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박승춘,상지강,오병철,김종춘,정규식,이명헌,윤효인,Mi-Hyun Hwang 대한수의학회 2007 Journal of Veterinary Science Vol.8 No.4
The pharmacokinetics and dosage regimen of norfloxacin- glycine acetate (NFLXGA) was investigated in pigs after a single intravenous (i.v.) or oral (p.o.) administration at a dosage of 7.2 mg/kg body weight. After both i.v. and p.o. administration, plasma drug concentrations were best fitted to an open two-compartment model with a rapid distribution phase. After i.v. administration of NFLXGA, the distribution (t1/2α) and elimination half-life (t1/2β) were 0.36 ± 0.07 h and 7.42 ± 3.55 h, respectively. The volume of distribution of NFLXGA at steady state (Vdss) was 4.66 ± 1.39 l/kg. After p.o. administration of NFLXGA, the maximal absorption concentration (Cmax) was 0.43 ± 0.06 μg/ ml at 1.36 ± 0.39 h (Tmax). The mean absorption (t1/2ka) and elimination half-life (t1/2β) of NFLXGA were 0.78 ± 0.27 h and 7.13 ± 1.41 h, respectively. The mean systemic bioavailability (F) after p.o. administration was 31.10 ± 15.16%. We suggest that the optimal dosage calculated from the pharmacokinetic parameters is 5.01 mg/kg per day i.v. or 16.12 mg/kg per day p.o.
이양숙,김남우,상지강,오병철,박승춘,신승렬 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1
In the present study, we analyzed the antioxidant, antiplatelet aggregation, anti-inflammatory, and tyrosinaseinhibitory activities of a variety of solvent extracts of Elaeagnus multifloraThunb. (Family Elaeagnaceae). Among the sol-vent extracts of E. multiflora, the ethyl acetate extract (EE) exhibited the highest 1,1-diphenyl-2-picrylhydrazyl radical andin-hibited platelet aggregation, and that was a weak effect with 19.29% inhibition at 250 .g/mL, as compared to controls. TheCE was also the most potent inhibitor of nitric oxide production among the tested fractions, with almost 100% inhibition at500 .g/mL. We also detected 2,4-bis(1,1-dimethylethyl)phenol in the CE and EE, via a gas chromatography-mass spectrom-etry assay. In conclusion, we found that E. multifloraThunb. has antioxidant and antiplatelet aggregation effects to some ex-tent, and its CE and EE possess potent inhibitory effects on nitric oxide production and tyrosinase activity.