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        Suppressive Effect of Clozapine through Regulation of Chemokine (C-C motif) Ligand Genes in SH-SY5Y Human Neuroblastoma Cells

        박해정,조아랑,박진경,강원섭 대한스트레스학회 2010 스트레스硏究 Vol.18 No.3

        Clozapine, an atypical antipsychotic agent, has proven to be effective in the treatment of refractory schizophrenia. As the idiosyncratic clozapine-induced adverse effects such as dyslipidemia and agranulocytosis occur in 0.5∼2% of the treated patients, the use of clozapine has been limited. In this study, we assessed the patterns of gene regulation by clozapine (10μM, 24 h) in SH-SY5Y human neuroblastoma cells through microarray analysis. Clozapine upregulated the expressions of 165 genes, and downregulated the expressions of 305 genes. Of these genes, clozapine potently increased the level of chemokine (C-C motif) ligand 3 gene (CCL3, 15.596-fold) and decreased the level of retinoic acid early transcript 1E (RAET1E, 0.171-fold). Both of these genes belong to the category of immune response-related genes. We also found the changes of the expressions of immune response-related genes were most remarkable. Especially, clozapine increased the levels of chemokine genes, such as CCL3 (also known as MIP-1α), CCL2 (also known as MCP-1), and chemokine (C-C motif) receptor 3 (CCR3). This result may contribute to understanding of adverse effects of clozapine. (Korean J Str Res 2010;18:229∼235) 비정형 항정신병 치료제인 clozapine은 정신분열병 치료에 매우 효과적인 약물이다. 그러나 clozapine으로 치료 받는 환자의 0.5∼2%에서 무과립구증과 같은 면역계 관련 부작용이 발생한다고 보고되어 왔으며, 따라서 clozapine의 사용은 제한되어 왔다. 본 연구는 microarray 분석법을 이용하여 사람 SH-SY5Y neuroblastoma 세포에서 clozapine (10μM, 24 h)에 의해 변화되는 유전자의 발현 양상을 알아보고자 하였다. 실험 결과, clozapine에 의해 165개의 유전자 발현이 증가하였으며, 306개의 유전자 발현이 감소하였다. 특히, 면역 관련 유전자의 발현 변화가 현저했으며, chemokine (C-C motif) ligand 3 (CCL3, 15.596-fold)가 가장 크게 증가하였고, retinoic acid early transcript 1E (RAET1E, 0.171-fold)가 가장 크게 감소하는 것을 확인하였다. Clozapine은 특히 CCL3 (MIP-1α), CCL2 (MCP-1) 및 CCR3과 같은 chemokine 유전자의 발현을 증가시켰다. 이러한 결과는 clozapine의 면역계 관련 부작용에 대한 기전을 이해하는데 중요한 자료를 제시할 것으로 생각한다.

      • KCI등재

        Theology of Inculturation: Its Terminology and Application in Korea

        박해정 한국실천신학회 2012 신학과 실천 Vol.0 No.33

        The cultural diverse in Korean society has impacted many social communities including Korean Christianity. Particularly in this postmodern ear, cultural trend and influence play a significant role to reform a content and frame of those communities. In this stream, the Korean Protestant churches started to pay attention to new worship patterns including praise and worship, seeker's service, and emerging worship, etc. However, before approaching those new trends, the Korean Protestant Church is genuinely asked who we are as a Korean. This paper tries to demonstrate an answer for the question not only from liturgical understanding but also from pastoral aspect. The Korean Protestant Church is asked “self-reformation.” The Korean Protestant Church is urgently claiming its openness toward Christian’s and non-Christian’s living context and culture. Thus, in this paper, I examine the current situation of the Korean Protestant Church in terms of a process of to-chak-wha (indigenization/inculturation), and look for an adequate possibility of to-chak-wha for the Korean Protestant Church. I describe several terminologies regarding of encountering local culture and Christian faith, such as adaptation, indigenization, contextulization, incarnation, and inculturation. Furthermore, I present the current address of Korean Church in terms of inculturation and look for the future possibility for the inculturated Korean Church; the ancestoral worship and church music. Ancestor worship has embraced a beautiful Korean tradition. Because Korean Protestant church observes Chu-do-sik to be in memory of the ancestors, I believe that a Korean Protestant church also, like a Korean Catholic Church, provides a Christian liturgy. Instead of a Confucian one, the Korean Protestant church should present a liturgy in terms which Christians can make ancestor worship into a Christian family worship together with ancestral souls. The church music needs to rediscover its criteria based on the context of Korean worship community. It is not right to treat Korean traditional music as simply a part of the products of pagan culture, but the heritage in which emotion of Koreaness is evoked. Rather by rediscovering the value and function of Korean traditional music in Christian culture, the Korean church can provide various and rich worship service in which Korean people constantly experience encounter with God. It is inculturation. I strongly believe that Jesus was the one who had a strong desire to inculturate the Gospel.

