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Rainbow Power Therapy의 경항통에 대한 효과
서정철 ( Jung Chul Seo ),서보명 ( Bo Myung Seo ),김성웅 ( Sung Woong Kim ),이경민 ( Kyung Min Lee ),윤종석 ( Jong Seok Yun ),이세연 ( Sea Youn Lee ),김경운 ( Kyung Woon Kim ),이윤경 ( Yoon Kyung Lee ),임성철 ( Seong Chul Lim ) 대한경락경혈학회 2004 Korean Journal of Acupuncture Vol.21 No.2
Objective: This study was designed to estimate the effects of Rainbow Power therapy on neck pain patients by using Visual Analogue Scale(VAS) and pressure algometer. Methods: Rainbow Power therapy group consisted of 18 patients and acupuncture therapy group consisted of 7 patients. The degree of improvement of neck pain was evaluated by VAS and pain pressure threshold(at the points of Jianjing GB21 and Jianwaishu SI14) before treatment, before 3rd treatment and before 5th treatment. Rainbow Power therapy was performed at the points of Jianjing GB21, Zhongfu LU1, Yangxi LI5, Ganshu BL18, Weishu BL21 and Shenshu, BL23. Each points were stimulated with RP-UM103(Rainbow Power therapy instrument) for 20 seconds. The points of acupuncture therapy were Jeonggeun, Jeongjong, Sangbaekn and Hegu LI4 and acupuncture was maintained for 15 minutes. After above therapy dry cupping was performed at the points of Jianjing GB21, Jianwaishu SI14, Gaohuang BL43, Tianzong, SI11 and Bingfeng SI12 for 5 minutes. Results: There was no significant difference between the two groups in VAS, pain threshold of Jianjing GB21 and Jianwaishu SI14 following treatment. In the two groups VAS was significantly decreased. In Rainbow Power therapy group the pain threshold of the two points was significantly increased. But there was no significant increase in acupuncture therapy groups about the pain threshold of Jianwaishu SI14. Conclusions: The effectiveness of Rainbow Power therapy on neck pain was shown through VAS and pressure algometer. These imply that Rainbow Power therapy may be useful for neck pain. Further study is needed about Rainbow Power therapy.
고려인삼과 서양삼의 Pyrosequencing법에 의한 감별
서정철 ( Jung Chul Seo ),임강현 ( Kang Hyun Leem ),한상원 ( Sang Won Han ) 대한본초학회 2004 大韓本草學會誌 Vol.19 No.2
N/A objective : This study was performed to determine if two ginseng species(Korean Ginseng and American Ginseng) could be identified by genetic analysis and to verify Pyrosequencing analyses, which was used to assess genetic variation. method : The DNAs of Panax species were extracted, and we have investigated the typing single-base variations of Panax species in DNA by using Pyrosequencing. result : The Pyrosequencing results showed clear data. American ginseng showed different pattern compared with Korean ginseng. The peak of American ginseng was very week in the first T nucleotide base but The peak of Korean ginseng was very high in the first T nucleotide base. conclusion : Pyrosequencing analysis might be able to provide the identifying the Panax species(Korean Ginseng and American Ginseng).
Mesna 사용 후 협부 발진양 알레르기 반응을 보인 2예
서정철 ( Jeong Cheol Seo ),배상철 ( Sang Cheol Bae ),심승철 ( Seung Cheol Shim ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),유대현 ( Dae Hyun Yoo ),김성윤 ( Seong Yoon Kim ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.2
Hemorrhagic cystitis is potentially life-threatening sequellae of chemotherapy using oxazaphosphorine alkylating agents (cyclophosphamide and ifosfamide). Mesna contains a sulfhydryl group that is believed to bind acrolein within the urinary collecting system and reduce the hemorrhagic cystitis without affecting the chemotherapeutic potential. To date, about thirty cases of hypersensitivity or allergic reactions of the delayed and urticarial type associated with mesna have been reported. We reported two patients with systemic lupus erythematosus who developed facial rash and flushing associated with mesna which imitate malar rash.
