각막상피제거술 후 흰쥐의 각막과 눈물샘에서의 신경성장인자의 변화

신혜영,양지욱,이영춘,김수영,Hye Young Shin,Ji Wook Yang,Young Chun Lee,Su Young Kim 대한안과학회 2011 대한안과학회지 Vol.52 No.5

Purpose: To evaluate the expression of nerve growth factor (NGF) in the rat cornea and lacrimal gland before and after corneal epithelial wounding. Methods: Twenty-nine Sprague-Dawley male rats were used in the present study. Corneal trephination was performed using a 4.0-mm diameter trephine before scratch and at 24, 48, 72 hours after debridement. The lacrimal gland was excised before scratch and at 24 hours after epithelial debridement. NGF levels of the excised cornea and lacrimal gland were measured in rat corneas by enzyme-linked immunosorbent assay (ELISA). Immunohistochemistry staining was performed on rat corneas and lacrimal glands. Results: The NGF/total protein ratio (NGF/tP) increased after wounding in the cornea and lacrimal gland. NGF levels in the cornea significantly increased in the wounded group until the 2nd day after wounding (p < 0.05). After NGF concentration peaked on the 1st day, there was a progressive decline after wounding. Additionally, the NGF concentration in the lacrimal gland of the wounded group was significantly higher than that of the control group at 24 hours after epithelial debridement (p = 0.001). Immunohistochemistry staining showed that NGF staining was stronger in rat corneas and lacrimal glands after epithelial debridement than before. Conclusions: Expression of NGF increased in rat corneas and lacrimal glands after corneal epithelial wounding, which suggests that NGF may play an important role in corneal wound healing. J Korean Ophthalmol Soc 2011;52(5):597-602

소용량 Vancomycin 주사액 조제방법의 차이에 의한 정확성 비교: 단일희석방법과 이중희석방법

신혜영,서옥경,이숙향,신현택,Shin, Hea Young,Suh, Ok Kyung,Lee, Suk Hyang,Shin, Hyun Taek 한국임상약학회 1997 한국임상약학회지 Vol.7 No.2

This study was to find a more accurate method fur measuring small vancomycin dosages which are commonly used in neonates by comparing single and double dilution method. For single dilution method, 500 mg of vancomycin powder was accurately measured and reconstituted with 5 ml of distilled water to make a concentration of 100 mg/ml. Volumes of 0.05, 0.1, 0.15, 0.2, 0.3, 0.4, and 0.5 ml, which equal the target dosages of 5, 10, 15, 20, 30, 40, and 50 mg, were measured using syringes made by Shina and each sample was further diluted with 2 ml of $5\%$ dextrose. The solution of 100 mg/ml concentration was further diluted with $5\%$ dextrose to make a concentration of 20 mg/ml. Volumes of 0.25, 0.5, 0.75, 1.0, 1.5, 2.0, and 2.5 ml, which correspond to 5, 10, 15, 20, 30, 40, and 50 mg, were sampled by the same Shina's syringe as in single dilution method and then each sample was further diluted to make a total volume of 10 ml. Each sample was analyzed by HPLC. The measured dosages of each sample in both single and double dilution methods were lower than the target dosages; however, e values in double dilution method were higher than those in single dilution method for seven target dosages. Percent target dosages in single dilution method were 65 to $90\%$, while in double dilution method 91 to $94\%$. Statistically significant difference between two groups was shown in 5, 10, 15, 20, and 40 mg dosages (p<0.05). In conclusion, when preparing small vancomycin dosages lower an 20 mg $(volume{\leq}0.2\;ml)$, using Shina's syringes, the double dilution method has a closer value to the target dosage than single dilution method.

2009 개정 교육과정에 따른 교과서에서 이온 화합물의 설명 개념과 모형 및 학생 이해도 분석

신혜영,우애자,Shin, He Young,Woo, Ae Ja 대한화학회 2016 대한화학회지 Vol.60 No.5

이 연구에서는 2009 개정 교육과정에 따른 교과서에서 제시하고 있는 이온 화합물의 설명 개념과 모형을 분석하고, 학생들이 이온 화합물에 대해 어떻게 이해하고 있는지 설문 검사하였다. 교과서 분석은 중학교 과학2 교과서 9종과 고등학교 화학 I과 화학 II 교과서 4종을 대상으로 하였고, 설문 검사는 중학교 2학년, 고등학교 1~3학년 학생 194명을 대상으로 실시하였다. 연구 결과는 다음과 같다. 첫째, 교과서 내용 분석 결과, 이온 화합물을 설명할 때 사용한 과학적 개념과 이를 표현하는 모형은 교과서 마다 차이가 있었다. 이온 화합물의 정의에서는 정전기적 인력, 강한 결합, 규칙적 배열, 결합비의 개념 중 몇 가지를, 이온 화합물의 성질에서는 녹는점, 부서짐, 용해, 전기 전도성 중 몇 가지를 선택적으로 제시하였다. 또한 설명 없이 모형만 제시하거나 설명만 하고 모형은 제시하지 않은 경우도 있었다. 이러한 차이는 중학교 과학2 교과서에서와 같이 이온 화합물에 대한 별도의 성취기준이 없는 경우와 결합비나 용해와 같이 학년별로 동일한 개념을 반복하여 다룰 때 더 크게 나타났다. 둘째, 이온 화합물에 대한 학생 설문 분석 결과, 이온의 형성 과정과 결합비를 설명할 때 과학적 개념을 잘 적용하지 못하였고 모형으로 표현하는 것을 어려워하였다. In this study, ionic compound in the science textbooks developed under the 2009 revised national curriculum were analyzed in terms of the scientific concept and model description and the student understanding through the questionnaires. Analysis of textbooks was performed for science2 of middle school and chemistry I & II of high school. Questionnaire was carried out with 194 students including middle school 2nd grade and high school 1st-3rd grade. The results are as follows: First, as a result of analysis of textbooks, scientific concepts and models used to explain the ionic compound showed differences depending on the types of textbooks. In addition, scientific models were provided with or without explanation for the scientific concepts. Second, analysis of the questionnaire showed that students didn’t properly understood scientific concepts and models in the ion formation, stoichiometric ratio between ions.

