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      • Dylan Thomas의 詩的 에너지 : 죽음의 극복을 주제로

        李世珪 檀國大學校英美文化硏究所 1983 英美文化 Vol.2 No.-

        Pound once said: "Great literature is simply language charged with meaning to the utmost possible degree". Pound's concise description reflects not only upon the achievements of the past but upon experiments undertaken in the present century. Pound's is susceptible of various interpretations depending upon where one directs the falling stress. Perhaps it is true to say that most modern experimental poets have been preoccupied with the charge of language, the energy with which meaning conveyed. The aesthetic problem sleeping in Pound's statement can give access to the poetry of Dylan Thomas. This paper aims to examine the contasted aspect of energy revealed in the earlier poetry with the later's of Dylan Thomas. dylan Thomas once descried his poetry as a record of passing from darkness into some measure of light. This represents a indication that he aims to quest for poetic identity by means of the poetry; he gropes for it in a round about way through the process of overcoming death. In the earlier poetry, he attempts to come to terms with death on the basis of "the principle of Process," identifying death with life. As a result, a single force which is creative and destructive as the same time unifies the poet with the natural environment. Therefore, the earlier poetry can be said to register the regularity of destructive and creative force; pulsation, systole and diastole, inhalation and exhalation. but in the later poetry, he tries to come to terms with death through the energetic love and belief; love and belief becomes agents subduing the conflict between poetic vision and realistic awareness. This is the reason why poetic energy becomes condensed on the image of love and belief; why it becomes visible as suddenly as an open artery.

      • KCI우수등재
      • KCI등재
      • β-Adrenalin 作用藥物이 水利尿에 미치는 影響

        李世圭,洪淳國 고려대학교 의과대학 1977 고려대 의대 잡지 Vol.14 No.1

        The infusion of isoproterenol has been shown to decrease urine volume and free water clearance without altering glomerular filtration rate and without altering or moderately increasing renal plasma flow. It was reported that isoproterenol increase water permeability on toad bladder by similar action of antidiuretic hormone. Recent findings that increased water permeability induced by isoproterenol was inhibited by propranolol, but not by antidiuretic hormone indicate that renal beta adrenergic receptors mediate the increase of water permeability induced by isoproterenol. It was well recognized that norepinephrine, the principal endogenous alpha adrenergic agent, produces constriction of renal arteries and vasa recta. It was also showed that in kidneys vasodilated with acetylcholine infusion of norepinephrine caused natriuresis while on the opposite, nonvasodilated kidney, sodium excretion decreased. Constriction of vasa recta reserve the medullary osmotic gradient and renal concentrating ability, on the contrary dilation of vasa recta abolish the medullary osmotic gradient and renal concentrating ability. The present study was designed to examine the effects of isoproterenol on renal function in the rabbit and to determine if these effects are related to changes in renal hemodynamics. On experiments 20 rabbits were infused with 2.5% dextrose solution until water diuresis were maintained and thereafter simultaneous administration of isuprel (0.1㎍/㎏/min), and then isuprel (0.1㎍/㎏/min) plus noradrenalin (0.5㎍/㎏/min) were performed. During experiments urine volume, C_(IN), Cosm, C_(H2O), sodium excretion and C_(PAH), E_(PAH), RPF, FF, NCPF were measured for four consecutive specimens every twenty minutes intervals. The results were as follows: 1) Total renal plasma flow, cortical plasma flow, filtration fraction and medullary plasma flow were not altered by administration of water, isuprel and noradrenalin. 2) Water diuresis was inhibited by isuprel, while isuprel antidiuresis was inhibited by noradrenalin. 3) Glomerular filtration rate, osmolar clearance and sodium excretion were not altered by water loading, isuprel and noradrenalin.

      • 향정신성약물(向精神性藥物)이 뇌(腦) amine 함량(含量) 변동(變動)에 미치는 영향(影響)(제 1 보고)(第 1 報告)

        이세규,김혜성,Lee, Se-Kyu,Kim, Hei-Sung 대한약리학회 1970 대한약리학잡지 Vol.6 No.1

        The present study is concerned with the demonstration of the relationship between the behavior and the brain concentration of noradrenaline resulted from pretreatment of amphetamine in isolated or aggregated rats. The experimental subjects were rats weighing from 120g to 200g housed 1, 2, and 6 in a cage. Analeptic activity of amphetamine was measured by determining the sleeping time induced by pentobarbital sod. The noradrenaline content in brain was determined with Aminco-Bowmann's spectro-photofluorometer by Lee's modification of Shore and Olin method. Results: 1) The analeptic activity of amphetamine on the sleeping time induced by pentobarbital sod. was more increased in the grouped rats than in isolated animal. 2) In being isolated and grouped rats, the sleeping time induced pentobarital sod, was markedly prolonged by pretreatment of amphetamine. 3) Means of housing rats, e.g., isolation or aggregation did not seem to affect the brain noradrenaline depleting action. 4) Repeated daily parenteral administration of amphetamine sulfate for a period 1 to 3 weeks resulted in decrement of brain noradrenaline concentration in being isolated and grouped rats. 5) The prolongation of sleeping time of the isolated or aggregated rats, when pretreated with amphetamine, compared with that of stock rats, seems to be attributable rather to the means of housing than the variation of the noradrenaline caused by amphetamine.

