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배용수 ( Yong Soo Bae ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.3
Dendritic cells (DCs) are a professional antigen presenting cell (APC) that has the ability to stimulate naive T-cells. They are widely distributed in all tissues, especially in those that provide an environmental interface. DCs exhibit a heterogeneous haematopoietic lineage, in that subsets from different tissues have been shown to posses a differential morphology, phenotype and function. It has been suggested that the myeloid and lymphoid-derived subsets of DCs perform specific stimulatory or tolerogenic function, respectively. DCs are derived from bone marrow progenitors and circulate in the blood as immature precursors prior to migration into peripheral tissues. Within different tissues, DCs differentiate and become active in the taking up and processing of antigens (Ags), and their subsequent presentation on the cell surface linked to major histocompatibility (MHC) molecules. Upon appropriate stimulation, DCs undergo further maturation and migrate to secondary lymphoid tissues where they present Ag to T-cells and induce an immune response. DCs draw increasing scientific and clinical interest due to their key role in anti-cancer host responses and potential use as biological adjuvants in tumor vaccines, as well as their involvement in the immunobiology of tolerance and autoimmunity. Theseobservations have led to clinical trials designed to investigate the immunological and clinical effects of Ag-pulsed DCs administered as a therapeutic vaccine to patients with cancer. In the design and conduct of such trials, important considerations include Ag selection, methods for introducing tumor-associated antigens into MHC class I and II processing pathways, methods for isolating and activating DCs, and routes of administration. Although current DC-based vaccination methods are cumbersome and complex, promising preliminary results from clinical trials in patients with malignant lymphoma, melanoma, and prostate cancer suggest that immuno-therapeutic strategies, that take advantage of the unique properties of DCs, may ultimately prove both efficacious and widely applicable treatment in patients with cancer.
배용수,강현삼,Bae, Yong-Soo,Kang, Hyen-Sam 생화학분자생물학회 1983 한국생화학회지 Vol.16 No.2
쥐의 태아섬유아세포에 MCMV가 감염한 후 16시에 DNA 합성효소가 최대로 유도되었다. 새로 유도된 DNA 합성효소를 DEAE와 phosphocellulose이온교환수지에서 순수 정제하고, 기존숙주 DNA 합성효소와 생화학적 특성 및 분자량을 비교하였다. 최적 pH, $Mg^{++}$이온 요구도, 교환수지에서 eluting되는 형 태와 분자량 등에서 MCMV가 유도한 DNA합성 효소와 기존숙주의 DNA합성효소에 있어 큰차이가 있었다. 이같은 결과는 MCMV가 유도한 합성효소는 MCMV의 유전자에 의하여 생산되었음을 암시한다. Infection of primary mouse embryo fibroblast (MEF) cell with Murine Cytomegalovirus (MCMV) lead to the induction of viral specific DNA polymerise. MCMV-infected MEF cells were harvested after 16 hours post infection (PI) and the induced-DNA polymerase was extracted and purified by DEAE-cellulose and phosphocellulose column chromatographies. Then the characterization of this enzyme was carried out. Viral enzyme can be distinguished from host cell enzyme by chromatographic behavior, optimal pH, $Mg^{+2}$ ion requirement and molecular weight. The sedimentation coefficients of these two enzymes were determined with the use of glycerol gradient centrifugation. Viral enzyme was 8S, and host enzymes were 10.3 S and 3.4 S. Based on these results, we would like to propose that this MCMV-induced DNA polymerise is viral specific enzyme, in other words, the gene of DNA polymerise, necessary to synthesize the viral DNA, is coded on the viral DNA.