마이토마이신을 병용한 치료적 레이저각막절제술을 이용한 라식 후 발생한 상피내생의 치료

신혜영,조경진,김만수,Hye Young Shin,Kyong Jin Cho,Man Soo Kim 대한안과학회 2011 대한안과학회지 Vol.52 No.8

Purpose: To report 2 cases of thick, late-onset and long-standing epithelial ingrowth after laser-assisted in situ keratomilusis (LASIK) using mitomycin C-assisted photorefractive keratectomy and flap suturing. Case summary: The first case involved a 29-year-old woman who had LASIK in both eyes in 2002. She was diagnosed with epithelial ingrowth OD after blunt ocular trauma in 2007. The second case involved a 30-year-old man who had LASIK in both eyes in 1999 followed by enhancements in 2004. Slit lamp examination showed dense epithelial ingrowth OS in a geographic pattern. Two eyes of the 2 patients with epithelial ingrowth had flap lifting followed by debridement of interface epithelial cells, photorefractive keratectomy, interface application of mitomycin C, and the placement of interrupted 10-0 nylon sutures. Two eyes regained better uncorrected visual acuity and showed reduced corneal astigmatism postoperatively. There was no evidence of residual or recurrent ingrowth throughout the follow-up period (case 1: 11 months, case 2: 1 month). Conclusions: Combined mitomycin C-assisted photorefractive keratectomy and flap suturing can be an effective and safe method for treating and preventing the recurrence of thick, late-onset and long-standing epithelial ingrowth involving the visual axis. J Korean Ophthalmol Soc 2011;52(8):984-989

망막중심정맥폐쇄에 동반된 황반부종에서 라니비주맙 주입술의 단기 임상 효과

신혜영,지동현.Hye Young Shin. MD. Dong Hyun Jee. MD 대한안과학회 2011 대한안과학회지 Vol.52 No.9

Purpose: To evaluate the short-term efficacy of intravitreal ranibizumab injection in eyes with macular edema secondary to central retinal vein occlusion (CRVO). Methods: The records of 17 patients (17 eyes, 11 ischemic, six ischemic) who received an intravitreal ranibizumab injection for macular edema secondary to CRVO were retrospectively analyzed. The ophthalmic examination included best corrected visual acuity (BCVA) and central macular thickness (CMT) at baseline and follow-up visits. Results: After intravitreal ranibizumab injection, the mean BCVA improved from log MAR 1.25 ± 0.47 at baseline to log MAR 0.78 ± 0.49 at 4 weeks and to log MAR 0.81 ± 0.52 at 12 weeks (p < 0.05). Additionally, the mean CMT decreased from 679.4 ± 230.5 μm at baseline to 224.4 ± 129.9 μm at 4 weeks and to 271.6 ± 174.1 μm at 12 weeks (<em>p</em> < 0.001). In subgroup analysis, the decreases in CMT at 4 weeks and 12 weeks were similar in ischemic CRVO and non-ischemic CRVO, but no significant changes in visual acuity were found at 12 weeks in the ischemic CRVO group (<em>p</em> = 0.138). Ten eyes (58.8%) did not require re-injections for macular edema for up to 12 weeks. Conclusions: Intravitreal ranibizumab injection appeared to be an effective option for the treatment of macular edema secondary to central retinal vein occlusion. J Korean Ophthalmol Soc 2011;52(9):1048-1054

비트코인 트랜잭션 데이터를 이용한 불법 거래 추적 연구

신혜영(Hye-yeong Shin),맹수훈(SooHoon Maeng),김정연(Jungyeon Kim),김애리(Aeri Kim),박세진,주홍택(Hongtaek Ju) 한국정보과학회 2021 한국정보과학회 학술발표논문집 Vol.2021 No.6