      • KCI등재

        All Saints Worship: Possible or not in a Korean Protestant Context?

        박해정 한국실천신학회 2015 신학과 실천 Vol.0 No.45

        The veneration of the saints is related to the cult of the dead. It initially took the form of praise and imitation of the deceased holy one, and involved as well, gatherings of celebration and prayer at the place of burial. The cult of the saints began in the early church with the commemoration(memoria) of the victims of persecution. So the primitive Christians linked witness to the centrality of the cross in which human was able to partake the passion of Christ. Already at the death of the first martyr in the New Testament, Stephen, the martyr’s prayer for his persecutors echoes the prayer of Jesus on the cross for those who knew not what they were about. In the primitive believers had a strong conviction that saints could intercede with Christ for them. In the ancient world, in which Christianity began, tombs were places of contact between humans and the gods. The tomb represented a home for the dead, a place to be visited by survivors. Libations were poured out upon the tomb, and funerary feasts (refrigerium) were celebrated near it, especially on the birthday of the deceased. Among the Jews it was customary to give special honor to the tombs of the patriarchs; among the pagans, to the tombs of dead heroes. In like manner, the early Christians held the tomb to be the privileged place of the saint. And like the Greek hero, the saint was considered to be an intercessor who functioned as an intermediary between this world and the next. The Korean Protestant Churches, however, strongly resist to bring the cult of the saints in their sanctoral cycle. Why not? The cult of saints, on behalf of perspective of the Korean Protestant churches, seems to be involved with the issue of ancestor worship which causes significant conflicts between Korean Catholic Church and Protestant Church, and even among non-believers. The first thing the Korean pastors and scholars discussed was idolatry which for Christians has been the main obstacle to the practice of ancestor worship. In terms of the Judeo-Christian perspective and belief, ancestor worship or idol worship is contrary to the first and second commandments of God. Because the Korean Christians believe in monotheism, they cannot accept the idol worship. Ancestor worship is a part of cultural heritage that is a precious gift of God to the Korean people. However, as a Korean Protestant Christian, it is not easy to say that traditional way of observing ancestor worship can be an acceptable and applicable practice from a Korean Christian perspective. As an inculturated practice of veneration of the saint, the Korean Protestant Church employed its own way of observing veneration of the ancestors, named Chumo-Shik.

