순위 비교를 기반으로 하는 다양한 유전자 개수로 이루어진 암 분류 결정 규칙의 생성

윤영미,변상재,박상현,Yoon, Young-Mi,Bien, Sang-Jay,Park, Sang-Hyun 한국정보처리학회 2008 정보처리학회논문지D Vol.15 No.6

마이크로어레이 기술은 최근 실험적 분자생물학 분야에서 활발히 사용되고 있는 기술이다. 마이크로어레이 데이터는 한 번의 실험으로 수 만개의 유전자에 대한 발현값을 얻을 수 있으므로, 여러 질병의 발현형질을 연구하는데 매우 유용하게 사용된다. 마이크로어레이 데이터의 문제점은 참여하는 유전자의 수에 비해 참여하는 샘플(생물조직샘플)의 수가 매우 적고, 분류분석 기법을 사용하여 얻어진 분류자의 해석이 어렵다는 점이다. 본 연구에서는 위의 문제점을 해결하고자, 샘플 내 순위를 이용하여 동일한 생물학적 목적으로 수행된 공개 마이크로어레이 데이터를 통합하고, 순위 비교를 기반으로 하는 다양한 유전자 개수로 이루어진 암 분류 결정 규칙들로 이루어진 분류자를 제안한다. 본 분류자는 k개의 규칙으로 이루어진 앙상블 방법을 기반으로 하며, 하나의 규칙은 최대N개의 유전자, 관련유전자간의 순위비교 관계식, 판별클래스로 이루어져 있다. 하나의 규칙에 참여하는 유전자의 수를 다양하게 함으로써 좀더 신뢰성 높은 분류자를 생성할 수 있다. 또한 본 분류자는 생물학적 해석이용이하며, 분류자를 구성하는 유전자를 명확히 식별할 수 있고, 총 개수가 많지 않으므로 임상환경에서의 사용가능성도 생각해 볼 수 있다. Microarray technology is extensively being used in experimental molecular biology field. Microarray experiments generate quantitative expression measurements for thousands of genes simultaneously, which is useful for the phenotype classification of many diseases. One of the two major problems in microarray data classification is that the number of genes exceeds the number of tissue samples. The other problem is that current methods generate classifiers that are accurate but difficult to interpret. Our paper addresses these two problems. We performed a direct integration of individual microarrays with same biological objectives by transforming an expression value into a rank value within a sample and generated rank-comparison decision rules with variable number of genes for cancer classification. Our classifier is an ensemble method which has k top scoring decision rules. Each rule contains a number of genes, a relationship among involved genes, and a class label. Current classifiers which are also ensemble methods consist of k top scoring decision rules. However these classifiers fix the number of genes in each rule as a pair or a triple. In this paper we generalized the number of genes involved in each rule. The number of genes in each rule is in the range of 2 to N respectively. Generalizing the number of genes increases the robustness and the reliability of the classifier for the class prediction of an independent sample. Also our classifier is readily interpretable, accurate with small number of genes, and shed a possibility of the use in a clinical setting.

청소년의 생의 의미에 영향을 미치는 요인

윤영미,조헌하,Yoon, Young-Mi,Cho, Hun-Ha 한국아동간호학회 2011 Child Health Nursing Research Vol.22 No.4

Purpose: The purpose of this study was to analyze factors affecting meaning of life in adolescents. Methods: Data were collected from April 5 to June 20, 2010. The participants for this study were 343 Korean middle and high school students, recruited from four middle and high schools located in Seoul. Data collection was conducted through the use of 7 questionnaires. The data were analyzed with the SPSS WIN 12.0 program using descriptive statistics, ANOVA, Pearson correlation coefficients and stepwise multiple regression. Results: 1) The mean total item score for the meaning of life scales was 2.99, which was slightly high. 2) There was a significant relationship between meaning of life and self-esteem, self control, parenting attitude, family satisfaction, school adjustment, and career maturity. 3) Stepwise multiple regression analysis showed that self-esteem, family satisfaction, school adjustment, parenting attitude and career maturity were predictors of meaning of life and accounted for 57.1% of the variance in meaning of life. Conclusion: Self-esteem, family satisfaction, school adjustment, parenting attitude and career maturity were variables influencing meaning of life in adolescents. These results indicate a need to develop nursing interventions to increase self-esteem, family satisfaction, school adjustment, parenting attitude and career maturity in order to improve meaning of life for adolescents.