      • KCI등재

        최근 10년간 1,500 g이하 극소 저출생 체중아의 신경학적 위험 요인 및 예후 변화에 관하여

        이세규,이지현,이상길 대한소아청소년과학회 2006 Clinical and Experimental Pediatrics (CEP) Vol.49 No.10

        Purpose : As a result of advances in neonatal intensive care and perinatal care, neurodevelopmental outcomes of very low birth weight infant(VLBWIS) is expected to lead to improvement. The aim of this study was to report neurodevelopmental outcomes and risk factors of neurologic impairment of very low birth weight infants during the past 10 years. Method : We performed a retrospective study of 447 newborn infants below 1,500 gm admitted to neonatal intensive care unit of Taegu Fatima Hospital between Janury 1996 and December 2004. Infants were subdivided into group 1(Jan. 1996 to Dec. 1998), group 2(Jan. 1999 to Dec. 2001), and group3(Jan. 2002 to Dec. 2004). We analyzed epidemiologic data to study changes of neurodevelopmental outcomes and risk factors of neurologic impairment. Result : The incidence of cerebral palsy and developmental delay decreased significantly in periods 2 and 3(vs period 1; cerebral palsy 10 percent, developmental delay; 18 percent, P<0.05). Periventricular leukomalacia incidence decreased in period 3(vs period 1; 14.5 percent, P<0.05). The overall survival rate of VLBWIS increased significantly in period 2 and 3(vs period 1; 90.0 percent, P<0.05). The risk factors of neurologic impairment are long-term ventilator care(above 1 wk), low Apgar score, low gestational age and low birth weight. Conclusion : In the most recent 10 years, neurologic impairments of VLBWIS significantly decreased, as a result of advances in neonatal intensive care and perinatal care. 목 적 : 최근 신생아 집중 치료술과 산전 진료의 발달로 1,500 g 미만의 극소 저출생 체중아의 신경학적 장애가 감소하였다. 이와 같은 치료 성적의 향상은 산전 관리 및 인공 호흡기 치료를 포함한 집중 치료술의 발전과 연관이 있을 것으로 생각된다. 극소 저출생 체중아에서의 신경학적 합병증의 변화 양상과 이에 영향을 미치는 위험 요인에 대해 알아보고자 본 연구를 시행하였다. 방 법 : 1996년 1월부터 2004년 12월까지 본원 신생아실에 입원한 1,500 g 미만의 극소 저출생 체중아 447례 대상으로 병력지를 이용하여 후향적 조사를 시행하였다. 1996년부터 2004년까지 각각 3년 단위로 병력지를 이용하여 후향적 조사를 시행하였다. 1996년부터 1998년까지를 1기, 1999년부터 2001년까지를 2기, 2002년부터 2004년까지를 3기로 나누어 생후 1년간 신경학적 합병증, 특히 뇌성마비와 발달 장애의 빈도 변화를 확인하였다. 그리고 기간별 영상진단 결과의 변화 양상을 비교하였으며 이러한 신경학적 합병증에 영향을 미치는 위험 요인들에 대해서 알아보았다. 결 과 : 1기에서 뇌성마비와 발달 장애로 확인된 환아는 각각 12명(10.2%), 21명(17.9%) 2기에서는 각각 5명(4.0%), 11명(8.8 %) 3기에서는 5명(3.6%), 12명(8.6%)로 통계학적으로 유의하게 감소하였다. 최근 10년간 영상소견상 IVH grade Ⅲ 이상은 1기, 2기, 3기 각각 10명(8.5%), 9명(7.2%), 9명(6.5%)으로 통계학적으로 유의성은 없었으나, 뇌실주위 백질연화증은 각각 17명(14.5%), 20명(16.0%), 10명(7.2%)로 3기에서 1기에 비해 유의하게 감소하였다(P<0.05). 최근 3년간의 생존율은 각 기간에서 90.0%, 96.1%, 97.1%로 2기, 3기에서 1기에 비해 유의하게 생존율이 향상되었다. 영상 소견상 뇌성마비 및 발달 장애가 있었던 군의 84%에서 grade Ⅲ 이상의 뇌실내 출혈, 뇌실주위 백질연화증 또는 수두증이 관찰되었다. 뇌성마비 및 발달 장애에 영향을 주는 위험 요인으로는 1주일 이상 인공 호흡기 치료를 받은 군, 낮은 Apgar 점수, 재태 연령 및 출생 체중이 중요한 위험 요인으로 생각되었다. 결 론 : 최근 10년간 신생아 집중치료술과 산전 진료의 발전으로 극소 저출생 체중아의 신경학적 장애가 유의하게 감소하였으며 신경학적 예후에 영향을 주는 요인으로는 인공 호흡기 치료와 Apgar 점수, 재태 연령 및 출생 체중이 중요할 것으로 생각된다.

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