      • KCI등재

        성찬 참여자의 자격에 대한 고찰 및 제언

        박해정 한국실천신학회 2018 신학과 실천 Vol.0 No.59

        오늘날 한국의 개신교 예배 상황에서 성찬 수찬자의 자격은 크게 논란이 되지 않는다. 대부분의 교단들이 세례자 성찬을 시행하고 있기 때문이다. 성찬 참여자의 자격에 대해서 교단법으로 명시한 교단도 있고, 비록 법으로 명시하고 있지는 않지만, 전통적으로 성찬의 자리가 세례를 받은 자들에게만 열려 있는 것으로 알고 시행하고 있다. 하지만, 오늘날 교회에서는 성찬 수찬자의 자격을 세례자로 한정하기 어려운 목회 현실을 경험하고 있다. 더욱이 대형교회의 경우 세례자인지 비세례자인지 확인할 방법이 없다. 그리고 세례자들만 성찬상 앞으로 나오라는 표현을 하는 것도 목회적으로 어렵다. 이미 서구 교회에서는 고교회 전통에 있는 교회에서도 성찬 수찬자의 자격에 대한 포괄적이며 수용적 입장을 취하고 있다. 샌프란시스코에 위치한 성 그레고리 닛사 교회는 40여 년 전부터 예배의 형식도 전통적인 성공회의 것을 따르지 않았으며, 성찬 참여자의 자격도 오픈 성찬의 형식을 취하였다. 성공회의 교회법은 아직도 세례인에게만 성찬을 허락하고 있지만, 북미대륙의 많은 성공회에서는 미사에 참여한 모든 사람은 성찬의 자리에 초대받고 있는 상황이다. 북미대륙의 개신교회는 성찬 수찬자의 자격에 대한 폭넓은 신학적 논의가 이루어졌으며, 지금도 예배학에서 가장 뜨거운 논쟁의 주제 가운데 하나이다. 더욱이 예전복고운동(Liturgical Movement)의 영향으로 매주 성찬을 강조하고 있는 북미대륙 개신교 상황에서, 교회를 방문하였거나 새로 나온 이들의 성찬 수찬에 대한 논쟁이 증폭될 수밖에 없는 상황이다. 성찬의 비중이 점점 늘어나고 있는 한국 개신교 예배 상황에서 성찬 수찬자의 자격에 대해서 어떤 자세를 취하는 것이 성서적 전통과 초대교회적 이해에 부합되는 것인지를 이 논문을 통해서 다루고자 한다. 특별히 오픈성찬의 신학적 정당성은 어디 있으며, 이를 시행함에 있어서 고려해야 될 영역이 무엇인지 살펴본다. ‘Who would be invited to the Lord's Table?’ is not a main question in Korean protestant churches. In Korean protestant church context, the baptized has been only invited to the table according to either its denominational law or tradition. However, in western churches, 'who would be invited to the Lord's table?' is one of the most controversial subjects in the liturgical gatherings either in academia or in ministry. In general, so called high church tradition denominations including Episcopal and Lutheran have been firmly maintained closed communion. However, about four decades ago, one of the local Episcopal churches in San Francisco opened the communion for those who attended its mass in the name of hospitality of Jesus. Since then, regarding the condition of participant of the communion brought up an controversial issue. Even though Korean protestant churches are not yet facing about 'who would be on the table?' I strongly believe that sooner or later, it would be a challenging matter to the church. In this paper, I examined how the Scripture and writings of the primitive church and its leaders deal with qualification of participants of the Lord's Supper. Additionally, I examined theological issues of open communion and the baptized communion in western context and Korean context. I proposed several reasons of supporting open communion. When the church performs open communion, there are several matters to be considered. I do not mean that I oppose the baptized communion. As a liturgical scholar, I strongly believe that the baptized communion must be accepted as a genuine and prototype sacrament presenting Christ's self giving grace. Unfortunately, from my observation, in Korean protestant ministry the ritual of baptism is not properly prepared and performed. I believe that the baptism cannot be a condition of communion. From Wesleyan perspective, communion is a converting ordinance, and the table can be open for those who earnestly repent their sin and love the Lord Jesus Christ. However, the open communion cannot be treated as cheap grace but free grace.