혈액투석 환자에서 Erythropoietin 의 피하주사와 저용량 Androgen 의 병용투여가 빈혈과 영양지표에 미치는 효과
서정철(Jeong Chul Seo),김혜영(Hye Young Kim),양용모(Yong Mo Yang),전원중(Won Joong Jeon),이현희(Hyun Hee Lee),이경수(Kyoung Soo Lee),정지봉(Ji Bong Jeong),엄재호(Jae Ho Earm),이기형(Ki Hyeong Lee) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.1
Recombinant human erythropoietin(r-HuEPO)은 말기 신부전 환자의 빈혈 치료에 있어서 가장 효과적이고 중요한 치료제로 이용되고 있다. 하지만, 상당한 비용이 필요하기 때문에 r-HuEPO의 조혈효과를 향상시키는 방법들이 제시되고 있는데, 이 중 안드로겐(androgen)과 r-HuEPO의 병용투여는 효과 면에서 아직까지 논란이 있다. r-HuEPO 투여 후 단백질 대사와 운동 능력 및 영양지표의 향상이 보고되고 있으며, 강한 단백 동화작용이 있는 안드로겐의 병용 투여시 영양지표가 더 호전될 것으로 기대되지만, 이에 대한 연구는 아직 없었다. 이에 저자들은 혈액투석 환자에서 r-HuEPO 피하 단독투여와 저용량 안드로겐의 병용투여시 빈혈의 치료 및 영양지표의 변화를 비교하고자 전향적 연구를 시행하였다. 충복대학교병원에서 혈액투석을 받는 환자 중 혈색소치가 8.0g/dL 이하 또는 헤마토그리트치 24% 이하인 환자를 대상으로 A군 ( r-HuEPO 단독투여군, n=12)은 주 2회 r-HuEPO 2000단위를 피하주사하였고, B군(r-HuEPO/안드로겐 병용투여군, n=12)은 동일한 양의 r-HuEPO와 nandrolone decanoate 100mg을 2주 마다 근주하였다. 6개월 투여 전후의 혈액검사와 인체계측을 시행하여 다음과 같은 결과를 얻었다. 1) 성별, 연령, 체중, Kt/V, 체중 당 r-HuEPO 용량(A군:71.8U/자,B군: 74.9U/wk)은 양군 간에 차이가 없었으며, nandrolone decanoate 용량은 주당 0.9±0.1mg/kg이었다. 투여 전혈색소, 헤마토크리트, 혈청 저장철, 혈청 부갑상선호르몬, 비타민 B12 folate, transferrin saturation과 영양지표인 알부민, 콜레스테를, prealbumin, transferrin, 인체계측지표는 양군 간에 차이가 없었다. 2)투여 6개월 후 A군의 혈색소는 7.1±0.7g/dL 에서 8.5±1.3g/dL로, 헤마토크리트는 20.7±2.2%에서 26.0±3.8%(P<0.05)로 상승하였고, B군의 혈색소는 6.8±0.4g/dL 에서 9.4±1.4g/dL로 헤마토크리트는 21.5±3.5%에서 30.1±2.8%(p<0.05)로 상승하였다. 치료시작 후 4개월 이후부터 평균 헤마토크리트는 A군에 비하여 B군에서 유의하게 높았다(p<0.05). 치료 후 혈색소 10.0g/dL 이상 또는 헤마토크리트 30% 이상에 도달한 환자수는 A군에서 12명 중 4명(33.3%)이었고,B군에서는 12명 중 10명(83.3%)으로 차이가 있었다(p<0.05). 3) 투여 6개월 후 영양지표는 양군 간에 차이가 없었다. 4) 연구기간 동안 안드로겐 투여에 따른 부작용은 근주부위의 동통 1예, 부종 1예 이외에는 없었다. 이상의 결과로 혈액투석환자에서 r-HuEPO 피하주사 단독투여에 비하여 저용량 안드로겐의 병용투여가 빈혈의 개선에 효과적이었다. 따라서, 경제적인 이유로 실제적으로 필요한 용량보구 Recombinant human erythropoietin(r-HuEPO) is the mainstay of anemia therapy in patient with end stage renal disease(ESRD), but the use of r-HuEPO is primarily limited by its high cost. So, it encourages any strategies that potentially enhance the erythropoietic response. However, studies designed to assess whether androgens would enhance the response to r-HuEPO were inconclusive. While androgens may be less expensive and may improve several nutritional parameters, their potential adverse effects discourage usage. We carried out a prospective study to examine the effect of low-dose androgen in combination with subcutaneous r-HuEPO on anemia and nutritional paramenters in hemodialysis patients. Twenty-four hemodialysis patients with hematocrit <24% or hemoglobin <8.0g/dL were randomly assigned into two groups. Group A(n=12) received 2000U r-HuEPO subcutaneously twice a week for six months. Group B(n=12) received the same dose of r-HuEPO plus nandrolone decanoate 100mg intramuscularly biweekly. Anthropometry, albumin, cholesterol, prealbumin, and transferrin were measured as nutritional parameters. The groups showed no differences in baseline levels of the followings : Hemoglobin, hematocrit; transferrin saturation, serum ferritin; intact serum parathyroid hormon, Kt/V; vitamin Biz, folate; nutritional parameters. At the cornpletion of the study, both groups showed significant increase in