Paclitaxel/Carboplain과 한의 치료를 병행한 원발성 복막암종 환자의 삶의 질 개선에 대한 증례보고

송시연,하수정,박소정,전형준,이연월,조종관,유화승,Song, Si-yeon,Ha, Su-jeong,Park, So-jung,Jeon, Hyung-joon,Lee, Yeon-weol,Cho, Chong-kwan,Yoo, Hwa-seung 대한암한의학회 2018 大韓癌韓醫學會誌 Vol.23 No.2

Objective: The purpose of this study is to report the therapeutic possibility of a primary peritoneal carcinoma (PPC) patient with Traditional Korean Medicine (TKM). Methods: A 37 years old female patient diagnosed with PPC suffered from operation site pain, neck pain, nausea, headache and fatigue after undergoing operation and chemotherapy (Paclitaxel/Carboplain). The patient was treated with acupuncture, pharmacoacupuncture, moxibution and herbal medicine. Laboratory study and National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 5.0 were used to evaluate the safety and adverse events of treatments. The performance status was measured by Eastern Cooperative Oncology Group (ECOG) scale. Results: After treatments, cancer did not show any progression. Related symptoms such as postoperative pain, nausea, fatigue and quality of life have improved. Conclusion: This case study implies that TKM may have therapeutic possibility in treating PPC patient.

체계적 문헌 고찰과 델파이 기법을 활용한 위암의 한약 치료에 관한 한의표준임상진료 지침 개발

송시연,반경태,하수정,박소정,이연월,조종관,조성훈,유화승,Song, Si Yeon,Ban, Kyung-tae,Ha, Su-jeung,Park, So-jung,Lee, Yeon-weol,Cho, Chong-kwan,Cho, Seung-Hun,Yoo, Hwa-Seung 대한암한의학회 2018 大韓癌韓醫學會誌 Vol.23 No.1

Objectives: This study was conducted towards developing guidelines of herbal medicine treatment for gastric cancer. Methods: We performed a systematic review and meta-analysis designed to investigate the efficacy of herbal medicine treatment for gastric cancer on four cancer questions; survival rate, metastasis, immune function, and quality of life. Based on the findings, we utilized a two-round delphi process with panel of 22 experts for their level of agreement. Results: Combined therapy group, herbal medicine treated with chemotherapy, was significantly higher in the 1-year survival rate (RR=1.27, 95% CI: 1.14 to 1.40, P=0.005, $I^2=71%$) and 3-years survival rate (RR=1.41, 95% CI: 1.16 to 1.71, P=0.91, $I^2=0%$) than chemotherapy group. The suppression of metastasis was higher in the combined therapy group (RR=0.62, 95% CI: 0.45 to 0.84, P=0.09, $I^2=54%$). The immunology function was higher in the combined therapy group compared with the chemotherapy group (MD=16.43, 95% CI: 13.25 to 29.61, P<0.001, $I^2=99%$). The quality of life score was higher in the combined therapy group compared with the chemotherapy group (RR=1.55, 95% CI: 1.21 to 2.00, P<0.66, $I^2=0%$). Conclusions: Among the Randomized controlled trials (RCT) included, the levels of survival rates, suppression of metastasis, immune function, and quality of life of the group treated with chemotherapy were lower compared to those treated with herbal medicine in addition to chemotherapy.

전이성 평활근육종 환자의 통합 암 치료에 대한 증례보고

송시연,장혁준,박소정,전형준,이연월,조종관,유화승,Song, Si-yeon,Chang, Hyeok-joon,Park, So-jung,Jun, Hyeong-joon,Lee, Yeon-weol,Cho, Chong-kwan,Yoo, Hwa-seung 대한암한의학회 2019 大韓癌韓醫學會誌 Vol.24 No.1

Objective: The purpose of this study is to report the effectiveness and possibility of Integrative Cancer Treatment (ICT) on an advanced metastatic leiomyosarcoma patient. Methods: The patient was diagnosed with recurred and advanced metastatic Leiomyosarcoma, suffering from dyspnea, abdominal discomfort, lower limb edema. The patient refused conventional treatment, such as chemotherapy, radiotherapy but was treated with ICT including acupuncture, pharmacopuncture, moxibustion, hypertherapy and herbal medicine for symptom management. The clinical outcomes were measured by NRS (Numeral rating scale). Results: After treatment, dyspnea, abdominal discomfort and lower limb edema was relieved from NRS 6 to 3, 7 to 3 and 7 to 6 respectively. Also, loss of body weight, decrease in abdominal, thigh and calf circumference were improved. During and after treatment, we found neither hepatotoxicity nor nephrotoxicity on laboratory findings. Conclusion: This case study suggests that ICT may improve symptom relief and life quality of leiomyosarcoma patient.