      • KCI등재

        한국 개신교 교회학교 예배에 대한 예배학적 고찰

        박해정 한국실천신학회 2018 신학과 실천 Vol.0 No.58

        In Korean protestant church situation, a worship for the Sunday School has not been considered as a liturgical subject from liturgical scholars but a academic and practical subjects from Christian education scholars. However, a worship for the Sunday School must be considered as a critical liturgical subject. Particularly, Korean protestant church is facing a critical crisis of declining numbers of Sunday School attendance. To overcome the crisis of Sunday school worship, church tried to adapt and to apply various worship styles including WowQKid, WingWing, Mebic, nFriends, and Kidsworship. Those efforts to boost up the crisis of Sunday School did not bring a positive result but brought more chaos. I, as a liturgical scholar who is academically and practically interested in Sunday School worship, proposed several pragmatic suggestions to renew the Sunday School worship service in this paper. Firstly, participation is needed. In general, participation in Sunday School means taking a part in worship, such as offering a prayer, reading a Bible lesson, or singing praises. However, participation does not mean simple physical joining, but full engagement of worship from the planning to review it. Secondly, education for the worship is needed. In general, Christians tend to believe that worship and sacrament are not teachable subject. But to participate in worship, providing a suitable education about worship and sacrament are definitely asked. Thirdly, worship environment should be considered a space for Sunday school services and their activities. In practical reasons, church uses a facility not for the Sunday school but for the group meetings, prayer meetings, and even funeral services. However, if the church expects vibrant Sunday worship community, the starting point of it is from its own worship space with suitable icons and symbols for their generation. Lastly, ritual for the Sunday School is definitely provided. Saying “this is body and blood of Jesus” for kindergarteners are too violent. Sunday School worship cannot be a show. It must reveal mysterious presence of God meaning of sacrament. Sacrament must be part of Sunday School worship service. It will be a huge challenge to bring sacramental practices into Sunday School worship in Korean protestant church situation. However, sacramental practices should be placed in Sunday School worship. 기독교교육 학자이면서 예배학을 전공한 신형섭은 그의 저서 『예배갱신의 사각지대 교회학교 예배』에서 교회학교 예배의 새로운 모델들을 제시하고 있다. 특별히 교회가 행해오던 전통적인 예배의 틀을 유지하면서도 연령대에 맞는 예배의 형식과 방법론을 제공하고 있다. 교회학교 예배의 주제를 교회력에 근거하는 것은 예배의 주제를 설정하는 가장 좋은 방법이다. 비록 교회력을 철저히 지키기 어려운 교회학교 현실이 있겠지만, 그리스도를 중심으로 하는 주제로 예배하는 것이 교회학교에서도 필요하다. 예배의 본질은 예수 그리스도 사건에 대한 응답이기에, 교회학교 예배를 통해서도 예배의 본질이 구현되어야 된다. 필자는 예수 그리스도를 중심으로 드리는 교회학교 예배 공동체를 어떻게 구체적으로 구현해 갈 수 있는지를 본 논문을 통해서 구체적으로 제언한다. 첫째, 교회학교 구성원들이 함께 참여하는 예배를 드림으로 예배의 본질적 의미를 구현할 수 있다. 단순한 참여가 아니라, 준비부터 마지막 평가까지 함께 할 수 있는 유기적 예배 공동체의 구성이 요구된다. 둘째, 예배에 대한 교육이 있어야 된다. 예배와 성례가 가지고 있는 성서적, 신학적, 그리고 역사적 의미와 이를 구성하는 요소들에 대해서, 그리고 현대를 사는 우리들에게 예배가 갖는 실제적인 의미에 대해서 교회학교 구성원들에게 가르쳐줘야 된다. 셋째, 교회학교 연령대에 맞는 예배 공간과 상징들이 제공되어야 된다. 교회학교 예배 공동체의 구성원들에게 공간은 하나님의 거룩함을 체험하기에 매우 중요한 공간이다. 연령대에 맞는 공간구성은 절대적으로 필요하다. 넷째, 교회학교 연령대에 맞는 예문집이 필요하다. 유치부 어린아이들에게 성인의 용어로 예배를 드릴 수 없듯이, 동일 언어의 성례전도 집례될 수 없다. 교회학교를 위한 세례문과 성찬문이 개발되어야 된다. 비록 예배학의 영역에서 소외되어 있는 영역으로 볼 수 있는 교회학교 예배이지만, 앞으로는 더욱 관심을 가지고 연구해야 될 영역이다. 특별히 교회학교가 감소하고 있는 상황에서 교회학교 예배의 역동적 회복이 예배학적 고찰을 통해서도 가능하기를 기대한다.

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