이민혁

이민혁 충북연구원 2009 앞,뒤 바라보다 Vol.- No.1

[Letter] 편집자로부터의 편지

이민혁 대한종양외과학회 2008 KSCO News&Education Vol.5 No.-

In vivo 및 in vitro 시험을 통한 페그마타이트의 항염증 효과

이민혁,김석권,권용석,이장호,이근철 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.1

Purpose: This work aimed to elucidate the anti-inflammatory effect of pegmatite in vitro and in vivo. Methods: Author evaluated the suppressive effects of pegmatite on lipopolysaccharide(LPS)-stimulated nitric oxide(NO) production, TNF-α and IL-6 release in the RAW 264.7 murine macrophages. Results: Treatment of RAW 264.7 cells with pegmatite significantly reduced LPS-stimulated NO production and inflammatory cytokine such as TNF-α and IL-6 secretion in a concentration-dependent manner. Also pegmatite showed topical anti-inflammatory activity in the arachidonic acid(AA)-induced ear edema and acetic acid-induced increase in capillary permeability assessment in mice. It was also found that pegmatite(10mg per ear in DW) inhibited arachidonic acid induced edema at 24 h more profoundly than 1h by topical application. Furthermore, the vascular permeability increase induced by acetic acid was significantly reduced in mice that received pegmatite in 50mg per mouse. Received February 3, 2009Revised June 9, 2009Accepted August 26, 2009Address Correspondence: Keun Cheol Lee, M.D., Ph.D., Department of Plastic & Reconstructive Surgery, College of Medicine Dong-A University, 1, 3ga, Dongdaesin-dong, Seo-gu, Busan 602-715, Korea. Tel: 051)240-2968/Fax: 051)243-5416/E-mail: pokdungi@dau.ac.kr Conclusion: Therefore the results of the present study suggest that pegmatite is a potent inhibitor of the LPS- induced NO and inflammatory cytokine in RAW 264.7 macrophages and showed anti-inflammatory activities in vivo animal model.

상악동 전벽을 이용한 안와결손의 재건

이민혁,이근철,박정민,김정태,김석권 대한성형외과학회 2002 Archives of Plastic Surgery Vol.29 No.2

Generally, blow out fractures have been operated using commercial materials such as silicone sheet, titanium mesh plate and Medpor(porous polyethylene sheet). However, it is thought that the autogenous bone graft is better,in consideration of infection, foreign body sensation, protrusion of inserted materials, and displacement. We have operated blow out fractures with or without Medpor or mesh plate in pure blow out fractures and have repaired orbital wall defect with “anterior wall of maxillary antrum” in case of impure ones associated with maxillary fracture. From January 1997 to July 2001, 93 patients were operated using the artificial or autogenous material and 11 of them using maxillary antral wall. The fragment of anterior antral wall which had been previously fractured was trimmed with saw and burr and inserted over the defect. The follow-up period ranges from 3 months to 3 years, and the results were satisfactory without complications. The postoperative orbital CT scannig showed that the bone graft was well attached. In repairing orbital wall defect with antral wall, we obtained satisfactory results without complications such as infection, foreign body sensation, pain, protrusion displacement, depression and sinusitis.

책임의 근거로서 목적론에 관한 비판적 고찰

이민혁 대한철학회 2023 哲學硏究 Vol.168 No.-

책임의 범위를 확대하고자 하는 근래의 시도들은 인간과 유사한 인간 아닌 존재들의 특성에 기반하여 자신의 이론을 전개한다. 목적론 역시 인간과 인간 아닌 존재들이 공통적으로 지니는 목적성에 기반하는 것으로 볼 수 있다. 이러한 목적론에 기반하여 인간 이외의 존재들에 대한 책임을 주장하는 사상가로는 한스 요나스가 있다. 아리스토텔레스의 영향을 받은 요나스의 목적론은 생명, 자연, 미래 세대의 목적성에 근거하여 그들에 대한 책임을 주장하는 것으로 볼 수 있다. 하지만 요나스의 목적론과 이에 근거한 책임은 자연주의적 오류, 목적성의 입증 등 몇 가지 이론적인 한계를 지닌다. 이러한 요나스의 한계를 극복하는 것으로 볼 수 있는 목적론에는 폴 테일러의 목적론이 있다. 그렇지만 그의 이론 역시 몇 가지 한계를 지니며, 이는 책임의 범주를 확장하려는 목적론이 극복해야 할 난점과 연결된다. 특히 최근 새롭게 등장한 합성생물학이 제기하는 문제는 목적론에 근거하여 책임의 범위를 확장하려는 시도를 어렵게 할 것으로 보인다. 결론적으로 목적론은 과학이 제기하는 문제를 이론적으로 해결할 수 있어야 책임의 근거로서 기능할 수 있다. Recent attempts to expand the scope of responsibility develop their theories based on the characteristics of non-human beings that are similar to humans. It can also be seen that teleology is based on the purpose that humans and non-human beings have in common. Hans Jonas is a thinker who claims responsibility for beings other than humans based on this teleology. Jonas' teleology, influenced by Aristotle, can be seen as claiming responsibility for them based on life, nature, and future generations based on their purposiveness. However, Jonas' teleology and responsibility based on it have several theoretical limitations, such as naturalistic fallacy and proof of purposiveness. The teleology of Paul Taylor's is one that can be seen as overcoming Jonas' limitations. However, his theory also has several limitations, which are linked to the difficulties that teleology to expand the category of responsibility must overcome. In particular, the problems posed by the newly emerging synthetic biology are expected to make it difficult to attempt to expand the scope of responsibility based on teleology. In conclusion, teleology can function as a basis for responsibility only when it can theoretically solve the problems posed by science.