신용카드 소비에 있어서 자아조절자원의 고갈과 모니터링 효과

송시연(Sie-Yeoun SONG) 조선대학교 지식경영연구원 2014 기업과 혁신연구 Vol.7 No.1

현대 생활에서 신용카드의 사용은 굉장히 빈번히 이루어지고 있는데, 그 사용률에 비해, 연체 비율은 매년 증가하고 있는 추세이다. 카드사용은 현금사용보다 과소비를 촉진한다는 견해도 많이 제기되고 있는데, 이러한 카드사용 과소비를 막고, 현명한 소비를 할 수 있게 하려면 어떻게 해야할까? 자아조절(self regulation)의 실패원인 중 하나는 피험자의 인지적 자아조절자원의 고갈에 있는데, 기존연구에 의하면, 인지적 자원이 고갈된 피험자는 그렇지 않은 피험자에 비해, 유혹재 혹은 악한 제품(vice product)을 더 많이 선택하는 것으로 나타났다. 본 연구는 자아조절자원의 고갈이, 카드 사용 총 금액(추가 신용카드 사용의도)에 부정적인 영향을 미칠 수 있음을 실험을 통해 증명하고, 이러한 부정적인 효과는 카드 사용 시 은행에 남아있는 본인계좌 금액 혹은 카드결제 금액을 피험자가 모니터링 할 수 있게 해준 경우에 줄어듦을 보여주었다. 이를 통해, 자아조절자원이 고갈된 피험자라 할지라도, 적절한 모니터링이 제공되면, 부정적 효과가 방지될 것으로 생각된다. This research is not only to show that setting goals related to self regulation and cognitive resource are important but also to show that monitoring is another key factor that is required to succeed in self regulation. It is widely known that there are many informations related to costs and benefits for product. However, the reason why previous researches showed failures to demonstrate the impact of resource depletion on the self regulation even if definite goals exist is that informations regarding monitoring were not provided appropriately. To issue above concerns, study provided cognitive resource depletion and monitoring information as independent variables and tried to verify whether those variables have any impacts on the total credit card consumption. As a result, in the condition where the monitoring information was not provided, there was a higher consumption while in the condition where the monitoring information was provided, resource-depleted group showed a low consumption in the total credit card amounts.

제품의 속성수준과 단위가 제품태도에 미치는 영향

송시연(Song Sie Yeoun),남아영(Nam Ah Young) 한국상품학회 2016 商品學硏究 Vol.34 No.6

A stream of research reveals that units influence judgments because of the size of the associated numbers. Lembregts and Pandelaere(2013) is that, in some conditions, individuals rely on the type of the units instead of the size of the numbers(numerosity effect of unit), leading to a reversal of judgments. Thismeans that individualsmake a decision focused on a type of unit than a number of unit. This study reveals the effect of product attribute level(positive vs negative) and unit level on cold medicine attractiveness. Product level is manipulated cold medicine s effective last and pain last, and, unit level is manipulated 360minutes, 6hours, and 0.25day. Regardless of product attribute level, individuals evaluated 6hours unit was higher than the rest unit type on the cold medicine attractiveness. In case of positive level of product attribute, the result was explained by unit s type effect when the product basic unit is small(6hours vs 0.25day), and the result was explained by unit s numerosity effect when the product basic unit is large(360minutes vs 6hours). In case of negative level of product attribute, the result has reverse effect. 기존 연구는 제품의 수량적 정보를 표시할 때, 단위(unit)가 사람들에게 미치는 영향력이 크다고 강조했다. 즉 작은 단위인 경우가 큰 단위보다 숫자가 크므로, 제품 평가에 유리하다고 주장했다. 그러나 Lembregts and Pandelaere (2013)은 제품마다 기준이 되는 단위가 틀리기 때문에, 기준단위가 작은 경우보다 큰 경우 제품이 더 좋게 평가될 때도 많으며, 이는 사람들이 단위의 수량보다는 단위 자체의 타입에 집중한 의사결정을 하였기 때문으로 설명될 수 있다. 본 연구는 제품의 기준이 되는 단위를 비교단위보다 큰 경우와 작은 경우로 조작하되, 기존연구가 수분크림의 지속시간처럼 제품 속성이 숫자가 커질수록 유리한 긍정적 상황만을 가지고 실험한 것을 확장하여, 노트북의 무게처럼 제품의 속성이 숫자가 작을수록 유리한 부정적인 상황에서의 효과를 살펴보았다. 본 연구는 제품의 속성을 감기약의 효과 지속시간(긍정적 속성)과 부작용 지속시간(부정적 속성)으로 구분하고, 제품의 단위를 360분, 6시간, 0.25일로 구분하여, 감기약의 매력도를 평가하였다. 그 결과, 제품의 속성과 상관없이, 사람들은 의약품의 기준이 되는 단위인 시간(6시간)을 사용할 때 제품을 가장 매력적으로 평가했다. 이러한 결과가 나타난 이유는 제품의 속성 및 기본 단위에 따라 서로 다른 매카니즘 때문이다. 먼저 제품의 속성이 긍정적일 경우, 제품의 단위가 기본적으로 작을 때(6시간 대 0.25일)에는 단위의 수량적 효과로 인해, 클 때 (360분 대 6시간)에는 단위의 타입 효과로 인해 이러한 결과가 나타났다. 제품의 속성이 부정적일 경우, 제품의 기본단위가 클 때(360분 대 6시간)에는 단위의 역의 수량적 효과 때문에, 작을 때(6시간 대 0.25일)에는 단위의 타입효과 때문에 이러한 결과가 나타남이 증명되었다.

