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송재욱,오재민,정명균,Song, Jae-Wook,Oh, Jae-Min,Chung, Myung-Kyoon 대한기계학회 2002 大韓機械學會論文集B Vol.26 No.6
The optimal design code of an axial flow pump has been developed to determine geometric and fluid dynamic variables under hydrodynamic as well as mechanical design constraints. The design code includes the optimization of the complete radial distribution of the geometry by determining the coefficients of 2$^{nd}$ order polynomials to represent the three-dimensional geometry. The optimization problem has been formulated with a nonlinear multivariable objective function, maximizing the efficiency and stall margin, while minimizing the net positive suction head required. Calculation of the objective function is based on the mean streamline analysis and through-flow analysis using the present state-of-the-art model. The optimal solution is calculated using the penalty function method in which the genetic optimizer is employed. The optimized efficiency and design variables are presented in this paper as a function of non-dimensional specific speed in the range, 2$\leq$ $n_{s}$ $\leq$10. The results can be used in preliminary design of axial flow pumps.
측뇌실내 Digitalis가 가토 순환기계 기능에 미치는 영향
송재욱,강삼석,우정현 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.2
Influences of intracerebroventricular(icv) ouabain on cardiovascular system and on pressor response to raised intracranial pressure(ICP) were investigated in urethane-anesthetized rabbits. Intravenous(iv) 40㎍/㎏ ouabain did not affect blood pressure of rabbit. Icv ouabain(5, 10, 20㎍/㎏) and digoxin(6.25, 12.5㎍/㎏) produced dose-dependent pressor responses and marked decrease of heart rate. After bilateral vagotomy, the bradycardiac effect of ouabain disappeared, while the pressor effect was significantly potentiated. The ouabain-induced pressor effect was not affected by iv and icv phentolamine or propranolol, and significantly inhibited by icv infusion of lidocaine(0.1㎎/㎏/min) and diazepam(0.025㎎/㎏/min). The pressor response to raised ICP was not affected by iv 40㎍/㎏ ouabain but disappeared by icv 10㎍/㎏ ouabain and 6.25㎍/㎏ digoxin. These data suggest that ouabain causes pressor effect through direct interaction with a site(s) in central nervous system and bradycardiac effect by direct activation of vagal center, and ouabain blocks central sympathetic stimulation by increase of ICP in rabbits.
송재욱,이종후 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.2
Purpose: Molecular testing in non-small cell lung cancer (NSCLC) aids in identifying oncogenic alterations. The aim of this study was to compare the rates of detection of oncogenic alterations and responsiveness to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) according to EGFR mutation status as determined by peptide nucleic acid (PNA) clamping or directsequencing (DS). Materials and Methods: We performed a systematic literature search using MEDLINE, EMBASE, and the Cochrane Central Register. Data from included studies were pooled to yield summary sensitivity, specificity, positive and negative likelihood ratios, diagnosticodds ratio, and receiver operating characteristic curves. A meta-regression analysis was conducted to identify potential sources of heterogeneity between selected studies. Results: We identified 10 studies comprising 924 patients. Oncogenic alterations were detected in 340 of 924 cases (36.8%) with PNA clamping and in 250 of 924 (27.1%) with DS. The pooled sensitivities of PNA clamping and DS were 0.93 [95% confidence interval(CI): 0.90−0.95] and 0.69 (95% CI: 0.64−0.73), respectively. According to meta-regression analysis, none of the covariates were found to be significant sources of heterogeneity. With respect to treatment responses to EGFR-TKIs, there was no significant difference therein between EGFR mutations detected by PNA clamping and DS (53.4% vs. 50.8%; risk ratio, 0.99; 95% CI 0.83−1.19; p=0.874). Conclusion: We demonstrated that PNA clamping has a higher sensitivity than DS for detecting oncogenic alterations in NSCLC. Our findings suggest that PNA clamping is a more useful method for clinical practice.
송재욱,장호원 한국IT서비스학회 2011 한국IT서비스학회 학술대회 논문집 Vol.2011 No.9
본 논문에서는 기업의 사이버보안을 예방,탐지,대응의 3가지 차원으로 이루어진 다차원 적인 개념으로 정의하고, ISO와 OECD의 지수개발원칙에 따라 금융권을 대상으로 사이버보안 지수(composite indicator)를 개발하였다. 각 차원의 측정지표는 Confirmatory Tetrad Analysis (CTA)를 통해 조형지표임을 통계적으로 검중하였다. 또한 세부지표를 종합하는 방법은 다속성의사결정 기법 중에 하나인 PROMETHEE를 사용하였다. 본 연구에서 개발된 지수체계를 실증하기 위해서 금융권의 설문 데이터를 이용해 지수를 산출하고,그 결과에 따라 순위를 부여하였다.