environment and the necessity of AIP. Then, we formulates some study hypotheses and finally verifies them using a high-order confirmatory factor analysis and structural equation model. The prime results of this study are as follows. The metropolitan elderly people, who feel uncomfortable the their own residential environment, perceive the AIP necessity very highly. And inconvenient residential environments affect the elderly"s health. Moreover, the physical ingravescence makes the mental worse. Therefore, the necessity of AIP is of importance. The implications of this study are as follows. To make AIP policy successful, it is important that aging-friendly residential environment design and community based welfare service are well-established first of all. The government should consider the elderly"s physical and mental health carefully when it establish AIP"s policy.

뉴타운 입주자의 거주후 만족도 및 지역 충성도에 미치는 영향요인분석

이세규(Lee Se Kyu),안형순(An Hyung-Soon) 한국도시행정학회 2009 도시 행정 학보 Vol.22 No.3

The purpose of this study is to examine the causal relationships among the satisfaction of New Town Residents and the local loyalty, and to find policy implications on successful New Town strategies. To achieve this purpose, this study reviews the existing literatures about Customer Satisfaction Index(CSI) and then formulates 9 study hypotheses, and finally verifies them using a structural equation model. This study uses a field survey data about residents who moved into a ‘Eun Pyeong New Town’and the final sample size is 336. The main results of this study are as follows. 1) New Town Image affects New Town Expectation and Perceived Quality. 2) New Town Expectation also affects Perceived Quality but doesn’t have any statistically significant effects on Perceived Value and New Town Satisfaction. Perceived Quality affects Perceived Value and New Town Satisfaction. And Perceived Value affects New Town Satisfaction. 3) New Town Satisfaction has a very strong positive effect on Loyalty. The policy implications of these findings are as follows. 1)In order to maximize residents’satisfaction, local government officials and the authorities concerned should make the best efforts to enhance perceived quality of New Town. 2)To make New Town loyalty effects come true, it is very important to retain the residents showing various methods which are operating and managing about the New Town.

주민효능감이 지역재생 및 활성화를 위한 지연산업 개발태도에 미치는 영향에 관한 연구

이세규 ( Sekyu Lee ) 성균관대학교 국정관리대학원 2013 국정관리연구 Vol.8 No.1

본 연구의 목적은 주민효능감이 침체 또는 쇠퇴를 겪고 있는 지역의 지연산업 개발태도에 미치는 영향에 관한 인과성을 검증하여 성공적인 산업화를 위한 정책적 제언을 하는데 있다. 이 같은 연구목적을 달성하기 위해, 본 연구에서는 주민효능감, 향토자원 산업화 인지도, 지연산업에 대한 선행연구를 고찰하여 연구가설을 설정하고, 이를 검증하기 위해 구조모형방정식(SEM)을 활용하였다. 본 연구의 검증결과는 다음과 같다. 우선, 주민효능감은 지연산업 개발태도에 정(+)의 인과관계에 있었다. 주민효능감과 지연산업 개발태도 간의 인과성은 향토자원 산업화 인지도를 매개변수로 할 경우, 정(+)의 인과성이 더욱 커지는 것으로 검증되었다. 이 같은 연구결과로 인해 다음과 같은 정책제언을 한다. 침체 또는 쇠퇴된 지역의 성공적인 지연산업을 위해서는 대상지를 선정하는 단계에서 본 연구에서 제시한 효능감(efficacy)의 측정지표(index)를 선정하여 평가에 반영하며, 정책의 추진과정 중에도 주민효능감을 높일 수 있는 프로그램을 개발하여 운용해야 한다. The purpose of this study is to examine the causal relationships among the perception of the collective efficacy, the local industry, and the attitude of local development and to find policy implications on successful local resources and place marketing`s strategies. To achieve this purpose, this study reviews the existing literatures about the collective efficacy, the local industry`s preception and the attitude of local development, and then formulates some study hypotheses and finally verifies them using a structural equation model. The main results of this study are as follows. 1) The collective efficacy affects the local industry perception and the local development positively. The policy implications of theses finding is as follow. In order to make successfully businesses using local resources which are included by collective efficacy. The local government should estimate residents and participatory agents` collective efficacy while they make the local resource`s business proposal. And The central government should reflect collective efficacy when they make a choice the order of priority.