자아조절자원(self regulatory resource)과 과제유형(task type)이 선한 제품(virtue products)과 악한 제품(vice products) 간 의사결정에 미치는 효과

송시연 ( Sie Yeoun Song ),박종원 ( Jong Won Park ) 한국소비자학회 2009 소비자학연구 Vol.20 No.4

선한 제품과 악한 제품 간 선택에 있어서 제품 배열이 미치는 효과

송시연(Sie Yeoun Song),박종원(Jong Won Park) 한국마케팅학회 2012 마케팅연구 Vol.27 No.1

본 연구는 세 개의 실험을 통해, 선택 대안이 여러 개일 경우 제품의 배열 여부가 소비자 선택에 미치는 영향을 살펴보았다. 실험에 참가한 피험자들은 선한 제품(virtue products)과 악한 제품(vice products)이 혼재되어있는 선택대안들을 놓고 하나를 선택하는 과제를 수행하였다. 그 결과, 선택대안들이 선한 제품과 악한 제품의 두 카테고리로 배열되어 있을 경우가 그렇지 않은 경우에 비해 선한 제품의 선택 비율이 높게 나타났다(실험1-3). 다만, 이러한 "배열 효과"는 피험자들이 조절자원이 고갈된 상태에서 선택을 하거나(실험 2) 또는 추상적마인드셋을 갖고 선택을 하는 경우(실험 3) 줄어드는 것으로 나타났다. 이러한 결과및 이외의 결과들을 종합적으로 고려해볼 때, 선택대안들이 선한 제품과 악한 제품 카테고리로 배열되어 있을 경우, 소비자들은 단기적 탐닉욕구에 대비되는 장기적 효용추구 목적을 강하게 인식하게 되어 탐닉욕구를 억제하는 자아조절을 하기 때문이 라는 것을 시사해준다. This research investigates the effect of arranging alternatives in a choice set on consumer choices and the conditions for the effect to occur. Participants in 3 experiments were asked to choose one alternative from a choice set which consisted of several vice and several virtue products. Participants were more likely to choose a virtue product when the choice alternatives were arranged according to the vice vs. virtue product category than when they were presented randomly (experiments 1-3). This "arrangement effect" was less apparent, however, if participants` regulatory resource was depleted prior to the choice task (experiment 2) or if they made a choice under a high-level, broad mindset (experiment 3). These and other results suggest that the arrangement effect might occur because arranging choice alternatives stimulates consumers to think about a long-term utilitarian goal vs. a short-term indulgent goal and leads them to exercise self control to pursue the long-term goal.

두경부 편평상피세포암에서 종양억제유전자들의 변이

송시연(Si Youn Song),박강식(Kang Shik Park),배창훈(Chang Hoon Bai) 대한두경부종양학회 2004 대한두경부 종양학회지 Vol.20 No.2

Objectives: Head and neck squamous cell carcinoma (HNSCC) is the most common head and neck malignant tumor. The molecular genetic changes involving both oncogenes and tumor suppressor genes are known to be involved in head and neck squamous cell carcinogenesis, but the roles of the known tumor suppressor genes in carcinogenesis are not fully elucidated. The objectives of this study are to demonstrate the genetic alterations including the loss of heterozygosity (LOH) , amplification, and microsatellite instability of known tumor suppressor genes in HNSCC and to evaluate the relationship between genetic alterations of tumor suppressor genes and clinicopathologic features. Materials and Methods: Genetic alterations of 10 micro satellite markers of the 6 known tumor suppressor genes (APC, EXT1, DPC4, p16, FHIT, and PTEN) were analysed by DNA-PCR in paraffin-embedded histologically confirmed HNSCC specimens. Results: The genetic alterations of tumor suppressor genes were found frequently. Among the genetic alterations, LOH was most frequently found one. LOH was found frequently in APC (45.4%), EXT1 (36.4%), DPC4 (54.5%), and p16 (50%), but not found in FHIT. Also, the author found that abnormalities of APC gene was related to cervical lymph node metastasis and recurrence and that abnormalities of EXT1 gene were coexisted with those of APC gene or DPC4 gene. But these coexistences had no correlation with clinical features. Conclusion: These results suggested that APC, EXT1, p16, and DPC4 genes might play important roles and multiple tumor suppressor genes may participate dependently or independently in the carcinogenesis of HNSCC. These results also suggested that APC gene might relate to prognosis.