비교정술후 장기적 결과 및 만족도에 관한 분석

이민혁,이근철,박정민,김정태,김석권 대한성형외과학회 2002 Archives of Plastic Surgery Vol.29 No.5

Since the nose is the most prominent and impressive part in the face, plastic surgeons try to make an ideal nose. Thus, plastic surgeons can aid patients to make significant psychosocial changes in their lives. 104 of 132 patients who received corrective rhinoplasty were requested to answer the study designed to assess their satisfaction and psychological reactions to the operation. Preoperatively, patients filled out a questionnaire about their expectations, relationships, self-confidence, self-esteem, and so on. Postoperatively, they completed a similar questionnaire. Preoperative and postoperative information was also obtained from the surgeons and nurses. 81% of the patients expected that rhinoplasty would change their lives. And 96% of the patients were satisfied with the results. The surgeons were usually more critical about the surgical results than the patients. A number of patients had increased self-confidence and self-esteem.These findings would be useful in understanding of postoperative satisfaction and psychological reactions after corrective rhinoplasties.

건강한 한국여성에서의 혈청 HER-2/neu 참고치 설정

이민혁 한국유방암학회 2006 Journal of breast cancer Vol.9 No.4

Purpose: HER-2/neu oncogene is known to play a part in the process of carcinogenesis, while the biological characteristics of HER-2/neu oncoprotein include regulating cell growth and increasing the reproductionability of a tumor. The extracelluar domain (ECD), whose molecular weight is between 95 and 105 kD among the HER-2/neu oncoprotein structures, is proteolyzed and separated from the cell surface by metalloproteases and goes into the blood stream where it starts circulation. Since monoclonal antibody was developed for the serum HER-2/neu ECD, it’s now possible to measure HER-2/neu ECD in the serum with the immunoassay method. The measurement of serum HER-2/neu ECD is used for prognosis of metastatic breast cancer and for testing the treating effect of trastuzumab (Herceptin ), a target agent for the patients positive to the HER-2/neu receptor. In Korea there is no report on the accurate reference range of serum HER-2/neu for healthy women. The purposes of this study were to measure the serum HER-2/neu ECD in healthy Korean women, analyze the reference range. Methods: The subjects of the study include 200 healthy Korean women with 50 from each in their twenties, thirties, forties, and fifties. As for methodology, the HER-2/neu in the serum separated from their blood was measured. The serum HER-2/neu level was measured quantitatively with the recently developed ADVIA Centaur automated immunoassay analyzer and ADVIA Centaur HER-2/neu assay reagent. With the measurement, you can use the sandwich immunoassay and direct chemiluminescence technique for two monoclonal antibodies for the epitopes located in the serum HER-2/neu ECD. The reference ranges were calculated based on the mean 2 SD. Results: One of the 200 healthy subjects was excluded from analysis for having the highest value of serum HER-2/neu (23.1 ng/ml), and the data of total 199 were used for analysis. The analysis results indicated that the minimum value was 3.5 ng/mL, the maximum value 14.5 ng/mL, the mean 8.6 ng/mL, average 8.77 ng/mL, and SD 1.61 ng/mL. The reference range of the 199 subjects’ serum HER-2/neu measurements was calculated by the mean 2 SD. Since the mean SD of their HER-2/neu measurements was 8.8 1.6 ng/mL, the reference range was 5.6~12.0 ng/mL. The reference ranges for the age groups were 6.1~10.9 ng/mL, 5.3~11.4 ng/mL, 5.0~12.6 ng/mL and 6.3~12.6 ng/mL for the twenties, thirties, forties and fifties, respectively. The reference ranges for the age groups were analyzed statistically and there was statistical difference (p= 0.002) between fifties and twenties or thirties. The upper limit level of the reference range of serum HER-2/neu in healthy Korean women was 12.0 ng/mL. Conclusion: The results suggest that the reference range of serum HER-2/neu in healthy Korean women is 6.1~10.9 ng/mL, 5.3~11.4 ng/mL, 5.0~12.6 ng/mL and 6.3~12.6 ng/mL for the twenties, thirties, forties, and fifties, respectively. There is no significant difference between the twenties, thirties, forties, each other. According to analyzed statistically, there is difference between fifties and twenties or thirties (p=0.002), but there is no statistically significant difference between forties and fifties.

New record of subfamily Prometopinae (Coleoptera: Cucujoidea: Nitidulidae) in Korea

이민혁,이승현,이승환 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.1

The subfamily Prometopinae Böving and Craighead, 1931 is recorded from Korea for the first time. Two speciesfrom different genera are recognized; Prometopia unidentata Hisamatsu, 1959 and Paramatopia x-rubrum Reitter,1884. Morphological comments, biology, illustrations of habitus with genitalia of both sexes and a key to speciesfrom Korea are provided.

Four new record genera of subfamily Nitidulinae (Coleoptera: Nitidulidae) in Korea

이민혁,Seung-Hwan Lee 국립중앙과학관 2020 Journal of Asia-Pacific Biodiversity Vol.13 No.2

Four genera of subfamily Nitidulinae: (Nitidula Fabricius, 1775, Hebasculinus Kirejtshuk, 1992, StelidotaErichson, 1843, and Xenostrongylus Wollaston, 1854) are recorded from Korea for the first time each withone species, respectively: Nitidula rufipes (Linnaeus, 1767), Hebasculinus japonus (Reitter, 1877a), Stelidotamultiguttata Reitter, 1877b, and Xenostrongylus variegatus Fairmaire, 1891. Morphological redescriptions,biological comments, and illustrations of habitus and genitalia of both sexes are provided.

A Comparison of Two-stage Penalized Regression Approaches for Estimating Directed Graphs

이민혁,태동현,석준희,한성원 대한산업공학회 2016 대한산업공학회 추계학술대회논문집 Vol.2016 No.11