이메일 방식을 사용한 멀티미디어 웹 설문지 관리 시스템

윤영미(Young-Mi Yoon),곽미라(Mi-Ra Kwak),조동섭(Dong-Sub Cho) 대한전기학회 2002 대한전기학회 학술대회 논문집 Vol.2002 No.7

초 · 중 · 고등학생의 집단따돌림 경향분석

윤영미(Yoon, Young Mi) 한국보건간호학회 2007 韓國保健看護學會誌 Vol.21 No.2

토픽 모델링을 활용한 COVID-19 발생 전후 간호사 관련 토픽 비교: 인터넷 포털과 소셜미디어를 중심으로

윤영미(Yoon, Young Mi),김성광(Kim, Seong Kwang),김혜경(Kim, Hye Kyeong),김은주(Kim, Eun Joo),정윤의(Jeong, Yuneui) 대한근관절건강학회 2020 근관절건강학회지 Vol.27 No.3

Purpose: The purpose of this study is to compare topics through keywords related to nurses in internet portals and social media Pre coronavirus disease (COVID-19) era and during the COVID-19 era. Methods: For six months before and during the outbreak of COVID-19 in Korea, nurse was searched on the internet. For data collection, we implemented web crawlers in programming languages such as Python and collected keywords. The keywords collected were classified into three domains of topic Modeling. Results: The keyword nurse increased by 15% during COVID-19 era. Keywords that ranked high in Term Frequency - Inverse Document Frequency (TF-IDF) values were before COVID-19, such as nurse and C-section. during COVID-19, however, they were not only nurse but also emergency and gown related to pandemics. Conclusion: Various topics were being uploaded into the internet media. Nursing professionals should be interested in the text that is revealed in the internet media and try to continuously identify and improve problems.

지역아동센터 레크레이션 활동 참여에 따른 아동의 일상적 정서경험과 우울 및 스트레스

윤영미(Yoon, Young Mee),이완정(Lee Wan Jeong) 한국생활과학회 2008 한국생활과학회지 Vol.17 No.5

흰 코뿔소 배설물로부터 분리한 Bacillus pumilus H10-1의 Xylanase 활성

윤영미(Young Mi Yoon),안기홍(Gi Hong An),김중곤(Jung Kon Kim),안승현(Seung-Hyun Ahn),차영록(Young-Lok Cha),양정우(Jungwoo Yang),유경단(Kyeong-Dan Yu),문윤호(Youn-Ho Moon),안종웅(Jong-Woong Ahn),구본철(Bon-Cheol Koo),최인후(In-Hoo Cho 한국생물공학회 2014 KSBB Journal Vol.29 No.5

Xylanase have been used to convert the polymetric xylan into fermentable sugars from the production of ethanol and xylitol from plant biomass. The aim of this study was to isolate and identify xylanolytic bacterium from herbivore feces and was to used the xylanase for enzymatic hydrolysis of biomass. Xylanolytic strains were isolated from 59 different feces of herbivores from Seoul Grand Park located in Gwacheon Gyeonggi-do. The xylanolytic strains were selected by congo red staining and DNS method. Total 67 strains isolated from the herbivores feces were tested for xylanase activity. Among the strains, H10-1, which has the highest xylanase activity, was isolated from feces of Ceratotherium simum. The H10-1 strain was identified as Bacillus pumilus based on its morphological/biochemical characteristics and partial 16S rDNA gene sequences. Culture conditions of B. pumilus H10- 1 such as initial medium pH, incubation temperature and incubation time were optimized for maximum xylanase production. And also xylanase produced by B. pumilus H10-1 was applied for the saccharification of Miscanthus sacchariflorus cv. ‘Geodae 1’, which was pretreated with 1.5M NaOH. The optimized culture conditions of B. pumilus H10-1 were pH 9, 30oC incubation temperature, and 7 day incubation time, respectively. This xylanase activity under the optimized conditions was 20.4±3.3 IU. The crude xylanase produced by B. pumilus H10-1 was used for the saccharification of xylan derived from pretreated ‘Geodae 1’. The saccharification conditions were 50℃, 200 rpm, and 5 days. Saccharification efficiency of pretreated ‘Geodae 1’ by B. pumilus H10-1 was 8.2%.