두경부 편평상피세포암 세포주에서 세포주기조절인자의 활성 및 이상 : 후두편평상피세포암에서 종양억제유전자 CDKN2 유전자의 발현이상

송시연 ( Si Youn Song ),한태희 ( Tae Hee Han ),배창훈 ( Chang Hoon Bai ),김용대 ( Yong Dae Kim ),송계원 ( Kei Won Song ) 영남대학교 기초/임상의학연구소 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Background: Cyclin-dependent kinase (CDK) inhibitors are family of molecules that regulate the cell cycle. The CDKN2, a CDK4 inhibitor, also called p16, has been implicated in human tumorigenesis. The CDKN2 inhibits the cyclin/CDK complexes which regulate the transition from G1 to S phase of cell cycle. There is a previous report that homozygous deletion of CDKN2 region on chromosome 9p21 was detected frequently in astrocytoma, glioma and osteosarcoma, less frequently in lung cancer, leukemia and ovarian cancer, but not detected in colon cancer and neuroblastoma. However, little is known about the relationship between CDKN2 and laryngeal cancer. Therefore this study was initiated to investigate the role of CDKN2 in human laryngeal squamous cell carcinoma development.1) Materials and methods: We used 5 human laryngeal carcinoma cell lines whether they have deletions or losses of CDKN2 gene expression by DNA-PCR or RT-PCR, respectively. We examined 8 fresh frozen human laryngeal cancer tissues to detect the loss of heterozygosity (LOH) of CDKN2. PCR was performed by using microsatellite markers of short arm of human chromosome 9 (D9S126, D9S144, D9S156, D9S161, D9S162, D9S166, D9S171, D9S200 and D9SIFNA). For informative cases, allelic loss was scored if the signal of one allele was significantly decreased in tumor DNA when compared to the same allele in normal DNA. Results: The CDKN2 DNA deletion was observed in 3 cell lines. The CDKN2 mRNA expression was observed in only one cell line, which was very weak. LOH was detected in 7 cases (87.5%). Conclusion: These results suggest that CDKN2 plays a role in the carcinogenesis of human laryngeal squamous cell carcinoma.

소셜커머스 제품 구매행동에서 자아조절자원과 충동성의 역할

송시연(Song, Sie-Yeoun),김영조(Kim, Yeung-Jo) 한국상품학회 2012 商品學硏究 Vol.30 No.2

소셜커머스의 등장은 소비자의 소비생활에 큰 변화를 주었음에도 불구하고 이에 대한 실증연구는 미미한 실정이다. 따라서 본 연구는 소비자 행동적 관점에서 소셜 커머스 제품의 태도 및 구매 의도에 영향을 주는 변수로 소비자의 개인적 특성인 충동적 구매 성향 및 상황적 특성인인지적 자아 조절 자원의 고갈 효과를 살펴보았다. 그 결과, 충동적 구매 성향이 낮은 그룹은 자아 조절 자원의 고갈 효과가 나타나지 않았으나 충동적 구매 성향이 높은 그룹은 자아 조절 자원이 고갈될수록 더욱더 소셜 커머스 제품에 대한 태도 및 구매 의도가 높게 나타났다. 이는 충동적 성향이 높은 소비자가 자아 조절 자원이 고갈되면 충동 구매의 가능성이 높다는 것을 보여주는 것이다. Although social commerce had a hugh impact on consumer behavior, less empirical research has been done so far. Thus, this research examined, in consumer behavior perspective, the role of self-regulatory resource and impulsiveness in social commerce product purchase behavior. The results revealed that compared with low impulsive condition, in high impulsive condition, participants with self-regulatory resource depletion showed more favorable attitudes toward the social commerce product than those with no self-regulatory resource depletion. Also, compared with low impulsive condition, in high impulsive condition, participants with self-regulatory resource depletion showed higher purchase intention than thosewith no self-regulatory resource depletion. Thus, this research demonstrated that the self-regulatory resource and impulsiveness influenced the purchase behavior of social commerce product and suggested potential implications in consumer behavior perspective.