전자책 콘텐츠로서의 멀티동화 현황과 발전방안에 대한 연구

신혜영(Hei Young Shin) 한국디자인문화학회 2004 한국디자인문화학회지 Vol.10 No.4

This study was aimed at reviewing the conditions and development of the multi fairy tales as contents of the electronic books. In order to construct a stable market for the rapidly growing multi fairy tale industry at its initial stage, it is necessary to improve its revenue/expenditure structure, produce perfect works and differentiate the multi fairy tales as the independent genre of electronic books. The problems of the multi fairy tales may be presented as poor profits and imperfect productions. These two problems seem to be inter-related with each other. In this regard, the reform measures for promotion of the multi fairy tales may be suggested as follows; First, it is required to positively support the multi fairy tale businesses suffering from financial problems. Second, it is necessary for our multi fairy businesses to transfer their production systems to such nations supplying cheap labor forces as China and Southeast Asian nations to save the production costs. Third, in order to create added values effectively, it is necessary to introduce the `OSMU` marketing technique which allows for systematic planning, marketing and distribution. Fourth, it is also necessary to make use of the domestic professionals to produce diverse and perfect multi fairy tales. In short, if the multi fairy tale markets should be promoted, the adults` electronic book markets will soon be activated.

20대 여성 대상 안티에이징 담론 분석-영패션잡지『쎄씨(Ceci)』를 중심으로-

신혜영 ( Hyeyoung Shin ),안진현 ( Jinhyun Ahn ),하지수 ( Jisoo Ha ) 한국의류학회 2017 한국의류학회지 Vol.41 No.4

With the increasing media representation of aging as negative and abnormal, anti-aging products and discourses are spreading to younger generations. This paper analyzes the anti-aging discourse in a fashion magazine targeted towards women in their 20s. It quantitatively analyzes the historical development of the antiaging industry and discourses from 1994 to 2014 in the magazine『Ceci』. It also analyzes the patterns of signification associated with aging in the magazine through the use of critical discourse analysis. This paper identifies five major discourses -“segmentation of the definitions of youthful appearance”, “scientific and medical discourse”, “self-care discourse”, “prevention of aging”, and “social values of youthful appearances”. The paper finds that the construction of anti-aging discourses towards women in their 20s is heavily influenced by the close link between the anti-aging industry and the fashion media. It also confirms the ideology of self-development though a rigorous appearance-management that is strongly imposed on Korean women and subsequently reproduced in an anti-aging discourse towards women in their 20s.

한국 미술생산장의 구조 변동 연구

신혜영(Hyeyoung Shin) 현대미술사학회 2018 현대미술사연구 Vol.0 No.43

본 논문은 현대미술 성립부터 현재에 이르기까지 한국 미술생산장의 구조적 변동을 사회적 맥락과 연결하여 파악하고자 한다. 장의 변동을 행위자들의‘ 상징투쟁’과 관련한 주요 쟁점을 중심으로 살펴보았다. 상징투쟁에 관한 이해를 위해, 현대미술의 성립 및 발전 단계에서 국가적 영향력 하에 추상 중심의 모더니즘이 득세하게 되는 과정과 1980년대 후반 이후 민중미술이 비평과 매개를 통해 장 내에서 위치를 정립해가는 사례를 살펴보았다. 본 논문의 주된 논의 대상이 되는 동시대 미술생산장으로 이행 시기인 1990년대 이후에는 예술 실천이 특정한 미술 사조에 따라 집단화되어 나타난 이전 시대와 달리 개별 예술가 중심으로 이루어지는 것을 주된 특징으로 보았고, 그 원인을 제도의 확충으로 파악하였다. 국가정책과 경제자본의 영향력 하에 변화된 제도들을 살펴보고, 1990년대 후반 새롭게 등장한 대안공간과 창작스튜디오의 역할을 중심으로 예술가들이 어떠한 궤적을 따라 미술계 내에서 위치를 정립해 가는가를 주요 제도 간 중복 여부를 통해 확인하였다. 한편 2000년대 후반 이후 주요 기성 제도의 역할이 약화되고 장의 구조가 양극화되는 가운데 새롭게 대두된 예술가의 생존 문제와 예술과 노동을 둘러싼 담론을 살피고, 그 연장선상에서 드러난 소규모 협업 활동의 증가 현상에 주목함으로써 현재의 한국 미술생산장의 본질적 문제에 다가가고자 하였다. This paper examines the structural change of the artistic production field in Korea from the establishment of modern art to the present in connection with the social context. I divide the structural change into three parts and focus on the main issues of each part. First, from the 1950s to 1980s, I look at the process of positioning of the abstract art as a mainstream under the national influence in the formation and development of modern art, and also I pay attention to the process of re-evaluation and positioning of Minjoong-misool. Then, in the 1990s and 2000s, it is understood that the art practice is centered on individual artists, unlike the previous period, which was grouped according to a certain art movement, and the causes were identified as expansion of the system. This study reviews the changing institutions and determines the trajectory of taking position of artists in the restricted production field by reviewing the overlap of the major exhibition and award systems. Meanwhile, this paper examines the problem as the artists’ survival and small-scale collaborative activities as the structure of the field has become more polarized since the late 2000s. As a result, I try to reach the essential problem of the current artistic field in Korea.

현장연구 - 구성주의 유아교육과정에서의 투표활동

신혜영(Hae Young Shin) 부산유아교육학회 1993 유아교육논총 Vol.3 No.1

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