hematocrit compared with baseline levels(group A 20.7±2.2M to 26.0±3.8%; group B: 21.5±3.5% to 30.1±2.8%). The mean hematocrit in group B was significantly higher than in group A after 4 month study period(p<0.05). Ten of 12 patients in group B achieved a target hematocrit of 30%, as compared with four of 12 patients in group A. Both groups didn't show significant changes in any nutritional parameters. No significant side effects of androgen were noted during this short-term study. We conclude that low-dose androgen in combination with subcutaneous r-HuEPO is effetive treatment on anemia in hemodialysis patients, but does not improve nutritional status.
한국인과 중국인에서 인삼과 서양삼 복용후 전신 증상 - 이중맹검 무작위배정 임상시험 -
서정철(Jung-Chul Seo),한상원(Sang-Won Han),변준석(Joon-Seok Byun),안희덕(Hee-Duk An),하일도(Il-Do Ha),조건호(Geon-Ho Cho),임강현(Kanghyun Leem),허정걸(Zheng-Jie Heo),이경림(Jinglin Yi),김명수(Mingxiu Jin) 고려인삼학회 2005 Journal of Ginseng Research Vol.29 No.1
In East-South Asia it has been said that ginseng(Panax ginseng) induces flushing and epistaxis, whereas American ginseng(Panax quinquefolius) dosen't. This study was designed to find out if ginseng really could increase flushing and epistaxis, compared with American ginseng. Double-blind randomized controlled trials on general symptom, such as flushing and epistaxis, of ginseng and American ginseng in Koreans and Chinese were performed by questionnaire. There was no significant accident or improvement in Koreans. But in Chinese dried mouth was significantly observed in placebo group and chest discomfort was significant in placebo group and American ginseng(4 years) group. In addition in Chinese chest discomfort was significantly observed in American ginseng(4 years) group and American ginseng(6 years) group. It was revealed that ginseng might not increase flushing and epistaxis.
한국인과 중국인에서 고려삼과 화기삼의 체표온도에 대한 이중맹검-무작위배정 임상시험
서정철 ( Jung Chul Seo ),이경림 ( Kyung Lim Lee ),변준석 ( Joon Seok Byun ),김명수 ( Myung Soo Kim ),하일도 ( Il Do Ha ),허정걸 ( Zheng Jie Heo ),임강현 ( Kang Hyun Leem ),한상원 ( Sang Won Han ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.2
N/A Objective ; Generally it was known that Korean ginseng(Pm ginseng-white ginseng & red ginseng) increases body temperature, whereas Amencan ginseng(Pm quinquefolius) decreases body temperature. This study was designed to find out if Korean ginseng could increase body temperature comparing with American ginseng. Methods ; Double-blind randomized controlled trials on superficial body temperature of Korean ginseng and American ginseng in Koreans and Chineses was performed by using thermography at 10 points(Yintang(EX-HN3), Shuigou(GV 261, Danzhong(CV 17), Zhongwan(CV 12), Right Quanliao(SI 18), Left Quanliao(S1 18), Right RenyingGT 91, Left Renying(ST 9), Right Yunmen(LI 2) and Left Yunmen(LI 2). Results ; There was no significant difference between Korean ginseng and American ginseng in both Koreans and Chineses by repeated-measures ANOVA. Conclusion ; It was revealed that Korean ginseng does not increase superficial body temperature. Maybe the concept that Korean ginseng increase body temperature is concerned with commercial interests dealing with American Ginseng.