이상훈(Sang Hoon Lee),배용수(Yong Soo Bae),최린(Lynn Choi) 한국정보과학회 2013 정보과학회 컴퓨팅의 실제 논문지 Vol.19 No.1
일반적으로 비동기식 센서 네트워크 MAC 프로토콜들은 별도의 충돌회피 알고리즘을 사용하지 않기 때문에 동기식 MAC 프로토콜에 비해 충돌에 의한 성능 저하가 크게 나타난다. 본 논문에서는 충돌에 따른 비동기식 MAC 프로토콜의 성능 저하 문제를 최소화하기 위해 수신 노드가 충돌을 야기한 송신 노드들의 전송 순서를 제어하여 추가적인 충돌을 제거할 수 있는 Transient Coordinator(TC)를 소개한다. TC는 충돌을 감지한 수신 노드가 충돌을 일으킨 송신 노드들에 대한 정보를 수집하고 이를 이용하여 충돌이 발생하지 않는 전송 순서를 각 송신 노드에게 지정하는 방식을 사용한다. 송신 노드들은 지정된 순서에 따라 독점적인 채널 사용 권한을 얻으며 이를 통해 송신 노드간의 충돌을 회피할 수 있다. 시뮬레이션 결과에 대한 분석에 따르면 TC는 반복적인 충돌을 방지하여 그로 인해 낭비되는 시간과 대역폭을 줄일 수 있다. 또한, 이를 통해 기존의 비동기식 MAC 프로토콜에 비해 에너지 소비를 91.1% 줄일 수 있고 각 노드당 평균 데이터 처리량을 약 19.4% 증가시킬 수 있다. 이는 본 논문에서 제안하는 TC가 성능, 자원 활용 및 에너지 효율성 측면에서 기존의 random back-off 방식에 비해 더욱 효율적인 충돌 해결 알고리즘임을 증명한다. Wireless sensor networks (WSN) often employ asynchronous MAC scheduling, which allows each sensor node to wake up independently. Random back-off used by most of asynchronous protocols cannot secure a receiver from potentially repetitive collisions and may lead to a substantial increase in the packet latency. In this paper, we propose a new collision resolution algorithm called Transient Coordinator (TC) for asynchronous WSN MAC protocols. TC resolves a collision on demand by ordering senders’ transmissions when a receiver detects a collision. To coordinate the transmission sequence both the receiver and the collided senders perform handshaking to collect the information and to derive a collision-free transmission sequence, which enables each sender to exclusively access the channel. According to the simulation results, our scheme can improve the average per-node throughput by up to 19.4% while it also reduces unnecessary energy consumption due to repetitive collisions by as much as 91.1% compared to the conventional asynchronous MAC protocols. This demonstrates that TC is more efficient in terms of performance, resource utilization, and energy compared to the random back-off scheme in dealing with collisions for asynchronous WSN MAC scheduling.
경기북부지역 지하수의 지역별 미량무기물질 함유실태 조사연구
오조교(Jin-Seok Son),손진석(Yong-Soo Bae),배용수(Eun-Hee Jung),정은희(Jin-Ho Park),박진호(Sun-Min Hwang),황선민(Yeon-Hoon Jung),정연훈(Jo-Gyo Oh) 대한환경위생공학회 2004 대한환경위생공학회지 Vol.19 No.1
Ground water samples were collected from residential, green" industrial, landfill and mining area and analyzed for 23 inorganics from March to October in 2002.<br/> The results are as follows;<br/> 1. The detection frequencies of inorganic materials such as As, Ba, B, Mo, Ca, Mg, AI, Cu,<br/> Fe, Mn, Zn, Na, K were 7.2-77.1% which showed that these inorganics were detected in many ground waters.<br/> 2. The detection frequencies of 7 inorganics (Cd, Cr, Pb, Se, Sb, Be, TJ) were commonly low<br/> at ranging from 0.42 to 2.5%. These inorganics were contained in ground water partially.<br/> 3. Three inorganics such as Hg, Ni, Ag were not detected in any ground-water samples. 4. Compared to the other areas, ground water samples from landfill area contained greater<br/> concentration in many inorgainics and then showed higher levels in industral, residential,<br/> mining and green area in order.<br/> 5. Compared to noted concentrations of bottled water, inorganic minerals including Ca, Mg,<br/> Na, K related to taste were fluent in target samples. The results showed that the average<br/> concentrations of Mg, Na, K were 4.0 mg/ℓ, 14.7 mg/ℓ, 1.5 mg/ℓ respectively.<br/> 6. The concentrations of inorganics such as Sb, Ba, Mo, Be, Tl, K in some ground water<br/> samples exceeded the water quality standards of WHO, the US and UK<br/> Especially, Ba, Mo, K also showed relatively high detection frequencies so these inorganics need to be considered as analytes in Korea Drinking Water Regulation in further study.