증례보고 : 비영양적 빨기습관으로 인한 부정교합의 치험례

윤영미 ( Young Mi Yoon ) , 이상호 ( Sang Ho Lee ) , 이난영 ( Nan Young Lee ) , 김진수 ( Jin Soo Kim ) 조선대학교 구강생물학연구소 2009 Oral Biology Research (Oral Biol Res) Vol.33 No.3

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미술치료를 통한 조현병 청년의 정체성에 대한 내러티브 탐구

윤영미(Yoon, Young-Mi),전순영(Chun, Soon-Young) 한국미술치료학회 2021 美術治療硏究 Vol.28 No.6

본 연구는 조현병 청년이 미술치료를 통해 경험한 삶에서 정체성을 중심으로 깊이 있게 살펴봄으로써, 참여자가 무엇을 경험하며 어떤 의미를 주는지 탐구하는데 그 목적이 있다. 그 과정에서 나타난 조현병 청년의 경험과 의미를 내러티브 방법으로 탐구하고자 하였다. 연구대상은 발병한지 6년 이상으로 조현병을 진단받은 27세 청년이다. 연구 기간은 2020년 7월부터 9월까지이며, 일주일에 2번 90~120분씩 총 20회기에 걸쳐 미술치료를 실시하였다. 재구성된 경험 이야기는 조현병 청년 자신의 정체성을 찾기 위한 큰 시간적 흐름에 따라 ‘관심 종자 같은 느낌’, ‘조현병과 우연한 조우’, ‘과거로의 여행’, ‘삶의 의미 있는 선택’로 구성되어 있다. 이를 바탕으로 조현병 청년의 미술치료를 통해서 자신의 정체성을 찾기 위한 경험의 의미는 ‘치유관계에서 편안하고 안전한 관계로 전환’, ‘사랑과 고뇌를 작품으로 승화’, ‘작품 속에서 나의 삶을 이해’, ‘미래로 향하는 길에서 꿈과 희망’이다. 이상의 결과를 통해서 볼 때 인생에서 가장 중요한 청년의 시기에 조현병으로 인한 불안과 두려움 속에서도 미술치료는 자기이해와 자기수용의 자기 재구성(self reconstruction)으로 성장의 기회가 되었고, 자신의 삶을 주체적으로 살아갈 수 있도록 도움을 주었다. 이러한 연구 결과를 바탕으로 본 연구의 의의와 제한점에 대하여 논의 하였다. The subject was a 27-year-old male diagnosed with schizophrenia more than 6 years ago. The subject is on medication after in-patient treatment in a closed psychiatric ward in city A. Twice-weekly art therapy sessions were conducted from July 2020 to September 2020 for a total of 20 sessions of 90 to 120 minutes each. “Feeling Like Being an Attention Seeker,” “a Chance Encounter with Schizophrenia,” “A Trip to the Past,” and “A Meaningful Choice in Life” were the parts of the subject’s reconstructed life story as he strove to find his identity over time. Through art therapy, several themes were identified to give meaning to his experiences of finding his own identity. These themes included “Transition from a Therapist-Patient Relationship to a Comfortable and Safe Relationship,” “Transforming Love and Anguish into Work,” “Understanding my Life in the Work,” and “Dream and Hope Met on the Road to the Future.” For the subject, art therapy became an opportunity for growth through self-reconstruction, which consists of self-understanding and self-acceptance despite his medical condition, which generates anxiety and fear during an important period in his life. Art therapy has also helped the subject to live an independent life. Based on these results, the implications and limitations of this study are discussed.

학령전기 아동의 시력건강증진 프로그램 효과

윤영미(Yoon, Young Mi) 한국간호교육학회 2006 한국간호교육학회지 Vol.12 No.2